Pesticidal arylpyrrolidines

ABSTRACT

The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): 
                         
wherein the respective substituents are defined in the specification.

The present invention relates to novel arylpyrrolidines and their use aspesticides in the agrocultural field or as pharmaceutical for treatingparasites in or on animals.

It is known that certain compounds containing a 5-membered heterocyclicring can be used as pesticides. Substituted benzamide compoundscontaining a 5-membered ring which is isoxazoline, and which compoundsare supposed to be useful for controlling noxious animal pests aredescribed in WO2005/085216. Compounds, wherein the 5-membered ring is apyrrolidine ring and which may be used as an agent for controllingnoxious bioorganisms are described in JP2008-110971A and WO2008/128711.

Modern crop protection compositions have to satisfy many demands, forexample in relation to efficacy, persistence and spectrum of theiraction, and possible use: Important questions relate to toxicity,combinability with other active ingredients or formulating assistants,and another is that of the effort and expense of synthesizing an activeingredient. Moreover, resistances can occur. For all these reasons, thesearch for novel crop protection compositions cannot be considered to becomplete, and there is a constant need for novel compounds with improvedproperties over the known compounds, at least in relation to individualaspects. Thus, the inventors of the present invention intensivelystudied to develop novel compounds which exhibit a high pesticidalefficacy and have a broad spectrum of use.

As a result, the inventors have found that novel arylpyrrolidinesrepresented by the following formula (I) have high pesticidal activity,a broad spectrum of use, safety, and also have an efficacy againstnoxious insects that are resistant to an organophosphorus agent or acarbamate agent.

Thus, this invention is directed to arylpyrrolidine compounds of formula(I)

wherein

R represents alkyl or haloalkyl;

Q represents one of the chemical groups represented by the formula (II)or (III)

wherein in formula (II) the carbon atom between A¹ and A⁴ is bound tothe nitrogen atom in formula (I) and wherein in formula (III) the carbonatom between the S atom and the N atom is bound to the nitrogen atom informula (I);

A¹, A², A³ and A⁴ each independently represents C—Y² or nitrogen, and ifA¹ and A² (or A³ and A⁴) stand for C—Y², then the substituents Y² maytogether with the carbon atoms to which they are bound form a 5- or6-membered saturated or unsaturated hydrocarbon ring or heterocyclicring;

B¹, B², B³ and B⁴ each independently represents C—X² or nitrogen, and ifeither B¹ and B², or B² and B³, or B³ and B⁴ stand for C—X², then thesubstituents X² may together with the carbon atoms to which they arebound form a 5- or 6-membered saturated or unsaturated hydrocarbon ringor heterocyclic ring;

X¹, X² each independently represents hydrogen, halogen, nitro, cyano,hydroxy, mercapto, amino, alkyl, haloalkyl, alkoxy, haloalkoxy,alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfanyl,haloalkylsulfinyl, haloalkylsulfonyl, acylamino, alkoxycarbonylamino,haloalkoxycarbonylamino, alkoxyimino, haloalkoxyimino,alkylsulfonylamino, or pentafluorosulfur;

Y¹, Y² each independently represents hydrogen, halogen, nitro, cyano,hydroxy, mercapto, amino, alkyl, haloalkyl, cycloalkyl, cyclohaloalkyl,alkenyl, alkynyl, alkoxy, haloalkoxy, alkylsulfanyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfanyl, haloalkylsulfinyl, haloalkylsulfonyl,alkylsulfonyloxy, haloalkylsulfonyloxy, alkylaminosulfonyl,haloalkylaminosulfonyl, dialkylaminosulfonyl,di(haloalkyl)aminosulfonyl, alkylamino, dialkylamino, acylamino,alkoxycarbonylamino, haloalkoxycarbonylamino, alkylsulfonylamino,haloalkylsulfonylamino, trialkylsilyl, alkoxyimino, haloalkoxyimino,alkoxyiminoalkyl, haloalkoxyiminoalkyl, alkylsulfinylimino,alkylsulfinyliminoalkyl, alkylsulfinyliminoalkylcarbonyl,alkylsulfoxyimino, alkylsulfoxyiminoalkyl, alkoxycarbonyl,alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, aminothiocarbonyl,alkylaminothiocarbonyl, dialkylaminocarbonyl, ordialkylaminothiocarbonyl;

G represents

l represents an integer of 1 to 3;

R¹ and R² each independently represents hydrogen, cyano, alkyl,haloalkyl, cycloalkyl, cyclohaloalkyl, alkenyl, alkynyl, haloalkenyl,haloalkynyl, alkoxycarbonyl, alkoxythiocarbonyl, alkylsulfonyl,haloalkylsulfonyl, aryl, aralkyl, a heterocyclic group, heterocyclicsubstituted alkyl, alkoxyalkyl, alkylsulfanylalkyl, alkylsulfinylalkyl,alkylsulfonylalkyl, alkyl-O—N═CH—, alkylaminocarbonylalkyl,haloalkylaminocarbonylalkyl or cycloalkylaminocarbonylalkyl, or

R¹ and R² may together with the nitrogen to which they are attached forma 3- to 7-membered heterocycle;

R³ and R⁴ each independently represents hydrogen, cyano, alkyl, alkenyl,alkynyl, cycloalkyl or alkoxycarbonyl, or

when A² or A³ is C—Y², then said Y² and R³, said Y² and R⁴ or said Y²,R³ and R⁴ together may form a 5- to 7-membered saturated or unsaturatedhydrocarbon ring or heterocyclic ring together with the carbon atoms towhich said Y² and R³, said Y² and R⁴ or said Y², R³ and R⁴ are bound andfurther with the carbon atom between the carbon atom to which Y² isbound and the carbon atom to which R³ and R⁴ are bound, or when A² or A³is C—Y² and 1 is 2, then the carbon atom bound to R⁶—N(R^(S))— may formcarbonyl together with R³ and R⁴, and the carbon atom bound to Q mayform a 5- to 7-membered saturated or unsaturated hydrocarbon ring orheterocyclic ring together with any one or both of R³ and R⁴ boundthereto and further with Y², wherein the ring may be substituted withalkyl, haloalkyl, alkoxy, haloalkoxy, alkylcarbonyl, alkoxycarbonyl orcarbonyl substituted with a 5- or 6-membered heterocyclic ring, and whenone or more of the carbon atoms of the ring are substituted with two ormore alkyls, any two of the alkyls may form cycloalkyl together with thecarbon atoms to which they are bound, or Y¹ may form a 5- to 7-memberedsaturated or unsaturated hydrocarbon ring or heterocyclic ring togetherwith any one or both of R³ and R⁴, with the carbon atoms to which saidY¹ and said R³ and R⁴ are bound and further with the carbon atom betweenthe carbon atom to which Y¹ is bound and the carbon atom to which R³ andR⁴ are bound, and when 1 is 2, then the carbon atom bound to R⁶—N(R⁵)—may form carbonyl together with R³ and R⁴, and the carbon atom bound toQ may form a 5- to 7-membered saturated or unsaturated hydrocarbon ringor heterocyclic ring together with any one or both of R³ and R⁴ boundthereto and further with Y¹, wherein the ring may be substituted withalkyl, haloalkyl, alkoxy, haloalkoxy, alkylcarbonyl, alkoxycarbonyl orcarbonyl substituted with a 5- or 6-membered heterocyclic ring, and whenone or more of the carbon atoms of the ring are substituted with two ormore alkyls, and any two of said alkyls may form cycloalkyl togetherwith the carbon atoms to which they are bound;

R⁵ represents hydrogen, amino, hydroxy, cyano, alkyl, haloalkyl,cycloalkyl, alkenyl, alkynyl, alkoxy, aminocarbonylalkyl, iminoalkyl,alkylcarbonyl, alkylcarbonylamino, alkylimino, aryl, aralkyl, aheterocycle, a heterocyclic ring substituted alkyl, R⁷—C(═O)— orR⁷—C(═S)—;

R⁶ represents hydrogen, cyano, carbonyl, thiocarbonyl, alkylcarbonyl,alkylthiocarbonyl, haloalkylcarbonyl, haloalkylthiocarbonyl,alkylaminocarbonyl, alkylaminothiocarbonyl, dialkylaminocarbonyl,dialkylaminothiocarbonyl, alkoxyaminocarbonyl, alkoxyaminothiocarbonyl,alkoxycarbonyl, alkoxythiocarbonyl, alkylsulfanylcarbonyl,alkylsulfanylthiocarbonyl, alkylsulfonyl, haloalkylsulfonyl,cycloalkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl,cycloalkylalkylcarbonyl, alkylsulfanylalkylcarbonyl,alkylsulfinylalkylcarbonyl, alkylsulfonylalkylcarbonyl,alkylcarbonylalkylcarbonyl, cycloalkylaminocarbonyl,alkenylaminocarbonyl, alkynylaminocarbonyl, alkylaminosulfonyl,dialkylaminosulfonyl, alkoxyalkylcarbonyl,alkylcarbonylaminoalkylcarbonyl, haloalkylcarbonylaminoalkylcarbonyl,alkylsulfanylalkylcarbonylaminoalkylcarbonyl,alkylsulfinylalkylcarbonylaminoalkylcarbonyl,alkylsulfonylalkylcarbonyl-aminoalkylcarbonyl, aralkylcarbonyl,heterocyclic substituted alkylcarbonyl, R⁷—C(═O)— or R⁷—C(═S)—, or

R⁵ and R⁶ may form a 3- to 6-membered heterocyclic ring, together withthe nitrogen atom to which they are bound, and said ring may besubstituted with keto, thioketo or a nitroimino group; and

R⁷ represents an optionally substituted phenyl or an optionallysubstituted heterocycle.

Compounds of formula (I) are preferred wherein

R represents C₁₋₆alkyl, or C₁₋₆haloalkyl; preferably represents C₁₋₄alkyl or C₁₋₄haloalkyl, more preferably represents trifluoromethyl;

Q stands for one of the chemical groups represented by formula (II) or(III) in which

A¹, A², A³ and A⁴ each independently represents C—Y² or nitrogen, and ifA¹ and A² (or A³ and A⁴) stand for C—Y², then the substituents Y² maytogether with the carbon atoms to which they are bound form a 5- or6-membered saturated or unsaturated hydrocarbon ring or heterocyclicring;

B¹, B², B³ and B⁴ each independently represents C—X² or nitrogen, and ifeither B¹ and B², or B² and B³, or B³ and B⁴ stand for C—X², then thesubstituents X² may together with the carbon atoms to which they arebound form a 5- or 6-membered saturated or unsaturated hydrocarbon ringor heterocyclic ring;

X¹, X² each independently represents hydrogen, halogen, nitro, cyano,hydroxy, mercapto, amino, C₁₋₆alkyl, C₁₋₆haloalkyl, C₁₋₆alkoxy,C₁₋₆haloalkoxy, C₁₋₆alkylsulfanyl, C₁₋₆alkylsulfinyl, C₁₋₆alkylsulfonyl,C₁₋₆haloalkylsulfanyl, C₁₋₆haloalkylsulfinyl, C₁₋₆haloalkylsulfonyl,(total carbon atom number) C₂₋₇acylamino, (total carbon atom number)C₂₋₇alkoxycarbonylamino, (total carbon atom number)C₂₋₇haloalkoxycarbonylamino, C₁₋₆alkoxyimino, C₁₋₆haloalkoxyimino,C₁₋₆alkylsulfonylamino or pentafluorosulfur; preferably representshydrogen, halogen, nitro, cyano, hydroxy, mercapto, amino, C₁₋₄alkyl,C₁₋₄haloalkyl, C₁₋₄alkoxy, C₁₋₄haloalkoxy, C₁₋₄alkylsulfanyl,C₁₋₄alkylsulfinyl, C₁₋₄alkylsulfonyl, C₁₋₄haloalkylsulfanyl,C₁₋₄haloalkylsulfinyl, C₁₋₄haloalkylsulfonyl, (total carbon atom number)C₂₋₅acylamino, (total carbon atom number) C₂₋₅alkoxycarbonylamino,(total carbon atom number) C₂₋₅haloalkoxycarbonylamino, C₁₋₄alkoxyimino,C₁₋₄haloalkoxyimino, C₁₋₄alkylsulfonylamino or pentafluorosulfur, morepreferably represents hydrogen, fluoro, chloro, bromo, trifluoromethyl;

Y¹, Y²′ each independently represents hydrogen, halogen, nitro, cyano,hydroxy, mercapto, amino, C₁₋₆alkyl, C₁₋₆haloalkyl, C₃₋₇cycloalkyl,C₃₋₇cyclohaloalkyl, C₂₋₆alkenyl, C₂₋₆alkynyl, C₁₋₆alkoxy,C₁₋₆haloalkoxy, C₁₋₆alkylsulfanyl, C₁₋₆alkylsulfinyl, C₁₋₆alkylsulfonyl,C₁₋₁₆haloalkylsulfanyl, C₁₋₆haloalkylsulfinyl, C₁₋₆haloalkylsulfonyl,C₁₋₆alkylsulfonyloxy, C₁₋₆haloalkylsulfonyloxy, C₁₋₆alkylaminosulfonyl,C₁₋₆haloalkylaminosulfonyl, (total carbon atom number)C₂₋₁₂dialkylaminosulfonyl, (total carbon atom number)C₂₋₁₂di(haloalkyl)aminosulfonyl, C₁₋₆alkylamino, (total carbon atomnumber) C₂₋₁₂dialkylamino, (total carbon atom number) C₂₋₇acylamino,(total carbon atom number) C₂₋₇alkoxycarbonylamino, (total carbon atomnumber) C₂₋₇haloalkoxycarbonylamino, C₁₋₆alkylsulfonylamino,C₁₋₆haloalkylsulfonylamino, (total carbon atom number)C₃₋₁₈trialkylsilyl, C₁₋₆alkoxyimino, C₁₋₆haloalkoxyimino, (total carbonatom number) C₂₋₁₂alkoxyiminoalkyl, (total carbon atom number)C₂₋₁₂haloalkoxyiminoalkyl, C₁₋₆alkylsulfinylimino, (total carbon atomnumber) C₂₋₁₂alkylsulfinyliminoalkyl, (total carbon atom number)C₃₋₁₃alkylsulfinyliminoalkylcarbonyl, C₁₋₆alkylsulfoxyimino, (totalcarbon atom number) C₂₋₁₂alkylsulfoxyiminoalkyl, (total carbon atomnumber) C₂₋₇alkoxycarbonyl, (total carbon atom number)C₂₋₇alkylcarbonyl, aminocarbonyl, (total carbon atom number)C₂₋₇alkylaminocarbonyl, aminothiocarbonyl, (total carbon atom number)C₂₋₇alkylaminothiocarbonyl, (total carbon atom number)C₃₋₁₃dialkylaminocarbonyl or (total carbon atom number)C₃₋₁₃dialkylaminothiocarbonyl, preferably represents hydrogen, halogen,nitro, cyano, hydroxy, mercapto, amino, C₁₋₄alkyl, C₁₋₄haloalkyl,C₃₋₆cycloalkyl, C₃₋₆cyclohaloalkyl, C₂₋₄alkenyl, C₂₋₄alkynyl,C₁₋₄alkoxy, C₁₋₄haloalkoxy, C₁₋₄alkylsulfanyl, C₁₋₄alkylsulfinyl,C₁₋₄alkylsulfonyl, C₁₋₄haloalkylsulfanyl, C₁₋₄haloalkylsulfinyl,C₁₋₄haloalkylsulfonyl, C₁₋₄alkylsulfonyloxy, C₁₋₄haloalkylsulfonyloxy,C₁₋₄alkylaminosulfonyl, C₁₋₄haloalkylaminosulfonyl, (total carbon atomnumber) C₂₋₈dialkylaminosulfonyl, (total carbon atom number) C₂₋₈di(haloalkyl)aminosulfonyl, C₁₋₄alkylamino, (total carbon atom number)C₂₋₈dialkylamino, (total carbon atom number) C₂₋₅acylamino, (totalcarbon atom number) C₂₋₅alkoxycarbonylamino, (total carbon atom number)C₂₋₅haloalkoxycarbonylamino, C₁₋₄alkylsulfonylamino,C₁₋₄haloalkylsulfonylamino, (total carbon atom number)C₃₋₁₂-trialkylsilyl, C₁₋₄alkoxyimino, C₁₋₄haloalkoxyimino, (total carbonatom number) C₂₋₈alkoxyiminoalkyl, (total carbon atom number)C₂₋₈haloalkoxyiminoalkyl, (total carbon atom number)C₁₋₄alkylsulfinylimino, (total carbon atom number)C₂₋₈alkylsulfinyliminoalkyl, (total carbon atom number)C₃₋₉alkylsulfinyliminoalkylcarbonyl, C₁₋₄alkylsulfoxyimino, (totalcarbon atom number) C₂₋₈alkylsulfoxyiminoalkyl, (total carbon atomnumber) C₂₋₅alkoxycarbonyl, (total carbon atom number)C₂₋₅alkylcarbonyl, aminocarbonyl, (total carbon atom number)C₂₋₅alkylaminocarbonyl, aminothiocarbonyl, (total carbon atom number)C₂₋₅alkylaminothiocarbonyl, (total carbon atom number)C₃₋₁₁dialkylaminocarbonyl or (total carbon atom number)C₃₋₉dialkylaminothiocarbonyl, more preferably represents hydrogen,halogen, methyl, or trifluoromethyl;

G represents

l represents 1 or 2, preferably 1;

R¹ and R² each independently represents hydrogen, cyano, C₁₋₆alkyl,C₁₋₆haloalkyl, C₃₋₇cycloalkyl, C₃₋₇cyclohaloalkyl, C₂₋₆alkenyl,C₂₋₆alkynyl, C₂₋₆haloalkenyl, C₂₋₆haloalkynyl, (total carbon atomnumber) C₂₋₇alkoxycarbonyl, (total carbon atom number)C₂₋₇alkoxythiocarbonyl, C₁₋₆alkylsulfonyl, C₁₋₆haloalkylsulfonyl,phenyl, 4-chlorophenyl, 4-bromophenyl, 4-cyanophenyl, 1-naphthyl,2-naphthyl, benzyl, 2-fluorobenzyl, 4-fluorobenzyl, 4-chlorobenzyl,4-bromobenzyl, 1-naphthylmethyl, 2-naphthylmethyl, 1,3-thiazol-2-yl,pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 2-chloropyridin-3-yl,2-chloropyridin-5-yl, pyrimidin-2-yl, pyrimidin-4-yl,5-chloropyrimidin-2-yl, 5-bromopyrimidin-2-yl, 5-cyanopyrimidin-2-yl,quinolin-3-yl, quinolin-6-yl, (1-methyl-1H-pyrazol-4-yl)methyl,(1,3-thiazol-4-yl)methyl, (2-chloro-1,3-thiazol-4-yl)methyl,pyridin-2-ylmethyl, pyridin-3-ylmethyl, pyridin-4-ylmethyl,(6-chloropyridin-3-yl)methyl, pyrimidin-2-ylmethyl, pyridine-2-ylethyl,1-(pyridin-2-yl)ethyl], (total carbon atom number) C₂₋₁₂alkoxyalkyl,(total carbon atom number) C₂₋₁₂alkylsulfanylalkyl, (total carbon atomnumber) C₂₋₁₂ alkylsulfinylalkyl, (total carbon atom number)C₂₋₁₂alkylsulfonylalkyl, (total carbon atom number) C₂₋₇alkyl-O—N═CH—,(total carbon atom number) C₃₋₁₃alkylaminocarbonylalkyl, (total carbonatom number) C₃₋₁₃haloalkylaminocarbonylalkyl or (total carbon atomnumber) C₅₋₁₄cycloalkylaminocarbonylalkyl, preferably representshydrogen, cyano, C₁₋₄alkyl, C₁₋₄haloalkyl, C₃₋₆cycloalkyl,C₃₋₆cyclohaloalkyl, C₂₋₄alkenyl, C₂₋₄alkynyl, C₂₋₄haloalkenyl,C₂₋₄haloalkynyl, (total carbon atom number) C₂₋₅alkoxycarbonyl, (totalcarbon atom number) C₂₋₅ alkoxythiocarbonyl, C₁₋₄alkylsulfonyl,C₁₋₄haloalkylsulfonyl, C₆₋₁₂ aryl, (total carbon atom number) benzyl,2-fluorobenzyl, 4-fluorobenzyl, 4-chlorobenzyl, 4-bromobenzyl,2-chloropyridin-5-yl, pyrimidin-2-yl, 5-chloropyrimidin-2-yl,5-bromopyrimidin-2-yl, 5-cyanopyrimidin-2-yl,(1-methyl-1H-pyrazol-4-yl)methyl, (1,3-thiazol-4-yl)methyl,pyridin-2-ylmethyl, pyrimidin-2-ylmethyl, 1-(pyridin-2-yl)ethyl, (totalcarbon atom number) C₂₋₈ alkoxyalkyl, (total carbon atom number)C₂₋₈alkylsulfanylalkyl, (total carbon atom number) C₂₋₈alkylsulfinylalkyl, (total carbon atom number) C₂₋₈alkylsulfonylalkyl,(total carbon atom number) C₂₋₅alkyl-O—N═CH—, (total carbon atom number)C₃₋₉alkylaminocarbonylalkyl, (total carbon atom number)C₃₋₉haloalkylaminocarbonylalkyl or (total carbon atom number) C₅₋₁₁cycloalkylaminocarbonylalk, more preferably represents C₁₋₂haloalkylparticularly 2,2,2-trifluoroethyl, heterocyclic substituted alkyl,particularly pyridin-2-ylmethyl and pyrimidin-2-ylmethyl), C₁₋₂haloalkylaminocarbonylmethyl, particularly2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl and2-oxo-2-[(2-chloroethyl)amino]ethyl;

R¹ and R² may together with the nitrogen to which they are attached forma 3- to 7-membered heterocycle;

R³ and R⁴ each independently represents hydrogen, cyano, C₁₋₆alkyl,C₂₋₆alkenyl, C₂₋₆alkynyl, C₃₋₇cycloalkyl or (total carbon atom number)C₂₋₇alkoxycarbonyl, preferably represents hydrogen, cyano, C₁₋₄alkyl,C₂₋₄alkenyl, C₂₋₄alkynyl, C₃₋₆cycloalkyl or (total carbon atom number)C₂₋₅ alkoxycarbonyl, more preferably represents hydrogen;

when A² or A³ is C—Y², then said Y² and R³, said Y² and R⁴, or said Y²,R³ and R⁴ together may form a 5- to 7-membered saturated or unsaturatedhydrocarbon ring or heterocyclic ring together with the carbon atoms towhich said Y² and R³, said Y² and R⁴, or said Y², R³ and R⁴ are boundand further with the carbon atom between the carbon atom to which Y² isbound and the carbon atom to which R³ and R⁴ are bound, or when A² or A³is C—Y² and l is 2, then the carbon atom bound to R⁶—N(R⁵)— may formcarbonyl together with R³ and R⁴, and the carbon atom bound to

Q may form a 5- to 7-membered saturated or unsaturated hydrocarbon ringor heterocyclic ring together with any one or both of R³ and R⁴ boundthereto and further with Y², wherein the ring may be substituted withC₁₋₆alkyl, C₁₋₆haloalkyl, C₁₋₆alkoxy, C₁₋₆haloalkoxy, (total carbon atomnumber) C₂₋₇alkylcarbonyl, (total carbon atom number)C₂₋₇alkoxycarbonyl, preferably with C₁₋₄ alkyl, C₁₋₄haloalkyl,C₁₋₄alkoxy, C₁₋₄haloalkoxy, (total carbon atom number)C₂₋₅alkylcarbonyl, (total carbon atom number) C₂₋₅alkoxycarbonyl, orcarbonyl substituted with a 5- or 6-membered heterocyclic ring, and whenone or more of the carbon atoms of the ring are substituted with two ormore alkyls, any two of the alkyls may form C₃₋₇ cycloalkyl, preferablyC₃₋₆cycloalkyl together with the carbon atoms to which they are bound,or Y¹ may form a 5- to 7-membered saturated or unsaturated hydrocarbonring or heterocyclic ring together with any one or both of R³ and R⁴,with the carbon atoms to which said Y¹ and said R³ and R⁴ are bound andfurther with the carbon atom between the carbon atom to which Y¹ isbound and the carbon atom to which R³ and R⁴ are bound, and when l is 2,then the carbon atom bound to R⁶—N(R⁵)— may form carbonyl together withR³ and R⁴, and the carbon atom bound to Q may form a 5- to 7-memberedsaturated or unsaturated hydrocarbon ring or heterocyclic ring togetherwith any one or both of R³ and R⁴ bound thereto and further with Y¹,wherein the ring may be substituted with C₁₋₆alkyl, C₁₋₆haloalkyl,C₁₋₆alkoxy, C₁₋₆ haloalkoxy, (total carbon atom number)C₂₋₇alkylcarbonyl, (total carbon atom number) C₂₋₇ alkoxycarbonyl,preferably with C₁₋₄alkyl, C₁₋₄haloalkyl, C₁₋₄alkoxy, C₁₋₄haloalkoxy,(total carbon atom number) C₂₋₅ alkylcarbonyl, (total carbon atomnumber) C₂₋₅alkoxycarbonyl or carbonyl substituted with a 5- or6-membered heterocyclic ring, and when one or more of the carbon atomsof the ring are substituted with two or more alkyls, and any two of saidalkyls may form C₃₋₇cycloalkyl, preferably C₃₋₆cycloalkyl together withthe carbon atoms to which they are bound;

R⁵ represents hydrogen, amino, hydroxy, cyano, C₁₋₆alkyl, C₁₋₆haloalkyl,C₃₋₇cycloalkyl, C₂₋₆alkenyl, C₂₋₆alkynyl, C₁₋₆alkoxy, (total carbon atomnumber) C₂₋₇aminocarbonylalkyl, C₁₋₆iminoalkyl, (total carbon atomnumber) C₂₋₇alkylcarbonyl, (total carbon atom number)C₂₋₇alkylcarbonylamino, (total carbon atom number) C₂₋₇alkylimino,(total carbon atom number) C₆₋₁₂aryl, (total carbon atom number)C₇₋₁₆aralkyl, a heterocyclic group, heterocyclic ring substituted alkyl,R⁷—C(═O)— or R⁷—C(═S)—, preferably represents hydrogen, amino, hydroxy,cyano, C₁₋₄alkyl, C₁₋₄haloalkyl, C₃₋₆cycloalkyl, C₂₋₄alkenyl,C₂₋₄alkynyl, C₁₋₄alkoxy, (total carbon atom number)C₂₋₅aminocarbonylalkyl, C₁₋₄iminoalkyl, (total carbon atom number)C₂₋₅alkylcarbonyl, (total carbon atom number) C₂₋₅alkylcarbonylamino,(total carbon atom number) C₂₋₅alkylimino, (total carbon atom number)C₆₋₁₂aryl, (total carbon atom number) C₇₋₁₀aralkyl, a heterocyclicgroup, heterocyclic ring substituted alkyl, R⁷—C(═O)— or R⁷—C(═S)—, morepreferably represents hydrogen or methyl;

R⁶ represents hydrogen, cyano, carbonyl, thiocarbonyl, (total carbonatom number) C₂₋₇alkylcarbonyl, (total carbon atom number)C₂₋₇alkylthiocarbonyl, (total carbon atom number) C₂₋₇haloalkylcarbonyl,(total carbon atom number) C₂₋₇haloalkylthiocarbonyl, (total carbon atomnumber) C₂₋₇alkylaminocarbonyl, (total carbon atom number)C₂₋₇alkylaminothiocarbonyl, (total carbon atom number)C₃₋₁₃dialkylaminocarbonyl, (total carbon atom number)C₃₋₁₃dialkylaminothiocarbonyl, (total carbon atom number)C₂₋₇alkoxyaminocarbonyl, (total carbon atom number)C₂₋₇alkoxyaminothiocarbonyl, (total carbon atom number)C₂₋₇alkoxycarbonyl, (total carbon atom number) C₂₋₇alkoxythiocarbonyl,(total carbon atom number) C₂₋₇alkylsulfanylcarbonyl, (total carbon atomnumber) C₂₋₇alkylsulfanylthiocarbonyl, C₁₋₆alkylsulfonyl,C₁₋₆haloalkylsulfonyl, (total carbon atom number)C₄₋₈cycloalkylcarbonyl, (total carbon atom number) C₃₋₇alkenylcarbonyl,(total carbon atom number) C₃₋₇alkynylcarbonyl, (total carbon atomnumber) C₅₋₁₄cycloalkylalkylcarbonyl, (total carbon atom number)C₃₋₁₃alkylsulfanylalkylcarbonyl, (total carbon atom number)C₃₋₁₃alkylsulfinylalkylcarbonyl, (total carbon atom number)C₃₋₁₃alkylsulfonylalkylcarbonyl, (total carbon atom number)C₄₋₁₄alkylcarbonylalkylcarbonyl, (total carbon atom number)C₄₋₈cycloalkylaminocarbonyl, (total carbon atom number)C₃₋₇alkenylaminocarbonyl, (total carbon atom number)C₃₋₇alkynylaminocarbonyl, C₁₋₆alkylaminosulfonyl, (total carbon atomnumber) C₂₋₁₂dialkylaminosulfonyl, (total carbon atom number)C₃₋₁₃alkoxyalkylcarbonyl, (total carbon atom number)C₄₋₁₄alkylcarbonylaminoalkylcarbonyl, (total carbon atom number)C₄₋₁₄haloalkylcarbonylaminoalkylcarbonyl, (total carbon atom number)C₅₋₂₀alkylsulfanylalkylcarbonylaminoalkylcarbonyl, (total carbon atomnumber) C₅₋₂₀alkylsulfinylalkylcarbonylaminoalkylcarbonyl, (total carbonatom number) C₅₋₂₀alkylsulfonylalkylcarbonylaminoalkylcarbonyl, (totalcarbon atom number) C₈₋₁₇aralkylcarbonyl, heterocyclic substituted(total carbon atom number) C₂₋₇alkylcarbonyl, R⁷—C(═O)— or R⁷—C(═S)—,preferably represents hydrogen, cyano, carbonyl, thiocarbonyl, (totalcarbon atom number) C₂₋₅alkylcarbonyl, (total carbon atom number)C₂₋₅alkylthiocarbonyl, (total carbon atom number) C₂₋₅haloalkylcarbonyl,(total carbon atom number) C₂₋₅haloalkylthiocarbonyl, (total carbon atomnumber) C₂₋₅alkylaminocarbonyl, (total carbon atom number)C₂₋₅alkylaminothiocarbonyl, (total carbon atom number)C₃₋₉dialkylaminocarbonyl, (total carbon atom number)C₃₋₉dialkylaminothiocarbonyl, (total carbon atom number)C₂₋₅alkoxyaminocarbonyl, (total carbon atom number)C₂₋₅alkoxyaminothiocarbonyl, (total carbon atom number)C₂₋₅alkoxycarbonyl, (total carbon atom number) C₂₋₅alkoxythiocarbonyl,(total carbon atom number) C₂₋₅alkylsulfanylcarbonyl, (total carbon atomnumber) C₂₋₅alkylsulfanylthiocarbonyl, C₁₋₄alkylsulfonyl,C₁₋₄haloalkylsulfonyl, (total carbon atom number)C₄₋₇cycloalkylcarbonyl, (total carbon atom number) C₃₋₅alkenylcarbonyl,(total carbon atom number) C₃₋₅alkynylcarbonyl, (total carbon atomnumber) C₅₋₁₁cycloalkylalkylcarbonyl, (total carbon atom number)C₃₋₁₃alkylsulfanylalkylcarbonyl, (total carbon atom number)C₃₋₉alkylsulfinylalkylcarbonyl, (total carbon atom number)C₃₋₉alkylsulfonylalkylcarbonyl, (total carbon atom number)C₄₋₁₀alkylcarbonylalkylcarbonyl, (total carbon atom number)C₄₋₇cycloalkylaminocarbonyl, (total carbon atom number)C₃₋₅alkenylaminocarbonyl, (total carbon atom number)C₃₋₅alkynylaminocarbonyl, C₁₋₄alkylaminosulfonyl, (total carbon atomnumber) C₂₋₈dialkylaminosulfonyl, (total carbon atom number)C₃₋₉alkoxyalkylcarbonyl, (total carbon atom number)C₄₋₁₀alkylcarbonylaminoalkylcarbonyl, (total carbon atom number)C₄₋₁₀haloalkylcarbonylaminoalkylcarbonyl, (total carbon atom number)C₅₋₁₄alkylsulfanylalkylcarbonylaminoalkylcarbonyl, (total carbon atomnumber) C₅₋₁₄alkylsulfinylalkylcarbonylaminoalkylcarbonyl, (total carbonatom number) C₅₋₁₄alkylsulfonylalkylcarbonylaminoalkylcarbonyl, (totalcarbon atom number) C₈₋₁₁aralkylcarbonyl, heterocyclic substituted(total carbon atom number) C₂₋₅alkylcarbonyl, R⁷—C(═O)— or R⁷—C(═S)—,more preferably represents C₂₋₅alkylcarbonyl particularly acetyl,propionyl, n-propylcarbonyl, iso-propylcarbonyl, n-butylcarbonyl, (totalcarbon atom number) C₂₋₃haloalkylcarbonyl particularly difluoroacetyl,3,3,3-trifluoropropanoyl, (total carbon atom number)C₂₋₃alkylaminocarbonyl particularly ethylcarbamoyl and propylcarbamoyl,(total carbon atom number) C₄₋₅cycloalkylcarbonyl particularlycyclopropylcarbonyl and cyclobutylcarbonyl,C₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl particularly cyclopropylacetyl, (totalcarbon atom number) C₄₋₇ cycloalkylaminocarbonyl particularlycyclopropylcarbamoyl, cyclobutylcarbamoyl andC₁₋₄alkoxy(C₁₋₄)alkylcarbonyl(3-methoxypropanoyl,C₁₋₂alkyl-S(C₁₋₂)alkylcarbonyl, C₁₋₂alkyl-SO(C₁₋₂)alkylcarbonyl,C₁₋₂alkyl-SO₂(C₁₋₂)alkylcarbonyl;

R⁵ and R⁶ may form a 3- to 6-membered heterocyclic ring, together withthe nitrogen atom to which they are bound, and said ring may besubstituted with keto, thioketo or a nitroimino group; and

R⁷ represents phenyl, or a saturated or unsaturated heterocyclic ring;

Moreover, the invention is directed to a pesticide comprising as anactive ingredient a compound according to the invention.

Additionally, the invention is directed to an animalparasite-controlling agent comprising as an active ingredient a compoundaccording to the invention.

In another aspect, the invention is directed to compounds which areuseful intermediates in the preparation of compounds according to theinvention and which are represented by the following formula (XXIV)

wherein

X¹, R, A¹ to A⁴ and B¹ to B⁴ have the same meaning as defined herein,and wherein T⁴ is selected among cyano, amino or nitro, and thefollowing chemical groups —C(O)OR⁸, —C(O)L², —(CR³R⁴)_(l)-L³,—(CR³R⁴)_(l)—NHR⁵). Wherein 1, R³, R⁴ and R⁵ have the same meaning asdefined herein;

R⁸ stands for hydrogen or C₁₋₄ alkyl;

L² represents chloro, bromo, (total carbon number) C₂₋₅alkylcarbonyloxy,(total carbon number) C₂₋₅alkoxycarbonyloxy or azolyl; and

L³ represents chloro, bromo, iodo, C₁₋₄alkylsulfonyloxy,C₁₋₄haloalkylsulfonyloxy, arylsulfonyloxy or azolyl.

Additionally, the invention is directed to a preparation method (a) forthe preparation of compounds of formula (I) which comprises

reacting a compound represented by formula (IV):

wherein X¹, R and B¹ to B⁴ have the same meaning as defined herein,

with a compound represented by formula (V-I)

wherein A¹ to A⁴, G and Y have the same meaning as defined above, and L¹stands for halogen or a C₁-C₄ haloalkylsulfonyloxy group,

or with a compound represented by formula (V-II):

wherein G, Y¹ and L¹ have the same meaning as defined herein, preferablyin the presence of a base and, if necessary, in the presence of a metalcatalyst.

And to a preparation method (b) for the preparation of compounds offormula (I) wherein G stands for —CONR¹R² which method comprises

reacting an amin represented by formula (VIII):

wherein R¹ and R² are as defined herein,

with a compound represented by formula (VI-I), (VI-II), (VII-I), or(VII-II)

wherein X¹, R, A¹ to A⁴ and B¹ to B⁴ have the same meaning as definedherein,

wherein X¹, Y¹, R and B¹ to B⁴ have the same meaning as defined herein,

wherein X¹, R, A¹ to A⁴ and B¹ to B⁴ have the same meaning as definedherein, and L² represents chloro, bromo, (total carbon number)C₂₋₅alkylcarbonyloxy, (total carbon number) C₂₋₅alkoxycarbonyloxy orazolyl,

wherein X¹, Y¹, R, B¹ to B⁴ and L² have the same meaning as definedabove,

in the presence of a condensation agent, and preferably in the presenceof a suitable base.

And to a preparation method (c) for the preparation of compounds offormula (I) wherein G stands for —CONR¹R² and which method comprises

reacting a compound represented by formula (Ib-I) or (Ib-II):

wherein X¹, R, R¹, A¹ to A⁴ and B¹ to B⁴ have the same meaning asdefined above,

wherein X¹, Y¹, R, R¹ and B¹ to B⁴ have the same meaning as definedherein,

with a compound R²-L³ (IX) wherein R² has the same meaning as definedherein, and L³ represents chloro, bromo, iodo, C₁₋₄alkylsulfonyloxy,C₁₋₄haloalkylsulfonyloxy, arylsulfonyloxy or azolyl, preferably, in thepresence of a base.

And to a preparation method (d) for the preparation of compounds offormula (I) wherein G stands for —CSNR¹R², which method comprises

reacting a compound represented by formula (Ia-I), or (Ia-II)

wherein X¹, R, R¹, R², A¹ to A⁴ and B¹ to B⁴ have the same meaning asdefined herein,

wherein X¹, Y¹, R, R¹, R² and B¹ to B⁴ have the same meaning as definedherein,

with a sulfurizing agent.

And to a preparation method (e) for the preparation of compounds offormula (I) wherein G stands for

which method comprises

reacting a compound represented by formula (X-I), or (X-II)

wherein X¹, R, R³, R⁴, A¹ to A⁴, B¹ to B⁴, l and L³ have the samemeaning as defined herein,

wherein X¹, Y¹, R, R³, R⁴, B¹ to B⁴, l and L³ have the same meaning asdefined herein,

with a compound represented by formula (XI)

wherein R⁵ and R⁶ have the same meaning as defined herein, preferably inthe presence of a base.

And to a preparation method (f) for the preparation of compounds offormula (I) wherein G stands for

which method comprises reacting a compound represented by formula(XII-I), or (XII-II):

wherein X¹, R, R³, R⁴, R⁵, A¹ to A⁴, l and B¹ to B⁴ have the samemeaning as defined herein,

wherein X¹, Y¹, R, R³, R⁴, R⁵, l and B¹ to B⁴ have the same meaning asdefined herein,

with a compound R⁶-L⁴ (XIII)

wherein R⁶ has the same meaning as defined above, and wherein L⁴represents fluoro, chloro, bromo, a C₁₋₄alkyl-carbonyloxy group, aC₁₋₄alkoxy-carbonyloxy group, an azolyl group, a C₁₋₄ alkylsulfonyloxygroup, a C₁₋₄haloalkylsulfonyloxy group, or an arylsulfonyloxy group),preferably in the presence of a base.

And to a preparation method (g) for the preparation of compounds offormula (I) wherein G stands for

which method comprises reacting a compound represented by formula (Ic-I)or (Ic-II):

wherein X¹, R, R³, R⁴, R⁶, A¹ to A⁴, l and B¹ to B⁴ have the samemeaning as defined herein,

wherein X¹, Y¹, R, R³, R⁴, R⁶, l and B′ to B⁴ have the same meaning asdefined herein,

with a compound R⁵-L⁴ (XIV), wherein R⁵ and L⁴ have the same meaning asdefined herein, preferably in the presence of a base.

According to the present invention, the arylpyrrolidines represented byformula (I) of the present invention have a very strong pesticidalefficacy.

In the present specification, the term “alkyl” indicates linear orbranched C₁₋₁₂ alkyl, for example, methyl, ethyl, n- or iso-propyl, n-,iso-, sec- or tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl,n-decyl, n-undecyl, n-dodecyl and the like, preferably C₁₋₆alkyl, andmore preferably C₁₋₄ alkyl.

In addition, for an alkyl moiety that is comprised in other groups as apart of their constitution, those described in the above for the “alkyl”can be exemplified.

The term “haloalkyl” indicates a carbon chain in which at least onehydrogen on linear or branched C₁₋₁₂ alkyl, preferably C₁₋₆alkyl, andmore preferably C₁₋₄alkyl is substituted with a halogen(s), for example,CH₂F, CHF₂, CF₃, CF₂Cl, CFCl₂, CF₂Br, CF₂CF₃, CFHCF₃, CH₂CF₃, CFClCF₃,CCl₂CF₃, CF₂CH₃, CF₂CH₂F, CF₂CHF₂, CF₂CF₂Cl, CF₂CF₂Br, CFHCH₃, CFHCHF₂,CFHCHF₂, CHFCF₃, CHFCF₂Cl, CHFCF₂Br, CFClCF₃, CCl₂CF₃, CF₂CF₂CF₃,CH₂CF₂CF₃, CF₂CH₂CF₃, CF₂CF₂CH₃, CHFC₂CF₃, CF₂CHFCF₃, CF₂CF₂CHF₂,CF₂CF₂CH₂F, CF₂CF₂CF₂Cl, and CF₂CF₂CF₂Br. The haloalkyl many be furthersubstituted.

The term “alkoxy” indicates linear or branched C₁₋₁₂, preferably C₁₋₆,and more preferably C₁₋₄ alkoxy, for example, methoxy, ethoxy,n-propoxy, i-propoxy, n-, iso-, sec- or tert-butoxy, pentyloxy, orhexyloxy. The alkoxy may be further substituted.

The term “acylamino” for example indicates alkylcarbonylamino,cyclopropylcarbonylamino and benzoylamino. In addition, for an alkylmoiety that is comprised in these groups as a part of theirconstitution, those described in the above for the “alkyl” can beexemplified.

The term “halogen” and the halogen moiety that is comprised inhalogen-substituted groups represent fluoro, chloro, bromo, or iodo, andpreferably fluoro, chloro, or bromo.

The term “cycloalkyl” indicates C₃₋₈cycloalkyl of cyclopropyl,cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl,preferably C₃₋₇ cycloalkyl, and more preferably C₃₋₆ cycloalkyl.

The term “alkenyl” indicates C₂₋₆alkenyl, preferably C₂₋₅ alkenyl, suchas vinyl, allyl, 1-propenyl, 1-(or 2-, or 3-) butenyl, 1-pentenyl, andthe like, and more preferably C₂₋₄ alkenyl.

The term “alkynyl” indicates C₂₋₆alkynyl, preferably C₂₋₅alkynyl such asethynyl, propargyl, 1-propynyl, butan-3-ynyl, pentan-4-ynyl, and thelike, and more preferably C₂₋₄ alkynyl.

The term “aryl” indicates a C₆-C₁₂ aromatic hydrocarbon group, forexample, phenyl, naphthyl, and biphenyl, and preferably a C₆₋₁₀ aromatichydrocarbon group, and more preferably phenyl.

The term “aralkyl” indicates arylalkyl, for example, benzyl andphenethyl.

The term “heterocyclic ring” represents a 5- or 6-membered heterocyclicring wherein at least one heteroatom selected from the group consistingof N, O and S is comprised and also the ring represents a fusedheterocyclic ring that can be benzo-fused.

Specific examples of the heterocyclic ring may include furyl, thienyl,pyrrolyl, isoxazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl,triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridyl, pyrimidinyl,pyridazinyl, pyrazinyl, triazinyl, indolyl, benzoxazolyl, quinolyl andthe like.

All chemical groups, particularly the groups amino, alkyl, haloalkyl,cycloalkyl, cyclohaloalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy,alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, haloalkylsulfanyl,haloalkylsulfinyl, haloalkylsulfonyl, alkylsulfonyloxy,haloalkylsulfonyloxy, alkylaminosulfonyl, haloalkylaminosulfonyl,dialkylaminosulfonyl, di(haloalkyl)aminosulfonyl, alkylamino,dialkylamino, acylamino, alkoxycarbonylamino, haloalkoxycarbonylamino,alkylsulfonylamino, haloalkylsulfonylamino, trialkylsilyl, alkoxyimino,haloalkoxyimino, alkoxyiminoalkyl, haloalkoxyiminoalkyl,alkylsulfinylimino, alkylsulfinyliminoalkyl,alkylsulfinyliminoalkylcarbonyl, alkylsulfoxyimino,alkylsulfoxyiminoalkyl, alkoxycarbonyl, alkylcarbonyl, aminocarbonyl,alkylaminocarbonyl, aminothiocarbonyl, alkylaminothiocarbonyl,dialkylaminocarbonyl, or dialkylaminothiocarbonyl, may be substituted byat least one substitutent which may be selected among amino, hydroxy,halogen, nitro, cyano, isocyano, mercapto, isothiocyanate, carboxy,carboamide, SF₅, aminosulfonyl, alkyl, cycloalkyl, alkenyl,cycloalkenyl, alkynyl, monoalkylamino, dialkylamino,N-alkylcarbonyl-amino, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy,cycloalkenyloxy, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl,aryloxycarbonyl, alkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl,arylcarbonyl, alkylthio, cycloalkylthio, alkenylthio, cycloalkenylthio,alkynylthio, alkylsulfanyl, alkylsulfinyl, alkylsulfinyl including theirisomers, alkylsulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl,alkylphosphinyl, alkylphosphonyl, alkylphosphinyl including theirisomers, alkylphosphonyl including their isomers, N-alkyl-aminocarbonyl,N,N-dialkyl-aminocarbonyl, N-alkyl-carbonyl-aminocarbonyl,N-alkylcarbonyl-N-alkylaminocarbonyl, aryl, aryloxy, benzyl, benzyloxy,benzylthio, arylthio, arylamino, benzylamino, heterocyclic ring,trialkylsilyl, alkoxyalkyl, alkylthioalkyl, alkylthioalkoxy,alkoxyalkoxy, phenethyl, benzyloxy, haloalkyl, haloalkoxy,haloalkylthio, haloalkylcarbonyl, haloalkoxycarbonyl, haloalkoxyalkoxy,haloalkoxyalkylthio, haloalkoxyalkylcarbonyl and haloalkoxyalkyl,preferably, chloro, fluoro, bromo, iodo, amino, nitro, cyano, hydroxy,thio and carboxy.

The expression, “Y², R³ and R⁴ together” in the expression, “said Y² andR³, said Y² and R⁴ or said Y², R³ and R⁴ together may form a 5- to7-membered saturated or unsaturated hydrocarbon ring or heterocyclicring together with the carbon atoms to which said Y² and R³, said Y² andR⁴ or said Y², R³ and R⁴ are bound and further with the carbon atombetween the carbon atom to which Y² is bound and the carbon atom towhich R³ and R⁴ are bound” which is specified when A² or A³ is C—Y²indicates that, for example, R³ and R⁴ together form an alkenylenegroup, and further form an unsaturated hydrocarbon ring (e.g., phenyl,cyclopentenyl or cyclohexenyl) together with Y². In addition, theexpression, “both of R³ and R⁴” in the expression, “the carbon atombound to R⁶—N(R⁵)— may form carbonyl together with R³ and R⁴, and thecarbon atom bound to Q may form a 5- to 7-membered saturated orunsaturated hydrocarbon ring or heterocyclic ring together with any oneor both of R³ and R⁴ bound thereto and further with Y²” which isspecified when 1 is 2 also indicates that, for example, R³ and R⁴together form an alkenylene group, and further form an unsaturatedhydrocarbon ring (e.g., phenyl, cyclopentenyl, cyclohexenyl) togetherwith the carbon atom bound to Q and Y².

The same is applied to the case where Y¹ forms a ring together with bothof R³ and R⁴.

The phrase “(total carbon atom number)”, which is used in relation to agroup with any substituent, indicates the number of carbon atom includedin the whole group without such substituent.

In an aspect of the invention compounds of formula (A) or (B) arepreferred

wherein B¹, B³, B⁴, X¹, A¹ to A⁴ and R² to R⁶ are as defined herein.

Among the compounds of formula (A), compounds having the followingstructures (A-I) to (A-III) are particularly preferred

and wherein X¹, R³, R⁴, R⁵ and R⁶ are as defined herein, each X²⁻¹,X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X², and wherein each Y²⁻¹,Y²⁻³ and Y²⁻⁴ are as defined herein for Y².

Among the compounds of formula (B), compounds having the followingstructures (B-I) to (B-III) are particularly preferred

and wherein X¹, R³, R⁴, R⁵ and R⁶ are as defined herein, each X²⁻¹,X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X², and wherein each Y²⁻¹,Y²⁻³ and Y²⁻⁴ are as defined herein for Y².

In another aspect of the invention compounds of formula (C-I) to (C-IV)are preferred having the following formula

and wherein the chemical groups X¹ is defined as for X¹, X²⁻¹, X²⁻²,X²⁻³, X²⁻⁴ are as defined for X² and Y²⁻¹, Y²⁻³ and Y²⁻⁴ are as definedfor Y², and R³, R⁴ are as defined herein, whereas R⁵⁻¹ is defined as forR⁵ and R⁶⁻¹ is as defined for R⁶.

In the formula (C-I) to (C-IV), the chemical groups

X¹, X²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ independently of each other preferablyrepresents hydrogen, halogen (i.e. F, Cl, Br, I) or C₁₋₄-haloalkyl (e.g.CF₃, CF₂H, CFH₂, CH₂CF₃, CF₂—CF₃), whereas it is preferred that at leastone of the groups X¹, X²⁻¹, X²⁻², X²⁻³, X²⁻⁴ stands for hydrogen,preferably one of X¹ and/or X²⁻⁴ and/or X²⁻² stands for hydrogen, it ismost preferred that X¹ and X²⁻⁴ both are standing for hydrogen while theother groups are standing independently of each other for CF₃, F, Cl,Br,

and/or the chemical groups Y²⁻¹, Y²⁻³ and Y²⁻⁴ independently of eachother preferably represents hydrogen, halogen (e.g. F, Cl, Br, I),C₁₋₄-alkyl, C₁₋₄-alkoxy, C₁₋₄-haloalkoxy, C₃₋₆-cycloalkyl,C₁₋₄-haloalkyl (e.g. CF₃, CF₂H, CFH₂, CH₂CF₃, CF₂—CF₃),C₁₋₄-alkylsulfanyl, or C₁₋₄-haloalkylsulfanyl,

and/or wherein R³ or R⁴ independently of each other preferably standsfor hydrogen, and wherein R⁵⁻¹ independently of each other preferablystands for hydrogen, C₁₋₄alkyl or C₁₋₄haloalkyl, preferably hydrogen;

and/or wherein R⁶⁻¹ preferably representsC₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl, C₁₋₄alkoxy(C₁₋₄)alkylcarbonyl,C₁₋₄alkyl-S(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-SO(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-SO₂(C₁₋₄)alkylcarbonyl, more preferably represents one of thefollowing groups

In another aspect of the invention compounds of formula (D-I) to (D-III)are preferred having the following formula

and wherein each X¹, R¹ and R² are as defined herein, and each X²⁻¹,X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X², and wherein Y²⁻³ is asdefined herein for Y².

In another aspect of the invention compounds of formula (E-I) to (E-III)are preferred having the following formula

and wherein each X¹, R³, R⁴, R⁵ and R⁶ are as defined herein, and eachX²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X², and wherein Y²⁻³is as defined herein for Y².

In another aspect of the invention compounds of formula (F-I) to (F-III)are preferred having the following formula

and wherein each X¹, Y¹, R¹ and R² are as defined herein, and whereineach X²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X².

In another aspect of the invention compounds of formula (G-I) to (G-III)are preferred having the following formula

and wherein each X¹, Y¹, R³, R⁴, R⁵ and R⁶ are as defined herein, andwherein each X²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X²

In another aspect of the invention compounds of formula (H-I) to (H-III)are preferred having the following formula

and wherein each X¹, Y¹, R⁵ and R⁶ are as defined herein, each X²⁻¹,X²⁻², X²⁻³ and X²⁻⁴ are as defined herein for X², and wherein W¹represents single bond or —CH₂—;

The compounds of formula (I) of the present invention have asymmetriccarbons, and thus the compounds encompass optical isomers.

The nitrogen atom on the pyrrolidine backbone of the compounds offormula (I) of the present invention may be substituted with oxygen,alkyl or haloalkyl or may form a salt.

Preparation method (a) is exemplified by the reaction given below inwhich 3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine andN-{[2-bromo-4-(trifluoromethyl)pyrimidin-5-yl]methyl}acetamide are usedas starting materials:

Preparation method (b) is exemplified by the reaction given below inwhich2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-pyrimidine-5-carboxylicacid and 2-picolylamine are used as starting materials:

Preparation method (c) is exemplified by the reaction given below inwhichN-(pyridin-2-ylmethyl)-2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxamide and iodomethane are used as startingmaterials:

Preparation method (d) is exemplified by the reaction given below inwhichN-(pyridin-2-ylmethyl)-2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxamideand Lawesson reagent are used as starting materials:

Preparation method (e) is exemplified by the reaction given below inwhich5-(bromomethyl)-2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidineand benzamide are used as starting materials:

Preparation method (f) is exemplified by the reaction given below inwhich1-{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-pyrimidin-5-yl}methanamineand acetyl chloride are used as starting materials:

Preparation method (g) is exemplified by the reaction given below inwhichN-({2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)pyrimidin-5-yl}methyl)acetamideand iodomethane are used as starting materials:

The compounds of formula (IV), which are the starting materials in thePreparation method (a), can be synthesized by the method describedbelow. Specifically, the compounds represented by the following formula(XV):

wherein X¹, B¹ to B⁴ and R have the same meaning as defined herein canbe reacted withN-benzyl-1-methoxy-N-[(trimethylsilyl)-methyl]methanamine in thepresence of a catalyst (e.g. trifluoroacetic acid, trimethylsilyltrifluoromethane sulfonate, iodotrimethylsilane, cesium fluoride) togive the compounds represented by formula (XVI):

wherein X¹, B¹ to B⁴ and R have the same meaning as defined herein,followed by debenzylation to obtain the compounds represented by theabove formula (IV).

The reaction which yields compounds of formula (XVI) may be carried outaccording to the methods described in “Chemistry Letters, 1984,1117-1120” and “Tetrahedron Letters, 1993, 34, 3279-3282”. Thedeprotection reaction such as the debenzylation of compounds of formula(XVI) may be carried out according to the methods described in “Journalof the Organic Chemistry, 1984, 49, 2081” and “PROTECTIVE GROUPS inORGANIC CHEMISTRY THIRD EDITION, JOHN WILEY & SONS, INC”.

The compounds of the above formula (XV) encompass the compounds that areknown and described, for example in “The Journal of Organic Chemistry,1991, vol. 56, pp. 7336-7340”; “The Journal of Organic Chemistry, 1994,vol. 59, pp. 2898-2901”; “Journal of Fluorine Chemistry, 1999, vol. 95,pp. 167-170”; “WO2005/05085216A”. Such compounds may be synthesized bythe methods described therein.

Representative examples of the compounds of formula (XV) include[1-(trifluoromethyl)vinyl]benzene,1-chloro-3-[1-(trifluoromethyl)vinyl]benzene,1-bromo-3-[1-(trifluoromethyl)vinyl]benzene,1-nitro-3-[1-(trifluoromethyl)vinyl]benzene,1-tri-fluoromethyl-3-[1-(trifluoromethyl)vinyl]benzene,1,3-difluoro-5-[1-(trifluoro-methyl)vinyl]benzene,1,3-dichloro-5-[1-(trifluoromethyl)vinyl]benzene,1,3-difluoro-5-[1-(trifluoromethyl)vinyl]benzene,1-fluoro-2-(trifluoro-methyl)-4-[1-(trifluoromethyl)vinyl]benzene,1,2,3-trichloro-5-[1-(trifluoromethyl)vinyl]benzene,1,3-dimethyl-2-nitro-5-[1-(trifluoromethyl)vinyl]benzene.

Instead of N-benzyl-1-methoxy-N-[(trimethylsilyl)methyl]methanamine inthe above reaction,N-benzyl-1-butoxy-N-[(trimethylsilyl)methyl]methanamine orN-(butoxy-methyl)-N-[(trimethylsilyl)methyl]cyclohexylamine may be used.

Representative examples of the compounds of formula (IV) in thePreparation method (a) include3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine,3-[3,5-bis(trifluoro-methyl)phenyl]-3-(trifluoromethyl)pyrrolidine,3-(3,4,5-trichloro-phenyl)-3-(trifluoromethyl)pyrrolidine, and3-(3,5-dimethyl-4-nitro-phenyl)-3-(trifluoromethyl)pyrrolidine.

Many of the compounds of formula (V-I) or (V-II), which are startingmaterials in the Preparation method (a), are known compounds, and theymay be readily synthesized by the methods widely known in organicchemistry.

The specific examples of formula (V-I) include for example2-chloro-N-ethyl-4-(trifluoromethyl)pyrimidine-5-carboxamide, tert-butyl(5-bromo-2,3-dihydro-1H-inden-1-yl)carbamate that is described in USPat. No. 2008/0021024.

Further, the specific examples of formula (V-II) may include:2-chloro-N-ethyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide and thelike.

The reaction of the Preparation method (a) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane, etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction of the Preparation method (a) can be carried out in thepresence of a base, such as alkali metal bases (e.g. lithium hydride,sodium hydride, potassium hydride, butyl lithium, tert-butyl lithium,trimethylsilyl lithium, lithium hexamethyldisilazide, sodium carbonate,potassium carbonate, cesium carbonate, tripotassium phosphate, sodiumacetate, potassium acetate, sodium methoxide, sodium ethoxide,sodium-tert-butoxide and potassium-tert-butoxide etc.), organic bases(e.g. triethylamine, diisopropylethylamine, tributylamine,N-methylmorpholine, N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole etc.) and optionallyin the presence of a metal catalyst such as transition metal catalysts(eg. Pd₂(dba)₃, Pd₂(dba)₃CHCl₃ (dba=dibenzylideneacetone), Pd(OAc)₂,CuI, Cu₂O). The transition metal catalyst can be used in the presence ofphosphine ligands such as 2,2′-bis(diphenylphosphino)-1,1′-binaphtalene(BINAP), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos),tributylphosphine, triphenyl-phosphine, or amine ligands such as8-quinolinol, proline, N,N-dimethylglycine.

The preparation method (a) can be carried out within a substantiallywide temperature range. It may be generally carried out at thetemperature between about −78° C. and about 200° C., preferably between−10° C. and about 150° C. Said reaction is desirably carried out atnormal pressure although it may be carried out under elevated or reducedpressure. The reaction time is 0.1 to 72 hours, preferably 0.1 to 24hours.

For carrying out the Preparation method (a), for example, 1 mole of thecompound of formula (IV) can be reacted with 1 to 3 moles of thecompound of formula (V-I) or (V-II) in the presence of 1 to 3 moles of abase (e.g. sodium-tert-butoxide and a catalytic amount (e.g. in therange of about 1 to 10 mol-%) of the transitional metal catalyst (e.g.Pd₂(dba)₃ or Pd₂(dba)₃CHCl₃) and a suitable amount (e.g. in the range ofabout 3 to 30 mol-%) of phosphine ligand compound (e.g.4,5-bis(diphenylphosphino)-9,9-dimethylxanthen) in a diluent (e.g.toluene) to obtain the compound of formula (I) of the present invention.

Some of the compounds of formula (VI-I) and (VI-II), which are thestarting materials in the Preparation method (b), are novel compoundsand they can be synthesized by the methods below. Specifically, thecompounds of the above formula (IV) can be reacted with a compoundrepresented by the following formula (XVII-I):

wherein A¹ to A⁴ and L¹ have the same meaning as defined above, and R⁸represents hydrogen or C₁₋₄ alkyl, or

with a compound represented by the following formula (XVII-II):

wherein Y¹, R⁸, A¹ to A⁴ and L¹ have the same meaning as defined herein

to obtain the compounds represented by formula (XVIII-I):

wherein X¹, B¹ to B⁴, R, A¹ to A⁴ and R⁸ have the same meaning asdefined herein, or

the compounds represented by formula (XVIII-II):

wherein X¹, B¹ to B⁴, R, Y¹ and R⁸ have the same meaning as definedherein. In addition, when R⁸ represents C₁₋₄ alkyl, by subjecting thecompounds represented by the above formula (XVIII-I) or (XVIII-II) to ahydrolysis reaction, the compounds represented by formula (VI-I) or(VI-II) can be obtained.

The compounds represented by the above formula (XVII-I) and (XVII-II) inabove Preparation method, which are well known compounds in the field oforganic chemistry, may include the following compounds, for example:ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate, and ethyl2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate.

Furthermore, the compounds represented by formula (VII-I) or (VII-II),which are the starting materials in the Preparation method (b), can besynthesized according to well known methods in the field of organicchemistry.

For example, they can be readily obtained by the method comprising areaction of the compounds represented by the above formula (VI-I) or(VI-II) with a chlorinating agent such as thionyl chloride, oxalylchloride, phosphorus pentachloride and the like, or by the methodcomprising a reaction with an organic acid halide such as pivaloylchloride and the like, or the method comprising a reaction with carbonyldiimidazole or sulfonyl imidazole and the like.

Representative compounds of formula (VI-I) or (VI-II) in the Preparationmethod (b) may include:2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic acid,2-chloro-4-(trifluoro-methyl)-1,3-thiazole-5-carboxylic acid, and thelike.

Representative compounds of formula (VII-I) or (VII-II) may include:2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride,2-chloro-4-(trifluoro-methyl)-1,3-thiazole-5-carbonyl chloride, and thelike.

The compounds of formula (VIII), which are the starting materials in thePreparation method (b), are well known compounds and their specificexamples may include: methylamine, ethylamine, cyclopropylamine,propargylamine, 2,2,2-trifluoroethylamine, 2-picolylamine,3-aminomethyl-6-chloropyridine, and the like.

The reaction of the Preparation method (b) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction can be carried out using the following bases such as alkalimetal bases including sodium hydroxide, potassium hydroxide, sodiumcarbonate, potassium carbonate, cesium carbonate, tripotassiumphosphate, sodium acetate, potassium acetate and the like and organicbases including triethylamine, diisopropylethylamine, tributylamine,N-methylmorpholine, N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole and the like.

The reaction can be carried out using the following condensation agents:1,3-dicyclohexylcarbodiimide (DCC),1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride (WSCI),carbonyldiimidazole (CDI), diethyl cyanophosphate (DEPC),2-chloro-1-methylpyridinium iodide (Mukaiyama's reagent) and the like.

The Preparation method (b) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between −10° C. and about 150° C.Said reaction is desirably carried out at normal pressure although itmay be carried out under elevated or reduced pressure. The reaction timeis 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (b), for example, 1 mole of thecompound of formula (VI-I) or (VI-II) can be reacted with 1 to 3 molesof the compound of formula (VIII) using 1 mole to 3 moles of acondensation agent and, if desired, with a catalytic amount of anadditive such as 1-hydroxybenzotriazole in a diluent (e.g. DMF) toobtain the corresponding compound of formula (I).

The compounds of formula (Ib-I) or (Ib-II), which are the startingmaterials in the Preparation method (c), are encompassed by formula (I)of the present invention obtained by above Preparation method (b).

The con pounds of formula (IX), which are the starting materials, arewell known compounds and their specific examples may includeiodomethane, iodoethane and the like. In addition, with respect toformula (IX), when L³ represents arylsulfonyloxy, the aryl includesphenyl, 4-methylphenyl, 4-chlorophenyl and the like.

The reaction of the Preparation method (c) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction can be carried out using the following bases such as alkalimetal bases including lithium hydride, sodium hydride, potassiumhydride, sodium hydroxide, potassium hydroxide, sodium carbonate,potassium carbonate, cesium carbonate, tripotassium phosphate, sodiumacetate, potassium acetate and the like, organic bases such astriethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine,N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole and the like.

The Preparation method (c) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between −10° C. and about 150° C.Said reaction is preferably carried out at normal pressure although itmay be carried out under elevated or reduced pressure. The reaction timeis 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (c), for example, 1 mole of thecompound of formula (Ib-I) or (Ib-II) can be reacted with 1 to 5 molesof the compound of formula (IX) in a diluent (e.g. THF) in the presenceof a base to obtain the corresponding compound of formula (I).

The compounds of formula (Ia-I) or (Ia-II), which are the startingmaterials in the Preparation method (d), are encompassed by formula (I)of the present invention obtained by the above Preparation method (b) orPreparation method (c).

As a sulfurizing agent used in the Preparation method (d), phosphoruspentasulfide, Lawesson reagent and the like can be mentioned.

The reaction of the Preparation method (d) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.) or mixed solventsthereof and the like.

The Preparation method (d) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between room temperature and about150° C. Said reaction is desirably carried out at normal pressurealthough it may be carried out under elevated or reduced pressure. Thereaction time is 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (d), for example, 1 mole of thecompound of formula (Ia-I) or (Ia-II) can be reacted with 0.5 mole to 3moles of a Lawesson reagent in a diluent (e.g. toluene) to obtain thecorresponding compound of formula (I).

The compounds of formula (X-I) or (X-II), which are the startingmaterials in the Preparation method (e), are novel compounds and may besynthesized by the method below, for example. Specifically, thecompounds of the above formula (VII-I) or (VII-II) can be reduced toobtain the compounds represented by the following formula (XIX-Ia):

wherein X¹, B¹ to B⁴, R and A¹ to A⁴ have the same meaning as definedherein, or

the compounds represented by the following formula (XIX-IIa):

wherein X¹, B¹ to B⁴, R and Y¹ have the same meaning as defined herein,

which are then subjected to the reaction such as halogenation oralkylsulfonylation in a typical manner to obtain the compoundsrepresented by the following formula (X-Ia):

wherein X¹, B¹ to B⁴, R, A¹ to A⁴ and L³ have the same meaning asdefined herein, or the compounds represented by the following formula(X-IIa):

wherein X¹, B¹ to B⁴, R, Y¹ and L³ have the same meaning as definedherein.

Representative examples of the compounds of formula (X-I) or (X-II) inthe Preparation method (e) may include:5-(chloromethyl)-2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine,5-(chloromethyl)-2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazole,and the like.

The compounds of formula (XI), which are the starting materials in thePreparation method (e), are well known compounds and the representativeexamples may include: ammonia, acetamide, propionamide, benzamide,2-chlorobenzamide, 3-chlorobenzamide, 4-chlorobenzamide and the like.

The reaction of the Preparation method (e) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction can be carried out using the following bases such as alkalimetal bases including lithium hydride, sodium hydride, potassiumhydride, sodium hydroxide, potassium hydroxide, sodium carbonate,potassium carbonate, cesium carbonate, tripotassium phosphate, sodiumacetate, potassium acetate and the like and organic bases such astriethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine,N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole and the like.

The Preparation method (e) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between −10° C. and about 150° C.Said reaction is desirably carried out at normal pressure although itmay be carried out under elevated or reduced pressure. The reaction timeis 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (e), for example, 1 mole of thecompound of formula (X-I) or (X-II) can be reacted with 1 to 3 moles ofthe compound of formula (XI) in the presence of a base in a diluent(e.g. THF) to obtain the corresponding compound of formula (I).

The compounds of formula (XII-I) or (XII-II), which are the startingmaterials in the Preparation method (f), are novel compounds and may beobtained by reacting a compound of the above formula (X-I) or (X-II)with a compound represented by the following formula (XX):R⁵—NH₂  (XX)

wherein R⁵ has the same meaning as described in the above).

Furthermore, regarding the compounds represented by formula (XII-I) or(XII-II) wherein l=1, they can be also synthesized by an alternativemethod comprising reacting a compound of the above formula (IV) with acompound represented by the following formula (XXI-I):

wherein A¹ to A⁴, R³, R⁴ and L¹ have the same meaning as defined herein

or with a compound represented by the following formula (XXI-II):

wherein Y¹, R³, R⁴ and L¹ have the same meaning as defined herein

to obtain the compounds represented by the following formula (XXII-I):

wherein X¹, B¹ to B⁴, A¹ to A⁴, R³, R⁴ and R have the same meaning asdefined herein, or

the compounds represented by the following formula (XXII-II):

wherein X¹, B¹ to B⁴, Y¹, R³, R⁴ and R have the same meaning as definedherein,

followed by carrying out an amino Gabriel amine synthesis reaction.

The compounds of above formula (XXI-I) or (XXI-II) are known compoundsand may include the followings:

2-{[2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]methyl}-1H-isoindol-1,3(2H)-dione,2-{[2-chloro-4-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-1H-isoindol-1,3(2H)-dione,2-(4-bromobenzyl)-1H-isoindol-1,3(2H)-dione,2-(4-bromo-2-nitrobenzyl)-1H-isoindol-1,3(2H)-dione,2-(4-iodobenzyl)-1H-isoindol-1,3(2H)-dione,2-(4-iodo-2-nitrobenzyl)-1H-isoindol-1,3(2H)-dione,2-(2-chloro-4-iodobenzyl)-1H-isoindol-1,3(2H)-dione and the like.

Furthermore, the compounds of formula (XII-I) or (XII-II) wherein R³, R⁴and R⁵ represent hydrogen may be also readily synthesized by analternative method which includes a usual reduction reaction of thenitrile compounds represented by formula (XXIII-I):

wherein X¹, B¹ to B⁴, A¹ to A⁴ and R have the same meaning as definedherein, or the nitrile compounds represented by formula (XXIII-II):

wherein X¹, B¹ to B⁴, Y¹ and R have the same meaning as defined herein,followed by a subsequent hydrolysis reaction.

Representative examples of the compounds of formula (XII-I) or (XII-II)in the Preparation method (f) may include:1-{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)pyrimidin-5-yl}methanamine,1-{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methanamine,1-{2-chloro-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-phenyl}methanamine,1-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-phenyl}methanamineand the like.

The compounds of formula (XIII), which are the starting materials in thePreparation method (f), are well known compounds, and the specificexamples may include: acetyl chloride; propionyl chloride; benzoylchloride; 2-chlorobenzoyl chloride;

3-chlorobenzoyl chloride; 4-chlorobenzoyl chloride; nicotinoylchloridehydrochloride salt and the like.

The reaction of the Preparation method (f) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction can be carried out using the following bases such as alkalimetal bases including lithium hydride, sodium hydride, potassiumhydride, sodium hydroxide, potassium hydroxide, sodium carbonate,potassium carbonate, cesium carbonate, tripotassium phosphate, sodiumacetate, potassium acetate and the like and organic bases such astriethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine,N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole and the like.

The Preparation method (f) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between −10° C. and about 150° C.Said reaction is desirably carried out at normal pressure although itmay be carried out under elevated or reduced pressure. The reaction timeis 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (f), for example, 1 mole of thecompound of formula (XII-I) or (XII-II) can be reacted with 1 to 3 molesof the compound of formula (XIII) in the presence of a base in a diluent(e.g. THF) to obtain the corresponding compound of formula (I).

The compounds of formula (Ic-I) or (Ic-II), which are the startingmaterials in the Preparation method (g), are encompassed by formula (I)of the present invention obtained by the above Preparation method (e) orPreparation method (f).

The compounds of formula (XIV) as the starting materials are well knownand the specific examples may include iodomethane, iodoethane, acetylchloride and the like.

The reaction of the Preparation method (g) can be carried out in asuitable diluent, and examples thereof include aliphatic hydrocarbons(e.g. hexane, cyclohexane, heptane etc.), aliphatic halogenatedhydrocarbons (e.g. dichloromethane, chloroform, carbon tetrachloride,dichloroethane etc.), aromatic hydrocarbons (e.g. benzene, toluene,xylene, chlorobenzene etc.), ethers (e.g. diethyl ether, dibutyl ether,dimethoxyethane (DME), tetrohydrofuran, dioxane etc.), esters (e.g.ethyl acetate, ethyl propionate etc.), acid amides (e.g.dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidoneetc.), nitriles (e.g. acetonitrile, propionitrile etc.),dimethylsulfoxide (DMSO), water or mixed solvents thereof and the like.

The reaction can be carried out using the following bases such as alkalimetal bases including lithium hydride, sodium hydride, potassiumhydride, sodium hydroxide, potassium hydroxide, sodium carbonate,potassium carbonate, cesium carbonate, tripotassium phosphate, sodiumacetate, potassium acetate and the like and organic bases such astriethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine,N,N-dimethylaniline, N,N-diethylaniline,4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine,diazabicycloundecene, diazabicyclooctane, imidazole and the like.

The Preparation method (g) can be carried out within a substantiallywide temperature range. It may be generally carried out between about−78° C. and about 200° C., preferably between −10° C. and about 150° C.Said reaction is desirably carried out at normal pressure although itmay be carried out under elevated or reduced pressure. The reaction timeis 0.1 to 72 hours, preferably 0.1 to 24 hours.

For carrying out the Preparation method (g), for example, 1 mole of thecompound of formula (Ic-I) or (Ic-II) can be reacted with 1 to 3 molesof the compound of formula (XIV) in the presence of a base in a diluent(e.g. THF) to obtain the corresponding compound of formula (I).

With respect to the above Preparation methods for the compounds offormula (I) of the present invention, novel raw materials thereof (i.e.,starting materials and intermediates) can be collectively represented byformula (XXIV) described below:

wherein X¹, R, A¹ to A⁴ and B¹ to B⁴ have the same meaning as definedabove, and T⁴ represents,

cyano, amino, or nitro, and l, L², L³, R³, R⁴, R⁵ and R⁸ have the samemeaning as defined above.

The active compounds of the invention, in combination with good planttolerance and favourable toxicity to warm-blooded animals and beingtolerated well by the environment, are suitable for protecting plantsand plant organs, for increasing harvest yields, for improving thequality of the harvested material and for controlling animal pests, inparticular insects, arachnids, helminths, nematodes and molluscs, whichare encountered in agriculture, in horticulture, in animal husbandry, inforests, in gardens and leisure facilities, in the protection of storedproducts and of materials, and in the hygiene sector. They can bepreferably employed as plant protection agents. They are active againstnormally sensitive and resistant species and against all or some stagesof development.

Such umwanted insects which may damage plants and/or technical materialsinclude e.g. beetles (Coleopteran), such as adzuki bean beetle(Callosobruchus Chinensis), maize weevil (Sitophilus zeamais), red flourbeetle (Tribolium Castaneum), large twenty-wight-spotted lady beetle(Epilachna vigintioctomaculata), barley wireworm (Agriotes oguraefuscicollis), soy bean beetle (Anomala rufocuprea), Colorado potatobeetle (Leptinotarsa decemlineata), corn root worm (Diabrotica spp.),Matsunomadra long-horned beetle (Monochamus alternatus endai), ricewater weevil (Lissorhoptrus oryzophilus), powder-post beetle (Lyctusbrunneus); lepidopteran pests, such as gypsy moth (Lymantria dispar),Lackey moth (Malacosoma neustria), small white (Pieris rapae crucivora),cotton leafworm (Spodoptera litura), cabbage moth (Mamestra brassicae),rice stem borer (Chilo suppressalis), European corn borer (Ostrinianubilalis), dried currant moth (Cadra cautella), chyanokokakumonhamaki(Adoxophyes honmai), codling moth (Cydia pomonella), Turnip Moth(Agrotis segetum), Wax Moth (Galleria mellonella), Diamondback moth(Plutella xylostella), tobacco budworm moth (Heliothis virescens),citrus leaf miner (Phyllocnistis citrella); hemipterous pests, such asgreen rice leafhopper (Nephotettix cincticeps), brown planthopper(Nilaparvata lugens), comstock mealybug (Pseudococcus comstocki),arrowheat scale (Unaspis yanonensis), Momoaka-aburamusi (Myzuspersicas), green apple aphid (Aphis pomi), cotton aphid (Aphisgossypii), turnip aphid (Lipaphis erysimi), Nashi-gunbai (Stephanitisnashi), Nezara (Nezara spp.), greenhouse whitefly (Trialeurodesvaporariorm), Pshylla (Pshylla spp.); thysanoptera pests, such as palmthrips (Thrips palmi), western flower thrips (Franklinellaoccidentalis); orthopteran pests, such as mole cricket (GryllotalpaAfricana), migratory locust (Locusta migratoria); blattarian pests, suchas German cockroach (Blatella germanica), American cockroach(Periplaneta americana), yamato white ant (Reticulitermes speratus),Formosan subterranean termite (Coptotermes formosanus);

dipterous pests, such as housefly (Musca domestica), yellow fevermosquito (Aedes aegypti), Seedcorn maggot (Delia platura), Aka-ie-ka(Culex pipiens pallens), Sina-hamadara-ka (Anopheles sinensis),kodaka-aka-ie-ka (Culex tritaeniorhynchus), serpentine leafminer(Liriomyza trifolii) and the like.

Further, as mites, Carmine spider mite (Tetranychus cinnabarinus),two-spotted spider mite (Tetrahychus urticae), Citrus red mite(Panonychus citri), Pink citrus rust mite (Aculops pelekassi),Tarsonemus (Tarsonemus spp.) and the like can be mentioned.

In addition, as nematodes, sweet potato root-knot nematode (Meloidogyneincognita), pine wood nematode (Bursaphelenchus xylophilus), ricewhite-tip nematode (Aphelenchoides besseyi), soybean cyst nematode(Heterodera glycines), meadow nematode (Pratylenchus spp.) and the likecan be mentioned.

The Abovementioned Pests Include:

From the order of the Anoplura (Phthiraptera), for example, Damaliniaspp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectesspp.

From the class of the Arachnida, for example, Acarus spp., Aceriasheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphitetranychusviennensis, Argas spp., Boophilus spp., Brevipalpus spp., Bryobiapraetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp.,Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Halotydeusdestructor, Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectusmactans, Metatetranychus spp., Nuphersa spp., Oligonychus spp.,Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora,Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp.,Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp.,Tarsonemus spp., Tetranychus spp., Vasates lycopersici.

From the class of the Bivalva, for example, Dreissena spp.

From the order of the Chilopoda, for example, Geophilus spp., Scutigeraspp.

From the order of the Coleoptera, for example, Acalymma vittatum,Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp.,Amphimallon solstitialis, Anobium punctatum, Anoplophora spp.,Anthonomus spp., Anthrenus spp., Apion spp., Apogonia spp., Atomariaspp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Cassida spp.,Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnema spp., Cleonusmendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica,Ctenicera spp., Curculio spp., Cryptorhynchus lapathi, Cylindrocopturusspp., Dermestes spp., Diabrotica spp., Dichocrocis spp., Diloboderusspp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides,Hellula undalis, Heteronychus arator, Heteronyx spp., Hylamorphaelegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp.,Lachnosterna consanguinea, Lema spp., Leptinotarsa decemlineata,Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp., Luperodes spp.,Lyctus spp., Megascelis spp., Melanotus spp., Meligethes aeneus,Melolontha spp., Migdolus spp., Monochamus spp., Naupactusxanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilussurinamensis, Oryzaphagus oryzae, Otiorrhynchus spp., Oxycetoniajucunda, Phaedon cochleariae, Phyllophaga spp., Phyllotreta spp.,Popillia japonica, Premnotrypes spp., Psylliodes spp., Ptinus spp.,Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorusspp., Sternechus spp., Symphyletes spp., Tanymecus spp., Tenebriomolitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechusspp., Zabrus spp.

From the order of the Collembola, for example, Onychiurus armatus.

From the order of the Diplopoda, for example, Blaniulus guttulatus.

From the order of the Diptera, for example, Aedes spp., Agromyza spp.,Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp.,Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata,Chironomus spp., Chrysomyia spp., Cochliomyia spp., Contarinia spp.,Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae,Dasyneura spp., Delia spp., Dermatobia hominis, Drosophila spp.,Echinocnemus spp., Fannia spp., Gastrophilus spp., Hydrellia spp.,Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp. Luciliaspp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyiaspp., Phorbia spp., Prodiplosis spp., Psila rosae, Rhagoletis spp.,Stomoxys spp., Tabanus spp., Tannia spp., Tetanops spp., Tipula spp.

From the class of the Gastropoda, for example, Arion spp., Biomphalariaspp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp.,Oncomelania spp., Pomacea spp., Succinea spp.

From the class of the Helminthen, for example, Ancylostoma duodenale,Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp.,Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori,Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp.,Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum,Dracunculus medinensis, Echinococcus granulosus, Echinococcusmultilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp.,Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa,Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocercavolvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp.,Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp.,Taenia saginata, Taenia solium, Trichinella spiralis, Trichinellanativa, Trichinella britovi, Trichinella nelsoni, Trichinellapseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereriabancrofti.

It is furthermore possible to control protozoa, such as Eimeria.

From the order of the Heteroptera, for example, Anasa tristis,Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida,Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynuspiperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp.,Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus,Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropesexcavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp.,Pentomidae, Piesma quadrata, Piezodorus spp., Psallus spp., Pseudacystapersea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea,Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.

From the order of the Homoptera, for example, Acyrthosipon spp.,Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp.,Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphiscardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridiaapicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthumsolani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp.,Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida,Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphonfragaefolii, Chionaspis tegalensis, Chilorita onukii, Chromaphisjuglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli,Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp.,Diaphorina spp., Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccusspp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelisbilobatus, Ferrisia spp., Geococcus coffeae, Hieroglyphus spp.,Homalodisea coaguiata, Hyalopterus arundinis, Icerya spp., Idiocerusspp., Idioscopus spp., Laodelphax striatellus, Lecanium spp.,Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva spp.,Melanaphis sacchari, Metcalfiella spp. Metopolophium dirhodum, Monelliacostalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri,Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Ortheziapraelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp.,Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzuspasserinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae,Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona,Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp.,Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphumspp., Saissetia spp., Scaphoides titanus, Schizaphis graminum,Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodesspp., Stictocephala festina, Tenalaphara malayensis, Tinocalliscaryaefoliae, Tomaspis spp., Toxoptera spp. Trialeurodes spp., Triozaspp., Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.

From the order of the Hymenoptera, for example, Athalia spp., Diprionspp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.

From the order of the Isopoda, for example, Armadillidium vulgare,Oniscus asellus, Porcellio scaber.

From the order of the Isoptera, for example, Acromyrmex spp., Atta spp.,Cornitermes cumulans, Microtermes obesi, Odontotermes spp.,Reticulitermes spp.

From the order of the Lepidoptera, for example, Acronicta major,Adoxophyes spp., Aedia leucomelas, Agrotis spp., Alabama spp., Amyeloistransitella, Anarsia spp., Anticarsia spp., Argyroploce spp., Barathrabrassicae, Borbo cinnara, Bucculatrix thurberiella, Bupalus piniarius,Busseola spp., Cacoecia spp., Caloptilia theivora, Capua reticulana,Carpocapsa pomonella, Carposina niponensis, Chematobia brumata, Chilospp., Choristoneura spp., Clysia ambiguella, Cnaphalocerus spp.,Cnephasia spp., Conopomorpha spp., Conotrachelus spp., Copitarsia spp.,Cydia spp., Dalaca noctuides, Diaphania spp., Diatraea saccharalis,Earias spp., Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldanasaccharina, Ephestia kuehniella, Epinotia spp., Epiphyas postvittana,Etiella spp., Eulia spp., Eupoecilia ambiguella, Euproctis spp., Euxoaspp., Feltia spp., Galleria mellonella, Gracillaria spp., Grapholithaspp., Hedylepta spp., Helicoverpa spp., Heliothis spp., Hofmannophilapseudospretella, Homoeosoma spp., Homona spp., Hyponomeuta padella,Kakivoria flavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodesorbonalis, Leucoptera spp., Lithocolletis spp., Lithophane antennata,Lobesia spp., Loxagrotis albicosta, Lymantria spp., Lyonetia spp.,Malacosoma neustria, Maruca testulalis, Mamestra brassicae, Mocis spp.,Mythimna separata, Nymphula spp., Oiketicus spp., Oria spp., Orthagaspp., Ostrinia spp., Oulema oryzae, Panolis flammea, Parnara spp.,Pectinophora spp., Perileucoptera spp., Phthorimaea spp., Phyllocnistiscitrella, Phyllonorycter spp., Pieris spp., Platynota stultana, Plusiaspp., Plutella xylostella, Prays spp., Prodenia spp., Protoparce spp.,Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis,Rachiplusia nu, Schoenobius spp., Scirpophaga spp., Scotia segetum,Sesamia spp., Sparganothis spp., Spodoptera spp., Stathmopoda spp.,Stomopteryx subsecivella, Synanthedon spp., Tecia solanivora, Thermesiagemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix spp.,Trichoplusia spp., Tuta absoluta, Virachola spp.

From the order of the Orthoptera, for example, Acheta domesticus, Blattaorientalis, Blattella germanica, Dichroplus spp., Gryllotalpa spp.,Leucophaea maderae, Locusta spp., Melanoplus spp., Periplanetaamericana, Schistocerca gregaria.

From the order of the Siphonaptera, for example, Ceratophyllus spp.,Xenopsylla cheopis.

From the order of the Symphyla, for example, Scutigerella spp.

From the order of the Thysanoptera, for example, Anaphothrips obscurus,Baliothrips biformis, Drepanothris reuteri, Enneothrips flavens,Frankliniella spp., Heliothrips spp., Hercinothrips femoralis,Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni,Thrips spp.

From the order of the Thysanura, for example, Lepisma saccharina.

The phytoparasitic nematodes include, for example, Aphelenchoides spp.,Bursaphelenchus spp., Ditylenchus spp., Globodera spp., Heterodera spp.,Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholussimilis, Trichodorus spp., Tylenchulus semipenetrans, Xiphinema spp.

All plants and plant parts can be treated in accordance with theinvention. Plants are to be understood as meaning in the present contextall plants and plant populations such as desired and undesired wildplants or crop plants (including naturally occurring crop plants). Cropplants can be plants which can be obtained by conventional plantbreeding and optimization methods or by biotechnological and geneticengineering methods or by combinations of these methods, including thetransgenic plants and including the plant cultivars protectable or notprotectable by plant breeders' rights. Plant parts are to be understoodas meaning all parts and organs of plants above and below the ground,such as shoot, leaf, flower and root, examples which may be mentionedbeing leaves, needles, stalks, stems, flowers, fruit bodies, fruits,seeds, roots, tubers and rhizomes. The plant parts also includeharvested material, and vegetative and generative propagation material,for example cuttings, tubers, rhizomes, offshoots and seeds.

Treatment according to the invention of the plants and plant parts withthe active compounds is carried out directly or by allowing thecompounds to act on their surroundings, habitat or storage space by thecustomary treatment methods, for example by immersion, spraying,evaporation, fogging, scattering, painting on, injecting and, in thecase of propagation material, in particular in the case of seed, also byapplying one or more coats.

As already mentioned above, it is possible to treat all plants and theirparts according to the invention. In a preferred embodiment, wild plantspecies and plant cultivars, or those obtained by conventionalbiological breeding methods, such as crossing or protoplast fusion, andparts thereof, are treated. In a further preferred embodiment,transgenic plants and plant cultivars obtained by genetic engineeringmethods, if appropriate in combination with conventional methods(Genetically Modified Organisms), and parts thereof, are treated. Theterms “parts”, “parts of plants” and “plant parts” have been explainedabove.

Particularly preferably, plants of the plant cultivars which are in eachcase commercially available or in use are treated according to theinvention. Plant cultivars are understood as meaning plants having novelproperties (“traits”) which have been obtained by conventional breeding,by mutagenesis or by recombinant DNA techniques. These can be cultivars,bio- or genotypes.

Depending on the plant species or plant cultivars, their location andgrowth conditions (soils, climate, vegetation period, diet), thetreatment according to the invention may also result in superadditive“synergistic”) effects. Thus, for example, reduced application ratesand/or a widening of the activity spectrum and/or an increase in theactivity of the substances and compositions which can be used accordingto the invention, better plant growth, increased tolerance to high orlow temperatures, increased tolerance to drought or to water or soilsalt content, increased flowering performance, easier harvesting,accelerated maturation, higher harvest yields, higher quality and/or ahigher nutritional value of the harvested products, better storagestability and/or processability of the harvested products are possible,which exceed the effects which were actually to be expected.

The preferred transgenic plants or plant cultivars (obtained by geneticengineering) which are to be treated according to the invention includeall plants which, by virtue of the genetic modification, receivedgenetic material which imparts particularly advantageous, useful traitsto these plants. Examples of such traits are better plant growth,increased tolerance to high or low temperatures, increased tolerance todrought or to water or soil salt content, increased floweringperformance, easier harvesting, accelerated maturation, higher harvestyields, higher quality and/or a higher nutritional value of theharvested products, better storage stability and/or processability ofthe harvested products. Further and particularly emphasized examples ofsuch traits are a better defence of the plants against animal andmicrobial pests, such as against insects, mites, phytopathogenic fungi,bacteria and/or viruses, and also increased tolerance of the plants tocertain herbicidally active compounds. Examples of transgenic plantswhich may be mentioned are the important crop plants, such as cereals(wheat, rice), maize, soya beans, potatoes, sugar beet, tomatoes, peasand other vegetable varieties, cotton, tobacco, oilseed rape and alsofruit plants (with the fruits apples, pears, citrus fruits and grapes),and particular emphasis is given to maize, soya beans, potatoes, cotton,tobacco and oilseed rape. Traits that are emphasized in particular arethe increased defence of the plants against insects, arachnids,nematodes and slugs and snails by virtue of toxins formed in the plants,in particular those formed in the plants by the genetic material fromBacillus thuringiensis (for example by the genes CryIA(a), CryIA(b),CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF andalso combinations thereof) (referred to hereinbelow as “Bt plants”).Traits that are also particularly emphasized are the increased defenceof the plants against fungi, bacteria and viruses by systemic acquiredresistance (SAR), system in, phytoalexins, elicitors and resistancegenes and correspondingly expressed proteins and toxins. Traits that arefurthermore particularly emphasized are the increased tolerance of theplants to certain herbicidally active compounds, for exampleimidazolinones, sulphonylureas, glyphosate or phosphinotricin (forexample the “PAT” gene). The genes which impart the desired traits inquestion can also be present in combination with one another in thetransgenic plants. Examples of “Bt plants” which may be mentioned aremaize varieties, cotton varieties, soya bean varieties and potatovarieties which are sold under the trade names YIELD gARD® (for examplemaize, cotton, soya beans), KnockOut® (for example maize), StarLink®(for example maize), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf®(potato). Examples of herbicide-tolerant plants which may be mentionedare maize varieties, cotton varieties and soya bean varieties which aresold under the trade names Roundup Ready® (tolerance to glyphosate, forexample maize, cotton, soya beans), Liberty Link® (tolerance tophosphinotricin, for example oilseed rape), IMI® (tolerance toimidazolinones) and STS® (tolerance to sulphonylureas, for examplemaize). Herbicide-resistant plants (plants bred in a conventional mannerfor herbicide tolerance) which may be mentioned include the varietiessold under the name Clearfield® (for example maize). Of course, thesestatements also apply to plant cultivars having these genetic traits orgenetic traits still to be developed, which plant cultivars will bedeveloped and/or marketed in the future.

The plants listed can be treated according to the invention in aparticularly advantageous manner with the compounds according to theinvention at a suitable concentration.

In the veterinary sector, that is, in veterinary medicine, the activecompounds according to the present invention are effective incontrolling animal parasites, specifically endoparasites orectoparasites. The term “endoparasite” includes, specifically, helminths(tapeworms, nematodes, trematodes, and the like) and protozoa (coccidiumand the like).

Ectoparasites include, typically and preferably, arthropods,specifically, insects (flies (stinging and licking), parasitic flylarvae, sucking lice, crab lice, biting lice, fleas, and the like),acaridae (ticks and the like, for example, hard ticks or soft ticks), oracarina (itchmites, trombiculid mites, bird mites, and the like).

These Parasites are as Follows:

from Anoplurida, for example, Haematopinus spp., Linognathus spp.,Pediculus spp., Phtirus spp., Solenopotes spp.; particularly, forrepresentative examples, Linognathus setosus, Linognathus vituli,Linognathus ovillus, Linognathus oviformis, Linognathus pedalis,Linognathus stenopsis, Haematopinus asini macrocephalus, Haematopinuseurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculushumanus corporis, Phylloera vastatrix, Phthirus pubis, Solenopotescapillatus;

from Mallophagida, Amblycerina, and Ischnocerina, for example,Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp.,Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp.,Felicola spp.; particularly, for representative examples, Bovicolabovis, Bovicola ovis, Bovicola limbata, Damalina bovis, Trichodectescanis, Felicola subrostratus, Bovicola caprae, Lepikentron ovis,Werneckiella equi;

from Diptera, Nematocerina, and Brachycerina, for example, Aedes spp.,Anopheles ssp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomusspp., Lutzomyia spp., Culicoides spp., Chrysops spp., Odagmia spp.,Wilhelmia spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopotaspp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp.,Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossinaspp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp.,Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp.,Hippobosca spp., Lipoptena spp., Melophagus spp., Rhinoestrus spp.,Tipula spp.; particularly, for representative examples, Aedes aegypti,Aedes albopictus, Aedes taeniorhynchus, Anopheles gambiae, Anophelesmaculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culexquinquefasciatus, Culex pipiens, Culex tarsalis, Fannia canicularis,Sarcophaga carnaria, Stomoxys calcitrans, Tipula paludosa, Luciliacuprina, Lucilia sericata, Simulium reptans, Phlebotomus papatasi,Phlebotomus longipalpis, Odagmia ornata, Wilhelmia equina, Boophthoraerythrocephala, Tabanus bromius, Tabanus spodopterus, Tabanus atratus,Tabanus sudeticus, Hybomitra ciurea, Chrysops caecutiens, Chrysopsrelictus, Haematopota pluvialis, Haematopota italica, Musca autumnalis,Musca domestica, Haematobia irritans irritans, Haematobia irritansexigua, Haematobia stimulans, Hydrotaea irritans, Hydrotaea albipuncta,Chrysomya chloropyga, Chrysomya bezziana, Oestrus ovis, Hypoderma bovis,Hypoderma lineatum, Przhevalskiana silenus, Dermatobia hominis,Melophagus ovinus, Lipoptena capreoli, Lipoptena cervi, Hippoboscavariegata, Hippobosca equina, Gasterophilus intestinalis, Gasterophilushaemorroidalis, Gasterophilus interrnis, Gasterophilus nasalis,Gasterophilus nigricornis, Gasterophilus pecorum, Braula coeca;

from Siphonapterida, for example, Pulex spp., Ctenocephalides spp.,Tunga spp., Xenopsylla spp., Ceratophyllus spp.; particularly, forrepresentative examples, Ctenocephalides canis, Ctenocephalides felis,Pulex irritans, Tunga penetrans, Xenopsylla cheopis;

from Heteropterida, for example, Ciimex spp., Triatoma spp., Rhodniusspp., Panstrongylus spp.;

from Blattarida, for example, Blatta orientalis, Periplaneta americana,Blattela germanica, Supella spp. (for example, Suppella longipalpa);

from Acari (Acarina), Metastigmata, and Mesostigmata, for example, Argasspp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp.,Rhipicephalus (Boophilus) spp., Dermacentor spp., Haemophysalis spp.,Hyalomma spp., Dermanyssus spp., Rhipicephalus spp. (original genus ofheteroxenous mites), Ornithonyssus spp., Pneumonyssus spp., Raillietiaspp., Pneumonyssus spp., Sternostoma spp., Varroa spp., Acarapis spp.);particularly, for representative examples, Argas persicus, Argasreflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus(Boophilus) microplus, Rhipicephalus (Boophilus) decoloratus,Rhipicephalus (Boophilus) annulatus, Rhipicephalus (Boophilus)calceratus, Hyalomma anatolicum, Hyalomma aegypticum, Hyalommamarginatum, Hyalomma transiens, Rhipicephalus evertsi, Ixodes ricinus,Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus,Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna,Haemaphysalis punctata, Haemaphysalis cinnabarina, Haemaphysalisotophila, Haemaphysalis leachi, Haemaphysalis longicorni, Dermacentormarginatus, Dermacentor reticulatus, Dermacentor pictus, Dermacentoralbipictus, Dermacentor andersoni, Dermacentor variabilis, Hyalommamauritanicum, Rhipicephalus sanguineus, Rhipicephalus bursa,Rhipicephalus appendiculatus, Rhipicephalus capensis, Rhipicephalusturanicus, Rhipicephalus zambeziensis, Amblyomma americanum, Amblyommavariegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyommacajennense, Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssussylviarum, Varroa jacobsconi;

from Actinedida (Prostigmata), and Acaridida (Astigmata), for example,Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp.,Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp.,Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp.,Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp.,Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp.,Laminosioptes spp.; particularly, for example, Cheyletiella yasguri,Cheyletiella blakei, Demodex canis, Demodex bovis, Demodex ovis, Demodexcaprae, Demodex equi, Demodex caballi, Demodex suis, Neotrombiculaautumnalis, Neotrombicula desaleli, Neoschonegastia xerothermobia,Trombicula akamushi, Otodectes cynotis, Notoedres cati, Sarcoptis canis,Sarcoptes bovis, Sarcoptes ovis, Sarcoptes rupicaprae (=S. caprae),Sarcoptes equi, Sarcoptes suis, Psoroptes ovis, Psoroptes cuniculi,Psoroptes equi, Chorioptes bovis, Psoergates ovis, Pneumonyssoidicmange, Pneumonyssoides caninum, Acarapis woodi.

In addition, the compounds according to the invention can be used forcontrolling pathogenic endoparasites which occur in humans and in animalbreeding and animal husbandry in livestock, breeding, zoo, laboratory,experimental and domestic animals. In this case they are effectiveagainst all or specific stages of development of the endoparasites andalso against resistant and normally sensitive species. By controllingthe pathogenic endoparasites, it is intended to reduce illness, deathsand performance reductions (e.g. in the production of meat, milk, wool,hides, eggs, honey and the like), so that more economical and simpleranimal keeping is made possible by the use of the active compounds.Pathogenic endoparasites include cestodes, trematodes, nematodes,acanthocephales.

The active compounds according to the present invention are suitable forthe control of arthropods, helminths, and protozoa that attack animals.The animals include, for example, agricultural animals such as cattle,sheep, goats, horses, pigs, donkeys, camels, buffalo, rabbits, chickens,turkeys, ducks, geese, hatchery fish, and bees. In addition, the animalsinclude pet animals (also known as companion animals), such as dogs,cats, cage birds, and aquarium fish, and experimental animals (forexample, hamsters, guinea pigs, rats and mice).

Death rates of host animals will be reduced and productivity (in thecases of meat, milk, wool, hides, eggs, honey, and the like) and animalhealth will be improved by the control of these arthropods, helminths,and/or protozoa using the active compounds according to the presentinvention, and as a result, a more economic and simpler animal husbandrycan be achieved.

For example, it is preferable that the acceptance of blood from a hostby parasites should be prevented or inhibited (where applicable). Thecontrol of parasites can be helpful for prevention of infections byinfectious organisms.

The term “control” used herein in the veterinary field means that theactive compounds are effective in reducing each parasite incidence inanimals infected by these parasites to harmless levels. Morespecifically, “controlling” used herein means that the active compoundsare effective in killing, inhibiting the growth of, or inhibiting theproliferation of each parasite.

In the present invention, substances having insecticidal efficaciesagainst noxious insects encompassing all of such pests are referred toas insecticides.

In the case of the active compounds of the present invention used asinsecticides, they may be formed in general formulation forms. Suchformulation forms may include, for example, solutions, emulsions,wettable powders, wettable granules, suspensions, powders, foams,pastes, tablets, granules, aerosols, natural products and syntheticproducts impregnated with the active compounds, microcapsules, coatingagents for seeds, formulations with combustion device (e.g. thecombustion devices include fumigation or fume cartridges, cans, coilsand the like), UVL (cold mist, warm mist) and the like.

These formulations may be prepared by a method known per se. Forexample, they can be prepared by mixing the active compounds togetherwith spreading agents, i.e. liquid diluents or carriers; liquefied gasdiluents or carriers; solid diluents or carriers, and, optionally, withsurfactants i.e. emulsifiers and/or dispersants and/or foam-formingagents.

When water is used as a spreading agent, for example, organic solventsmay be used as an auxiliary solvent.

Liquid diluents or carriers may include, for example, aromatichydrocarbons (e.g. xylene, toluene, alkylnaphthalene etc.), chlorinatedaromatic or chlorinated aliphatic hydrocarbons (e.g. chlorobenzenes,ethylene chlorides, methylene chlorides etc.), aliphatic hydrocarbons(e.g. cyclohexanes or paraffins (e.g. mineral oil fractions)), alcohols(e.g. butanol, glycol and ethers or esters thereof, etc.), ketones (e.g.acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanoneetc.), strong polar solvents (e.g. dimethylformamide, dimethylsulfoxideetc.), water and the like.

Liquefied gas diluents or carriers may include substances which exist asgas at ambient temperature and normal pressure, for example aerosolpropellants such as bulan, propane, nitrogen gas, carbon dioxide andhalogenated hydrocarbons.

Solid diluents may include, for example, crushed natural minerals (e.g.kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite ordiatomaceous earth etc.), crushed synthetic minerals (e.g.highly-dispersive silic acid, alumina, silicate etc.) and the like.

Solid carriers for granules may include, for example, crushed andfractionated rocks (e.g. calcite, marble, pumice stone, sepiolite,dolomite etc.), synthetic granules of inorganic or organic powders, fineparticles of organic materials (e.g. sawdust, coconut shells, maizecobs, tobacco stalks, etc.).

Emulsifiers and/or foam-forming agents may include, for example,nonionic or anionic emulsifiers (e.g. polyoxyethylene fatty acid esters,polyoxyethylene fatty alcohol ethers (e.g. alkylarylpolyglycol ether),alkyl sulfonates alkyl sulfates, aryl sulfonates etc.), albuminhydrolysates and the like.

Examples of dispersants include, for example, lignin sulfite wasteliquor, methylcellulose and the like.

Adhesive agents may also be used for the formulations (powders,granules, emulsions), such as carboxymethylcellulose, natural orsynthetic polymers (e.g. gum Arabic, polyvinyl alcohols, polyvinylacetates etc.) and the like.

Colorants may be used, such as inorganic pigments (e.g. iron oxide,titanium oxide, Prussian blue etc.), organic pigments (e.g. alizarindyes, azo dyes or metallophthalocyanine dyes etc.) as well as traceelements (e.g. salts of iron, manganese, boron, copper, cobalt,molybdenum or zinc etc.).

Generally such formulations may contain the active compounds describedabove in a range from 0.1 to 95% by weight, preferably 0.5 to 90% byweight.

The active compounds of formula (I) of the present invention may bepresent in the commercially useful formulations and usage forms preparedfrom their formulations, as mixed formulation forms with other activecompounds such as insecticides, poison baits, bactericides, acaricides,nematocides, fungicides, growth regulating agents, herbicides and thelike. Above mentioned insecticides may include, for example,organophosphorus agents, carbamate agents, carboxylate chemical agents,chlorohydrocarbon type chemical agents, neonicotinoid type insecticides,insecticidal substances produced by microorganisms and the like.

In addition, the active compounds of formula (I) of the presentinvention may be present as mixed formulations with synergists and suchformulations and usage forms may include commercially usefulformulations and forms. Such synergists, which are not necessarilyactive per se, are the compounds that are capable of enhancing theactivity of the active compounds.

The content of the active compounds of formula (I) of the presentinvention in a commercially useful usage form may vary over a widerange.

The practical usage concentration of the active compounds of formula (I)of the present invention may be within a range of 0.0000001 to 100% byweight, preferably 0.00001 to 1% by weight.

The compounds of formula (I) of the present invention may be used ingeneral manners suitable for their usage forms.

The active compounds of the present invention, when used againsthygienic insects and stored grain pests, have effective stabilityagainst alkaline substances present in lime materials. In addition, theyhave excellent residual efficacies in woods and soils.

In general, for the treatment of animals, the active compounds of thepresent invention may be directly applied to animals. Preferably, theyare applied as pharmaceutical compositions which may contain either oneor both of pharmaceutically acceptable excipients and adjuvants widelyknown in the art.

The active compounds in the veterinary field and animal husbandry areapplied (administered) by known means, such as by enteral administrationin the form of, for example, tablets, capsules, drinks, orally-takenmedicines, granulates, pastes, boluses, the feed-through process, andsuppositories; by parenteral administration, for example, by injection(intramuscular, subcutaneous, intravenous, intraperitoneal, and thelike), by implants, by intranasal application, by dermal use in the formof, for example, dipping or immersing, spraying, pour-on and spot-on,washing, and powdering, and with the help of appliances containing theactive compound, such as collars, ear markers, tail markers, limb bands,halters, marking devices, and the like. The active compounds may beformulated in a suitable form such as shampoo, aerosol, ornon-pressurized spray, for example, pump spray and nebulizer.

When used in live stock, poultry, and pet animals, the active compoundsaccording to the present invention may be applied in any formulation(for example, powder, wettable powder (WP), emulsion, emulsionconcentrate (EC), flowable agent, homogenous solution, and suspensionconcentrate (SC)) containing the active compounds in an amount of 1 to80% by weight, either directly or after dilution (for example, 10- to10000-fold dilution), or by other methods such as chemical baths.

When used in the veterinary field, the active compounds according to thepresent invention may be used in combination with a suitable synergistor another active compound, such as a tickicide, insecticide,anthelmintic, and antiprotozoal agent.

Furthermore, the active compounds of the present invention have lowtoxicity and can be safely used for warm-blooded animals.

For the use in the animal health field, in particular for controllingectoparasitic arthropods, the following compounds may be mentioned aspreferred examples:

1-174, 1-967, 1-729, 1-968, 1-1471, 1-1472, 1-1998, 1-945, 1-308, 1-143,1-317, 1-307, 1-301, 1-305, 6-267, 6-4, 6-273, 1-675, 1-404, 1-313,1-1488, 1-1490, 1-494, 1-495, 1-730, 1-491, 1-146, 1-319, 1-357, 1-304,1-338, 1-1991, 1-345, 1-1291, 1-1292, 1-19, 1-36, 1-150, 1-258, 1-173,1-180, 1-186, 1-231, 1-224, 1-966, 1-963, 1-500, 1-1467, 1-925, 1-926,1-314, 1-312, 1-296, 1-297, 1-327, 1-302, 1-309, 1-220, 1-330, 1-341,1-339, 6-268, 1-866, 1-856, 5-144, 1-346, 1-347, 1-285, 1-398, 1-1289,1-1290, 1-1489, 1-1427, 1-1434, 1-155, 1-329, 1-340,

As more preferred examples for the abovementioned use in the animalhealth field the following compounds may be mentioned:

1-174, 1-967, 1-729, 1-968, 1-1471, 1-1472, 1-1998, 1-945, 1-308, 1-143,1-317, 1-307, 1-301, 1-305, 6-267, 6-4, 6-273, 1-675, 1-404, 1-313,1-1488, 1-1490, 1-494, 1-495, 1-730, 1-491, 1-146, 1-319, 1-357, 1-304,1-338, 1-1991, 1-345, 1-1291, 1-1292, 1-1471,

Of these compounds the following are particularly preferred:

1-967, 1-729, 1-968, 1-1998, 1-945, 1-308, 1-143, 1-307, 1-301, 1-305,6-267, 6-4, 6-273, 1-675, 1-404, 1-313, 1-1488, 1-1490,

In the field of animal health the compound 1-967 may be mentioned as anespecially preferred example.

Further, in the field of animal health the compound 1-729 may bementioned as an especially preferred example.

Further, in the field of animal health the compound 1-143 may bementioned as an especially preferred example.

Further, in the field of animal health the compound 1-307 may bementioned as an especially preferred example.

Further, in the field of animal health the compound 6-4 may be mentionedas an especially preferred example.

Further, in the field of animal health the compound 6-273 may bementioned as an especially preferred example.

When used in the animal health field the active compounds according tothe invention may be used in combination with suitable synergists orother active compounds, such as for example, acaricides, insecticides,anthelmintics, growth regulators (e.g. juvenile hormone analogues,chitin synthesis inhibitors) and anti-protozoal drugs.

An active compound of the present invention can be prepared inconventional formulation forms, when used as an insecticide. Examples ofthe formulation forms include solutions, emulsions, wettable powders,water dispersible granules, suspensions, powders, foams, pastes,tablets, granules, aerosols, active compound-infiltrated natural andsynthetic materials, microcapsules, seed coating agents, formulationsused with a combustion apparatus (for example, fumigation and smokingcartridges, cans, coils or the like as the combustion apparatus), ULV(cold mist, warm mist), and the like.

These formulations can be produced by methods that are known per se. Forexample, a formulation can be produced by mixing the active compoundwith a developer, that is, a liquid diluent or carrier; a liquefied gasdiluent or carrier; a solid diluent or carrier, and optionally with asurfactant, that is, an emulsifier and/or dispersant and/or foamingagent.

In the case where water is used as the developer, for example, anorganic solvent can also be used as an auxiliary solvent.

Examples of the liquid diluent or carrier include aromatic hydrocarbons(for example, xylene, toluene, alkylnaphthalene and the like),chlorinated aromatic or chlorinated aliphatic hydrocarbons (for example,chlorobenzenes, ethylene chlorides, methylene chlorides), aliphatichydrocarbons (for example, cyclohexanes), paraffins (for example,mineral oil fractions), alcohols (for example, butanol, glycols andtheir ethers, esters and the like), ketones (for example, acetone,methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and thelike), strongly polar solvents (for example, dimethylformamide,dimethylsulfoxide and the like), water and the like.

The liquefied gas diluent or carrier may be those which are gaseous atnormal temperature and normal pressure, for example, aerosol propellantssuch as butane, propane, nitrogen gas, carbon dioxide and halogenatedhydrocarbons.

Examples of the solid diluent include pulverized natural minerals (forexample, kaolin, clay, talc, chalk, quartz, attapulgite,montmorillonite, diatomaceous earth, and the like), pulverized syntheticminerals (for example, highly dispersed silicic acid, alumina, silicatesand the like), and the like.

Examples of the solid carrier for granules include pulverized andscreened rocks (for example, calcite, marble, pumice, sepiolite,dolomite and the like), synthetic granules of inorganic and organicpowder, fine particles of organic materials (for example, sawdust,coconut shells, maize cobs, tobacco stalk and the like), and the like.

Examples of the emulsifier and/or foaming agent include nonionic andanionic emulsifiers [for example, polyoxyethylene fatty acid esters,polyoxyethylene fatty acid alcohol ethers (for example, alkylarylpolyglycol ether), alkylsulfonates, alkylsulfates, arylsulfonates andthe like], albumin hydrolyzate, and the like.

Examples of the dispersant include lignin sulfite waste liquor andmethylcellulose.

Fixing agents can also be used in the formulations (powders, granules,emulsions), and examples of the fixing agent includecarboxymethylcellulose, natural and synthetic polymers (for example, gumarabic, polyvinyl alcohol, polyvinyl acetate, and the like) and thelike.

Colorants can also be used, and examples of the colorants includeinorganic pigments (for example, iron oxide, titanium oxide, PrussianBlue and the like), organic dyes such as alizarin dyes, azo dyes ormetal phthalocyanine dyes, and in addition, trace elements such as thesalts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The formulations in general can contain the active ingredient in anamount ranging from 0.1 to 95% by weight, and preferably 0.5 to 90% byweight.

The compound according to the present invention can also exist as anadmixture with other active compounds, for example, insecticides,poisonous baits, bactericides, miticides, nematicides, fungicides,growth regulators, herbicides and the like, in the form of theircommercially useful formulation forms and in the application formsprepared from those formulations.

The content of the compound according to the present invention in acommercially useful application form can be varied within a wide range.

The concentration of the active compound according to the presentinvention in actual usage can be, for example, in the range of 0.0000001to 100% by weight, and preferably 0.00001 to 1% by weight.

The compounds according to the present invention can be used throughconventional methods that are appropriate for the usage form.

The active compound of the present invention have, when used againsthygiene pests and pests associated with stored products, stabilityeffective against alkali on lime materials, and also shows excellentresidual effectiveness on wood and soil.

Next, the present invention is exemplified by way of the followingexamples, but the invention is not intended to be limited thereto.

SYNTHESIS EXAMPLE 1 Synthesis of6-chloro-N-{4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)benzyl}pyridine-3-carboxamide(No. 1-198)

Step 1-1. Synthesis of4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g),4-fluoro-2-trifluoromethylbenzo-nitrile (4.5 g) and potassium carbonate(5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture wasstirred at 110° C. for 4 hours. After cooling the mixture to roomtemperature, the solution was diluted with ethyl acetate and washed withwater three times. The organic layer was dried over anhydrous magnesiumsulfate. The solvent was evaporated off under reduced pressure, and theresidue was then purified by a column chromatography to obtain the titlecompound (3.8 g).

¹H-NMR (CDCl₃) δ: 2.56-2.66 (1H, m), 2.91-2.99 (1H, m), 3.55-3.71 (2H,m), 3.84 (1H, d), 4.16 (1H, d), 6.72 (1H, dd), 6.86 (1H, d), 7.27 (2H,d), 7.42 (1H, t), 7.65 (1H, d).

Step 1-2. Synthesis of t-butyl{4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)-benzyl}carbamate

To the mixture comprising4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-2-(trifluoro-methyl)benzonitrile(3.2 g), di-t-butyl bicarbonate (3.1 g), nickel chloride dihydrate (1.7g), methanol (50 mL) and dioxane (100 mL), sodium borohydride (1.3 g)was added under ice cooling, followed by stirring for 30 minutes. Afterthe dilution with ethyl acetate, the solution was washed with water,saturated sodium bicarbonate solution, and saturated brine. The organiclayer was dried over anhydrous magnesium sulfate. The solvent wasevaporated off under reduced pressure, and the residue was then purifiedby a column chromatography to obtain the title compound (2.5 g).

¹H-NMR (CDCl₃) δ: 1.45 (9H, s), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.45-3.61 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.38 (2H, d), 4.83 (1H,br s), 6.71 (1H, dd), 6.79 (1H, d), 7.29 (2H, d), 7.39 (1H, t), 7.44(1H, d).

Step 1-3. Synthesis of1-{4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)phenyl}methanamine

A mixture comprising t-butyl{4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)benzyl}carbamate(6.0 g), concentrated hydrochloric acid (20 mL) and ethanol (100 mL) wasstirred at 50° C. for three hours. After cooling the mixture to roomtemperature, the reaction solution was diluted by adding water (150 mL)and ethyl acetate (150 mL). By adding sodium carbonate in smallportions, the solution was neutralized. After the extraction using ethylacetate, the organic layer was washed with saturated brine, and driedover anhydrous magnesium sulfate. The solvent was evaporated off underreduced pressure to obtain the title compound (5.2 g).

¹H-NMR (CDCl₃) δ: 2.50-2.60 (1H, m), 2.83-2.91 (1H, m), 3.48-3.61 (2H,m), 3.79 (1H, d), 3.91 (2H, s), 4.06 (1H, d), 6.74 (1H, d), 6.80 (1H,d), 7.30 (2H, d), 7.40 (2H, dd).

Step 1-4. Synthesis of6-chloro-N-{4-[3-(3,5-dichlorophenyl)-3-(trifluoro-methyl)-pyrrolidin-1-yl]-2-(trifluoromethyl)benzyl}pyridine-3-carboxyamide

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine(0.1 g) and 6-chloronicotinic acid chloride (0.04 g) were dissolved inmethylene chloride (5 mL), and then pyridine (0.03 g) was added thereto.The resulting mixture was stirred at room temperature for one hour. Thesolvent was evaporated off under reduced pressure, and the residue wasthen purified by a column chromatography to obtain the title compound(0.1 g).

¹H-NMR (CDCl₃) δ: 2.50-2.64 (1H, m), 2.83-2.88 (1H, m), 3.36 (2H, s),3.49-3.60 (2H, m), 3.79 (1H, d), 4.08 (1H, d), 4.70 (2H, d), 6.30 (1H,bt), 6.70-6.83 (2H, m), 7.26-7.51 (5H, m), 8.01-8.71 (2H, m).

SYNTHESIS EXAMPLE 2 Synthesis ofN-({2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-(tri-fluoromethyl)pyrimidin-5-yl}methyl)propanamide(No. 3-168)

Step 2-1. Synthesis of ethyl2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (1.2 g) [seeJ. Med. Chem., 43, 3995 (2000)],3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine (1.5 g), andpotassium carbonate (0.7 g) were added to N,N-dimethylformamide (50 mL)and the mixture was heated at 100° C. for 5 hours. After cooling, thereaction solution was poured over ice water, and then extracted withethyl acetate. The organic layer was dried over magnesium sulfate. Thesolvent was evaporated off under reduced pressure, and the residue wasthen purified by a silica gel chromatography to obtain the titlecompound (2.4 g, 95%).

¹H-NMR (CDCl₃) δ: 1.39 (3H, t), 2.50-2.60 (1H, m), 2.89-2.93 (1H, m),3.87-3.89 (2H, m), 4.08-4.16 (1H, m), 4.37 (2H, q), 4.52-4.56 (1H, m),7.45 (2H, s), 8.95 (1H, s).

Step 2-2. Synthesis of2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylicacid

Ethyl2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate(2.4 g) was added to a mixture solution comprising 1,4-dioxane (40 mL)and an aqueous solution (40 mL) of sodium hydroxide (2.0 g), and thenheated at 80° C. for 10 hours. After cooling, the reaction solution waspoured over ice water, acidified by adding concentrated hydrochloricacid, and then extracted with ethyl acetate. The organic layer was driedover magnesium sulfate. The solvent was evaporated off under reducedpressure to obtain the title compound (2.1 g, 92%).

Step 2-3. Synthesis of{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-pyrimidin-5-yl}methanol

2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)pyrimidine-5-carboxylicacid (2.0 g) was added to 1,2-dichloroethane (50 mL). To the resultingmixture, thionyl chloride (1.0 g), and one drop of N,N-dimethylformamidewas added and the mixture was refluxed under heating for 5 hours. Afterremoving the solvent by evaporation, the residues were dissolved in1,4-dioxane (20 mL), and the resulting solution was added dropwise tothe mixture solution comprising water (30 mL), 1,4-dioxane (30 mL), andsodium borohydride (0.4 g) under ice cooling. After the dropwiseaddition was completed, the solution was refluxed under heating for onehour. After cooling, the reaction solution was poured over ice water andthen extracted with ethyl acetate. After cooling, the extraction wascarried out by adding water and ethyl acetate to the solution. Theorganic layer was dried over magnesium sulfate. The solvent wasevaporated off under reduced pressure, and the residue was then purifiedby a silica gel chromatography to obtain the title compound (1.65 g,86%).

¹H-NMR (CDCl₃) δ: 1.81 (1H, t), 2.35-2.58 (1H, m), 2.83-2.92 (1H, m),3.82-3.88 (2H, m), 4.02-4.06 (1H, m), 4.47-4.51 (1H, m), 4.73 (2H, d),7.44 (2H, s), 8.63 (1H, s).

Step 2-4. Synthesis of1-{2-[3-(3,4,5-trichlorophenyl)-3-(tri-fluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanamine

{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(tri-fluoromethyl)pyrimidin-5-yl}methanol(1.0 g) was added to tetrahydrofuran (30 mL), and then, under icecooling, tetrahydrofuran solution (10 mL) comprising methanesulfonylchloride (0.3 g) was added dropwise thereto. After the dropwise additionwas completed, the solution was stirred at room temperature for onehour. The resulting solution was added dropwise to a mixture solution,which was separately prepared to comprise 28% ammonia water (50 mL),tetrahydrofuran (100 mL), and methanol (100 mL), under ice cooling.After the stirring for 12 hours at room temperature, the reactionsolution was poured over ice water, and then extracted with ethylacetate. The organic layer was dried over magnesium sulfate. The solventwas evaporated off under reduced pressure, and the residue was thenpurified by a silica gel chromatography to obtain the title compound(0.4 g, 45%).

¹H-NMR (CDCl₃) δ: 1.65 (2H, br s), 2.49-2.54 (1H, m), 2.82-2.91 (1H, m),3.68-4.16 (6H, m), 4.46-4.50 (1H, m), 7.44 (2H, s), 8.58 (1H, s).

Step 2-5. Synthesis ofN-{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methyl)propanamide

1-{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanamine(0.1 g) and triethylamine (0.05 g) were added to dichloromethane (20mL), and then dichloromethane solution (10 mL) comprising anhydrouspropionic acid (0.05 g) was added dropwise thereto under ice cooling.After the dropwise addition was completed, the reaction solution wasstirred at room temperature for one hour. The solvent was evaporated offunder reduced pressure, and the residue was then purified by a silicagel chromatography to obtain the title compound (0.1 g, 90%).

¹H-NMR (CDCl₃) δ: 1.16 (3H, t), 2.21 (2H, q), 2.46-2.56 (1H, m),2.82-2.90 (1H, m), 3.80-3.83 (2H, m), 3.98-4.02 (1H, m), 4.42-4.47 (3H,m), 5.75-5.78 (1H, m), 7.43 (2H, s), 8.63 (1H, s).

SYNTHESIS EXAMPLE 3 Synthesis ofN-({2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-trifluoromethyl)-1,3-thiazol-5-yl}methyl)propanamide(No. 5-142)

Step 3-1. Synthesis of ethyl2-[3-(3,4,5-trichlorophenyl)-3-(trifluoro-methyl)pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate (1.4 g)[see J. Het. Chem., 22, 1621 (1985)],3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidine (1.7 g), andpotassium carbonate (0.8 g) were added to N,N-dimethylformamide (50 mL),followed by heating at 100° C. for five hours. After cooling, thereaction solution was poured over ice water, and then extracted withethyl acetate. The organic layer was dried over magnesium sulfate. Thesolvent was evaporated off under reduced pressure, and the residue wasthen purified by a silica gel chromatography to obtain the titlecompound (2.5 g, 86%).

¹H-NMR (CDCl₃) δ: 1.35 (3H, t), 2.59-2.64 (1H, m), 2.93-2.97 (1H, m),3.61-3.73 (2H, m), 3.96-4.00 (1H, m), 4.32 (2H, q), 4.42-4.46 (1H, m),7.41 (2H, s).

Step 3-2. Synthesis of2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxylicacid

Ethyl2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(tri-fluoromethyl)-1,3-thiazole-5-carboxylate(2.4 g) was added to a mixture solution comprising 1,4-dioxane (40 mL)and an aqueous solution (40 mL) of sodium hydroxide (2.0 g), followed byheating at 80° C. for ten hours. After cooling, the reaction solutionwas poured over ice water, acidified by adding concentrated hydrochloricacid, and then extracted with ethyl acetate. The organic layer was driedover magnesium sulfate. The solvent was evaporated off under reducedpressure to obtain the title compound (2.25 g, 99%).

Step 3-3. Synthesis of{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methanol

2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)-1,3-thiazole-5-carboxylicacid (2.2 g) was added to 1,2-dichloroethane (50 mL). Thionyl chloride(1.0 g) and one drop of N,N-dimethylformamide were added to the mixture,which was then refluxed under heating for 5 hours. After removing thesolvent by evaporation, the residues were dissolved in 1,4-dioxane (20mL), and then added dropwise to the mixture solution comprising water(30 mL), 1,4-dioxane (30 mL), and sodium borohydride (0.5 g) under icecooling. After the dropwise addition was completed, the reactionsolution was refluxed under heating for one hour. After cooling, thereaction solution was poured over ice water, and then extracted withethyl acetate. After cooling, the extraction was again carried out byadding water and ethyl acetate. The organic layer was dried overmagnesium sulfate. The solvent was evaporated off under reducedpressure, and the residue was then purified by a silica gelchromatography to obtain the title compound (1.1 g, 65%).

¹H-NMR (CDCl₃) δ: 1.94 (1H, t), 2.57-2.61 (1H, m), 2.87-2.95 (1H, m),3.56-3.70 (2H, m), 3.93-3.97 (1H, m), 4.36-4.40 (1H, m), 4.86 (2H, d),7.40 (2H, s).

Step 3-4. Synthesis of1-{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methanamine

{2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)-1,3-thiazol-5-yl}methanol(1.05 g) was added to tetrahydrofuran (30 mL). Then, tetrahydrofuransolution (10 mL) comprising methanesulfonyl chloride (0.3 g) was addeddropwise thereto under ice cooling. After the dropwise addition wascompleted, the reaction solution was stirred at room temperature for onehour. The resulting solution was added dropwise to a mixture solution,which was separately prepared to contain 28% ammonia water (50 mL),tetrahydrofuran (100 mL), and methanol (100 mL), under ice cooling.After stirring the mixture at room temperature for 12 hours, thereaction solution was poured over ice water, and then extracted withethyl acetate. The organic layer was dried over magnesium sulfate. Thesolvent was evaporated off under reduced pressure, and the residue wasthen purified by a silica gel chromatography to obtain the titlecompound (0.4 g, 45%).

¹H-NMR (CDCl₃) δ: 1.64 (2H, br s), 2.51-2.61 (1H, m), 2.88-2.92 (1H, m),3.56-3.65 (2H, m), 3.92-3.96 (1H, m), 4.02-4.16 (2H, m), 4.16-4.38 (1H,m), 7.41 (2H, s).

Step 3-5. Synthesis ofN-({2-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)-pyrrolidin-1-yl]-4-(trifluoromethyl)-1,3-thiazol-5-yl}methyl)propanamide

1-{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoro-methyl)-1,3-thiazol-5-yl}methanamine(0.1 g) and triethylamine (0.05 g) were added to dichloromethane (20mL), followed by the dropwise addition of dichloromethane solution (10mL) comprising anhydrous propionic acid (0.05 g) under ice cooling.After the dropwise addition was completed, the reaction solution wasstirred at room temperature for one hour. The solvent was evaporated offunder reduced pressure, and the residue was then purified by a silicagel chromatography to obtain the title compound (0.1 g, 90%).

¹H-NMR (CDC₃) δ: 1.14 (3H, t), 2.25 (2H, q), 2.52-2.58 (1H, m),2.87-2.91 (1H, m), 3.55-3.64 (2H, m), 3.91 (1H, m), 4.34 (1H, m),4.55-4.57 (2H, m), 5.91-5.93 (1H, m), 7.39 (2H, s).

SYNTHESIS EXAMPLE 4 Synthesis ofN-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)-pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide(No. 6-273)

Step 4-1. Synthesis of 5-bromo-N-hydroxyindan-1-imine

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammoniumchloride (2.5 g) and sodium acetate (2.9 g) were added to the solutionat room temperature, and then stirred overnight. The reaction solutionwas diluted with water and extracted twice with ethyl acetate. Theorganic layers were combined, washed with water, and dried overanhydrous magnesium sulfate. The desiccant was filtered and separated,and then the solvent was evaporated off under reduced pressure to obtain5-bromo-N-hydroxyindan-1-imine (5.1 g).

¹H-NMR (DMSO-d₆) δ: 2.76-2.81 (2H, m), 2.98-3.03 (2H, m), 7.41-7.49 (2H,m), 7.59 (1H, s), 10.98 (1H, s).

Step 4-2. Synthesis of N-(5-bromo-2,3-dihydro-1H-inden-1-yl)propanamide

5-Bromo-N-hydroxyindan-1-imine (2.0 g), propionic acid anhydride (2.3 g)and nickel chloride dihydrate (1.1 g) were dissolved in methanol. Sodiumborohydride (1.3 g) was slowly added to the solution under ice cooling,and the mixture was stirred for 30 minutes. Diethylenetriamine (2.9 ml)was added to the reaction solution, which was heated back to roomtemperature, and stirred for 30 minutes. The mixture was diluted withethyl acetate and water, and stirred for 5 minutes. The organic layerwas separated and the aqueous layer was extracted with ethyl acetate.The organic layers were combined, washed with saturated sodiumbicarbonate aqueous solution, and dried over magnesium sulfate. Thedesiccant was filtered and separated, and the solvent was evaporated offunder reduced pressure. The Residue was separated and purified by acolumn chromatography to obtainN-(5-bromo-2,3-dihydro-1H-inden-1-yl)propanamide (1.1 g).

¹H-NMR (acetone-d₆) δ: 1.19 (3H, t), 1.84-1.96 (1H, m), 2.26 (2H, q),2.49-2.60 (1H, m), 2.88-3.10 (2H, m), 5.36-5.46 (1H, m), 6.65 (1H, s),7.24 (1H, d), 7.44 (1H, d), 7.51 (1H, s).

Step 4-3. Synthesis ofN-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoro-methyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide

3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidine (0.46g) and N-(5-bromo-2,3-dihydro-1H-inden-1-yl)propanamide (0.35 g) weredissolved in toluene and deaeration procedure was performed three timesunder argon atmosphere. Sodium tert-butoxide (0.25 g), Xantphos (0.05 g)and tris(dibenzylideneacetone)dipalladium (0) (chloroform adduct) (0.03g) were added to the mixture and heated and stirred at 100° C. underargon atmosphere for 2 hours. The solution was cooled to roomtemperature and the reaction liquid was diluted with ethyl acetatefollowed by washing with water and brine. The organic layer was driedover anhydrous magnesium sulfate. The desiccant was filtered andseparated, the solvent was evaporated off under reduced pressure, andthe residue was purified by a silica gel chromatography to obtainN-(5-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-2,3-dihydro-1H-inden-1-yl)propanamide(0.51 g).

¹H-NMR (CDCl₃) δ: 1.18 (3H, t), 1.75-1.86 (1H, m), 2.23 (2H, q),2.54-2.64 (2H, m), 2.79-3.02 (3H, m), 3.47-3.64 (2H, m), 3.84 (1H, d),4.15 (1H, d), 5.38-5.57 (2H, m), 6.52-6.49 (2H, m), 7.20 (1H, d), 7.85(2H, s), 7.91 (1H, s).

The compounds according to the present invention as well as usefulintermediates for the manufacturing of the compounds are described inthe following tables.

In tables, abbreviations are as follows: Me: methyl, Et: ethyl, Pr:propyl, Bu: butyl, Allyl: allyl, Pen: pentyl, Hex: hexyl, Ph: phenyl,cyclo-: cyclic, py: pyridyl, pyrro or pyrrolidine: pyrrolidinyl, pipe orpiperidine: piperidinyl, morph or morpholine: morpholinyl, thiomorph orthiomorpholine: thiomorpholinyl. In the tables, cyclic groups to which acarbonyl group is attached to,

are bound to the appropriate position in the general formula through thecarbonyl carbon atom as follows:

TABLE 1

Table 1-Ex.-No. B¹ B² B³ B⁴ X¹ R A¹ A² A³ A⁴ R³ R⁴ R⁵ R⁶ 1 1-1 C—Cl C—HC—Cl C—H H CF3 CH CH C-Cl CH H H H H 1 1-2 C—Cl C—H C—Cl C—H H CF3 CH CHC-Cl CH H H H n-PrCO 1 1-3 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H Hiso-PrCO 1 1-4 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H cyclo-PrCO 11-5 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H n-BuCO 1 1-6 C—Cl C—HC—Cl C—H H CF3 CH CH C-Cl CH H H H tert-BuCO 1 1-7 C—Cl C—H C—Cl C—H HCF3 CH CH C-Cl CH H H H iso-BuCO 1 1-8 C—Cl C—H C—Cl C—H H CF3 CH CHC-Cl CH H H H cyclo-BuCO 1 1-9 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H HH (CH3)3CCH2CO 1 1-10 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H Hcyclo-PenCO 1 1-11 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H Hcyclo-HexCO 1 1-12 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H Hcyclo-PrCH2CO 1 1-13 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H CF3CO 11-14 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H CCl3CO 1 1-15 C—Cl C—HC—Cl C—H H CF3 CH CH C-Cl CH H H H ClCH2CO 1 1-16 C—Cl C—H C—Cl C—H HCF3 CH CH C-Cl CH H H H CF2ClCO 1 1-17 C—Cl C—H C—Cl C—H H CF3 CH CHC-Cl CH H H H CICH2CH2CO 1 1-18 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH HH H HCF2CF2CO 1 1-19 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H HCF3CH2CO 1 1-20 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H (CF3)2CHCO 11-21 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H HCF2CO 1 1-22 C—Cl C—HC—Cl C—H H CF3 CH CH C-Cl CH H H H ClCH2CO 1 1-23 C—Cl C—H C—Cl C—H HCF3 CH CH C-Cl CH H H H

1 1-24 C—Cl C—H C—Cl C—H H CF3 CH CH C-Cl CH H H H

1 1-25 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-26 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-27 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-28 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-29 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH2═CH—CO 1 1-30 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH═CH—CO 1 1-31 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H CH2═C(CH3)—CO 1 1-32 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H CH3CH═C(CH3)—CO 1 1-33 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl CH H H H (CH3)2C═CH—CO 1 1-34 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H CH2═C(Cl)—CO 1 1-35 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CHH H H ClCH═C(CH3)—CO 1 1-36 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH2═CHCH2—CO 1 1-37 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H HCC—CO 11-38 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CC—CO 1 1-39 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H NCCH2—CO 1 1-40 C—Cl C—H C—Cl C—HH CF3 CH CH C—Cl CH H H H CH3OCH2CO 1 1-41 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H C2H5OCH2—CO 1 1-42 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH HH H CH3SCH2CO 1 143 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3O(CO)CH2—CO 1 1-44 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3(CO)OCH2—CO 1 1-45 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3O(CO)—CO 1 1-46 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCF3O(CO)—CO 1 1-47 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3(CO)CH2—CO 1 1-48 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H(CH3)2NCH2—CO 1 1-49 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H PhCO 11-50 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H PhCH2CO 1 1-51 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl CH H H H 2-py—CO 1 1-52 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H 3-py—CO 1 1-53 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H 4-py—CO 1 1-54 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-55 C—Cl C—H C—Cl C—H H CF3 CH CHF C—Cl CH H H H 2-F—PhCO 1 1-56 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 3-F—PhCO 1 1-57 C—Cl C—H C—Cl C—HH CF3 CH CH C—Cl CH H H H 4-F—PhCO 1 1-58 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H 2-Cl—PhCO 1 1-59 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H HH 3-Cl—PhCO 1 1-60 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 4-Cl—PhCO1 1-61 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 2-Br—PhCO 1 1-62 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 2-CF3—PhCO 1 1-63 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H 2-CH3—PhCO 1 1-64 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl CH H H H

1 1-65 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-66 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-67 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-68 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-69 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-70 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-72 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3 CH3CO 1 1-73 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3 CH3CH2CO 1 1-74 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H CH3 cyclo-PrCO 1 1-75 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H CH3 CF3CH2CO 1 1-76 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H CH3NHCO 1 1-77 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-78 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CF3CH2NHCO1 1-79 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H n-PrNHCO 1 1-80 C—ClC—H C—Cl C—H H CF3 CH CHI C—Cl CH H H H iso-PrNHCO 1 1-81 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H cyclo-PrNHCO 1 1-82 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H n-BuNHCO 1 1-83 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H tert-BuNHCO 1 1-84 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH HH H cyclo-BuNHCO 1 1-85 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-PenNHCO 1 1-86 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-HexNHCO 1 1-87 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH2═CHCH2NHCO 1 1-88 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HHCCCH2NHCO 1 1-89 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCH2NHCO 1 1-90 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HNCCH2NHCO 1 1-91 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCF3(CH3)CHNHCO 1 1-92 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCF3(CH3)2CNCO 1 1-94 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HFCH2CH2NHCO 1 1-95 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCF3CH2CH2NHCO 1 1-96 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HHCF2CF2CH2NHCO 1 1-97 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3OCH2CH2NHCO 1 1-98 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CH2NHCO 1 1-99 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-100 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-101 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H EtO2CCH2NHCO 1 1-102C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 2-CF3—PhNHCO 1 1-103 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H 3-CF3—PhNHCO 1 1-104 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl CH H H H 4-CF3—PhNHCO 1 1-105 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H 2-py—NHCO 1 1-106 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl CH H H H 3-py—NHCO 1 1-107 C—Cl C—H C—Cl C—H H CF3 CH CH C—ClCH H H H 4-py—NHCO 1 1-108 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-109 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-110 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H PhCH2HNCO 1 1-111C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-112 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3 CH3NHCO 1 1-113C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3 CH3CH2NHCO 1 1-114 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3 cyclo-PrNHCO 1 1-115 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl CH H H H pyrrolidineCO 1 1-116 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H piperidineCO 1 1-117 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H morpholineCO 1 1-118 C—Cl C—H C—Cl C—H H CF3 CHCH C—Cl CH H H H (CH3)2NCO 1 1-119 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CHH H H CH3OCO 1 1-120 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2OCO 1 1-121 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H c-PrOCO 11-122 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H c-PrCH2OCO 1 1-123C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CF3CH2OCO 1 1-124 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl CH H H H CH2═CHCH2OCO 1 1-125 C—Cl C—H C—ClC—H H CF3 CH CH C—Cl CH H H H HCCCH2OCO 1 1-126 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl CH H H H PhOCO 1 1-127 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CHH H H PhCH2OCO 1 1-128 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Htert-BuOCO 1 1-129 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H CH3tert-BuOCO 1 1-130 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3SO2 11-131 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH2SO2 1 1-132 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CF3SO2 1 1-133 C—Cl C—H C—Cl C—HH CF3 CH CH C—Cl CH H H H CF3CH2SO2 1 1-134 C—Cl C—H C—Cl C—H H CF3 CHCH C—Cl CH H H H PhSO2 1 1-135 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H HH CH3NHCONHSO2 1 1-136 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H(CH3)2NCONHSO2 1 1-137 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CS1 1-138 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH2CS 1 1-139C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCS 1 1-140 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl CH H H H CF3CH2CS 1 1-141 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H H 1 1-143 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H CH3CH2CO 1 1-144 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hn-PrCO 1 1-145 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H iso-PrCO 11-146 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-147C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H n-BuCO 1 1-148 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H tert-BuCO 1 1-149 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H iso-BuCO 1 1-150 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H cyclo-BuCO 1 1-151 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H (CH3)3CCH2C 1 1-152 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH cyclo-PenCO 1 1-153 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-HexCO 1 1-154 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-155 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 11-156 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3CO 1 1-157 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CCl3CO 1 1-158 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H ClCH2CO 1 1-159 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF2ClCO 1 1-160 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH HH H ClCH2CH2CO 1 1-161 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HHCF2CF2CO 1 1-162 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3CH2CO1 1-163 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H (CF3)2CHCO 1 1-164C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H HCF2CO 1 1-165 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H ClCH2CO 1 1-166 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H

1 1-167 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-168 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-169 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-170 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-171 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-172 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-173 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH2═CH—CO 1 1-174C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH═CH—CO 1 1-175 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH2═C(CH3)—CO 1 1-176 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH═C(CH3)—CO 1 1-177 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H (CH3)2C═CH—CO 1 1-178 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH2═C(Cl)—CO 1 1-179 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H ClCH═(CH3)—CO 1 1-180 C—Cl C—H C—Cl C—H H CF3CH CH C—CF3 CH H H H CH2═CHCH2—CO 1 1-181 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H HCC—CO 1 1-182 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH CH3CC—CO 1 1-183 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H NCCH2—CO1 1-184 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CO 1 1-185C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H C2H5OCH2—CO 1 1-186 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-187 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3O(CO)CH2—CO 1 1-188 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H CH3(CO)OCH2—CO 1 1-189 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H CH3O(CO)—CO 1 1-190 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H CF3O(CO)—CO 1 1- 191 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CH3(CO)CH2—CO 1 1-192 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H (CH3)2NCH2—CO 1 1-193 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH HH H PhCO 1 1-194 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H PhCH2CO 11-195 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 2-py-CO 1 1-196 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 3-py-CO 1 1-197 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H 4-py-CO 1 1-198 C—Cl C—H C—Cl C—H H CF3CH CH C—CF3 CH H H H

1 1-199 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 2-F—PhCO 1 1-200C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 3-F—PhCO 1 1-201 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H 4-F—PhCO 1 1-202 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H 2-Cl—PhCO 1 1-203 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H 3-Cl—PhCO 1 1-204 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CHH H H 4-Cl—PhCO 1 1-205 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H2-Br—PhCO 1 1-206 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H2-CF3—PhCO 1 1-207 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H2-CH3—PhCO 1 1-208 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-209 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-210 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-211 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-212 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-213 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-214 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-215 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-216 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-217 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H CH3 CH3CO 1 1-218C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H CH3 cyclo-PrCO 1 1-219 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3NHCO 1 1-220 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-221 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H CF3CH2NHCO 1 1-222 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H n-PrNHCO 1 1-223 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H iso-PrNHCO 1 1-224 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrNHCO 1 1-225 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hn-BuNHCO 1 1-226 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Htert-BuNHCO 1 1-227 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-BuNHCO 1 1-228 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PenNHCO 1 1-229 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-HexNHCO 1 1-230 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH2═CHCH2NHCO 1 1-231 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HHCCCH2NHCO 1 1-232 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2NHCO 1 1-233 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HNCCH2NHCO 1 1-234 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCF3(CH3)CHNHCO 1 1-235 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCF3(CH3)2CNCO 1 1-237 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HFCH2CH2NHCO 1 1-238 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CH2NHCO 1 1-239 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HHCF2CF2CH2NHCO 1 1-240 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-241 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-242 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H EtO2CCH2NHCO 11-243 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2NHCO 11-244 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CH2NHCO 11-245 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 2-CF3—PhNHCO 1 1-246C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 3-CF3—PhNHCO 1 1-247 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H 4-CF3—PhNHCO 1 1-248 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H 2-py—NHCO 1 1-249 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H 3-py—NHCO 1 1-250 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H 4-py—NHCO 1 1-251 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H

1 1-252 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-253 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H PhCH2HNCO 1 1-254C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-255 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H pyrrolidineCO 11-256 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H piperidineCO 1 1-257C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H morpholineCO 1 1-258 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H CH3 CH3NHCO 1 1-259 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H CH3 CH3CH2NHCO 1 1-260 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H CH3 cyclo-PrNHCO 1 1-261 C—Cl C—H C—Cl C—H H CF3CH CH C—CF3 CH H H H CH3OCO 1 1-262 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H CH3CH2OCO 1 1-263 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hc-PrOCO 1 1-264 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H c-PrCH2OCO1 1-265 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3CH2OCO 1 1-266C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH2═CHCH2OCO 1 1-267 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H HCCCH2OCO 1 1-268 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H PhOCO 1 1-269 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H PhCH2OCO 1 1-270 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H tert-BuOCO 1 1-271 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HCH3 tert-BuOCO 1 1-272 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2 1 1-273 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2SO2 11-274 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3SO2 1 1-275 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3CH2SO2 1 1-276 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H PhSO2 1 1-277 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H CH3NHCONHSO2 1 1-278 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H (CH3)2NCONHSO2 1 1-279 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CH3CS 1 1-280 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH CH3CH2CS 1 1-281 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCS 1 1-282 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CF3CH2CS1 1-283 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH H H H H 1 1-284 C—Cl C—HC—Cl C—H H CF3 CH CH C—Br CH H H H n-PrCO 1 1-285 C—Cl C—H C—Cl C—H HCF3 CH CH C—Br CH H H H CH3CH2CO 1 1-286 C—Cl C—H C—Cl C—H H CF3 CH CHC—Br CH H H H cyclo-PrCO 1 1-287 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH HH H CF3CH2CO 1 1-288 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-289 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 CH H H H H 11-290 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 CH H H H CH3CO 1 1-291 C—ClC—H C—Cl C—H H CF3 CH CH C—CH3 CH H H H CH3CH2CO 1 1-292 C—Cl C—H C—ClC—H H CF3 CH CH C—CH3 CH H H H cyclo-PrCO 1 1-293 C—Cl C—H C—Cl C—H HCF3 CH CH C—CH3 CH H H H CF3CH2CO 1 1-294 C—Cl C—H C—Cl C—H H CF3 CH CHC—CH3 CH H H H CH3CH2NHCO 1 1-295 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3CH H H H H 1 1-296 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-297 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HClCH2CH2CO 1 1-298 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3OCO1 1-299 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CH2OCO 1 1-300C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H tert-BuOCO 1 1-301 C—CF3C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3NHCO 1 1-302 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-303 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—CF3 CH H H H n-PrNHCO 1 1-304 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—CF3 CH H H H iso-PrNHCO 1 1-305 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CF3 CH H H H cyclo-PrNHCO 1 1-306 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—ClCH H H H H 1 1-307 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3CH2CO 1 1-308 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCO 1 1-309 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCF3CH2CO 1 1-310 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H Htert-BuOCO 1 1-311 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H H 11-312 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-313C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-314 C—CF3C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CF3CH2CO 1 1-315 C—CF3 C—H C—CF3C—H H CF3 CH CH C—Br CH H H H tert-BuOCO 1 1-316 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—NO2 CH H H H H 1 1-317 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—NO2CH H H H CH3CO 1 1-318 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—NO2 CH H H HCH3CH2CO 1 1-319 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—NO2 CH H H Hcyclo-PrCO 1 1-320 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—NO2 CH H H HCF3CH2CO 1 1-321 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SO2 11-322 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CH2SO2 1 1-323C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CF3SO2 1 1-324 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—CF3 CH H H H CF3CH2SO2 1 1-325 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CF3 CH H H H PhSO2 1 1-326 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—CF3 CH H H H H 1 1-327 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H HH CF3CH2CO 1 1-328 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H n-PrCO1 1-329 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H iso-PrCO 1 1-330C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-331 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SO2 1 1-332 C—Cl C—Cl C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3CH2SO2 1 1-333 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—CF3 CH H H H CF3SO2 1 1-334 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF3CH2SO2 1 1-335 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CHH H H PhSO2 1 1-336 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H H 11-337 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CO 1 1-338 C—ClC—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-339 C—Cl C—Cl C—ClC—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-340 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—Cl CH H H H CF3CH2CO 1 1-341 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Cl CH H H H CH3CH2NHCO 1 1-342 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CHH H H CH3SO2 1 1-343 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H H H 11-344 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H H CH3CO 1 1-345 C—ClC—Cl C—Cl C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-346 C—Cl C—Cl C—ClC—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-347 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—Br CH H H H CF3CH2CO 1 1-348 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Br CH H H H CH3CH2NHCO 1 1-349 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CHH H H CH3SO2 1 1-350 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CO1 1-351 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-352C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-353 C—Cl C—HC—CF3 C—H H CF3 CH CH C—Cl CH H H H CF3CH2CO 1 1-354 C—Cl C—H C—CF3 C—HH CF3 CH CH C—Cl CH H H H CH3CH2NHCO 1 1-355 C—Cl C—H C—CF3 C—H H CF3 CHCH C—CF3 CH H H H CH3CO 1 1-356 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CHH H H CH3CH2CO 1 1-357 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCO 1 1-358 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-359 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-360 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CO 11-361 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-362C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-363 C—ClC—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H H CF3CH2CO 1 1-364 C—Cl C—ClC—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CH2NHCO 1 1-365 C—Cl C—Cl C—CF3C—H H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-366 C—Cl C—Cl C—CF3 C—H H CF3CH CH C—CF3 CH H H H CH3CH2CO 1 1-367 C—Cl C—Cl C—CF3 C—H H CF3 CH CHC—CF3 CH H H H cyclo-PrCO 1 1-368 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3CH H H H CF3CH2CO 1 1-369 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-370 C—Cl C—H C—Cl C—H H CF3 N CH C—CF3 CH H H H H 1 1-372C—Cl C—H C—Cl C—H H CF3 N CH C—CF3 CH H H H CH3CH2CO 1 1-373 C—Cl C—HC—Cl C—H H CF3 N CH C—CF3 CH H H H cyclo-PrCO 1 1-374 C—Cl C—H C—Cl C—HH CF3 N CH C—CF3 CH H H H CF3CH2CO 1 1-375 C—Cl C—H C—Cl C—H H CF3 N CHC—CF3 CH H H H CH3CH2NHCO 1 1-376 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 CHH H H H 1 1-377 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 CH H H H CH3CO 11-378 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 CH H H H CH3CH2CO 1 1-379 C—ClC—Cl C—Cl C—H H CF3 N CH C—CF3 CH H H H cyclo-PrCO 1 1-380 C—Cl C—ClC—Cl C—H H CF3 N CH C—CF3 CH H H H CF3CH2CO 1 1-381 C—Cl C—Cl C—Cl C—H HCF3 N CH C—CF3 CH H H H CH3CH2NHCO 1 1-382 C—CF3 C—H C—CF3 C—H H CF3 NCH C—CF3 CH H H H H 1 1-386 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3 CH H HH CF3CH2CO 1 1-387 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3 CH H H HCH3CH2NHCO 1 1-388 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H H H 1 1-390C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-391 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-392 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-393 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3CH2NHCO 1 1-394 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 NH H H H 1 1-398 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CF3CH2CO 11-399 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2NHCO 1 1-400C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H H H 1 1-404 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-405 C—CF3 C—H C—CF3 C—H H CF3CH CH C—CF3 N H H H CH3CH2NHCO 1 1-406 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SCF3 CH H H H H 1 1-407 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H HCH3CO 1 1-408 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3CH2CO 11-409 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H cyclo-PrCO 1 1-410C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H CF3CH2CO 1 1-411 C—ClC—Cl C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H H 1 1-412 C—Cl C—Cl C—ClC—H H CF3 CH CH C—S(O)CF3 CH H H H CH3CO 1 1-413 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—S(O)CF3 CH H H H CH3CH2CO 1 1-414 C—Cl C—Cl C—Cl C—H H CF3CH CH C—S(O)CF3 CH H H H cyclo-PrCO 1 1-415 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—S(O)CF3 CH H H H CF3CH2CO 1 1-416 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3CH2NHCO 1 1-417 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H H 1 1-418 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 CH HH H CH3CO 1 1-419 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 CH H H HCH3CH2CO 1 1-420 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 CH H H Hcyclo-PrCO 1 1-421 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 CH H H HCF3CH2CO 1 1-422 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 CH H H HCH3CH2NHCO 1 1-423 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH H H H H1 1-424 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH H H H CH3CO 11-425 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH H H H CH3CH2CO 11-426 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH H H H cyclo-PrCO 11-427 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH H H H CF3CH2CO 11-428 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H H 1 1-429C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H CH3CO 1 1-430C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H CH3CH2CO 1 1-431C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H cyclo-PrCO 11-432 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H CF3CH2CO 11-433 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH H H H CH3CH2NHCO1 1-434 C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H H 1 1-435C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H CH3CO 1 1-436C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H CH3CH2CO 1 1-437C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H cyclo-PrCO 1 1-438C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H CF3CH2CO 1 1-439C—CF3 C—Cl C—CF3 C—H H CF3 CH CH C—SO2CH2CF3 CH H H H CH3CH2NHCO 1 1-440C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3(CO)CO 1 1-441 C—ClC—H C—Cl C—H H CF3 CH CH C—Cl CH H H H NCCO 1 1-442 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H CF3CH(CH3)NHCO 1 1-443 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl CH H H H thiomorpholineCO 1 1-444 C—Cl C—H C—Cl C—H H CF3 CHCH C—Cl CH H H H (CH3O)2CHCH2NHCO 1 1-445 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl CH H H H tetrahydrofurufuryl aminoCO 1 1-446 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl CH H H H 1-(2-thiazolyl)ethyl aminoCO 1 1-447 C—Cl C—HC—Cl C—H H CF3 CH CH C—F CH H H H CH3CO 1 1-448 C—Cl C—H C—Cl C—H H CF3CH CH C—F CH H H H CH3CH2CO 1 1-449 C—Cl C—H C—Cl C—H H CF3 CH CH C—F CHH H H nPrCO 1 1-450 C—Cl C—H C—Cl C—H H CF3 CH CH C—F CH H H Hcyclo-PrCO 1 1-451 C—Cl C—H C—Cl C—H H CF3 CH CH C—F CH H H Hcyclo-PrCH2CO 1 1452 C—Cl C—H C—Cl C—H H CF3 CH CH C—F CH H H H CF3CH2CO1 1-453 C—Cl C—H C—Cl C—H H CF3 CH CH C—F CH H H H CH3SCH2CO 1 1-454C—Cl C—H C—Cl C—H H CF3 CH CH C—F CH H H H CH3S(O)CH2CO 1 1 455 C—Cl C—HC—Cl C—H H CF3 CH CH C—F CH H H H CH3SO2CH2CO 1 1-456 C—Cl C—H C—Cl C—HH CF3 CH CH C—F CH H H H CH3CH2NHCO 1 1-457 C—Cl C—H C—Cl C—H H CF3 CHCH C—Cl CH H H H CH3 1 1-458 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH(Br)CO 1 1-459 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-460 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-461 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2SCH2CO 1 1-462 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2S(O)CH2CO 1 1-463 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2SO2CH2CO 1 1 464 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hiso-PrSCH2CO 1 1-465 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hiso-PrS(O)CH2CO 1 1-466 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hiso-PrSO2CH2CO 1 1-467 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CH2CO 1 1-468 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrNHCS 1 1-469 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H H

1 1-470 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 11-471 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH H H H CH3SCH2CO 1 1-472 C—ClC—H C—Cl C—H H CF3 CH CH C—Br CH H H H CH3S(O)CH2CO 1 1-473 C—Cl C—HC—Cl C—H H CF3 CH CH C—Br CH H H H CH3SO2CH2CO 1 1-474 C—Cl C—H C—Cl C—HH CF3 CH CH C—I CH H H H CH3CH2CO 1 1-475 C—Cl C—H C—Cl C—H H CF3 CH CHC—I CH H H H n-PrCO 1 1-476 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H Hcyclo-PrCO 1 1-477 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H Hcyclo-PrCH2CO 1 1-478 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H HCF3CH2CO 1 1-479 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H H CH3SCH2CO 11-480 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H H CH3S(O)CH2CO 1 1-481C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH H H H CH3SO2CH2CO 1 1-482 C—Cl C—HC—Cl C—H H CF3 CH CH C—I CH H H H CH3CH2NHCO 1 1-483 C—Cl C—H C—Cl C—H HCF3 CH CH C—CH3 CH H H H n-PrCO 1 1-484 C—Cl C—H C—Cl C—H H CF3 CH CHC—CH3 CH H H H cyclo-PrCH2CO 1 1-485 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3CH H H H CH3SCH2CO 1 1-486 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 CH H H HCH3S(O)CH2CO 1 1-487 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 CH H H HCH3SO2CH2CO 1 1-488 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr CH H H HCH3CH2CO 1 1-489 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr CH H H HCF3CH2CO 1 1-490 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3(CO)CO1 1-491 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2CO 11-492 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2OCH2CH2CO 11-493 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H HSCH2CO 1 1-494 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-495 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-496 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CF3SCH2CO 1 1-497 C—Cl C—H C—Cl C—H H CF3CH CH C—CF3 CH H H H CF3S(O)CH2CO 1 1-498 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF3SO2CH2CO 1 1-499 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H CH3CH2SCH2CO 1 1-500 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH CH3CH2S(O)CH2CO 1 1-501 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2SO2CH2CO 1 1-502 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3COSCH2CO 1 1-503 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H(Allyl)SCH2CO 1 1-504 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H(Allyl)S(O)CH2CO 1 1-505 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H(Allyl)SO2CH2CO 1 1-506 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SCH(CH3)CO 1 1-507 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH(CH3)CO 1 1-508 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH(CH3)CO 1 1-509 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SCH2CH2CO 1 1-510 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SC(CH3)2CO 1 1-511 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)C(CH3)2CO 1 1-512 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2C(CH3)2CO 1 1-513 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CONHCH2CO 1 1-514 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2CONHCH2CO 1 1-515 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCONHCH2CO 1 1-516 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CONHCH2CO 1 1-517 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SCH2CONHCH2CO 1 1-518 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CONHCH2CO 1 1-519 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CONHCH2CO 1 1-520 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Htert-BuOCONHCH2CO 1 1-521 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CONHCH(CH3)CO 1 1-522 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2CONHCH(CH3)CO 1 1-523 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCONHCH(CH3)CO 1 1-524 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH CF3CH2CONHCH(CH3)CO 1 1-525 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H HH CH3SCH2CONHCH(CH3)CO 1 1-526 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH HH H CH3S(O)CH2CONHCH(CH3)CO 1 1-527 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3CH H H H CH3SO2CH2CONHCH(CH3)CO 1 1-528 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CH3CONHC(CH3)2CO 1 1-529 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H CH3CH2CONHC(CH3)2CO 1 1-530 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H cyclo-PrCONHC(CH3)2CO 1 1-531 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H CF3CH2CONHC(CH3)2CO 1 1-532 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 CH H H H CH3SCH2CONHC(CH3)2CO 1 1-533 C—Cl C—H C—Cl C—H H CF3CH CH C—CF3 CH H H H CH3S(O)CH2CONHC(CH3)2CO 1 1-534 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH H H H CH3SO2CH2CONHC(CH3)2CO 1 1-535 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3CONHCH2CH2CO 1 1-536 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H CH3CH2CONHCH2CH2CO 1 1-537 C—Cl C—H C—Cl C—HH CF3 CH CH C—CF3 CH H H H cyclo-PrCONHCH2CH2CO 1 1-538 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CF3CH2CONHCH2CH2CO 1 1-539 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CONHCH2CH2CO 1 1-540 C—Cl C—H C—ClC—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CONHCH2CH2CO 1 1-541 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CONHCH2CH2CO 1 1-542 C—ClC—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-543 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-544 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-545 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-546 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-547 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-548 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-549 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-550 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-551 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-552 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-553 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-554 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-555 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-556 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-557 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-558 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-559 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-560 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-561 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-562 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-563 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-564 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-565 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-566 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-567 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-568 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-569 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-570 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-571 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-572 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-573 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-574 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 CH H H H (CH3)2NSO2 1 1-575C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H H CH3CO 1 1-576 C—Cl C—H C—ClC—H H CF3 CH CH C—CN CH H H H CH3CH2CO 1 1-577 C—Cl C—H C—Cl C—H H CF3CH CH C—CN CH H H H nPrCO 1 1-578 C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CHH H H cyclo-PrCO 1 1-579 C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H Hcyclo-PrCH2CO 1 1-580 C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H HCF3CH2CO 1 1-581 C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H H CH3SCH2CO 11-582 C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H H CH3S(O)CH2CO 1 1-583C—Cl C—H C—Cl C—H H CF3 CH CH C—CN CH H H H CH3SO2CH2CO 1 1-584 C—Cl C—HC—Cl C—H H CF3 CH CH C—CN CH H H H CH3CH2NHCO 1 1-586 C—Cl C—H C—Cl C—HH CF3 CH CH C—SCH3 CH H H H CH3CH2CO 1 1-587 C—Cl C—H C—Cl C—H H CF3 CHCH C—SCH3 CH H H H cyclo-PrCO 1 1-588 C—Cl C—H C—Cl C—H H CF3 CH CHC—SCH3 CH H H H CF3CH2CO 1 1-589 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CH3CH H H H CH3CO 1 1-590 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CH3 CH H H HCH3CH2CO 1 1-591 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CH3 CH H H Hcyclo-PrCO 1 1-592 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CH3 CH H H HCF3CH2CO 1 1-593 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CH3 CH H H HCH3SCH2CO 1 1-594 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CH3 CH H H H CH3CO1 1-595 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CH3 CH H H H CH3CH2CO 1 1-596C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CH3 CH H H H cyclo-PrCO 1 1-597 C—ClC—H C—Cl C—H H CF3 CH CH C—SO2CH3 CH H H H CF3CH2CO 1 1-598 C—Cl C—HC—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3CH2CO 1 1-599 C—Cl C—H C—Cl C—HH CF3 CH CH C—SCF3 CH H H H nPrCO 1 1-600 C—Cl C—H C—Cl C—H H CF3 CH CHC—SCF3 CH H H H cyclo-PrCO 1 1-601 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3CH H H H cyclo-PrCH2CO 1 1-602 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 CH HH H CF3CH2CO 1 1-603 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 CH H H HCH3SCH2CO 1 1-604 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 CH H H HCH3S(O)CH2CO 1 1-605 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 CH H H HCH3SO2CH2CO 1 1-606 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 CH H H HCH3CH2NHCO 1 1-607 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H HCH3CH2CO 1 1-608 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H nPrCO1 1-609 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H cyclo-PrCO 11-610 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H cyclo-PrCH2CO 11-611 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H CF3CH2CO 1 1-612C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H CH3SCH2CO 1 1-613 C—ClC—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H CH3S(O)CH2CO 1 1-614 C—ClC—H C—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H CH3SO2CH2CO 1 1-615 C—Cl C—HC—Cl C—H H CF3 CH CH C—S(O)CF3 CH H H H CH3CH2NHCO 1 1-616 C—Cl C—H C—ClC—H H CF3 CH CH C—SO2CF3 CH H H H CH3CH2CO 1 1-617 C—Cl C—H C—Cl C—H HCF3 CH CH C—SO2CF3 CH H H H nPrCO 1 1-618 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H cyclo-PrCO 1 1-619 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H cyclo-PrCH2CO 1 1-620 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CF3CH2CO 1 1-621 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SCH2CO 1 1-622 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3S(O)CH2CO 1 1-623 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SO2CH2CO 1 1-624 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3CH2NHCO 1 1-625 C—Br C—H C—Br C—H H CF3 CH CH C—ClCH H H H CH3CH2CO 1 1-626 C—Br C—H C—Br C—H H CF3 CH CH C—Cl CH H H Hn-PrCO 1 1-627 C—Br C—H C—Br C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 11-628 C—Br C—H C—Br C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCH2CO 1 1-629C—Br C—H C—Br C—H H CF3 CH CH C—Cl CH H H H CF3CH2CO 1 1-630 C—Br C—HC—Br C—H H CF3 CH CH C—Cl CH H H H CH3SCH2CO 1 1-631 C—Br C—H C—Br C—H HCF3 CH CH C—Cl CH H H H CH3S(O)CH2CO 1 1-632 C—Br C—H C—Br C—H H CF3 CHCH C—Cl CH H H H CH3SO2CH2CO 1 1-633 C—Br C—H C—Br C—H H CF3 CH CH C—ClCH H H H CH3CH2NHCO 1 1-634 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH H H HCH3CO 1 1-635 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 11-636 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH H H H n-PrCO 1 1-637 C—BrC—H C—Br C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-638 C—Br C—H C—BrC—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-639 C—Br C—H C—Br C—H HCF3 CH CH C—Br CH H H H CF3CH2CO 1 1-640 C—Br C—H C—Br C—H H CF3 CH CHC—Br CH H H H CH3SCH2CO 1 1-641 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH HH H CH3S(O)CH2CO 1 1-642 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-643 C—Br C—H C—Br C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-644 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-645 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-646 C—BrC—H C—Br C—H H CF3 CH CH C—CF3 CH H H H n-PrCO 1 1-647 C—Br C—H C—Br C—HH CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-648 C—Br C—H C—Br C—H H CF3 CHCH C—CF3 CH H H H cyclo-PrCH2CO 1 1-649 C—Br C—H C—Br C—H H CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-650 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-651 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-652 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-653 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-654 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CO 11-655 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-656 C—ClC—F C—Cl C—H H CF3 CH CH C—Cl CH H H H nPrCO 1 1-657 C—Cl C—F C—Cl C—H HCF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-658 C—Cl C—F C—Cl C—H H CF3 CH CHC—Cl CH H H H cyclo-PrCH2CO 1 1-659 C—Cl C—F C—Cl C—H H CF3 CH CH C—ClCH H H H CF3CH2CO 1 1-660 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CO 1 1-661 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-662 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-663 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-664 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H H CH3CO 11-665 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-666 C—ClC—F C—Cl C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-667 C—Cl C—F C—Cl C—H HCF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-668 C—Cl C—F C—Cl C—H H CF3 CH CHC—Br CH H H H cyclo-PrCH2CO 1 1-669 C—Cl C—F C—Cl C—H H CF3 CH CH C—BrCH H H H CF3CH2CO 1 1-670 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H HCH3SCH2CO 1 1-671 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-672 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-673 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-674 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-675 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-676 C—ClC—F C—Cl C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-677 C—Cl C—F C—Cl C—HH CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-678 C—Cl C—F C—Cl C—H H CF3 CHCH C—CF3 CH H H H cyclo-PrCH2CO 1 1-679 C—Cl C—F C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-680 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-681 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-682 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-683 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-684 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H H CH3CO 11-685 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H H CH3CH2CO 1 1-686 C—ClC—Cl C—Cl C—H H CF3 CH CH C—F CH H H H nPrCO 1 1-687 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—F CH H H H cyclo-PrCO 1 1-688 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—F CH H H H cyclo-PrCH2CO 1 1-689 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—FCH H H H CF3CH2CO 1 1-690 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H HCH3SCH2CO 1 1-691 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H HCH3S(O)CH2CO 1 1-692 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H HCH3SO2CH2CO 1 1-693 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH H H HCH3CH2NHCO 1 1-694 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H Htert-BuOCO 1 1-695 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H n-PrCO 11-696 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCH2CO 1 1-697C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H H HSCH2CO 1 1-698 C—Cl C—ClC—Cl C—H H CF3 CH CH C—Cl CH H H H CH3SCH2CO 1 1-699 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—Cl CH H H H CH3S(O)CH2CO 1 1-700 C—Cl C—Cl C—Cl C—H H CF3CH CH C—Cl CH H H H CH3SO2CH2CO 1 1-701 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Cl CH H H H CH3COSCH2CO 1 1-702 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CHH H H n-PrCO 1 1-707 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H Hcyclo-PrCH2CO 1 1-708 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H HCH3SCH2CO 1 1-709 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-710 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-711 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 CH H H H CH3CO1 1-712 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 CH H H H CH3CH2CO 1 1-713C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 CH H H H nPrCO 1 1-714 C—Cl C—ClC—Cl C—H H CF3 CH CH C—CH3 CH H H H cyclo-PrCO 1 1-715 C—Cl C—Cl C—ClC—H H CF3 CH CH C—CH3 CH H H H cyclo-PrCH2CO 1 1-716 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—CH3 CH H H H CF3CH2CO 1 1-717 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—CH3 CH H H H CH3SCH2CO 1 1-718 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3CH H H H CH3S(O)CH2CO 1 1-719 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 CH HH H CH3SO2CH2CO 1 1-720 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 CH H H HCH3CH2NHCO 1 1-721 C—Cl C—Cl C—Cl C—H H CF3 CH CH C-cyclo-Pr CH H H HCH3CH2CO 1 1-722 C—Cl C—Cl C—Cl C—H H CF3 CH CH C-cyclo-Pr CH H H HCF3CH2CO 1 1-723 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H ClCH2CO 11-724 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 11-725 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2CO 1 1-726C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2OCH2CH2CO 1 1-727C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H HSCH2CO 1 1-728 C—Cl C—ClC—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-729 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-730 C—Cl C—Cl C—Cl C—H H CF3CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-731 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF3SCH2CO 1 1-732 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CHH H H (Allyl)SCH2CO 1 1-733 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H HH (Allyl)S(O)CH2CO 1 1-734 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H(Allyl)SO2CH2CO 1 1-735 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3COSCH2CO 1 1-736 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH H H H CH3CO 11-737 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH H H H CH3CH2CO 1 1-738 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CN CH H H H nPrCO 1 1-739 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—CN CH H H H cyclo-PrCO 1 1-740 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—CN CH H H H cyclo-PrCH2CO 1 1-741 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—CN CH H H H CF3CH2CO 1 1-742 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH HH H CH3SCH2CO 1 1-743 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH H H HCH3S(O)CH2CO 1 1-744 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH H H HCH3SO2CH2CO 1 1-745 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CN CH H H HCH3CH2NHCO 1 1-746 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCH3 CH H H H CH3CO1 1-747 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCH3 CH H H H CH3CH2CO 1 1-748C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCH3 CH H H H cyclo-PrCO 1 1-749 C—ClC—Cl C—Cl C—H H CF3 CH CH C—SCH3 CH H H H CF3CH2CO 1 1-750 C—Cl C—ClC—Cl C—H H CF3 CH CH C—S(O)CH3 CH H H H CH3CO 1 1-751 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—S(O)CH3 CH H H H CH3CH2CO 1 1-752 C—Cl C—Cl C—Cl C—H H CF3CH CH C—S(O)CH3 CH H H H cyclo-PrCO 1 1-753 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—S(O)CH3 CH H H H CF3CH2CO 1 1-754 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 CH H H H CH3SCH2CO 1 1-755 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CH3 CH H H H CH3CO 1 1-756 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3CH H H H CH3CH2CO 1 1-757 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3 CH H HH cyclo-PrCO 1 1-758 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3 CH H H HCF3CH2CO 1 1-759 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H nPrCO 11-760 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H cyclo-PrCH2CO 11-761 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3SCH2CO 1 1-762C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3S(O)CH2CO 1 1-763 C—ClC—Cl C—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3SO2CH2CO 1 1-764 C—Cl C—ClC—Cl C—H H CF3 CH CH C—SCF3 CH H H H CH3CH2NHCO 1 1-765 C—Cl C—Cl C—ClC—H H CF3 CH CH C—S(O)CF3 CH H H H nPrCO 1 1-766 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—S(O)CF3 CH H H H cyclo-PrCH2CO 1 1-767 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—S(O)CF3 CH H H H CH3SCH2CO 1 1-768 C—Cl C—Cl C—Cl C—H H CF3CH CH C—S(O)CF3 CH H H H CH3S(O)CH2CO 1 1-769 C—Cl C—Cl C—Cl C—H H CF3CH CH C—S(O)CF3 CH H H H CH3SO2CH2CO 1 1-770 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—SO2CF3 CH H H H nPrCO 1 1-771 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H cyclo-PrCH2CO 1 1-772 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SCH2CO 1 1-773 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3S(O)CH2CO 1 1-774 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SO2CH2CO 1 1-775 C—Cl C—Br C—Cl C—H H CF3 CH CHC—Cl CH H H H CH3CO 1 1-776 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3CH2CO 1 1-777 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl CH H H H nPrCO 11-778 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-779C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCH2CO 1 1-780 C—ClC—Br C—Cl C—H H CF3 CH CH C—Cl CH H H H CF3CH2CO 1 1-781 C—Cl C—Br C—ClC—H H CF3 CH CH C—Cl CH H H H CH3SCH2CO 1 1-782 C—Cl C—Br C—Cl C—H H CF3CH CH C—Cl CH H H H CH3S(O)CH2CO 1 1-783 C—Cl C—Br C—Cl C—H H CF3 CH CHC—Cl CH H H H CH3SO2CH2CO 1 1-784 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl CHH H H CH3CH2NHCO 1 1 785 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br CH H H HCH3CO 1 1-786 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 11-787 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-788 C—ClC—Br C—Cl C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-789 C—Cl C—BrC—Cl C—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-790 C—Cl C—Br C—ClC—H H CF3 CH CH C—Br CH H H H CF3CH2CO 1 1-791 C—Cl C—Br C—Cl C—H H CF3CH CH C—Br CH H H H CH3SCH2CO 1 1-792 C—Cl C—Br C—Cl C—H H CF3 CH CHC—Br CH H H H CH3S(O)CH2CO 1 1-793 C—Cl C—Br C—Cl C—H H CF3 CH CH C—BrCH H H H CH3SO2CH2CO 1 1-794 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br CH H HH CH3CH2NHCO 1 1-795 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CO1 1-796 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-797C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-798 C—Cl C—BrC—Cl C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-799 C—Cl C—Br C—ClC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-800 C—Cl C—Br C—Cl C—HH CF3 CH CH C—CF3 CH H H H CF3CH2CO 1 1-801 C—Cl C—Br C—Cl C—H H CF3 CHCH C—CF3 CH H H H CH3SCH2CO 1 1-802 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3CH H H H CH3S(O)CH2CO 1 1-803 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 CH HH H CH3SO2CH2CO 1 1-804 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-805 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH H H H CH3CO 11-806 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-807 C—ClC—Cl C—Br C—H H CF3 CH CH C—Cl CH H H H nPrCO 1 1-808 C—Cl C—Cl C—Br C—HH CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-809 C—Cl C—Cl C—Br C—H H CF3 CHCH C—Cl CH H H H cyclo-PrCH2CO 1 1-810 C—Cl C—Cl C—Br C—H H CF3 CH CHC—Cl CH H H H CF3CH2CO 1 1-811 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH HH H CH3SCH2CO 1 1-812 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-813 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-814 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-815 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH H H H CH3CO 11-816 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-817 C—ClC—Cl C—Br C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-818 C—Cl C—Cl C—Br C—HH CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-819 C—Cl C—Cl C—Br C—H H CF3 CHCH C—Br CH H H H cyclo-PrCH2CO 1 1-820 C—Cl C—Cl C—Br C—H H CF3 CH CHC—Br CH H H H CF3CH2CO 1 1-821 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH HH H CH3SCH2CO 1 1-822 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-823 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-824 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-825 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-826 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-827C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-828 C—Cl C—ClC—Br C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-829 C—Cl C—Cl C—BrC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-830 C—Cl C—Cl C—Br C—HH CF3 CH CH C—CF3 CH H H H CF3CH2CO 1 1-831 C—Cl C—Cl C—Br C—H H CF3 CHCH C—CF3 CH H H H CH3SCH2CO 1 1-832 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3CH H H H CH3S(O)CH2CO 1 1-833 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 CH HH H CH3SO2CH2CO 1 1-834 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-835 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H H CH3CO 11-836 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-837 C—ClC—F C—Cl C—H F CF3 CH CH C—Cl CH H H H nPrCO 1 1-838 C—Cl C—F C—Cl C—H FCF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-839 C—Cl C—F C—Cl C—H F CF3 CH CHC—Cl CH H H H cyclo-PrCH2CO 1 1-840 C—Cl C—F C—Cl C—H F CF3 CH CH C—ClCH H H H CF3CH2CO 1 1-841 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H HCH3SCH2CO 1 1-842 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-843 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-844 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-845 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H H CH3CO 11-846 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-847 C—ClC—F C—Cl C—H F CF3 CH CH C—Br CH H H H nPrCO 1 1-848 C—Cl C—F C—Cl C—H FCF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-849 C—Cl C—F C—Cl C—H F CF3 CH CHC—Br CH H H H cyclo-PrCH2CO 1 1-850 C—Cl C—F C—Cl C—H F CF3 CH CH C—BrCH H H H CF3CH2CO 1 1-851 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H HCH3SCH2CO 1 1-852 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-853 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-854 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-855 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH H H H CH3CO 11-856 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-857 C—ClC—F C—Cl C—H F CF3 CH CH C—CF3 CH H H H nPrCO 1 1-858 C—Cl C—F C—Cl C—HF CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-859 C—Cl C—F C—Cl C—H F CF3 CHCH C—CF3 CH H H H cyclo-PrCH2CO 1 1-860 C—Cl C—F C—Cl C—H F CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-861 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-862 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-863 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-864 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-865 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-866 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-867C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-868 C—CF3 C—H C—HC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-869 C—CF3 C—H C—H C—H HCF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-870 C—CF3 C—H C—H C—H H CF3CH CH C—CF3 CH H H H CF3CH2CO 1 1-871 C—CF3 C—H C—H C—H H CF3 CH CHC—CF3 CH H H H CH3SOCH2CO 1 1-872 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CHH H H CH3S(O)CH2CO 1 1-873 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-874 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-875 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-876 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-877C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-878 C—CF3 C—F C—HC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-879 C—CF3 C—F C—H C—H HCF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-880 C—CF3 C—F C—H C—H H CF3CH CH C—CF3 CH H H H CF3CH2CO 1 1-881 C—CF3 C—F C—H C—H H CF3 CH CHC—CF3 CH H H H CH3SOCH2CO 1 1-882 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CHH H H CH3S(O)CH2CO 1 1-883 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-884 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-885 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CH H H H CH3CO 11-886 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-887C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CH H H H nPrCO 1 1-888 C—CF3 C—H C—HC—H F CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-889 C—CF3 C—H C—H C—H FCF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-890 C—CF3 C—H C—H C—H F CF3CH CH C—CF3 CH H H H CF3CH2CO 1 1-891 C—CF3 C—H C—H C—H F CF3 CH CHC—CF3 CH H H H CH3SOCH2CO 1 1-892 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CHH H H CH3S(O)CH2CO 1 1-893 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-894 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-895 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H nPrCO 11-896 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-897C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H H CH3CO 1 1-898 C—Cl C—HC—CF3 C—H H CF3 CH CH C—CH3 CH H H H CH3CH2CO 1 1-899 C—Cl C—H C—CF3 C—HH CF3 CH CH C—CH3 CH H H H nPrCO 1 1-900 C—Cl C—H C—CF3 C—H H CF3 CH CHC—CH3 CH H H H cyclo-PrCO 1 1-901 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3CH H H H cyclo-PrCH2CO 1 1-902 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH HH H CF3CH2CO 1 1-903 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3SCH2CO 1 1-904 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3S(O)CH2CO 1 1-905 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3SO2CH2CO 1 1-906 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3CH2NHCO 1 1-907 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3OCH2CH2CO 1 1-908 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3CH2OCH2CH2CO 1 1-909 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CO 1 1-910 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-911 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-912 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CO 11-913 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-914 C—ClC—H C—CF3 C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-915 C—Cl C—H C—CF3 C—HH CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-916 C—Cl C—H C—CF3 C—H H CF3 CHCH C—Br CH H H H cyclo-PrCH2CO 1 1-917 C—Cl C—H C—CF3 C—H H CF3 CH CHC—Br CH H H H CF3CH2CO 1 1-918 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH HH H CH3SCH2CO 1 1-919 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-920 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-921 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-922 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H nPrCO 11-923 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-924C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-925 C—Cl C—HC—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-926 C—Cl C—H C—CF3C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-927 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—F CH H H H CH3CO 1 1-928 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—FCH H H H CH3CH2CO 1 1-929 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F CH H H HnPrCO 1 1-930 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F CH H H H cyclo-PrCO 11-931 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F CH H H H cyclo-PrCH2CO 1 1-932C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F CH H H H CF3CH2CO 1 1-933 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—F CH H H H CH3SCH2CO 1 1-934 C—CF3 C—H C—CF3 C—HH CF3 CH CH C—F CH H H H CH3S(O)CH2CO 1 1-935 C—CF3 C—H C—CF3 C—H H CF3CH CH C—F CH H H H CH3SO2CH2CO 1 1-936 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—F CH H H H CH3CH2NHCO 1 1-937 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CHH H H nPrCO 1 1-938 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCH2CO 1 1-939 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CO 1 1-940 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-941 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-942 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-943 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H nPrCO 11-944 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 11-945 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3SCH2CO 1 1-946C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3S(O)CH2CO 1 1-947 C—CF3C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3SO2CH2CO 1 1-948 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2NHCO 1 1-949 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CH3 CH H H H CH3CO 1 1-950 C—CF3 C—H C—CF3 C—H H CF3CH CH C—CH3 CH H H H CH3CH2CO 1 1-951 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CH3 CH H H H nPrCO 1 1-952 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH HH H cyclo-PrCO 1 1-953 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H Hcyclo-PrCH2CO 1 1-954 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCF3CH2CO 1 1-955 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3SCH2CO 1 1-956 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3S(O)CH2CO 1 1-957 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3SO2CH2CO 1 1-958 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 CH H H HCH3CH2NHCO 1 1-959 C—CF3 C—H C—CF3 C—H H CF3 CH CH C-cyclo-Pr CH H H HCH3CH2CO 1 1-960 C—CF3 C—H C—CF3 C—H H CF3 CH CH C-cyclo-Pr CH H H HCF3CH2CO 1 1-961 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H nPrCO 11-962 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 11-963 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3C(O)CH2CO 11-964 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2CO 11-965 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CH2OCH2CH2CO 11-966 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-967C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3S(O) CH2CO 1 1-968C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-969 C—CF3C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H (Allyl)SCH2CO 1 1-970 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—CF3 CH H H H (Allyl)S(O)CH2CO 1 1-971 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—CF3 CH H H H (Allyl)SO2CH2CO 1 1-972 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—CN CH H H H CH3CO 1 1-973 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—CN CH H H H CH3CH2CO 1 1-974 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CN CH H H H nPrCO 1 1-975 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H HH cyclo-PrCO 1 1-976 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H Hcyclo-PrCH2CO 1 1-977 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H HCF3CH2CO 1 1-978 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H H CH3SCH2CO1 1-979 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H H CH3S(O)CH2CO 11-980 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H H CH3SO2CH2CO 1 1-981C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CN CH H H H CH3CH2NHCO 1 1-982 C—CF3C—H C—CF3 C—H H CF3 CH CH C—SCH3 CH H H H CH3CO 1 1-983 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCH3 CH H H H CH3CH2CO 1 1-984 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—SCH3 CH H H H cyclo-PrCO 1 1-985 C—CF3 C—H C—CF3 C—H H CF3CH CH C—SCH3 CH H H H CF3CH2CO 1 1-986 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CH3 CH H H H CH3CO 1 1-987 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CH3 CH H H H CH3CH2CO 1 1-988 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CH3 CH H H H cyclo-PrCO 1 1-989 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CH3 CH H H H CF3CH2CO 1 1-990 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CH3 CH H H H CH3SCH2CO 1 1-991 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CH3 CH H H H CH3CO 1 1-992 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3CH H H H CH3CH2CO 1 1-993 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3 CH HH H cyclo-PrCO 1 1-994 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3 CH H H HCF3CH2CO 1 1-995 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 CH H H H CH3CO 11-996 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 CH H H H CH3CH2CO 1 1-997C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 CH H H H nPrCO 1 1-998 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—SCF3 CH H H H cyclo-PrCO 1-999 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCF3 CH H H H cyclo-PrCH2CO 1 1-1000 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCF3 CH H H H CF3CH2CO 1 1-1001 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—SCF3 CH H H H CH3SCH2CO 1 1-1002 C—CF3 C—H C—CF3 C—H H CF3CH CH C—SCF3 CH H H H CH3S(O)CH2CO 1 1-1003 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—SCF3 CH H H H CH3SO2CH2CO 1 1-1004 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SCF3 CH H H H CH3CH2NHCO 1 1-1005 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3CO 1 1-1006 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3CH2CO 1 1-1007 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H nPrCO 1 1-1008 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H cyclo-PrCO 1 1-1009 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H cyclo-PrCH2CO 1 1-1010 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—S(O)CF3 CH H H H CF3CH2CO 1 1-1011 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3SCH2CO 1 1-1012 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3S(O)CH2CO 1 1-1013 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3SO2CH2CO 1 1-1014 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 CH H H H CH3CH2NHCO 1 1-1015 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3CO 1 1-1016 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3CH2CO 1 1-1017 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H nPrCO 1 1-1018 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H cyclo-PrCO 1 1-1019 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H cyclo-PrCH2CO 1 1-1020 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CF3CH2CO 1 1-1021 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SCH2CO 1 1-1022 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3S(O)CH2CO 1 1-1023 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3SO2CH2CO 1 1-1024 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 CH H H H CH3CH2NHCO 1 1-1025 C—Cl C—Cl C—CF3 C—H H CF3 CH CHC—Cl CH H H H nPrCO 1 1-1026 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H HH cyclo-PrCO 1 1-1027 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SCH2CO 1 1-1028 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-1029 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-1030 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CO1 1-1031 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-1032C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-1033 C—Cl C—ClC—CF3 C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-1034 C—Cl C—Cl C—CF3C—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-1035 C—Cl C—Cl C—CF3 C—HH CF3 CH CH C—Br CH H H H CF3CH2CO 1 1-1036 C—Cl C—Cl C—CF3 C—H H CF3 CHCH C—Br CH H H H CH3SCH2CO 1 1-1037 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—BrCH H H H CH3S(O)CH2CO 1 1-1038 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH HH H CH3SO2CH2CO 1 1-1039 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-1040 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H H nPrCO1 1-1041 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 11-1042 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-1043C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-1044C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1045 C—ClN C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CO 1 1-1046 C—Cl N C—Cl C—H HCF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-1047 C—Cl N C—Cl C—H H CF3 CH CHC—Cl CH H H H nPrCO 1 1-1048 C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCO 1 1-1049 C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCH2CO 1 1-1050 C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H HCF3CH2CO 1 1-1051 C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3SCH2CO 11-1052 C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3S(O)CH2CO 1 1-1053C—Cl N C—Cl C—H H CF3 CH CH C—Cl CH H H H CH3SO2CH2CO 1 1-1054 C—Cl NC—Cl C—H H CF3 CH CH C—Cl CH H H H CH3CH2NHCO 1 1-1055 C—Cl N C—Cl C—H HCF3 CH CH C—Br CH H H H CH3CO 1 1-1056 C—Cl N C—Cl C—H H CF3 CH CH C—BrCH H H H CH3CH2CO 1 1-1057 C—Cl N C—Cl C—H H CF3 CH CH C—Br CH H H HnPrCO 1 1-1058 C—Cl N C—Cl C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 11-1059 C—Cl N C—Cl C—H H CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-1060C—Cl N C—Cl C—H H CF3 CH CH C—Br CH H H H CF3CH2CO 1 1-1061 C—Cl N C—ClC—H H CF3 CH CH C—Br CH H H H CH3SCH2CO 1 1-1062 C—Cl N C—Cl C—H H CF3CH CH C—Br CH H H H CH3S(O)CH2CO 1 1-1063 C—Cl N C—Cl C—H H CF3 CH CHC—Br CH H H H CH3SO2CH2CO 1 1-1064 C—Cl N C—Cl C—H H CF3 CH CH C—Br CH HH H CH3CH2NHCO 1 1-1065 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CO1 1-1066 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1067C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1068 C—Cl N C—ClC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1069 C—Cl N C—Cl C—H H CF3CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1070 C—Cl N C—Cl C—H H CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-1071 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-1072 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1073 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1074 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1075 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-1076 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1077C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1078 C—CF3 N C—HC—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1079 C—CF3 N C—H C—H H CF3CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1080 C—CF3 N C—H C—H H CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-1081 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-1082 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1083 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1084 C—CF3 N C—H C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1085 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H H CH3CO 11-1086 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1087C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1088 C—CF3 C—H C—HN H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1089 C—CF3 C—H C—H N H CF3CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1090 C—CF3 C—H C—H N H CF3 CH CHC—CF3 CH H H H CF3CH2CO 1 1-1091 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH HH H CH3SCH2CO 1 1-1092 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1093 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1094 C—CF3 C—H C—H N H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1095 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H H CH3CO 11-1096 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1097 C—HC—H C—CF3 N H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1098 C—H C—H C—CF3 N HCF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1099 C—H C—H C—CF3 N H CF3 CH CHC—CF3 CH H H H cyclo-PrCH2CO 1 1-1100 C—H C—H C—CF3 N H CF3 CH CH C—CF3CH H H H CF3CH2CO 1 1-1101 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3SCH2CO 1 1-1102 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1103 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1104 C—H C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1105 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CO 11-1106 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-1107C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H H nPrCO 1 1-1108 C—CF3 N C—CF3C—H H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-1109 C—CF3 N C—CF3 C—H HCF3 CH CH C—Cl CH H H H cyclo-PrCH2CO 1 1-1110 C—CF3 N C—CF3 C—H H CF3CH CH C—Cl CH H H H CF3CH2CO 1 1-1111 C—CF3 N C—CF3 C—H H CF3 CH CH C—ClCH H H H CH3SCH2CO 1 1-1112 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-1113 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3SOCH2CO 1 1-1114 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-1115 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CO 11-1116 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-1117C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H H nPrCO 1 1-1118 C—CF3 N C—CF3C—H H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-1119 C—CF3 N C—CF3 C—H HCF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-1120 C—CF3 N C—CF3 C—H H CF3CH CH C—Br CH H H H CF3CH2CO 1 1-1121 C—CF3 N C—CF3 C—H H CF3 CH CH C—BrCH H H H CH3SCH2CO 1 1-1122 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-1123 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-1124 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-1125 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CO 11-1126 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1127C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 11128 C—CF3 N C—CF3C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1129 C—CF3 N C—CF3 C—H HCF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1130 C—CF3 N C—CF3 C—H H CF3CH CH C—CF3 CH H H H CF3CH2CO 1 1-1131 C—CF3 N C—CF3 C—H H CF3 CH CHC—CF3 CH H H H CH3SCH2CO 1 1-1132 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CHH H H CH3S(O)CH2CO 1 1-1133 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1134 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1135 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H H CH3CO 11-1136 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-1137C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H H nPrCO 1 1-1138 C—CF3 C—HC—CF3 N H CF3 CH CH C—Cl CH H H H cyclo-PrCO 1 1-1139 C—CF3 C—H C—CF3 NH CF3 CH CH C—Cl CH H H H cyclo-PrCH2CO 1 1-1140 C—CF3 C—H C—CF3 N H CF3CH CH C—Cl CH H H H CF3CH2CO 1 1-1141 C—CF3 C—H C—CF3 N H CF3 CH CH C—ClCH H H H CH3SCH2CO 1 1-1142 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H HCH3S(O)CH2CO 1 1-1143 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H HCH3SO2CH2CO 1 1-1144 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl CH H H HCH3CH2NHCO 1 1-1145 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H H CH3CO 11-1146 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H H CH3CH2CO 1 1-1147C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H H nPrCO 1 1-1148 C—CF3 C—HC—CF3 N H CF3 CH CH C—Br CH H H H cyclo-PrCO 1 1-1149 C—CF3 C—H C—CF3 NH CF3 CH CH C—Br CH H H H cyclo-PrCH2CO 1 1-1150 C—CF3 C—H C—CF3 N H CF3CH CH C—Br CH H H H CF3CH2CO 1 1-1151 C—CF3 C—H C—CF3 N H CF3 CH CH C—BrCH H H H CH3SCH2CO 1 1-1152 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H HCH3S(O)CH2CO 1 1-1153 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H HCH3SO2CH2CO 1 1-1154 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br CH H H HCH3CH2NHCO 1 1-1155 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CH H H H CH3CO 11-1156 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1157C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1158 C—CF3 C—HC—CF3 N H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1159 C—CF3 C—H C—CF3 NH CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1160 C—CF3 C—H C—CF3 N HCF3 CH CH C—CF3 CH H H H CF3CH2CO 1 1-1161 C—CF3 C—H C—CF3 N H CF3 CH CHC—CF3 CH H H H CH3SCH2CO 1 1-1162 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CHH H H CH3S(O)CH2CO 1 1-1163 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1164 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1167 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H H n-PrCO 11-1168 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1169C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H H 1 1-1170 C—Cl C—H C—Cl C—H HCF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1171 C—Cl C—H C—Cl C—H H CF3 CHCH C—Cl N H H H CF3CH2CO 1 1-1172 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N HH H CH3SCH2CO 1 1-1173 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1174 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1175 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1178 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N H H H nPrCO 11-1179 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1180C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1181 C—ClC—H C—Cl C—H H CF3 CH CH C—Br N H H H CF3CH2CO 1 1-1182 C—Cl C—H C—ClC—H H CF3 CH CH C—Br N H H H CH3SCH2CO 1 1-1183 C—Cl C—H C—Cl C—H H CF3CH CH C—Br N H H H CH3S(O)CH2CO 1 1-1184 C—Cl C—H C—Cl C—H H CF3 CH CHC—Br N H H H CH3SO2CH2CO 1 1-1185 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N HH H CH3CH2NHCO 1 1-1186 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H Hn-PrCO 1 1-1187 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H Hcyclo-PrCH2CO 1 1-1188 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CO 1 1-1189 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2OCH2CO 1 1-1190 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2OCH2CH2CO 1 1-1192 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-1193 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-1194 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1196 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H HCH3CH2CO 1 1-1197 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H Hcyclo-PrCO 1 1-1198 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H HCF3CH2CO 1 1-1200 C—Cl C—H C—Cl C—H H CF3 CH CH C—SOCH3 N H H H CH3CH2CO1 1-1201 C—Cl C—H C—Cl C—H H CF3 CH CH C—SOCH3 N H H H cyclo-PrCO 11-1202 C—Cl C—H C—Cl C—H H CF3 CH CH C—SOCH3 N H H H CF3CH2CO 1 1-1203C—Cl C—H C—Cl C—H H CF3 CH CH C—SOCH3 N H H H CH3SCH2CO 1 1-1205 C—ClC—H C—Cl C—H H CF3 CH CH C—SO2CH3 N H H H CH3CH2CO 1 1-1206 C—Cl C—HC—Cl C—H H CF3 CH CH C—SO2CH3 N H H H cyclo-PrCO 1 1-1207 C—Cl C—H C—ClC—H H CF3 CH CH C—SO2CH3 N H H H CF3CH2CO 1 1-1209 C—Cl C—H C—Cl C—H HCF3 CH CH C—SCF3 N H H H CH3CH2CO 1 1-1210 C—Cl C—H C—Cl C—H H CF3 CH CHC—SCF3 N H H H nPrCO 1 1-1211 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H HH cyclo-PrCO 1 1-1212 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H Hcyclo-PrCH2CO 1 1-1213 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H HCF3CH2CO 1 1-1214 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3SCH2CO1 1-1215 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3S(O)CH2CO 11-1216 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3SO2CH2CO 1 1-1217C—Cl C—H C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3CH2NHCO 1 1-1219 C—ClC—H C—Cl C—H H CF3 CH CH C—S(O)CF3 N H H H CH3CH2CO 1 1-1220 C—Cl C—HC—Cl C—H H CF3 CH CH C—S(O)CF3 N H H H nPrCO 1 1-1221 C—Cl C—H C—Cl C—HH CF3 CH CH C—S(O)CF3 N H H H cyclo-PrCO 1 1-1222 C—Cl C—H C—Cl C—H HCF3 CH CH C—S(O)CF3 N H H H cyclo-PrCH2CO 1 1-1223 C—Cl C—H C—Cl C—H HCF3 CH CH C—S(O)CF3 N H H H CF3CH2CO 1 1-1224 C—Cl C—H C—Cl C—H H CF3 CHCH C—S(O)CF3 N H H H CH3SCH2CO 1 1-1225 C—Cl C—H C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3S(O)CH2CO 1 1-1226 C—Cl C—H C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3SO2CH2CO 1 1-1227 C—Cl C—H C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CH2NHCO 1 1-1229 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 N H H H CH3CH2CO 1 1-1230 C—Cl C—H C—Cl C—H H CF3 CH CHC—SO2CF3 N H H H nPrCO 1 1-1231 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 NH H H cyclo-PrCO 1 1-1232 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H Hcyclo-PrCH2CO 1 1-1233 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCF3CH2CO 1 1-1234 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3SCH2CO 1 1-1235 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3S(O)CH2CO 1 1-1236 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3SO2CH2CO 1 1-1237 C—Cl C—H C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3CH2NHCO 1 1-1238 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CO 11-1239 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1240 C—ClC—F C—Cl C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1241 C—Cl C—F C—Cl C—H HCF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1242 C—Cl C—F C—Cl C—H H CF3 CH CHC—Cl N H H H cyclo-PrCH2CO 1 1-1243 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl NH H H CF3CH2CO 1 1-1244 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H HCH3SCH2CO 1 1-1245 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1246 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1247 C—Cl C—F C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1248 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br N H H H CH3CO 11-1249 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1250 C—ClC—F C—Cl C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1251 C—Cl C—F C—Cl C—H HCF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1252 C—Cl C—F C—Cl C—H H CF3 CH CHC—Br N H H H cyclo-PrCH2CO 1 1-1253 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br NH H H CF3CH2CO 1 1-1254 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br N H H HCH3SCH2CO 1 1-1255 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1256 C—Cl C—F C—Cl C—H H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1257 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1258 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1259 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1260C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1261 C—Cl C—F C—ClC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1262 C—Cl C—F C—Cl C—H HCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1263 C—Cl C—F C—Cl C—H H CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1264 C—Cl C—F C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3SCH2CO 1 1-1265 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N HH H CH3S(O)CH2CO 1 1-1266 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1267 C—Cl C—F C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1269 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2CO1 1-1270 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1271 C—ClC—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1272 C—Cl C—ClC—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1273 C—Cl C—Cl C—ClC—H H CF3 CH CH C—Cl N H H H CF3CH2CO 1 1-1274 C—Cl C—Cl C—Cl C—H H CF3CH CH C—Cl N H H H CH3SCH2CO 1 1-1275 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Cl N H H H CH3S(O)CH2CO 1 1-1276 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl NH H H CH3SO2CH2CO 1 1-1277 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1278 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H CH3CO 11-1279 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1280C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1281 C—Cl C—ClC—Cl C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1282 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1283 C—Cl C—Cl C—Cl C—H H CF3CH CH C—Br N H H H CF3CH2CO 1 1-1284 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—BrN H H H CH3SCH2CO 1 1-1285 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1286 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1287 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1288 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 11-1289 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 11-1290 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3SCH2CO 1 1-1291C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3S(O)CH2CO 1 1-1292 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3SO2CH2CO 1 1-1293 C—Cl C—ClC—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3CO 1 1-1294 C—Cl C—Cl C—Cl C—H HCF3 CH CH C—SCH3 N H H H CH3CH2CO 1 1-1295 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—SCH3 N H H H cyclo-PrCO 1 1-1296 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SCH3 N H H H CF3CH2CO 1 1-1297 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 N H H H CH3CO 1 1-1298 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 N H H H CH3CH2CO 1 1-1299 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 N H H H cyclo-PrCO 1 1-1300 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 N H H H CF3CH2CO 1 1-1301 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH3 N H H H CH3SCH2CO 1 1-1302 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CH3 N H H H CH3CO 1 1-1303 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3N H H H CH3CH2CO 1 1-1304 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3 N H HH cyclo-PrCO 1 1-1305 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CH3 N H H HCF3CH2CO 1 1-1306 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3CO 11-1307 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 N H H H CH3CH2CO 1 1-1308C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCF3 N H H H nPrCO 1 1-1309 C—Cl C—ClC—Cl C—H H CF3 CH CH C—SCF3 N H H H cyclo-PrCO 1 1-1310 C—Cl C—Cl C—ClC—H H CF3 CH CH C—SCF3 N H H H cyclo-PrCH2CO 1 1-1311 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—SCF3 N H H H CF3CH2CO 1 1-1312 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—SCF3 N H H H CH3SCH2CO 1 1-1313 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SCF3 N H H H CH3S(O)CH2CO 1 1-1314 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SCF3 N H H H CH3SO2CH2CO 1 1-1315 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SCF3 N H H H CH3CH2NHCO 1 1-1316 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CO 1 1-1317 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CH2CO 1 1-1318 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H nPrCO 1 1-1319 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H cyclo-PrCO 1 1-1320 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H cyclo-PrCH2CO 1 1-1321 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CF3CH2CO 1 1-1322 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3SCH2CO 1 1-1323 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3S(O)CH2CO 1 1-1324 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3SO2CH2CO 1 1-1325 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CH2NHCO 1 1-1326 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—SO2CF3 N H H H CH3CO 1 1-1327 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3N H H H CH3CH2CO 1 1-1328 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H HH nPrCO 1 1-1329 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H Hcyclo-PrCO 1 1-1330 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H Hcyclo-PrCH2CO 1 1-1331 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCF3CH2CO 1 1-1332 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3SCH2CO 1 1-1333 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3S(O)CH2CO 1 1-1334 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3SO2CH2CO 1 1-1335 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SO2CF3 N H H HCH3CH2NHCO 1 1-1336 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CO 11-1337 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1338C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1339 C—Cl C—BrC—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1340 C—Cl C—Br C—Cl C—HH CF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1341 C—Cl C—Br C—Cl C—H H CF3CH CH C—Cl N H H H CF3CH2CO 1 1-1342 C—Cl C—Br C—Cl C—H H CF3 CH CH C—ClN H H H CH3SCH2CO 1 1-1343 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1344 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1345 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1346 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H H CH3CO 11-1347 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1348C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1349 C—Cl C—BrC—Cl C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1350 C—Cl C—Br C—Cl C—HH CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1351 C—Cl C—Br C—Cl C—H H CF3CH CH C—Br N H H H CF3CH2CO 1 1-1352 C—Cl C—Br C—Cl C—H H CF3 CH CH C—BrN H H H CH3SCH2CO 1 1-1353 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1354 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1355 C—Cl C—Br C—Cl C—H H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1356 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1357 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1358C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1359 C—Cl C—BrC—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1360 C—Cl C—Br C—ClC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1361 C—Cl C—Br C—Cl C—HH CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1362 C—Cl C—Br C—Cl C—H H CF3 CHCH C—CF3 N H H H CH3SCH2CO 1 1-1363 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3N H H H CH3S(O)CH2CO 1 1-1364 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 N H HH CH3SO2CH2CO 1 1-1365 C—Cl C—Br C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1366 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H H CH3CO 11-1367 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1368C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1369 C—Cl C—ClC—Br C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1370 C—Cl C—Cl C—Br C—HH CF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1371 C—Cl C—Cl C—Br C—H H CF3CH CH C—Cl N H H H CF3CH2CO 1 1-1372 C—Cl C—Cl C—Br C—H H CF3 CH CH C—ClN H H H CH3SCH2CO 1 1-1373 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1374 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1375 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1376 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H H CH3CO 11-1377 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1378C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1379 C—Cl C—ClC—Br C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1380 C—Cl C—Cl C—Br C—HH CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1381 C—Cl C—Cl C—Br C—H H CF3CH CH C—Br N H H H CF3CH2CO 1 1-1382 C—Cl C—Cl C—Br C—H H CF3 CH CH C—BrN H H H CH3SCH2CO 1 1-1383 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1384 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1- 1385 C—Cl C—Cl C—Br C—H H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1386 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1387 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1388C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1389 C—Cl C—ClC—Br C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1390 C—Cl C—Cl C—BrC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1391 C—Cl C—Cl C—Br C—HH CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1392 C—Cl C—Cl C—Br C—H H CF3 CHCH C—CF3 N H H H CH3SCH2CO 1 1-1393 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3N H H H CH3S(O)CH2CO 1 1-1394 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 N H HH CH3SO2CH2CO 1 1-1395 C—Cl C—Cl C—Br C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1396 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H H CH3CO 11-1397 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1398 C—ClC—F C—Cl C—H F CF3 CH CH C—Cl N H H H nPrCO 1 1-1399 C—Cl C—F C—Cl C—H FCF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1400 C—Cl C—F C—Cl C—H F CF3 CH CHC—Cl N H H H cyclo-PrCH2CO 1 1-1401 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl NH H H CF3CH2CO 1 1-1402 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H HCH3SCH2CO 1 1-1403 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1404 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1405 C—Cl C—F C—Cl C—H F CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1406 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H H CH3CO 11-1407 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1408 C—ClC—F C—Cl C—H F CF3 CH CH C—Br N H H H nPrCO 1 1-1409 C—Cl C—F C—Cl C—H FCF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1410 C—Cl C—F C—Cl C—H F CF3 CH CHC—Br N H H H cyclo-PrCH2CO 1 1-1411 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br NH H H CF3CH2CO 1 1-1412 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H HCH3SCH2CO 1 1-1413 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1414 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1415 C—Cl C—F C—Cl C—H F CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1416 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N H H H CH3CO 11-1417 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1418C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N H H H nPrCO 1 1-1419 C—Cl C—F C—ClC—H F CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1420 C—Cl C—F C—Cl C—H FCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1421 C—Cl C—F C—Cl C—H F CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1422 C—Cl C—F C—Cl C—H F CF3 CH CHC—CF3 N H H H CH3SCH2CO 1 1-1423 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N HH H CH3S(O)CH2CO 1 1-1424 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1425 C—Cl C—F C—Cl C—H F CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1426 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1427 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1428C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1429 C—CF3 C—H C—HC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1430 C—CF3 C—H C—H C—H HCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1431 C—CF3 C—H C—H C—H H CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1432 C—CF3 C—H C—H C—H H CF3 CH CHC—CF3 N H H H CH3SCH2CO 1 1-1433 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N HH H CH3S(O)CH2CO 1 1-1434 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1435 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1436 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1437 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1438C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1439 C—CF3 C—F C—HC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1440 C—CF3 C—F C—H C—H HCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1441 C—CF3 C—F C—H C—H H CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1442 C—CF3 C—F C—H C—H H CF3 CH CHC—CF3 N H H H CH3SOCH2CO 1 1-1443 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 NH H H CH3S(O)CH2CO 1 1-1444 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1445 C—CF3 C—F C—H C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1446 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 N H H H CH3CO 11-1447 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1448C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 N H H H nPrCO 1 1-1449 C—CF3 C—H C—HC—H F CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1450 C—CF3 C—H C—H C—H FCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1451 C—CF3 C—H C—H C—H F CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1452 C—CF3 C—H C—H C—H F CF3 CH CHC—CF3 N H H H CH3SOCH2CO 1 1-1453 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 NH H H CH3S(O)CH2CO 1 1-1454 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1455 C—CF3 C—H C—H C—H F CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1456 C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1457 C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1458C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1459 C—Cl C—CF3C—H C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1460 C—Cl C—CF3 C—H C—HH CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1461 C—Cl C—CF3 C—H C—H HCF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1462 C—Cl C—CF3 C—H C—H H CF3 CH CHC—CF3 N H H H CH3SOCH2CO 1 1-1463 C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 NH H H CH3S(O)CH2CO 1 1-1464 C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1465 C—Cl C—CF3 C—H C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1467 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3CH2CO 1 1-1468 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H H nPrCO 11-1469 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H H cyclo PrCO 1 1-1470C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1471C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H H CF3CH2CO 1 1-1472 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—Cl N H H H CH3SCH2CO 1 1-1473 C—CF3 C—H C—CF3C—H H CF3 CH CH C—Cl N H H H CH3S(O)CH2CO 1 1-1474 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—Cl N H H H CH3SO2CH2CO 1 1-1475 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—Cl N H H H CH3CH2NHCO 1 1-1476 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—BrN H H H CH3CO 1 1-1477 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H HCH3CH2CO 1 1-1478 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H H nPrCO 11-1479 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1480C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1481C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H H CF3CH2CO 1 1-1482 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—Br N H H H CH3SCH2CO 1 1-1483 C—CF3 C—H C—CF3C—H H CF3 CH CH C—Br N H H H CH3S(O)CH2CO 1 1-1484 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—Br N H H H CH3SO2CH2CO 1 1-1485 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—Br N H H H CH3CH2NHCO 1 1-1486 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CF3 N H H H nPrCO 1 1-1487 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H HH cyclo-PrCH2CO 1 1-1488 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-1489 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-1490 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1491 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH3 N H H HCH3CO 1 1-1492 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH3 N H H H CH3CH2CO 11-1493 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH3 N H H H cyclo-PrCO 11-1494 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH3 N H H H CF3CH2CO 1 1-1495C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SOCH3 N H H H CH3CO 1 1-1496 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—SOCH3 N H H H CH3CH2CO 1 1-1497 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SOCH3 N H H H cyclo-PrCO 1 1-1498 C—CF3 C—H C—CF3 C—HH CF3 CH CH C—SOCH3 N H H H CF3CH2CO 1 1-1499 C—CF3 C—H C—CF3 C—H H CF3CH CH C—SOCH3 N H H H CH3SCH2CO 1 1-1500 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CH3 N H H H CH3CO 1 1-1501 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3N H H H CH3CH2CO 1 1-1502 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3 N H HH cyclo-PrCO 1 1-1503 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CH3 N H H HCF3CH2CO 1 1-1504 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 N H H H CH3CO 11-1505 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 N H H H CH3CH2CO 1 1-1506C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 N H H H nPrCO 1 1-1507 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—SCF3 N H H H cyclo-PrCO 1 1-1508 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCF3 N H H H cyclo-PrCH2CO 1 1-1509 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCF3 N H H H CF3CH2CO 1 1-1510 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—SCF3 N H H H CH3SCH2CO 1 1-1511 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—SCF3 N H H H CH3S(O)CH2CO 1 1-1512 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SCF3 N H H H CH3SO2CH2CO 1 1-1513 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SCF3 N H H H CH3CH2NHCO 1 1-1514 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CO 1 1-1515 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CH2CO 1 1-1516 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H nPrCO 1 1-1517 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H cyclo-PrCO 1 1-1518 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H cyclo-PrCH2CO 1 1-1519 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CF3CH2CO 1 1-1520 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3SCH2CO 1 1-1521 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3S(O)CH2CO 1 1-1522 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3SO2CH2CO 1 1-1523 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—S(O)CF3 N H H H CH3CH2NHCO 1 1-1524 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—SO2CF3 N H H H CH3CO 1 1-1525 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3N H H H CH3CH2CO 1 1-1526 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H HH nPrCO 1 1-1527 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H Hcyclo-PrCO 1 1-1528 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H Hcyclo-PrCH2CO 1 1-1529 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H HCF3CH2CO 1 1-1530 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H HCH3SCH2CO 1 1-1531 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H HCH3S(O)CH2CO 1 1-1532 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H HCH3SO2CH2CO 1 1-1533 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SO2CF3 N H H HCH3CH2NHCO 1 1-1534 C—Cl C—CF3 C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CO1 1-1535 C—Cl C—CF3 C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1536C—Cl C—CF3 C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1537 C—Cl C—CF3C—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1538 C—Cl C—CF3 C—ClC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1539 C—Cl C—CF3 C—Cl C—HH CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1540 C—Cl C—CF3 C—Cl C—H H CF3 CHCH C—CF3 N H H H CH3SOCH2CO 1 1-1541 C—Cl C—CF3 C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3S(O)CH2CO 1 1-1542 C—Cl C—CF3 C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3SO2CH2CO 1 1-1543 C—Cl C—CF3 C—Cl C—H H CF3 CH CH C—CF3N H H H CH3CH2NHCO 1 1-1544 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CO 1 1-1545 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 11-1546 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1547 C—CF3C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1548 C—CF3 C—ClC—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1549 C—CF3 C—Cl C—ClC—H H CF3 CH CH C—Cl N H H H CF3CH2CO 1 1-1550 C—CF3 C—Cl C—Cl C—H H CF3CH CH C—Cl N H H H CH3SCH2CO 1 1-1551 C—CF3 C—Cl C—Cl C—H H CF3 CH CHC—Cl N H H H CH3S(O)CH2CO 1 1-1552 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—ClN H H H CH3SO2CH2CO 1 1-1553 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Cl N H HH CH3CH2NHCO 1 1-1554 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H CH3CO1 1-1555 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1556C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1557 C—CF3 C—ClC—Cl C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1558 C—CF3 C—Cl C—ClC—H H CF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1559 C—CF3 C—Cl C—Cl C—HH CF3 CH CH C—Br N H H H CF3CH2CO 1 1-1560 C—CF3 C—Cl C—Cl C—H H CF3 CHCH C—Br N H H H CH3SCH2CO 1 1-1561 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—BrN H H H CH3S(O)CH2CO 1 1-1562 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Br N H HH CH3SO2CH2CO 1 1-1563 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1564 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CO1 1-1565 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1566C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1567 C—CF3 C—ClC—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1568 C—CF3 C—Cl C—ClC—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1569 C—CF3 C—Cl C—Cl C—HH CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1570 C—CF3 C—Cl C—Cl C—H H CF3 CHCH C—CF3 N H H H CH3SCH2CO 1 1-1571 C—CF3 C—Cl C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3S(O)CH2CO 1 1-1572 C—CF3 C—Cl C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3SO2CH2CO 1 1-1573 C—CF3 C—Cl C—Cl C—H H CF3 CH CH C—CF3N H H H CH3CH2NHCO 1 1-1574 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H HCH3CO 1 1-1575 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1576 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1577 C—Cl NC—Cl C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1578 C—Cl N C—Cl C—H HCF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1579 C—Cl N C—Cl C—H H CF3 CHCH C—Cl N H H H CF3CH2CO 1 1-1580 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H HH CH3SCH2CO 1 1-1581 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1582 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1583 C—Cl N C—Cl C—H H CF3 CH CH C—Cl N H H H CH3CH2NHCO1 1-1584 C—Cl N C—Cl C—H H CF3 CH CH C—Br N H H H CH3CO 1 1-1585 C—Cl NC—Cl C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1586 C—Cl N C—Cl C—H HCF3 CH CH C—Br N H H H nPrCO 1 1-1587 C—Cl N C—Cl C—H H CF3 CH CH C—Br NH H H cyclo-PrCO 1 1-1588 C—Cl N C—Cl C—H H CF3 CH CH C—Br N H H Hcyclo-PrCH2CO 1 1-1589 C—Cl N C—Cl C—H H CF3 CH CH C—Br N H H H CF3CH2CO1 1-1590 C—Cl N C—Cl C—H H CF3 CH CH C—Br N H H H CH3SCH2CO 1 1-1591C—Cl N C—Cl C—H H CF3 CH CH C—Br N H H H CH3S(O)CH2CO 1 1-1592 C—Cl NC—Cl C—H H CF3 CH CH C—Br N H H H CH3SO2CH2CO 1 1-1593 C—Cl N C—Cl C—H HCF3 CH CH C—Br N H H H CH3CH2NHCO 1 1-1594 C—Cl N C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3CO 1 1-1595 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2CO 1 1-1596 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 N H H H nPrCO 11-1597 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1598C—Cl N C—Cl C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1599 C—Cl NC—Cl C—H H CF3 CH CH C—CF3 N H H H CF3CH2CO 1 1-1600 C—Cl N C—Cl C—H HCF3 CH CH C—CF3 N H H H CH3SCH2CO 1 1-1601 C—Cl N C—Cl C—H H CF3 CH CHC—CF3 N H H H CH3S(O)CH2CO 1 1-1602 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 NH H H CH3SO2CH2CO 1 1-1603 C—Cl N C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1604 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H H CH3CO 11-1605 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1606 C—CF3C—H C—H N H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1607 C—CF3 C—H C—H N H CF3CH CH C—CF3 N H H H cyclo-PrCO 1 1-1608 C—CF3 C—H C—H N H CF3 CH CHC—CF3 N H H H cyclo-PrCH2CO 1 1-1609 C—CF3 C—H C—H N H CF3 CH CH C—CF3 NH H H CF3CH2CO 1 1-1610 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-1611 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-1612 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1613 C—CF3 C—H C—H N H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1614 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H H CH3CO 11-1615 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1616 C—HC—H C—CF3 N H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1617 C—H C—H C—CF3 N HCF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1618 C—H C—H C—CF3 N H CF3 CH CHC—CF3 N H H H cyclo-PrCH2CO 1 1-1619 C—H C—H C—CF3 N H CF3 CH CH C—CF3 NH H H CF3CH2CO 1 1-1620 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-1621 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-1622 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1623 C—H C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1624 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1625 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1626 C—CF3N C—H C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1627 C—CF3 N C—H C—H H CF3CH CH C—CF3 N H H H cyclo-PrCO 1 1-1628 C—CF3 N C—H C—H H CF3 CH CHC—CF3 N H H H cyclo-PrCH2CO 1 1-1629 C—CF3 N C—H C—H H CF3 CH CH C—CF3 NH H H CF3CH2CO 1 1-1630 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-1631 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-1632 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1633 C—CF3 N C—H C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1634 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H H CH3CO 11-1635 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1636C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H H nPrCO 1 1-1637 C—CF3 N C—CF3C—H H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1638 C—CF3 N C—CF3 C—H H CF3CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1639 C—CF3 N C—CF3 C—H H CF3 CH CHC—Cl N H H H CF3CH2CO 1 1-1640 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H HH CH3SCH2CO 1 1-1641 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1642 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1643 C—CF3 N C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1644 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H H CH3CO 11-1645 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1646C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H H nPrCO 1 1-1647 C—CF3 N C—CF3C—H H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1648 C—CF3 N C—CF3 C—H H CF3CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1649 C—CF3 N C—CF3 C—H H CF3 CH CHC—Br N H H H CF3CH2CO 1 1-1650 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H HH CH3SCH2CO 1 1-1651 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1652 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1653 C—CF3 N C—CF3 C—H H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1654 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N H H H CH3CO 11-1655 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1656C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N H H H nPrCO 1 1-1657 C—CF3 N C—CF3C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1658 C—CF3 N C—CF3 C—H HCF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1659 C—CF3 N C—CF3 C—H H CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1660 C—CF3 N C—CF3 C—H H CF3 CH CHC—CF3 N H H H CH3SCH2CO 1 1-1661 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N HH H CH3S(O)CH2CO 1 1-1662 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1663 C—CF3 N C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1664 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H H CH3CO 11-1665 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H H CH3CH2CO 1 1-1666C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H H nPrCO 1 1-1667 C—CF3 C—HC—CF3 N H CF3 CH CH C—Cl N H H H cyclo-PrCO 1 1-1668 C—CF3 C—H C—CF3 N HCF3 CH CH C—Cl N H H H cyclo-PrCH2CO 1 1-1669 C—CF3 C—H C—CF3 N H CF3 CHCH C—Cl N H H H CF3CH2CO 1 1-1670 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N HH H CH3SCH2CO 1 1-1671 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H HCH3S(O)CH2CO 1 1-1672 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H HCH3SO2CH2CO 1 1-1673 C—CF3 C—H C—CF3 N H CF3 CH CH C—Cl N H H HCH3CH2NHCO 1 1-1674 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H H CH3CO 11-1675 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H H CH3CH2CO 1 1-1676C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H H nPrCO 1 1-1677 C—CF3 C—HC—CF3 N H CF3 CH CH C—Br N H H H cyclo-PrCO 1 1-1678 C—CF3 C—H C—CF3 N HCF3 CH CH C—Br N H H H cyclo-PrCH2CO 1 1-1679 C—CF3 C—H C—CF3 N H CF3 CHCH C—Br N H H H CF3CH2CO 1 1-1680 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N HH H CH3SCH2CO 1 1-1681 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H HCH3S(O)CH2CO 1 1-1682 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H HCH3SO2CH2CO 1 1-1683 C—CF3 C—H C—CF3 N H CF3 CH CH C—Br N H H HCH3CH2NHCO 1 1-1684 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N H H H CH3CO 11-1685 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N H H H CH3CH2CO 1 1-1686C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N H H H nPrCO 1 1 -1687 C—CF3 C—HC—CF3 N H CF3 CH CH C—CF3 N H H H cyclo-PrCO 1 1-1688 C—CF3 C—H C—CF3 NH CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 1 1-1689 C—CF3 C—H C—CF3 N H CF3CH CH C—CF3 N H H H CF3CH2CO 1 1-1690 C—CF3 C—H C—CF3 N H CF3 CH CHC—CF3 N H H H CH3SCH2CO 1 1-1691 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N HH H CH3S(O)CH2CO 1 1-1692 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-1693 C—CF3 C—H C—CF3 N H CF3 CH CH C—CF3 N H H HCH3CH2NHCO 1 1-1694 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCH3 N H H HCF3CH2CO 1 1-1695 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH3 N H H HCF3CH2CO 1 1-1696 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3SCH2CO1 1-1697 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3S(O)CH2CO 11-1698 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3SO2CH2CO 1 1-1699C—Cl C—Cl C—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3SCH2CO 1 1-1700 C—ClC—Cl C—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3S(O)CH2CO 1 1-1701 C—Cl C—ClC—Cl C—H H CF3 CH CH C—SCH3 N H H H CH3SO2CH2CO 1 1-1702 C—CF3 C—H C—CF3C—H H CF3 CH CH C—SCH3 N H H H CH3SCH2CO 1 1-1703 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—SCH3 N H H H CH3S(O)CH2CO 1 1-1704 C—CF3 C—H C—CF3 C—H H CF3CH CH C—SCH3 N H H H CH3SO2CH2CO 1 1-1705 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3CO 1 1-1706 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H n-PrCO 1 1-1707 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCO 1 1-1708 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCH2CO 1 1-1709 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3SCH2CO 1 1-1710 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3S(O)CH2CO 1 1-1711 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3SO2CH2CO 1 1-1712 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3CH2NHCO 1 1-1713 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3CO 1 1-1714 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H n-PrCO 1 1 -1715 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCO 1 1-1716 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCH2CO 1 1-1717 C—Cl C—Cl C—Cl C—H H CF3 CHCH C-cyclo-Pr CH H H H CH3SCH2CO 1 1-1718 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3S(O)CH2CO 1 1-1719 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3SO2CH2CO 1 1-1720 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3CH2NHCO 1 1-1721 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr CH H H H CH3CO 1 1-1722 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr CH H H H n-PrCO 1 1-1723 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCO 1 1-1724 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr CH H H H cyclo-PrCH2CO 1 1-1725 C—CF3 C—H C—CF3 C—H H CF3 CHCH C-cyclo-Pr CH H H H CH3SCH2CO 1 1-1726 C—CF3 C—H C—CF3 C—H H CF3 CHCH C-cyclo-Pr CH H H H CH3S(O)CH2CO 1 1-1727 C—CF3 C—H C—CF3 C—H H CF3CH CH C-cyclo-Pr CH H H H CH3SO2CH2CO 1 1-1728 C—CF3 C—H C—CF3 C—H H CF3CH CH C-cyclo-Pr CH H H H CH3CH2NHCO 1 1-1730 C—Cl C—H C—Cl C—H H CF3 CHCH C—CH3 N H H H CH3CH2CO 1 1-1731 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 NH H H n-PrCO 1 1-1732 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H Hcyclo-PrCO 1 1-1733 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H Hcyclo-PrCH2CO 1 1-1734 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H HCF3CH2CO 1 1-1735 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3SCH2CO1 1-1736 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3S(O)CH2CO 11-1737 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3SO2CH2CO 1 1-1738C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3CH2NHCO 1 1-1739 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3CO 1 1-1740 C—Cl C—Cl C—ClC—H H CF3 CH CH C—CH3 N H H H CH3CH2CO 1 1-1741 C—Cl C—Cl C—Cl C—H H CF3CH CH C—CH3 N H H H nPrCO 1 1-1742 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3N H H H cyclo-PrCO 1 1-1743 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H Hcyclo-PrCH2CO 1 1-1744 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H HCF3CH2CO 1 1-1745 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3SCH2CO1 1-1746 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3S(O)CH2CO 11-1747 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3SO2CH2CO 1 1-1748C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 N H H H CH3CH2NHCO 1 1-1749 C—CF3C—H C—H C—H H CF3 CH CH C—CH3 N H H H CH3CO 1 1-1750 C—CF3 C—H C—H C—H HCF3 CH CH C—CH3 N H H H CH3CH2CO 1 1-1751 C—CF3 C—H C—H C—H H CF3 CH CHC—CH3 N H H H nPrCO 1 1-1752 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H Hcyclo-PrCO 1 1-1753 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H Hcyclo-PrCH2CO 1 1-1754 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H HCF3CH2CO 1 1-1755 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H H CH3SCH2CO1 1-1756 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H H CH3S(O)CH2CO 11-1757 C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H H CH3SO2CH2CO 1 1-1758C—CF3 C—H C—H C—H H CF3 CH CH C—CH3 N H H H CH3CH2NHCO 1 1-1759 C—CF3C—H C—CF3 C—H H CF3 CH CH C—CH3 N H H H CH3CO 1 1-1760 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CH3 N H H H CH3CH2CO 1 1-1761 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—CH3 N H H H nPrCO 1 1-1762 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CH3 N H H H cyclo-PrCO 1 1-1763 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3N H H H cyclo-PrCH2CO 1 1-1764 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 N HH H CF3CH2CO 1 1-1765 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 N H H HCH3SCH2CO 1 1-1766 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 N H H HCH3S(O)CH2CO 1 1-1767 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 N H H HCH3SO2CH2CO 1 1-1768 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 N H H HCH3CH2NHCO 1 1-1769 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H HCH3CO 1 1-1770 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3CH2CO1 1-1771 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H nPrCO 1 1-1772C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H cyclo-PrCO 1 1-1773C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H cyclo-PrCH2CO 1 1-1774C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CF3CH2CO 1 1-1775 C—ClC—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3SCH2CO 1 1-1776 C—Cl C—HC—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3S(O)CH2CO 1 1-1777 C—Cl C—HC—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3SO2CH2CO 1 1-1778 C—Cl C—HC—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3CH2NHCO 1 1-1779 C—Cl C—ClC—Cl C—H H CF3 CH CH C-cyclo-Pr N H H H CH3CO 1 1-1780 C—Cl C—Cl C—ClC—H H CF3 CH CH C-cyclo-Pr N H H H CH3CH2CO 1 1-1781 C—Cl C—Cl C—Cl C—HH CF3 CH CH C-cyclo-Pr N H H H nPrCO 1 1-1782 C—Cl C—Cl C—Cl C—H H CF3CH CH C-cyclo-Pr N H H H cyclo-PrCO 1 1-1783 C—Cl C—Cl C—Cl C—H H CF3 CHCH C-cyclo-Pr N H H H cyclo-PrCH2CO 1 1-1784 C—Cl C—Cl C—Cl C—H H CF3 CHCH C-cyclo-Pr N H H H CF3CH2CO 1 1-1785 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SCH2CO 1 1-1786 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr N H H H CH3S(O)CH2CO 1 1-1787 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SO2CH2CO 1 1-1788 C—Cl C—Cl C—Cl C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CH2NHCO 1 1-1789 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CO 1 1-1790 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CH2CO 1 1-1791 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H nPrCO 1 1-1792 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H cyclo-PrCO 1 1-1793 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H cyclo-PrCH2CO 1 1-1794 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CF3CH2CO 1 1-1795 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SCH2CO 1 1-1796 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3S(O)CH2CO 1 1-1797 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SO2CH2CO 1 1-1798 C—CF3 C—H C—H C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CH2NHCO 1 1-1799 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CO 1 1-1800 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CH2CO 1 1-1801 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H nPrCO 1 1-1802 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H cyclo-PrCO 1 1-1803 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H cyclo-PrCH2CO 1 1-1804 C—CF3 C—H C—CF3 C—H H CF3 CHCH C-cyclo-Pr N H H H CF3CH2CO 1 1-1805 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SCH2CO 1 1-1806 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3S(O)CH2CO 1 1-1807 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3SO2CH2CO 1 1-1808 C—CF3 C—H C—CF3 C—H H CF3 CH CHC-cyclo-Pr N H H H CH3CH2NHCO 1 1-1809 C—Cl C—H C—Cl C—H H CF3 CH CHC—CH2CF3 N H H H CH3CO 1 1-1810 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 NH H H CH3CH2CO 1 1-1811 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H HnPrCO 1 1-1812 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H H cyclo-PrCO1 1-1813 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H H cyclo-PrCH2CO 11-1814 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H H CF3CH2CO 1 1-1815C—Cl C—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H H CH3SCH2CO 1 1-1816 C—ClC—H C—Cl C—H H CF3 CH CH C—CH2CF3 N H H H CH3S(O)CH2CO 1 1-1817 C—Cl C—HC—Cl C—H H CF3 CH CH C—CH2CF3 N H H H CH3SO2CH2CO 1 1-1818 C—Cl C—H C—ClC—H H CF3 CH CH C—CH2CF3 N H H H CH3CH2NHCO 1 1-1819 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—CH2CF3 N H H H CH3CO 1 1-1820 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—CH2CF3 N H H H CH3CH2CO 1 1-1821 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—CH2CF3 N H H H nPrCO 1 1-1822 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3N H H H cyclo-PrCO 1 1-1823 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N HH H cyclo-PrCH2CO 1 1-1824 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N H HH CF3CH2CO 1 1-1825 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N H H HCH3SCH2CO 1 1-1826 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N H H HCH3S(O)CH2CO 1 1-1827 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N H H HCH3SO2CH2CO 1 1-1828 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH2CF3 N H H HCH3CH2NHCO 1 1-1829 C—CF3 C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H CH3CO1 1-1830 C—CF3 C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H CH3CH2CO 11-1831 C—CF3 C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H nPrCO 1 1-1832C—CF3 C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H cyclo-PrCO 1 1-1833 C—CF3C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H cyclo-PrCH2CO 1 1-1834 C—CF3C—H C—H C—H H CF3 CH CH C—CH2CF3 N H H H CF3CH2CO 1 1-1835 C—CF3 C—H C—HC—H H CF3 CH CH C—CH2CF3 N H H H CH3SCH2CO 1 1-1836 C—CF3 C—H C—H C—H HCF3 CH CH C—CH2CF3 N H H H CH3S(O)CH2CO 1 1-1837 C—CF3 C—H C—H C—H H CF3CH CH C—CH2CF3 N H H H CH3SO2CH2CO 1 1-1838 C—CF3 C—H C—H C—H H CF3 CHCH C—CH2CF3 N H H H CH3CH2NHCO 1 1-1839 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CH2CF3 N H H H CH3CO 1 1-1840 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3N H H H CH3CH2CO 1 1-1841 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H HH nPrCO 1 1-1842 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H Hcyclo-PrCO 1 1-1843 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H Hcyclo-PrCH2CO 1 1-1844 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H HCF3CH2CO 1 1-1845 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H HCH3SCH2CO 1 1-1846 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H HCH3S(O)CH2CO 1 1-1847 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H HCH3SO2CH2CO 1 1-1848 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH2CF3 N H H HCH3CH2NHCO 1 1-1849 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CH2CO 1 1-1850 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CH2CO 1 1 -1851 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CH2CO 1 1-1852 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CH2CO 1 1-1853 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3OCH2CH2CO 1 1-1854 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3CO 1 1-1855 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 11-1856 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1857 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1858 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1859 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CF3CH2CO 1 1-1860 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2CO 1 1-1861 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-1862 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-1863 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1864 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1865 C—ClC—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1866 C—Cl C—OCH2O—CC—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1867 C—Cl C—OCH2O—C C—H HCF3 CH CH C—CF3 CH H H H nPrCO 1 1-1868 C—Cl C—OCH2O—C C—H H CF3 CH CHC—CF3 CH H H H cyclo-PrCO 1 1-1869 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3CH H H H cyclo-PrCH2CO 1 1-1870 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CHH H H CF3CH2CO 1 1-1871 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3OCH2CH2CO 1 1-1872 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3SCH2CO 1 1-1873 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1874 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1875 C—Cl C—OCH2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1876 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3CO 1 1-1877 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3CH2CO 1 1-1878 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HnPrCO 1 1-1879 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCO 1 1-1880 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2CO 1 1-1881 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1882 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3OCH2CH2CO 1 1-1883 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3SCH2CO 1 1-1884 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1885 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1886 C—Cl C—OC(CH3)2O—C C—H H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1887 C—Cl C—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CO1 1-1888 C—Cl C—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1889C—Cl C—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H nPrCO 1 1-1890 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCO 1 1-1891 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H cyclo-PrCH2CO 1 1-1892 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CF3CH2CO 1 1-1893 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3OCH2CH2CO 1 1-1894 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO 1 1-1895 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 1 1-1896 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1897 C—ClC—OCF2O—C C—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1898 C—F C—HC—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CO 1 1-1899 C—F C—H C—CF3 C—H HCF3 CH CH C—Cl CH H H H CH3CH2CO 1 1-1900 C—F C—H C—CF3 C—H H CF3 CH CHC—Cl CH H H H nPrCO 1 1-1901 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCO 1 1-1902 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H Hcyclo-PrCH2CO 1 1-1903 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCF3CH2CO 1 1-1904 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3SCH2CO1 1-1905 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3S(O)CH2CO 11-1906 C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3SO2CH2CO 1 1-1907C—F C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H H CH3CH2NHCO 1 1-1908 C—F C—HC—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CO 1 1-1909 C—F C—H C—CF3 C—H HCF3 CH CH C—Br CH H H H CH3CH2CO 1 1-1910 C—F C—H C—CF3 C—H H CF3 CH CHC—Br CH H H H nPrCO 1 1-1911 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H Hcyclo-PrCO 1 1-1912 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H Hcyclo-PrCH2CO 1 1-1913 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H HCF3CH2CO 1 1-1914 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3SCH2CO1 1-1915 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3S(O)CH2CO 11-1916 C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3SO2CH2CO 1 1-1917C—F C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CH2NHCO 1 1-1918 C—F C—HC—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1919 C—F C—H C—CF3 C—H HCF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1920 C—F C—H C—CF3 C—H H CF3 CH CHC—CF3 CH H H H nPrCO 1 1-1921 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H HH cyclo-PrCO 1 1-1922 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2CO 1 1-1923 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1924 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SCH2CO1 1-1925 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 11-1926 C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1927C—F C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1928 C—CF3C—H C—Cl N H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1929 C—CF3 C—H C—Cl N HCF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1930 C—CF3 C—H C—Cl N H CF3 CH CHC—CF3 CH H H H nPrCO 1 1-1931 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H HH cyclo-PrCO 1 1-1932 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2CO 1 1-1933 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1934 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H H CH3SCH2CO1 1-1935 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 11-1936 C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1937C—CF3 C—H C—Cl N H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1938 C—CF3C—H C—Br N H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1939 C—CF3 C—H C—Br N HCF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1940 C—CF3 C—H C—Br N H CF3 CH CHC—CF3 CH H H H nPrCO 1 1-1941 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H HH cyclo-PrCO 1 1-1942 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2CO 1 1-1943 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1944 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H H CH3SCH2CO1 1-1945 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 11-1946 C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1947C—CF3 C—H C—Br N H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1948 C—CF3C—H C—CH3 N H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1949 C—CF3 C—H C—CH3 NH CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1950 C—CF3 C—H C—CH3 N H CF3 CHCH C—CF3 CH H H H nPrCO 1 1-1951 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CHH H H cyclo-PrCO 1 1-1952 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H Hcyclo-PrCH2CO 1 1-1953 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1954 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H H CH3SCH2CO1 1-1955 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H H CH3S(O)CH2CO 11-1956 C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H H CH3SO2CH2CO 1 1-1957C—CF3 C—H C—CH3 N H CF3 CH CH C—CF3 CH H H H CH3CH2NHCO 1 1-1958 C—CF3C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H H CH3CO 1 1-1959 C—CF3 C—H C—OCH3N H CF3 CH CH C—CF3 CH H H H CH3CH2CO 1 1-1960 C—CF3 C—H C—OCH3 N H CF3CH CH C—CF3 CH H H H nPrCO 1 1-1961 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3CH H H H cyclo-PrCO 1 1-1962 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H HH cyclo-PrCH2CO 1 1-1963 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H HCF3CH2CO 1 1-1964 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H HCH3SCH2CO 1 1-1965 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H HCH3S(O)CH2CO 1 1-1966 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H HCH3SO2CH2CO 1 1-1967 C—CF3 C—H C—OCH3 N H CF3 CH CH C—CF3 CH H H HCH3CH2NHCO 1 1-1968 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl CH H H H CH3CO 11-1969 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl CH H H H CH3CH2CO 1 1-1970C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl CH H H H cyclo-PrCO 1 1-1971 C—ClC—H C—Cl C—H H CF3 C—F CH C—Cl CH H H H CF3CH2CO 1 1-1972 C—Cl C—Cl C—ClC—H H CF3 C—F CH C—Cl CH H H H CH3CO 1 1-1973 C—Cl C—Cl C—Cl C—H H CF3C—F CH C—Cl CH H H H CH3CH2CO 1 1-1974 C—Cl C—Cl C—Cl C—H H CF3 C—F CHC—Cl CH H H H cyclo-PrCO 1 1-1975 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—ClCH H H H CF3CH2CO 1 1-1976 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl CH H HH CH3CO 1 1-1977 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl CH H H H CH3CH2CO1 1-1978 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl CH H H H cyclo-PrCO 11-1979 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl CH H H H CF3CH2CO 1 1-1980C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl C—F H H H CH3CO 1 1-1981 C—Cl C—HC—Cl C—H H CF3 CH CH C—Cl C—F H H H CH3CH2CO 1 1-1982 C—Cl C—H C—Cl C—HH CF3 CH CH C—Cl C—F H H H cyclo-PrCO 1 1-1983 C—Cl C—H C—Cl C—H H CF3CH CH C—Cl C—F H H H CF3CH2CO 1 1-1984 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Cl C—F H H H CH3CO 1 1-1985 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F HH H CH3CH2CO 1 1-1986 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F H H Hcyclo-PrCO 1 1-1987 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F H H HCF3CH2CO 1 1-1988 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl C—F H H H CH3CO 11-1989 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl C—F H H H CH3CH2CO 1 1-1990C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl C—F H H H cyclo-PrCO 1 1-1991 C—CF3C—H C—CF3 C—H H CF3 CH CH C—Cl C—F H H H CF3CH2CO 1 1-1992 C—Cl C—H C—ClC—H H CF3 CH CH C—SCH3 CH H H H CH3SCH2CO 1 1-1993 C—Cl C—H C—Cl C—H HCF3 CH CH C—SCH3 CH H H H CH3S(O)CH2CO 1 1-1994 C—Cl C—H C—Cl C—H H CF3CH CH C—SCH3 CH H H H CH3SO2CH2CO 1 1-1995 C—Cl C—H C—Cl C—H H CF3 CH CHC—CF3 CH H H H

1 1 -1996 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH H H H

1 1-1997 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 CH H H H

1 1-1998 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3CO 1 1-999C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H

1 1-2000 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CH H H H CH3OCH2CH2CO 11-2001 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N H H H CH3OCH2CH2CO 1 1-2002C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH H H H CH3OCH2CH2CO 1 1-2003 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CF3 N H H H CH3SO2 1 1-2004 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CF3 N H H H CH3SO2 1 1-2005 C—CF3 C—H C—CF3 C—H H CF3CH CH C—CF3 N H H H 2-py—CO 1 1-2006 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—ICH H H H H 1 1-2007 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—I CH H H H CH3CO 11-2008 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—I CH H H H CH3CH2CO 1 1-2009C—CF3 C—H C—CF3 C—H H CF3 CH CH C—I CH H H H cyclo-PrCO 1 1-2010 C—CF3C—H C—CF3 C—H H CF3 CH CH C—I CH H H H CF3CH2CO 1 1-2011 C—CF3 C—H C—CF3C—H H CF3 CH CH C—I CH H H H CH3SCH2CO 1 1-2012 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—I CH H H H CH3S(O)CH2CO 1 1-2013 C—CF3 C—H C—CF3 C—H H CF3CH CH C—I CH H H H CH3SO2CH2CO 1 1-2014 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—F C—F H H H H 1 1-2015 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F C—F H H HCH3CO 1 1-2016 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F C—F H H H CH3CH2CO 11-2017 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F C—F H H H cyclo-PrCO 1 1-2018C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F C—F H H H CF3CH2CO 1 1-2019 C—CF3C—H C—CF3 C—H H CF3 CH CH C—F C—F H H H CH3SCH2CO 1 1-2020 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—F C—F H H H CH3S(O)CH2CO 1 1-2021 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—F C—F H H H CH3SO2CH2CO 1 1-2022 C—CF3 C—H C—CF3C—H H CF3 CH CH C—F C—F H H H tert-BuOCO 1 1-2023 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—Cl C—F H H H CH3SCH2CO 1 1-2024 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—Cl C—F H H H CH3S(O)CH2CO 1 1-2025 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—Cl C—F H H H CH3SO2CH2CO 1 1-2026 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—ClC—F H H H CH3SCH2CO 1 1-2027 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F H HH CH3S(O)CH2CO 1 1-2028 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F H H HCH3SO2CH2CO 1 1-2029 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 C—F H H H H 11-2030 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 C—F H H H CH3CO 1 1-2031C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 C—F H H H CH3CH2CO 1 1-2632 C—CF3C—H C—CF3 C—H H CF3 CH CH C—CH3 C—F H H H cyclo-PrCO 1 1-2033 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—CH3 C—F H H H CF3CH2CO 1 1-2034 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CH3 C—F H H H CH3SCH2CO 1 1-2035 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—CH3 C—F H H H CH3S(O)CH2CO 1 1-2036 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—CH3 C—F H H H CH3SO2CH2CO 1 1-2037 C—Cl C—Cl C—Cl C—H H CF3CH CH C—CH3 C—F H H H H 1 1-2038 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3C—F H H H CH3CO 1 1-2039 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H HCH3CH2CO 1 1-2040 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H Hcyclo-PrCO 1 1-2041 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H HCF3CH2CO 1 1-2042 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H HCH3SCH2CO 1 1-2043 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H HCH3S(O)CH2CO 1 1-2044 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F H H HCH3SO2CH2CO 1 1-2045 C—Cl C—H C—Cl C—H H CF3 CH CH CH CH H H CH3CH3CH2CO 1 1-2046 C—Cl C—Cl C—Cl C—H H CF3 CH CH CH CH H H H CH3CH2CO 11-2047 C—CF3 C—H C—CF3 C—H H CF3 CH CH CH CH H H H CH3CH2CO 1 1-2048C—Cl C—H C—Cl C—H H CF3 CH CH CH CH H H H CH3CH2CO 1 1-2049 C—Cl C—ClC—Cl C—H H CF3 CH CH CH CH H H H CH3CH2CO 1 1-2050 C—CF3 C—H C—CF3 C—H HCF3 CH CH CH CH H H H CH3CH2CO 1 1-2051 C—Cl C—H C—Cl C—H H CF3 CH CHC—OCH3 CH H H H CH3CH2CO 1 1-2052 C—Cl C—H C—Cl C—H H CF3 CH CH C—OCH3CH H H H CH3SCH2CO 1 1-2053 C—Cl C—H C—Cl C—H H CF3 CH CH C—OCH3 CH H HH CH3S(O)CH2CO 1 1-2054 C—Cl C—H C—Cl C—H H CF3 CH CH C—OCH3 CH H H HCH3SO2CH2CO 1 1-2055 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3OCH2CH2CO 1 1-2056 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH H H HCH3OCH2CH2CO 1 1-2057 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3OCH2CH2CO 1 1-2058 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl CH H H HCH3OCH2CH2CO 1 1-2059 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N H H HCH3OCH2CH2CO 1 1-2060 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H HCH3OCH2CH2CO 1 1-2061 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3OCH2CH2CO 1 1-2062 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H HCH3OCH2CH2CO 1 1-2063 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br CH H H HCH3OCH2CH2CO 1 1-2064 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br CH H H HCH3OCH2CH2CO 1 1-2065 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H HCH3OCH2CH2CO 1 1-2066 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br N H H HCH3OCH2CH2CO 1 1-2067 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H HCH3OCH2CH2CO 1 1-2068 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3CH2CO 1 1-2069 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H Hcyclo-PrCO 1 1-2070 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H Hcyclo-PrCH2CO 1 1-2071 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3SCH2CO 1 1-2072 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3S(O)CH2CO 1 1-2073 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N H H HCH3SO2CH2CO 1 1-2074 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N H H HCH3CH2CO 1 1-2075 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCO1 1-2076 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N H H H cyclo-PrCH2CO 11-2077 C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N H H H CH3SCH2CO 1 1-2078C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N H H H CH3S(O)CH2CO 1 1-2079 C—BrC—H C—Br C—H H CF3 CH CH C—CF3 N H H H CH3SO2CH2CO 1 1-2080 C—Br C—HC—Br C—H H CF3 CH CH C—CF3 N H H H CH3OCH2CH2CO 1 1-2081 C—Cl C—H C—ClC—H H CF3 CH CH CH N H H H H 1 1-2082 C—Cl C—H C—Cl C—H H CF3 CH CH CH NH H H cyclo-PrCO 1 1-2083 C—Cl C—H C—Cl C—H H CF3 CH CH CH N H H Hcyclo-PrCH2CO 1 1-2084 C—Cl C—H C—Cl C—H H CF3 CH CH CH N H H H CF3CH2CO1 1-2085 C—Cl C—H C—Cl C—H H CF3 CH CH CH N H H H CH3SCH2CO 1 1-2086C—Cl C—H C—Cl C—H H CF3 CH CH CH N H H H CH3S(O)CH2CO 1 1-2087 C—Cl C—HC—Cl C—H H CF3 CH CH CH N H H H CH3SO2CH2CO 1 1-2088 C—Cl C—H C—Cl C—H HCF3 CH CH CH N H H H CH3OCH2CH2CO 1 1-2089 C—Cl C—H C—Cl C—H H CF3 C—FCH CH N H H H H 1 1-2090 C—Cl C—H C—Cl C—H H CF3 C—F CH CH N H H H CH3CO1 1-2091 C—Cl C—H C—Cl C—H H CF3 C—F CH CH N H H H CH3CH2CO 1 1-2092C—Cl C—H C—Cl C—H H CF3 C—F CH CH N H H H cyclo-PrCO 1 1-2093 C—Cl C—HC—Cl C—H H CF3 C—F CH CH N H H H CF3CH2CO 1 1-2094 C—Cl C—H C—Cl C—H HCF3 C—F CH CH N H H H CH3SCH2CO 1 1-2095 C—Cl C—H C—Cl C—H H CF3 C—F CHCH N H H H CH3S(O)CH2CO 1 1-2096 C—Cl C—H C—Cl C—H H CF3 C—F CH CH N H HH CH3SO2CH2CO 1 1-2097 C—Cl C—H C—Cl C—H H CF3 C—F CH CH N H H HCH3OCH2CH2CO 1 1-2098 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H H H H 11-2099 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H H H CH3CO 1 1-2100 C—ClC—Cl C—Cl C—H H CF3 C—F CH CH N H H H CH3CH2CO 1 1-2101 C—Cl C—Cl C—ClC—H H CF3 C—F CH CH N H H H cyclo-PrCO 1 1-2102 C—Cl C—Cl C—Cl C—H H CF3C—F CH CH N H H H CF3CH2CO 1 1-2103 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH NH H H CH3SCH2CO 1 1-2104 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H H HCH3S(O)CH2CO 1 1-2105 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H H HCH3SO2CH2CO 1 1-2106 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H H HCH3OCH2CH2CO 1 1-2107 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H H H H 11-2108 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H H H CH3CO 1 1-2109 C—CF3C—H C—CF3 C—H H CF3 C—F CH CH N H H H CH3CH2CO 1 1-2110 C—CF3 C—H C—CF3C—H H CF3 C—F CH CH N H H H cyclo-PrCO 1 1-2111 C—CF3 C—H C—CF3 C—H HCF3 C—F CH CH N H H H CF3CH2CO 1 1-2112 C—CF3 C—H C—CF3 C—H H CF3 C—F CHCH N H H H CH3SCH2CO 1 1-2113 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H HH CH3S(O)CH2CO 1 1-2114 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H H HCH3SO2CH2CO 1 1-2115 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H H HCH3OCH2CH2CO 1 1-2116 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl N H H H H 11-2117 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl N H H H CH3CO 1 1-2118 C—ClC—H C—Cl C—H H CF3 C—F CH C—Cl N H H H CH3CH2CO 1 1-2119 C—Cl C—H C—ClC—H H CF3 C—F CH C—Cl N H H H cyclo-PrCO 1 1-2120 C—Cl C—H C—Cl C—H HCF3 C—F CH C—Cl N H H H CF3CH2CO 1 1-2121 C—Cl C—H C—Cl C—H H CF3 C—F CHC—Cl N H H H CH3SCH2CO 1 1-2122 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl N HH H CH3S(O)CH2CO 1 1-2123 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl N H H HCH3SO2CH2CO 1 1-2124 C—Cl C—H C—Cl C—H H CF3 C—F CH C—Cl N H H HCH3OCH2CH2CO 1 1-2125 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—Cl N H H H H 11-2126 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—Cl N H H H CH3CO 1 1-2127 C—ClC—Cl C—Cl C—H H CF3 C—F CH C—Cl N H H H CH3CH2CO 1 1-2128 C—Cl C—Cl C—ClC—H H CF3 C—F CH C—Cl N H H H cyclo-P rCO 1 1-2129 C—Cl C—Cl C—Cl C—H HCF3 C—F CH C—Cl N H H H CF3CH2CO 1 1-2130 C—Cl C—Cl C—Cl C—H H CF3 C—FCH C—Cl N H H H CH3SCH2CO 1 1-2131 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—ClN H H H CH3S(O)CH2CO 1 1-2132 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—Cl N H HH CH3SO2CH2CO 1 1-2133 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—Cl N H H HCH3OCH2CH2CO 1 1-2134 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl N H H H H 11-2135 C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl N H H H CH3CO 1 1-2136C—CF3 C—H C—CF3 C—H H CF3 C—F CH C—Cl N H H H CH3CH2CO 1 1-2137 C—CF3C—H C—CF3 C—H H CF3 C—F CH C—Cl N H H H cyclo-PrCO 1 1-2138 C—CF3 C—HC—CF3 C—H H CF3 C—F CH C—Cl N H H H CF3CH2CO 1 1-2139 C—CF3 C—H C—CF3C—H H CF3 C—F CH C—Cl N H H H CH3SCH2CO 1 1-2140 C—CF3 C—H C—CF3 C—H HCF3 C—F CH C—Cl N H H H CH3S(O)CH2CO 1 1-2141 C—CF3 C—H C—CF3 C—H H CF3C—F CH C—Cl N H H H CH3SO2CH2CO 1 1-2142 C—CF3 C—H C—CF3 C—H H CF3 C—FCH C—Cl N H H H CH3OCH2CH2CO 1 1-2143 C—Cl C—H C—Cl C—H H CF3 CH CH C—ClN H H H H 1 1-2144 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N H H H H 11-2145 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N H H H H 1 1-2146 C—Cl C—HC—Cl C—H H CF3 CH CH C—SCH3 CH H H H H 1 1-2147 C—Cl C—H C—Cl C—H H CF3CH CH C—Br N H H H H 1 1-2148 C—Cl C—H C—CF3 C—H H CF3 CH CH C—Br N H HH H 1 1-2149 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N H H H H 1 1-2150C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br N H H H H 1 1-2151 C—Cl C—H C—ClC—H H CF3 C—F CH C—Cl N H H H tert-BuOCO 1 1-2152 C—Cl C—Cl C—Cl C—H HCF3 C—F CH C—Cl N H H H tert-BuOCO 1 1-2153 C—CF3 C—H C—CF3 C—H H CF3C—F CH C—Cl N H H H tert-BuOCO 1 1-2154 C—Cl C—H C—Cl C—H H CF3 C—F CHCH N H H H tert-BuOCO 1 1-2155 C—Cl C—Cl C—Cl C—H H CF3 C—F CH CH N H HH tert-BuOCO 1 1-2156 C—CF3 C—H C—CF3 C—H H CF3 C—F CH CH N H H Htert-BuOCO 1 1-2157 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—OCF3 CH H H H H 11-2158 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—OCF3 CH H H H CH3CO 1 1-2159C—CF3 C—H C—CF3 C—H H CF3 CH CH C—OCF3 CH H H H CH3CH2CO 1 1-2160 C—CF3C—H C—CF3 C—H H CF3 CH CH C—OCF3 CH H H H cyclo-PrCO 1 1-2161 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—OCF3 CH H H H CF3CH2CO 1 1-2162 C—CF3 C—H C—CF3C—H H CF3 CH CH C—OCF3 CH H H H CH3SCH2CO 1 1-2163 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—OCF3 CH H H H CH3S(O)CH2CO 1 1-2164 C—CF3 C—H C—CF3 C—H HCF3 CH CH C—OCF3 CH H H H CH3SO2CH2CO 1 1-2165 C—CF3 C—H C—CF3 C—H H CF3CH CH C—OCF3 CH H H H CH3OCH2CH2CO 1 1-2166 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—OCF3 CH H H H tert-BuOCO 1 1-2167 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl C—F H H H H 1 1-2168 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl C—F H H HH 1 1-2169 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl C—F H H H H 1 1-2170C—Cl C—Cl C—Cl C—H H CF3 CH CH CH N H H H CH3CH2CO 1 1-2171 C—CF3 C—HC—CF3 C—H H CF3 CH CH CH N H H H CH3CH2CO 1

TABLE 2

Table 2-Ex.-No. B¹ B² B³ B⁴ X¹ R A³ R¹ R² 2-1 C—Cl C—H C—Cl C—H H CF3C—CF3 H H 2-2 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3 2-3 C—Cl C—H C—Cl C—HH CF3 C—CF3 H CH3CH2 2-4 C—Cl C—H C—Cl C—H H CF3 C—CF3 H n-Pr 2-5 C—ClC—H C—Cl C—H H CF3 C—CF3 H cyclo-Pr 2-6 C—Cl C—H C—Cl C—H H CF3 C—CF3 Hn-Bu 2-7 C—Cl C—H C—Cl C—H H CF3 C—CF3 H tert-Bu 2-8 C—Cl C—H C—Cl C—H HCF3 C—CF3 H CF3CH2 2-9 C—Cl C—H C—Cl C—H H CF3 C—CF3 H 2-PyridylCH2 2-10C—Cl C—H C—Cl C—H H CF3 C—CF3 H Ph 2-11 C—Cl C—H C—Cl C—H H CF3 C—CF3 HPhCH2 2-12 C—Cl C—H C—Cl C—H H CF3 C—CF3 H MeO2CCH2 2-13 C—Cl C—H C—ClC—H H CF3 C—CF3 H cyclo-PrCH2 2-14 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H2-15 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3 2-16 C—Cl C—Cl C—Cl C—H H CF3C—CF3 H CH3CH2 2-17 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H n-Pr 2-18 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H cyclo-Pr 2-19 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 Hn-Bu 2-20 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H tert-Bu 2-21 C—Cl C—Cl C—ClC—H H CF3 C—CF3 H CF3CH2 2-22 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H2-PyridylCH2 2-23 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H Ph 2-24 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H PhCH2 2-25 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HMeO2CCH2 2-26 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H cyclo-PrCH2 2-27 C—CF3C—H C—CF3 C—H H CF3 C—CF3 H H 2-28 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH32-29 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3CH2 2-30 C—CF3 C—H C—CF3 C—H HCF3 C—CF3 H n-Pr 2-31 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H cyclo-Pr 2-32C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H n-Bu 2-33 C—CF3 C—H C—CF3 C—H H CF3C—CF3 H tert-Bu 2-34 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CF3CH2 2-35 C—CF3C—H C—CF3 C—H H CF3 C—CF3 H 2-PyridylCH2 2-36 C—CF3 C—H C—CF3 C—H H CF3C—CF3 H Ph 2-37 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H PhCH2 2-38 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H MeO2CCH2 2-39 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Hcyclo-PrCH2 2-40 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H H 2-41 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H CH3 2-42 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3CH2 2-43 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H n-Pr 2-44 C—Cl C—Cl C—CF3C—H H CF3 C—CF3 H cyclo-Pr 2-45 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H n-Bu2-46 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H tert-Bu 2-47 C—Cl C—Cl C—CF3 C—HH CF3 C—CF3 H CF3CH2 2-48 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H 2-PyridylCH22-49 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H Ph 2-50 C—Cl C—Cl C—CF3 C—H H CF3C—CF3 H PhCH2 2-51 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H MeO2CCH2 2-52 C—ClC—Cl C—CF3 C—H H CF3 C—CF3 H cyclo-PrCH2 2-53 C—Cl C—H C—Cl C—H H CF3C—H H CH3 2-54 C—Cl C—H C—Cl C—H H CF3 C—H H CF3CH2 2-55 C—Cl C—H C—ClC—H H CF3 C—H H 2-PyridylCH2 2-56 C—Cl C—H C—Cl C—H H CF3 C—H H PhCH22-57 C—Cl C—H C—Cl C—H H CF3 C—H H MeO2CCH2 2-58 C—Cl C—Cl C—Cl C—H HCF3 C—H H CH3 2-59 C—Cl C—Cl C—Cl C—H H CF3 C—H H CF3CH2 2-60 C—Cl C—ClC—Cl C—H H CF3 C—H H 2-PyridylCH2 2-61 C—Cl C—Cl C—Cl C—H H CF3 C—H HPhCH2 2-62 C—Cl C—Cl C—Cl C—H H CF3 C—H H MeO2CCH2 2-63 C—CF3 C—Cl C—CF3C—H H CF3 C—H H CH3 2-64 C—CF3 C—Cl C—CF3 C—H H CF3 C—H H CF3CH2 2-65C—CF3 C—Cl C—CF3 C—H H CF3 C—H H 2-PyridylCH2 2-66 C—CF3 C—Cl C—CF3 C—HH CF3 C—H H PhCH2 2-67 C—CF3 C—Cl C—CF3 C—H H CF3 C—H H MeO2CCH2 2-68C—Cl C—H C—Cl C—H H CF3 C—CH3 H CH3 2-69 C—Cl C—H C—Cl C—H H CF3 C—CH3 HCF3CH2 2-70 C—Cl C—H C—Cl C—H H CF3 C—CH3 H 2-PyridylCH2 2-71 C—Cl C—HC—Cl C—H H CF3 C—CH3 H PhCH2 2-72 C—Cl C—H C—Cl C—H H CF3 C—CH3 HMeO2CCH2 2-73 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H CH3 2-74 C—Cl C—Cl C—ClC—H H CF3 C—CH3 H CF3CH2 2-75 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H2-PyridylCH2 2-76 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H PhCH2 2-77 C—Cl C—ClC—Cl C—H H CF3 C—CH3 H MeO2CCH2 2-78 C—CF3 C—Cl C—CF3 C—H H CF3 C—CH3 HCH3 2-79 C—CF3 C—Cl C—CF3 C—H H CF3 C—CH3 H CF3CH2 2-80 C—CF3 C—Cl C—CF3C—H H CF3 C—CH3 H 2-PyridylCH2 2-81 C—CF3 C—Cl C—CF3 C—H H CF3 C—CH3 HPhCH2 2-82 C—CF3 C—Cl C—CF3 C—H H CF3 C—CH3 H MeO2CCH2 2-83 C—Cl C—HC—Cl C—H H CF3 C—Cl H CH3 2-84 C—Cl C—H C—Cl C—H H CF3 C—Cl H CF3CH22-85 C—Cl C—H C—Cl C—H H CF3 C—Cl H 2-PyridylCH2 2-86 C—Cl C—H C—Cl C—HH CF3 C—Cl H PhCH2 2-87 C—Cl C—H C—Cl C—H H CF3 C—Cl H MeO2CCH2 2-88C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3 2-89 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCF3CH2 2-90 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H 2-PyridylCH2 2-91 C—Cl C—ClC—Cl C—H H CF3 C—Cl H PhCH2 2-92 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HMeO2CCH2 2-93 C—CF3 C—Cl C—CF3 C—H H CF3 C—Cl H CH3 2-94 C—CF3 C—ClC—CF3 C—H H CF3 C—Cl H CF3CH2 2-95 C—CF3 C—Cl C—CF3 C—H H CF3 C—Cl H2-PyridylCH2 2-96 C—CF3 C—Cl C—CF3 C—H H CF3 C—Cl H PhCH2 2-97 C—CF3C—Cl C—CF3 C—H H CF3 C—Cl H MeOCCH2 2-98 C—CF3 C—H C—CF3 C—H H CF3 C—H HCF3CH2 2-99 C—CF3 C—H C—CF3 C—H H CF3 C—H H 2-PyridylCH2 2-100 C—CF3 C—HC—CF3 C—H H CF3 C—CH3 H CF3CH2 2-101 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H2-PyridylCH2 2-102 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3OCH2 2-103 C—Cl C—HC—Cl C—H H CF3 C—Cl CH3CO CH3OCH2 2-104 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3CH2OCH2 2-105 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3OCH2CH2 2-106 C—ClC—H C—Cl C—H H CF3 C—Cl H CH3CH2OCH2CH2 2-107 C—Cl C—H C—Cl C—H H CF3C—Cl H tetrahydrofuran-2-yl 2-108 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3SCH2CH2 2-109 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3S(O)CH2CH2 2-110 C—ClC—H C—Cl C—H H CF3 C—Cl H CH3SO2CH2CH2 2-111 C—Cl C—H C—Cl C—H H CF3C—Cl H CH3SCH2CH(CH3) 2-112 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3S(O)CH2CH(CH3) 2-113 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3SO2CH2CH(CH3)2-114 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3SCH2C(CH3)2 2-115 C—Cl C—H C—ClC—H H CF3 C—Cl H CH3S(O)CH2C(CH3)2 2-116 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3SO2CH2C(CH3)2 2-117 C—Cl C—H C—Cl C—H H CF3 C—Cl H(Methoxyimino)methyl 2-118 C—Cl C—H C—Cl C—H H CF3 C—Cl H(Ethoxyimino)methyl 2-119 C—Cl C—H C—Cl C—H H CF3 C—Cl H[1-(1,3-thiazol-4-yl)]CH2 2-120 C—Cl C—H C—Cl C—H H CF3 C—Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-121 C—Cl C—H C—Cl C—H H CF3 C—Cl H5-chloropyrimidin-2-yl 2-122 C—Cl C—H C—Cl C—H H CF3 C—Cl H5-bromopyrimidin-2-yl 2-123 C—Cl C—H C—Cl C—H H CF3 C—Cl H5-cyanopyrimidin-2-yl 2-124 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3NHC(O)CH22-125 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3CH2NHC(O)CH2 2-126 C—Cl C—H C—ClC—H H CF3 C—Cl H iso-PrNHC(O)CH2 2-127 C—Cl C—H C—Cl C—H H CF3 C—Cl Hcyclo-PrNHC(O)CH2 2-128 C—Cl C—H C—Cl C—H H CF3 C—Cl H CF3CH2NHC(O)CH22-129 C—Cl C—H C—Cl C—H H CF3 C—Cl H CH3NHC(O)CH(CH3) 2-130 C—Cl C—HC—Cl C—H H CF3 C—Cl H CH3CH2NHC(O)CH(CH3) 2-131 C—Cl C—H C—Cl C—H H CF3C—Cl H iso-PrNHC(O)CH(CH3) 2-132 C—Cl C—H C—Cl C—H H CF3 C—Cl Hcyclo-PrNHC(O)CH(CH3) 2-133 C—Cl C—H C—Cl C—H H CF3 C—Cl HCF3CH2NHC(O)CH(CH3) 2-134 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3NHC(O)C(CH3)2 2-135 C—Cl C—H C—Cl C—H H CF3 C—Cl HCH3CH2NHC(O)C(CH3)2 2-136 C—Cl C—H C—Cl C—H H CF3 C—Cl Hiso-PrNHC(O)C(CH3)2 2-137 C—Cl C—H C—Cl C—H H CF3 C—Cl Hcyclo-PrNHC(O)C(CH3)2 2-138 C—Cl C—H C—Cl C—H H CF3 C—Cl HCF3CH2NHC(O)C(CH3)2 2-139 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3OCH2 2-140C—Cl C—Cl C—Cl C—H H CF3 C—Cl CH3CO CH3OCH2 2-141 C—Cl C—Cl C—Cl C—H HCF3 C—Cl H CH3CH2OCH2 2-142 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3OCH2CH22-143 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3CH2OCH2CH2 2-144 C—Cl C—Cl C—ClC—H H CF3 C—Cl H tetrahydrofuran-2-yl 2-145 C—Cl C—Cl C—Cl C—H H CF3C—Cl H CH3SCH2CH2 2-146 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3S(O)CH2CH22-147 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3SO2CH2CH2 2-148 C—Cl C—Cl C—ClC—H H CF3 C—Cl H CH3SCH2CH(CH3) 2-149 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCH3S(O)CH2CH(CH3) 2-150 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3SO2CH2CH(CH3)2-151 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3SCH2C(CH3)2 2-152 C—Cl C—ClC—Cl C—H H CF3 C—Cl H CH3S(O)CH2C(CH3)2 2-153 C—Cl C—Cl C—Cl C—H H CF3C—Cl H CH3SO2CH2C(CH3)2 2-154 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H(Methoxyimino)methyl 2-155 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H(Ethoxyimino)methyl 2-156 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H[1-(1,3-thiazol-4-yl)]CH2 2-157 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-158 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H5-chloropyrimidin-2-yl 2-159 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H5-bromopyrimidin-2-yl 2-160 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H5-cyanopyrimidin-2-yl 2-161 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3NHC(O)CH22-162 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3CH2NHC(O)CH2 2-163 C—Cl C—ClC—Cl C—H H CF3 C—Cl H iso-PrNHC(O)CH2 2-164 C—Cl C—Cl C—Cl C—H H CF3C—Cl H cyclo-PrNHC(O)CH2 2-165 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCF3CH2NHC(O)CH2 2-166 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3NHC(O)CH(CH3)2-167 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H CH3CH2NHC(O)CH(CH3) 2-168 C—ClC—Cl C—Cl C—H H CF3 C—Cl H iso-PrNHC(O)CH(CH3) 2-169 C—Cl C—Cl C—Cl C—HH CF3 C—Cl H cyclo-PrNHC(O)CH(CH3) 2-170 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCF3CH2NHC(O)CH(CH3) 2-171 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCH3NHC(O)C(CH3)2 2-172 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCH3CH2NHC(O)C(CH3)2 2-173 C—Cl C—Cl C—Cl C—H H CF3 C—Cl Hiso-PrNHC(O)C(CH3)2 2-174 C—Cl C—Cl C—Cl C—H H CF3 C—Cl Hcyclo-PrNHC(O)C(CH3)2 2-175 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HCF3CH2NHC(O)C(CH3)2 2-176 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CF3CH2 2-177C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3OCH2 2-178 C—Cl C—H C—CF3 C—H H CF3C—Cl CH3CO CH3OCH2 2-179 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3CH2OCH22-180 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3OCH2CH2 2-181 C—Cl C—H C—CF3C—H H CF3 C—Cl H CH3CH2OCH2CH2 2-182 C—Cl C—H C—CF3 C—H H CF3 C—Cl Htetrahydrofuran-2-yl 2-183 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3SCH2CH22-184 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3S(O)CH2CH2 2-185 C—Cl C—H C—CF3C—H H CF3 C—Cl H CH3SO2CH2CH2 2-186 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCH3SCH2CH(CH3) 2-187 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3S(O)CH2CH(CH3)2-188 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3SO2CH2CH(CH3) 2-189 C—Cl C—HC—CF3 C—H H CF3 C—Cl H CH3SCH2C(CH3)2 2-190 C—Cl C—H C—CF3 C—H H CF3C—Cl H CH3S(O)CH2C(CH3)2 2-191 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCH3SO2CH2C(CH3)2 2-192 C—Cl C—H C—CF3 C—H H CF3 C—Cl H(Methoxyimino)methyl 2-193 C—Cl C—H C—CF3 C—H H CF3 C—Cl H(Ethoxyimino)methyl 2-194 C—Cl C—H C—CF3 C—H H CF3 C—Cl H 2-PyridylCH22-195 C—Cl C—H C—CF3 C—H H CF3 C—Cl H [1-(1,3-thiazol-4-yl)]CH2 2-196C—Cl C—H C—CF3 C—H H CF3 C—Cl H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-197C—Cl C—H C—CF3 C—H H CF3 C—Cl H 5-chloropyrimidin-2-yl 2-198 C—Cl C—HC—CF3 C—H H CF3 C—Cl H 5-bromopyrimidin-2-yl 2-199 C—Cl C—H C—CF3 C—H HCF3 C—Cl H 5-cyanopyrimidin-2-yl 2-200 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCH3NHC(O)CH2 2-201 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3CH2NHC(O)CH2 2-202C—Cl C—H C—CF3 C—H H CF3 C—Cl H iso-PrNHC(O)CH2 2-203 C—Cl C—H C—CF3 C—HH CF3 C—Cl H cyclo-PrNHC(O)CH2 2-204 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCF3CH2NHC(O)CH2 2-205 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3NHC(O)CH(CH3)2-206 C—Cl C—H C—CF3 C—H H CF3 C—Cl H CH3CH2NHC(O)CH(CH3) 2-207 C—Cl C—HC—CF3 C—H H CF3 C—Cl H iso-PrNHC(O)CH(CH3) 2-208 C—Cl C—H C—CF3 C—H HCF3 C—Cl H cyclo-PrNHC(O)CH(CH3) 2-209 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCF3CH2NHC(O)CH(CH3) 2-210 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCH3NHC(O)C(CH3)2 2-211 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCH3CH2NHC(O)C(CH3)2 2-212 C—Cl C—H C—CF3 C—H H CF3 C—Cl Hiso-PrNHC(O)C(CH3)2 2-213 C—Cl C—H C—CF3 C—H H CF3 C—Cl Hcyclo-PrNHC(O)C(CH3)2 2-214 C—Cl C—H C—CF3 C—H H CF3 C—Cl HCF3CH2NHC(O)C(CH3)2 2-215 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CF3CH2 2-216C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3OCH2 2-217 C—CF3 C—H C—CF3 C—H H CF3C—Cl CH3CO CH3OCH2 2-218 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3CH2OCH22-219 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3OCH2CH2 2-220 C—CF3 C—H C—CF3C—H H CF3 C—Cl H CH3CH2OCH2CH2 2-221 C—CF3 C—H C—CF3 C—H H CF3 C—Cl Htetrahydrofuran-2-yl 2-222 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3SCH2CH22-223 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3S(O)CH2CH2 2-224 C—CF3 C—HC—CF3 C—H H CF3 C—Cl H CH3SO2CH2CH2 2-225 C—CF3 C—H C—CF3 C—H H CF3 C—ClH CH3SCH2CH(CH3) 2-226 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3S(O)CH2CH(CH3) 2-227 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3SO2CH2CH(CH3) 2-228 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3SCH2C(CH3)22-229 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3S(O)CH2C(CH3)2 2-230 C—CF3 C—HC—CF3 C—H H CF3 C—Cl H CH3SO2CH2C(CH3)2 2-231 C—CF3 C—H C—CF3 C—H H CF3C—Cl H (Methoxyimino)methyl 2-232 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H(Ethoxyimino)methyl 2-233 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H 2-PyridylCH22-234 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H [1-(1,3-thiazol-4-yl)]CH2 2-235C—CF3 C—H C—CF3 C—H H CF3 C—Cl H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-236C—CF3 C—H C—CF3 C—H H CF3 C—Cl H 5-chloropyrimidin-2-yl 2-237 C—CF3 C—HC—CF3 C—H H CF3 C—Cl H 5-bromopyrimidin-2-yl 2-238 C—CF3 C—H C—CF3 C—H HCF3 C—Cl H 5-cyanopyrimidin-2-yl 2-239 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3NHC(O)CH2 2-240 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H CH3CH2NHC(O)CH22-241 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H iso-PrNHC(O)CH2 2-242 C—CF3 C—HC—CF3 C—H H CF3 C—Cl H cyclo-PrNHC(O)CH2 2-243 C—CF3 C—H C—CF3 C—H H CF3C—Cl H CF3CH2NHC(O)CH2 2-244 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3NHC(O)CH(CH3) 2-245 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3CH2NHC(O)CH(CH3) 2-246 C—CF3 C—H C—CF3 C—H H CF3 C—Cl Hiso-PrNHC(O)CH(CH3) 2-247 C—CF3 C—H C—CF3 C—H H CF3 C—Cl Hcyclo-PrNHC(O)CH(CH3) 2-248 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCF3CH2NHC(O)CH(CH3) 2-249 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3NHC(O)C(CH3)2 2-250 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCH3CH2NHC(O)C(CH3)2 2-251 C—CF3 C—H C—CF3 C—H H CF3 C—Cl Hiso-PrNHC(O)C(CH3)2 2-252 C—CF3 C—H C—CF3 C—H H CF3 C—Cl Hcyclo-PrNHC(O)C(CH3)2 2-253 C—CF3 C—H C—CF3 C—H H CF3 C—Cl HCF3CH2NHC(O)C(CH3)2 2-254 C—Cl C—H C—Cl C—H H CF3 C—Br H CF3CH2 2-255C—Cl C—H C—Cl C—H H CF3 C—Br H 2-PyridylCH2 2-256 C—Cl C—Cl C—Cl C—H HCF3 C—Br H CF3CH2 2-257 C—Cl C—Cl C—Cl C—H H CF3 C—Br H 2-PyridylCH22-258 C—Cl C—H C—CF3 C—H H CF3 C—Br H CF3CH2 2-259 C—Cl C—H C—CF3 C—H HCF3 C—Br H 2-PyridylCH2 2-260 C—CF3 C—H C—CF3 C—H H CF3 C—Br H CF3CH22-261 C—CF3 C—H C—CF3 C—H H CF3 C—Br H 2-PyridylCH2 2-262 C—Cl C—H C—ClC—H H CF3 C—I H CF3CH2 2-263 C—Cl C—H C—Cl C—H H CF3 C—I H 2-PyridylCH22-264 C—Cl C—Cl C—Cl C—H H CF3 C—I H CF3CH2 2-265 C—Cl C—Cl C—Cl C—H HCF3 C—I H 2-PyridylCH2 2-266 C—Cl C—H C—CF3 C—H H CF3 C—I H CF3CH2 2-267C—Cl C—H C—CF3 C—H H CF3 C—I H 2-PyridylCH2 2-268 C—CF3 C—H C—CF3 C—H HCF3 C—I H CF3CH2 2-269 C—CF3 C—H C—CF3 C—H H CF3 C—I H 2-PyridylCH22-270 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3OCH2 2-271 C—Cl C—H C—Cl C—H HCF3 C—CF3 CH3CO CH3OCH2 2-272 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3CH2OCH22-273 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3OCH2CH2 2-274 C—Cl C—H C—Cl C—HH CF3 C—CF3 H CH3CH2OCH2CH2 2-275 C—Cl C—H C—Cl C—H H CF3 C—CF3 Htetrahydrofuran-2-yl 2-276 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3SCH2CH22-277 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3S(O)CH2CH2 2-278 C—Cl C—H C—ClC—H H CF3 C—CF3 H CH3SO2CH2CH2 2-279 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCH3SCH2CH(CH3) 2-280 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3)2-281 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3SO2CH2CH(CH3) 2-282 C—Cl C—HC—Cl C—H H CF3 C—CF3 H CH3SCH2C(CH3)2 2-283 C—Cl C—H C—Cl C—H H CF3C—CF3 H CH3S(O)CH2C(CH3)2 2-284 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCH3SO2CH2C(CH3)2 2-285 C—Cl C—H C—Cl C—H H CF3 C—CF3 H(Methoxyimino)methyl 2-286 C—Cl C—H C—Cl C—H H CF3 C—CF3 H(Ethoxyimino)methyl 2-287 C—Cl C—H C—Cl C—H H CF3 C—CF3 H[1-(1,3-thiazol-4-yl)]CH2 2-288 C—Cl C—H C—Cl C—H H CF3 C—CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-289 C—Cl C—H C—Cl C—H H CF3 C—CF3 H5-chloropyrimidin-2-yl 2-290 C—Cl C—H C—Cl C—H H CF3 C—CF3 H5-bromopyrimidin-2-yl 2-291 C—Cl C—H C—Cl C—H H CF3 C—CF3 H5-cyanopyrimidin-2-yl 2-292 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3NHC(O)CH22-293 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3CH2NHC(O)CH2 2-294 C—Cl C—HC—Cl C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-295 C—Cl C—H C—Cl C—H H CF3C—CF3 H cyclo-PrNHC(O)CH2 2-296 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)CH2 2-297 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3NHC(O)CH(CH3)2-298 C—Cl C—H C—Cl C—H H CF3 C—CF3 H CH3CH2NHC(O)CH(CH3) 2-299 C—Cl C—HC—Cl C—H H CF3 C—CF3 H iso-PrNHC(O)CH(CH3) 2-300 C—Cl C—H C—Cl C—H H CF3C—CF3 H cyclo-PrNHC(O)CH(CH3) 2-301 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-302 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-303 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-304 C—Cl C—H C—Cl C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-305 C—Cl C—H C—Cl C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-306 C—Cl C—H C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-307 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3OCH2 2-308C—Cl C—Cl C—Cl C—H H CF3 C—CF3 CH3CO CH3OCH2 2-309 C—Cl C—Cl C—Cl C—H HCF3 C—CF3 H CH3CH2OCH2 2-310 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3OCH2CH22-311 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3CH2OCH2CH2 2-312 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H tetrahydrofuran-2-yl 2-313 C—Cl C—Cl C—Cl C—H HCF3 C—CF3 H CH3SCH2CH2 2-314 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3S(O)CH2CH2 2-315 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3SO2CH2CH2 2-316C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3SCH2CH(CH3) 2-317 C—Cl C—Cl C—Cl C—HH CF3 C—CF3 H CH3S(O)CH2CH(CH3) 2-318 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3SO2CH2CH(CH3) 2-319 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3SCH2C(CH3)22-320 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)2 2-321 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-322 C—Cl C—Cl C—Cl C—H H CF3C—CF3 H (Methoxyimino)methyl 2-323 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H(Ethoxyimino)methyl 2-324 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H[1-(1,3-thiazol-4-yl)]CH2 2-325 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-326 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H5-chloropyrimidin-2-yl 2-327 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H5-bromopyrimidin-2-yl 2-328 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H5-cyanopyrimidin-2-yl 2-329 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-330 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H CH3CH2NHC(O)CH22-331 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-332 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-333 C—Cl C—Cl C—Cl C—H H CF3C—CF3 H CF3CH2NHC(O)CH2 2-334 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3NHC(O)CH(CH3) 2-335 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3CH2NHC(O)CH(CH3) 2-336 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 Hiso-PrNHC(O)CH(CH3) 2-337 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH(CH3) 2-338 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-339 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-340 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-341 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-342 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-343 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-344 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CF3CH2 2-345C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3OCH2 2-346 C—Cl C—H C—CF3 C—H H CF3C—CF3 CH3CO CH3OCH2 2-347 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3CH2OCH22-348 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3OCH2CH2 2-349 C—Cl C—H C—CF3C—H H CF3 C—CF3 H CH3CH2OCH2CH2 2-350 C—Cl C—H C—CF3 C—H H CF3 C—CF3 Htetrahydrofuran-2-yl 2-351 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3SCH2CH22-352 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2CH2 2-353 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H CH3SO2CH2CH2 2-354 C—Cl C—H C—CF3 C—H H CF3C—CF3 H CH3SCH2CH(CH3) 2-355 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3S(O)CH2CH(CH3) 2-356 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3SO2CH2CH(CH3) 2-357 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3SCH2C(CH3)22-358 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)2 2-359 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-360 C—Cl C—H C—CF3 C—H H CF3C—CF3 H (Methoxyimino)methyl 2-361 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H(Ethoxyimino)methyl 2-362 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H 2-PyridylCH22-363 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H [1-(1,3-thiazol-4-yl)]CH2 2-364C—Cl C—H C—CF3 C—H H CF3 C—CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-365C—Cl C—H C—CF3 C—H H CF3 C—CF3 H 5-chloropyrimidin-2-yl 2-366 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H 5-bromopyrimidin-2-yl 2-367 C—Cl C—H C—CF3 C—H HCF3 C—CF3 H 5-cyanopyrimidin-2-yl 2-368 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-369 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H CH3CH2NHC(O)CH22-370 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-371 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-372 C—Cl C—H C—CF3 C—H H CF3C—CF3 H CF3CH2NHC(O)CH2 2-373 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH(CH3) 2-374 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)CH(CH3) 2-375 C—Cl C—H C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)CH(CH3) 2-376 C—Cl C—H C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH(CH3) 2-377 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-378 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-379 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-380 C—Cl C—H C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-381 C—Cl C—H C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-382 C—Cl C—H C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-383 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3OCH22-384 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 CH3CO CH3OCH2 2-385 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H CH3CH2OCH2 2-386 C—CF3 C—H C—CF3 C—H H CF3 C—CF3H CH3OCH2CH2 2-387 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3CH2OCH2CH2 2-388C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H tetrahydrofuran-2-yl 2-389 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H CH3SCH2CH2 2-390 C—CF3 C—H C—CF3 C—H H CF3 C—CF3H CH3S(O)CH2CH2 2-391 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3SO2CH2CH22-392 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3SCH2CH(CH3) 2-393 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3) 2-394 C—CF3 C—H C—CF3 C—H HCF3 C—CF3 H CH3SO2CH2CH(CH3) 2-395 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3SCH2C(CH3)2 2-396 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)22-397 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-398 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H (Methoxyimino)methyl 2-399 C—CF3 C—H C—CF3 C—H HCF3 C—CF3 H (Ethoxyimino)methyl 2-400 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H[1-(1,3-thiazol-4-yl)]CH2 2-401 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-402 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H5-chloropyrimidin-2-yl 2-403 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H5-bromopyrimidin-2-yl 2-404 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H5-cyanopyrimidin-2-yl 2-405 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-406 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H CH3CH2NHC(O)CH22-407 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-408 C—CF3 C—HC—CF3 C—H H CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-409 C—CF3 C—H C—CF3 C—H HCF3 C—CF3 H CF3CH2NHC(O)CH2 2-410 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH(CH3) 2-411 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)CH(CH3) 2-412 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)CH(CH3) 2-413 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH(CH3) 2-414 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-415 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-416 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-417 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-418 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-419 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-420 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3OCH22-421 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 CH3CO CH3OCH2 2-422 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H CH3CH2OCH2 2-423 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3H CH3OCH2CH2 2-424 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3CH2OCH2CH2 2-425C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H tetrahydrofuran-2-yl 2-426 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H CH3SCH2CH2 2-427 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3H CH3S(O)CH2CH2 2-428 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3SO2CH2CH22-429 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3SCH2CH(CH3) 2-430 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3) 2-431 C—Cl C—Cl C—CF3 C—H HCF3 C—CF3 H CH3SO2CH2CH(CH3) 2-432 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3SCH2C(CH3)2 2-433 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)22-434 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-435 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H (Methoxyimino)methyl 2-436 C—Cl C—Cl C—CF3 C—H HCF3 C—CF3 H (Ethoxyimino)methyl 2-437 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H[1-(1,3-thiazol-4-yl)]CH2 2-438 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 2-439 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H5-chloropyrimidin-2-yl 2-440 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H5-bromopyrimidin-2-yl 2-441 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H5-cyanopyrimidin-2-yl 2-442 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-443 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H CH3CH2NHC(O)CH22-444 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-445 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-446 C—Cl C—Cl C—CF3 C—H HCF3 C—CF3 H CF3CH2NHC(O)CH2 2-447 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH(CH3) 2-448 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)CH(CH3) 2-449 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)CH(CH3) 2-450 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH(CH3) 2-451 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-452 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-453 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-454 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-455 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-456 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-457 C—Cl N C—Cl C—H H CF3 C—CF3 H CF3CH2 2-458C—Cl N C—Cl C—H H CF3 C—CF3 H CH3OCH2 2-459 C—Cl N C—Cl C—H H CF3 C—CF3CH3CO CH3OCH2 2-460 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3CH2OCH2 2-461 C—ClN C—Cl C—H H CF3 C—CF3 H CH3OCH2CH2 2-462 C—Cl N C—Cl C—H H CF3 C—CF3 HCH3CH2OCH2CH2 2-463 C—Cl N C—Cl C—H H CF3 C—CF3 H tetrahydrofuran-2-yl2-464 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3SCH2CH2 2-465 C—Cl N C—Cl C—H HCF3 C—CF3 H CH3S(O)CH2CH2 2-466 C—Cl N C—Cl C—H H CF3 C—CF3 HCH3SO2CH2CH2 2-467 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3SCH2CH(CH3) 2-468C—Cl N C—Cl C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3) 2-469 C—Cl N C—Cl C—H HCF3 C—CF3 H CH3SO2CH2CH(CH3) 2-470 C—Cl N C—Cl C—H H CF3 C—CF3 HCH3SCH2C(CH3)2 2-471 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)22-472 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-473 C—Cl N C—ClC—H H CF3 C—CF3 H (Methoxyimino)methyl 2-474 C—Cl N C—Cl C—H H CF3 C—CF3H (Ethoxyimino)methyl 2-475 C—Cl N C—Cl C—H H CF3 C—CF3 H 2-PyridylCH22-476 C—Cl N C—Cl C—H H CF3 C—CF3 H [1-(1,3-thiazol-4-yl)]CH2 2-477 C—ClN C—Cl C—H H CF3 C—CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-478 C—Cl NC—Cl C—H H CF3 C—CF3 H 5-chloropyrimidin-2-yl 2-479 C—Cl N C—Cl C—H HCF3 C—CF3 H 5-bromopyrimidin-2-yl 2-480 C—Cl N C—Cl C—H H CF3 C—CF3 H5-cyanopyrimidin-2-yl 2-481 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3NHC(O)CH22-482 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3CH2NHC(O)CH2 2-483 C—Cl N C—ClC—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-484 C—Cl N C—Cl C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH2 2-485 C—Cl N C—Cl C—H H CF3 C—CF3 H CF3CH2NHC(O)CH22-486 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3NHC(O)CH(CH3) 2-487 C—Cl N C—ClC—H H CF3 C—CF3 H CH3CH2NHC(O)CH(CH3) 2-488 C—Cl N C—Cl C—H H CF3 C—CF3H iso-PrNHC(O)CH(CH3) 2-489 C—Cl N C—Cl C—H H CF3 C—CF3 Hcyclo-PrNHC(O)CH(CH3) 2-490 C—Cl N C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-491 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3NHC(O)C(CH3)22-492 C—Cl N C—Cl C—H H CF3 C—CF3 H CH3CH2NHC(O)C(CH3)2 2-493 C—Cl NC—Cl C—H H CF3 C—CF3 H iso-PrNHC(O)C(CH3)2 2-494 C—Cl N C—Cl C—H H CF3C—CF3 H cyclo-PrNHC(O)C(CH3)2 2-495 C—Cl N C—Cl C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-496 C—CF3 N C—H C—H H CF3 C—CF3 H CF3CH2 2-497C—CF3 N C—H C—H H CF3 C—CF3 H CH3OCH2 2-498 C—CF3 N C—H C—H H CF3 C—CF3CH3CO CH3OCH2 2-499 C—CF3 N C—H C—H H CF3 C—CF3 H CH3CH2OCH2 2-500 C—CF3N C—H C—H H CF3 C—CF3 H CH3OCH2CH2 2-501 C—CF3 N C—H C—H H CF3 C—CF3 HCH3CH2OCH2CH2 2-502 C—CF3 N C—H C—H H CF3 C—CF3 H tetrahydrofuran-2-yl2-503 C—CF3 N C—H C—H H CF3 C—CF3 H CH3SCH2CH2 2-504 C—CF3 N C—H C—H HCF3 C—CF3 H CH3S(O)CH2CH2 2-505 C—CF3 N C—H C—H H CF3 C—CF3 HCH3SO2CH2CH2 2-506 C—CF3 N C—H C—H H CF3 C—CF3 H CH3SCH2CH(CH3) 2-507C—CF3 N C—H C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3) 2-508 C—CF3 N C—H C—H HCF3 C—CF3 H CH3SO2CH2CH(CH3) 2-509 C—CF3 N C—H C—H H CF3 C—CF3 HCH3SCH2C(CH3)2 2-510 C—CF3 N C—H C—H H CF3 C—CF3 H CH3S(O)CH2C(CH3)22-511 C—CF3 N C—H C—H H CF3 C—CF3 H CH3SO2CH2C(CH3)2 2-512 C—CF3 N C—HC—H H CF3 C—CF3 H (Methoxyimino)methyl 2-513 C—CF3 N C—H C—H H CF3 C—CF3H (Ethoxyimino)methyl 2-514 C—CF3 N C—H C—H H CF3 C—CF3 H 2-PyridylCH22-515 C—CF3 N C—H C—H H CF3 C—CF3 H [1-(1,3-thiazol-4-yl)]CH2 2-516C—CF3 N C—H C—H H CF3 C—CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-517C—CF3 N C—H C—H H CF3 C—CF3 H 5-chloropyrimidin-2-yl 2-518 C—CF3 N C—HC—H H CF3 C—CF3 H 5-bromopyrimidin-2-yl 2-519 C—CF3 N C—H C—H H CF3C—CF3 H 5-cyanopyrimidin-2-yl 2-520 C—CF3 N C—H C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-521 C—CF3 N C—H C—H H CF3 C—CF3 H CH3CH2NHC(O)CH2 2-522C—CF3 N C—H C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-523 C—CF3 N C—H C—H HCF3 C—CF3 H cyclo-PrNHC(O)CH2 2-524 C—CF3 N C—H C—H H CF3 C—CF3 HCF3CH2NHC(O)CH2 2-525 C—CF3 N C—H C—H H CF3 C—CF3 H CH3NHC(O)CH(CH3)2-526 C—CF3 N C—H C—H H CF3 C—CF3 H CH3CH2NHC(O)CH(CH3) 2-527 C—CF3 NC—H C—H H CF3 C—CF3 H iso-PrNHC(O)CH(CH3) 2-528 C—CF3 N C—H C—H H CF3C—CF3 H cyclo-PrNHC(O)CH(CH3) 2-529 C—CF3 N C—H C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-530 C—CF3 N C—H C—H H CF3 C—CF3 H CH3NHC(O)C(CH3)22-531 C—CF3 N C—H C—H H CF3 C—CF3 H CH3CH2NHC(O)C(CH3)2 2-532 C—CF3 NC—H C—H H CF3 C—CF3 H iso-PrNHC(O)C(CH3)2 2-533 C—CF3 N C—H C—H H CF3C—CF3 H cyclo-PrNHC(O)C(CH3)2 2-534 C—CF3 N C—H C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-535 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CF3CH2 2-536C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3OCH2 2-537 C—CF3 N C—CF3 C—H H CF3C—CF3 CH3CO CH3OCH2 2-538 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3CH2OCH22-539 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3OCH2CH2 2-540 C—CF3 N C—CF3 C—HH CF3 C—CF3 H CH3CH2OCH2CH2 2-541 C—CF3 N C—CF3 C—H H CF3 C—CF3 Htetrahydrofuran-2-yl 2-542 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3SCH2CH22-543 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2CH2 2-544 C—CF3 N C—CF3C—H H CF3 C—CF3 H CH3SO2CH2CH2 2-545 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCH3SCH2CH(CH3) 2-546 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3S(O)CH2CH(CH3)2-547 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3SO2CH2CH(CH3) 2-548 C—CF3 NC—CF3 C—H H CF3 C—CF3 H CH3SCH2C(CH3)2 2-549 C—CF3 N C—CF3 C—H H CF3C—CF3 H CH3S(O)CH2C(CH3)2 2-550 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCH3SO2CH2C(CH3)2 2-551 C—CF3 N C—CF3 C—H H CF3 C—CF3 H(Methoxyimino)methyl 2-552 C—CF3 N C—CF3 C—H H CF3 C—CF3 H(Ethoxyimino)methyl 2-553 C—CF3 N C—CF3 C—H H CF3 C—CF3 H 2-PyridylCH22-554 C—CF3 N C—CF3 C—H H CF3 C—CF3 H [1-(1,3-thiazol-4-yl-)]CH2 2-555C—CF3 N C—CF3 C—H H CF3 C—CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-556C—CF3 N C—CF3 C—H H CF3 C—CF3 H 5-chloropyrimidin-2-yl 2-557 C—CF3 NC—CF3 C—H H CF3 C—CF3 H 5-bromopyrimidin-2-yl 2-558 C—CF3 N C—CF3 C—H HCF3 C—CF3 H 5-cyanopyrimidin-2-yl 2-559 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)CH2 2-560 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3CH2NHC(O)CH2 2-561C—CF3 N C—CF3 C—H H CF3 C—CF3 H iso-PrNHC(O)CH2 2-562 C—CF3 N C—CF3 C—HH CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-563 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)CH2 2-564 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3NHC(O)CH(CH3)2-565 C—CF3 N C—CF3 C—H H CF3 C—CF3 H CH3CH2NHC(O)CH(CH3) 2-566 C—CF3 NC—CF3 C—H H CF3 C—CF3 H iso-PrNHC(O)CH(CH3) 2-567 C—CF3 N C—CF3 C—H HCF3 C—CF3 H cyclo-PrNHC(O)CH(CH3) 2-568 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-569 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-570 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-571 C—CF3 N C—CF3 C—H H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-572 C—CF3 N C—CF3 C—H H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-573 C—CF3 N C—CF3 C—H H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-574 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CF3CH2 2-575C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3OCH2 2-576 C—CF3 C—H C—CF3 N H CF3C—CF3 CH3CO CH3OCH2 2-577 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3CH2OCH22-578 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3OCH2CH2 2-579 C—CF3 C—H C—CF3 NH CF3 C—CF3 H CH3CH2OCH2CH2 2-580 C—CF3 C—H C—CF3 N H CF3 C—CF3 Htetrahydrofuran-2-yl 2-581 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3SCH2CH22-582 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3S(O)CH2CH2 2-583 C—CF3 C—HC—CF3 N H CF3 C—CF3 H CH3SO2CH2CH2 2-584 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCH3SCH2CH(CH3) 2-585 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3S(O)CH2CH(CH3)2-586 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3SO2CH2CH(CH3) 2-587 C—CF3 C—HC—CF3 N H CF3 C—CF3 H CH3SCH2C(CH3)2 2-588 C—CF3 C—H C—CF3 N H CF3 C—CF3H CH3S(O)CH2C(CH3)2 2-589 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCH3SO2CH2C(CH3)2 2-590 C—CF3 C—H C—CF3 N H CF3 C—CF3 H(Methoxyimino)methyl 2-591 C—CF3 C—H C—CF3 N H CF3 C—CF3 H(Ethoxyimino)methyl 2-592 C—CF3 C—H C—CF3 N H CF3 C—CF3 H 2-PyridylCH22-593 C—CF3 C—H C—CF3 N H CF3 C—CF3 H [1-(1,3-thiazol-4-yl)]CH2 2-594C—CF3 C—H C—CF3 N H CF3 C—CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 2-595C—CF3 C—H C—CF3 N H CF3 C—CF3 H 5-chloropyrimidin-2-yl 2-596 C—CF3 C—HC—CF3 N H CF3 C—CF3 H 5-bromopyrimidin-2-yl 2-597 C—CF3 C—H C—CF3 N HCF3 C—CF3 H 5-cyanopyramidin-2-yl 2-598 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCH3NHC(O)CH2 2-599 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3CH2NHC(O)CH2 2-600C—CF3 C—H C—CF3 N H CF3 C—CF3 H iso-PrNHC(O)CH2 2-601 C—CF3 C—H C—CF3 NH CF3 C—CF3 H cyclo-PrNHC(O)CH2 2-602 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCF3CH2NHC(O)CH2 2-603 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3NHC(O)CH(CH3)2-604 C—CF3 C—H C—CF3 N H CF3 C—CF3 H CH3CH2NHC(O)CH(CH3) 2-605 C—CF3C—H C—CF3 N H CF3 C—CF3 H iso-PrNHC(O)CH(CH3) 2-606 C—CF3 C—H C—CF3 N HCF3 C—CF3 H cyclo-PrNHC(O)CH(CH3) 2-607 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCF3CH2NHC(O)CH(CH3) 2-608 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCH3NHC(O)C(CH3)2 2-609 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCH3CH2NHC(O)C(CH3)2 2-610 C—CF3 C—H C—CF3 N H CF3 C—CF3 Hiso-PrNHC(O)C(CH3)2 2-611 C—CF3 C—H C—CF3 N H CF3 C—CF3 Hcyclo-PrNHC(O)C(CH3)2 2-612 C—CF3 C—H C—CF3 N H CF3 C—CF3 HCF3CH2NHC(O)C(CH3)2 2-613 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 Htert-BuOC(O)CH2

TABLE 3

Table 3- Ex.-No. B¹ B² B³ B⁴ X¹ R A³ R³ R⁴ R⁵ R⁶ 1 3-1 C—Cl C—H C—Cl C—HH CF3 C—CF3 H H H H 1 3-2 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H HCO 1 3-3C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CO 1 3-4 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH3CH2CO 1 3-5 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H n-PrCO 13-6 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H iso-PrCO 1 3-7 C—Cl C—H C—Cl C—HH CF3 C—CF3 H H H cyclo-PrCO 1 3-8 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H Hn-BuCO 1 3-9 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H tert-BuCO 1 3-10 C—ClC—H C—Cl C—H H CF3 C—CF3 H H H iso-BuCO 1 3-11 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H cyclo-BuCO 1 3-12 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H(CH3)3CCH2CO 1 3-13 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H cyclo-PenCO 13-14 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H cyclo-HexCO 1 3-15 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-16 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CF3CO 1 3-17 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CCl3CO 13-18 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H ClCH2CO 1 3-19 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H CF2ClCO 1 3-20 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HClCH2CH2CO 1 3-21 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H HCF2CF2CO 1 3-22C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-23 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H (CF3)2CHCO 1 3-24 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HHCF2CO 1 3-25 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H ClCH2CO 1 3-26 C—ClC—H C—Cl C—H H CF3 C—CF3 H H H

1 3-27 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-28 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-29 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-30 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-31 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-32 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH2═CH—CO 1 3-33 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H CH3CH═CH—CO 1 3-34 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH2═C(CH3)—CO 1 3-35 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HCH3CH═C(CH3)—CO 1 3-36 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H (CH3)2C═CH—CO1 3-37 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH2═C(Cl)—CO 1 3-38 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H ClCH═C(CH3)—CO 1 3-39 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH2═CHCH2—CO 1 3-40 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HHCC—CO 1 3-41 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CC—CO 1 3-42 C—ClC—H C—Cl C—H H CF3 C—CF3 H H H NCCH2—CO 1 3-43 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH3OCH2—CO 1 3-44 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HC2H5OCH2—CO 1 3-45 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-46C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3O(CO)CH2—CO 1 3-47 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H CH3(CO)OCH2—CO 1 3-48 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH3O(CO)—CO 1 3-49 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HCF3O(CO)—CO 1 3-50 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3(CO)CH2—CO 13-51 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H (CH3)2NCH2—CO 1 3-52 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H PhCO 1 3-53 C—Cl C—H C—Cl C—H H CF3 C—CF3 H HH PhCH2CO 1 3-54 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-py-CO 1 3-55 C—ClC—H C—Cl C—H H CF3 C—CF3 H H H 3-py-CO 1 3-56 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H 4-py-CO 1 3-57 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-58 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-F—PhCO 1 3-59 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H 3-F—PhCO 1 3-60 C—Cl C—H C—Cl C—H H CF3 C—CF3 H HH 4-F—PhCO 1 3-61 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-Cl—PhCO 1 3-62C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 3-Cl—PhCO 1 3-63 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H 4-Cl—PhCO 1 3-64 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H2-Br—PhCO 1 3-65 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-CF3—PhCO 1 3-66C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-CH3—PhCO 1 3-67 C—Cl C—H C—Cl C—HH CF3 C—CF3 H H H

1 3-68 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-69 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-70 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-71 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-72 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-73 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-74 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-75 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H CH3 CH3CO 1 3-76 C—Cl C—H C—ClC—H H CF3 C—CF3 H H CH3 cyclo-PrCO 1 3-77 C—Cl C—H C—Cl C—H H CF3 C—CF3H H H CH3NHCO 1 3-78 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CH2NHCO 13-79 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CF3CH2NHCO 1 3-80 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H n-PrNHCO 1 3-81 C—Cl C—H C—Cl C—H H CF3 C—CF3 H HH iso-PrNHCO 1 3-82 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H cyclo-PrNHCO 13-83 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H n-BuNHCO 1 3-84 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H tert-BuNHCO 1 3-85 C—Cl C—H C—Cl C—H H CF3 C—CF3 HH H cyclo-BuNHCO 1 3-86 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H Hcyclo-PenNHCO 1 3-87 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H cyclo-HexNHCO 13-88 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH2═CHCH2NHCO 1 3-89 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H HCCCH2NHCO 1 3-90 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H cyclo-PrCH2NHCO 1 3-91 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HNCCH2NHCO 1 3-92 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CF3(CH3)CHNHCO 13-93 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CF3(CH3)2CNCO 1 3-95 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H FCH2CH2NHCO 1 3-96 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CF3CH2CH2NHCO 1 3-97 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HHCF2CF2CH2NHCO 1 3-98 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-99 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-100 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H EtO2CCH2NHCO 1 3-101 C—ClC—H C—Cl C—H H CF3 C—CF3 H H H 2-CF3—PhNHCO 1 3-102 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H 3-CF3—PhNHCO 1 3-103 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H4-CF3—PhNHCO 1 3-104 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 2-py-NHCO 13-105 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H 3-py-NHCO 1 3-106 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H 4-py-NHCO 1 3-107 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H

1 3-108 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H

1 3-109 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H PhCH2HNCO 1 3-110 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H

1 3-111 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H (CH3)2NCO 1 3-112 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H CH3 CH3NHCO 1 3-113 C—Cl C—H C—Cl C—H H CF3C—CF3 H H CH3 CH3CH2NHCO 1 3-114 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H CH3cyclo-PrNHCO 1 3-115 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H pyrrolidineCO 13-116 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H piperidineCO 1 3-117 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H morpholineCO 1 3-118 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CH3OCO 1 3-119 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CH2OCO1 3-120 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H n-PrOCO 1 3-121 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H cyclo-PrOCO 1 3-122 C—Cl C—H C—Cl C—H H CF3C—CF3 H H H CF3CH2OCO 1 3-123 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HCH2═CHCH2OCO 1 3-124 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H HCCCH2OCO 13-125 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H PhOCO 1 3-126 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H PhCH2OCO 1 3-127 C—Cl C—H C—Cl C—H H CF3 C—CF3 H HH tert-BuOCO 1 3-128 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H CH3 tert-BuOCO 13-129 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3SO2 1 3-130 C—Cl C—H C—ClC—H H CF3 C—CF3 H H H CH3CH2SO2 1 3-131 C—Cl C—H C—Cl C—H H CF3 C—CF3 HH H CF3SO2 1 3-132 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CF3CH2SO2 1 3-133C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H PhSO2 1 3-134 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H CH3NHCONHSO2 1 3-135 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H(CH3)2NCONHSO2 1 3-136 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CS 1 3-137C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CH2CS 1 3-138 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H cyclo-PrCS 1 3-139 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HCF3CH2CS 1 3-140 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H H H 1 3-141 C—ClC—Cl C—Cl C—H H CF3 C—CF3 H H H CH3CO 1 3-142 C—Cl C—Cl C—Cl C—H H CF3C—CF3 H H H CH3CH2CO 1 3-143 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H Hcyclo-PrCO 1 3-144 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-145C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H H CH3CH2NHCO 1 3-146 C—CF3 C—H C—CF3C—H H CF3 C—CF3 H H H H 1 3-147 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H HCH3CO 1 3-148 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-149C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-150 C—CF3 C—H C—CF3C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-151 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 HH H CH3CH2NHCO 1 3-152 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H H H CH3CO 13-153 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-154 C—Cl C—ClC—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-155 C—Cl C—Cl C—CF3 C—H H CF3C—CF3 H H H CF3CH2CO 1 3-156 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H H HCH3CH2NHCO 1 3-157 C—Br C—H C—Br C—H H CF3 C—CF3 H H H CH3CO 1 3-158C—Br C—H C—Br C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-159 C—Br C—H C—Br C—H HCF3 C—CF3 H H H cyclo-PrCO 1 3-160 C—Br C—H C—Br C—H H CF3 C—CF3 H H HCF3CH2CO 1 3-161 C—Br C—H C—Br C—H H CF3 C—CF3 H H H CH3CH2NHCO 1 3-162C—Cl C—H C—Cl C—H H CF3 C—H H H H CH3CO 1 3-163 C—Cl C—H C—Cl C—H H CF3C—H H H H CH3CH2CO 1 3-164 C—Cl C—H C—Cl C—H H CF3 C—H H H H cyclo-PrCO1 3-165 C—Cl C—H C—Cl C—H H CF3 C—H H H H CF2CH2CO 1 3-166 C—Cl C—H C—ClC—H H CF3 C—H H H H CH3CH2NHCO 1 3-167 C—Cl C—Cl C—Cl C—H H CF3 C—H H HH CH3CO 1 3-168 C—Cl C—Cl C—Cl C—H H CF3 C—H H H H CH3CH2CO 1 3-169 C—ClC—Cl C—Cl C—H H CF3 C—H H H H cyclo-PrCO 1 3-170 C—Cl C—Cl C—Cl C—H HCF3 C—H H H H CF3CH2CO 1 3-171 C—Cl C—Cl C—Cl C—H H CF3 C—H H H HCH3CH2NHCO 1 3-172 C—CF3 C—H C—CF3 C—H H CF3 C—H H H H CH3CO 1 3-173C—CF3 C—H C—CF3 C—H H CF3 C—H H H H CH3CH2CO 1 3-174 C—CF3 C—H C—CF3 C—HH CF3 C—H H H H cyclo-PrCO 1 3-175 C—CF3 C—H C—CF3 C—H H CF3 C—H H H HCF3CH2CO 1 3-176 C—CF3 C—H C—CF3 C—H H CF3 C—H H H H CH3CH2NHCO 1 3-177C—Cl C—H C—Cl C—H H CF3 C—CH3 H H H CH3CO 1 3-178 C—Cl C—H C—Cl C—H HCF3 C—CH3 H H H CH3CH2CO 1 3-179 C—Cl C—H C—Cl C—H H CF3 C—CH3 H H Hcyclo-PrCO 1 3-180 C—Cl C—H C—Cl C—H H CF3 C—CH3 H H H CF3CH2CO 1 3-181C—Cl C—H C—Cl C—H H CF3 C—CH3 H H H CH3CH2NHCO 1 3-182 C—Cl C—Cl C—ClC—H H CF3 C—CH3 H H H CH3CO 1 3-183 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H HCH3CH2CO 1 3-184 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H H cyclo-PrCO 1 3-185C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H H CF3CH2CO 1 3-186 C—Cl C—Cl C—Cl C—HH CF3 C—CH3 H H H CH3CH2NHCO 1 3-187 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H HH CH3CO 1 3-188 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H H H CH3CH2CO 1 3-189C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H H H cyclo-PrCO 1 3-190 C—CF3 C—H C—CF3C—H H CF3 C—CH3 H H H CF3CH2CO 1 3-191 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 HH H CH3CH2NHCO 1 3-192 C—Cl C—H C—Cl C—H H CF3 C—Cl H H H CH3CO 1 3-193C—Cl C—H C—Cl C—H H CF3 C—Cl H H H CH3CH2CO 1 3-194 C—Cl C—H C—Cl C—H HCF3 C—Cl H H H cyclo-PrCO 1 3-195 C—Cl C—H C—Cl C—H H CF3 C—Cl H H HCF3CH2CO 1 3-196 C—Cl C—H C—Cl C—H H CF3 C—Cl H H H CH3CH2NHCO 1 3-197C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H H CH3CO 1 3-198 C—Cl C—Cl C—Cl C—H HCF3 C—Cl H H H CH3CH2CO 1 3-199 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H Hcyclo-PrCO 1 3-200 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H H CF3CH2CO 1 3-201C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H H CH3CH2NHCO 1 3-202 C—CF3 C—H C—CF3C—H H CF3 C—Cl H H H CH3CO 1 3-203 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H HCH3CH2CO 1 3-204 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H H cyclo-PrCO 1 3-205C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H H CF3CH2CO 1 3-206 C—CF3 C—H C—CF3C—H H CF3 C—Cl H H H CH3CH2NHCO 1 3-207 C—Cl C—H C—Cl C—H H CF3 C—H H HH n-PrCO 1 3-208 C—Cl C—H C—Cl C—H H CF3 C—H H H H cyclo-PrCH2CO 1 3-209C—Cl C—H C—Cl C—H H CF3 C—H H H H CH3SCH2CO 1 3-210 C—Cl C—H C—Cl C—H HCF3 C—H H H H CH3S(O)CH2CO 1 3-211 C—Cl C—H C—Cl C—H H CF3 C—H H H HCH3SO2CH2CO 1 3-212 C—Cl C—Cl C—Cl C—H H CF3 C—H H H H n-PrCO 1 3-213C—Cl C—Cl C—Cl C—H H CF3 C—H H H H cyclo-PrCH2CO 1 3-214 C—Cl C—Cl C—ClC—H H CF3 C—H H H H CH3SCH2CO 1 3-215 C—Cl C—Cl C—Cl C—H H CF3 C—H H H HCH3S(O)CH2CO 1 3-216 C—Cl C—Cl C—Cl C—H H CF3 C—H H H H CH3SO2CH2CO 13-217 C—CF3 C—H C—CF3 C—H H CF3 C—H H H H n-PrCO 1 3-218 C—CF3 C—H C—CF3C—H H CF3 C—H H H H cyclo-PrCH2CO 1 3-219 C—CF3 C—H C—CF3 C—H H CF3 C—HH H H CH3SCH2CO 1 3-220 C—CF3 C—H C—CF3 C—H H CF3 C—H H H H CH3S(O)CH2CO1 3-221 C—CF3 C—H C—CF3 C—H H CF3 C—H H H H CH3SO2CH2CO 1 3-222 C—ClC—Cl C—CF3 C—H H CF3 C—H H H H n-PrCO 1 3-223 C—Cl C—Cl C—CF3 C—H H CF3C—H H H H cyclo-PrCH2CO 1 3-224 C—Cl C—Cl C—CF3 C—H H CF3 C—H H H HCH3SCH2CO 1 3-225 C—Cl C—Cl C—CF3 C—H H CF3 C—H H H H CH3S(O)CH2CO 13-226 C—Cl C—Cl C—CF3 C—H H CF3 C—H H H H CH3SO2CH2CO 1 3-227 C—Cl C—HC—Cl C—H H CF3 C—CH3 H H H n-PrCO 1 3-228 C—Cl C—H C—Cl C—H H CF3 C—CH3H H H cyclo-PrCH2CO 1 3-229 C—Cl C—H C—Cl C—H H CF3 C—CH3 H H HCH3SCH2CO 1 3-230 C—Cl C—H C—Cl C—H H CF3 C—CH3 H H H CH3S(O)CH2CO 13-231 C—Cl C—H C—Cl C—H H CF3 C—CH3 H H H CH3SO2CH2CO 1 3-232 C—Cl C—ClC—Cl C—H H CF3 C—CH3 H H H n-PrCO 1 3-233 C—Cl C—Cl C—Cl C—H H CF3 C—CH3H H H cyclo-PrCH2CO 1 3-234 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H HCH3SCH2CO 1 3-235 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H H CH3S(O)CH2CO 13-236 C—Cl C—Cl C—Cl C—H H CF3 C—CH3 H H H CH3SO2CH2CO 1 3-237 C—CF3 C—HC—CF3 C—H H CF3 C—CH3 H H H n-PrCO 1 3-238 C—CF3 C—H C—CF3 C—H H CF3C—CH3 H H H cyclo-PrCH2CO 1 3-239 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H H HCH3SCH2CO 1 3-240 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H H H CH3S(O)CH2CO 13-241 C—CF3 C—H C—CF3 C—H H CF3 C—CH3 H H H CH3SO2CH2CO 1 3-242 C—ClC—Cl C—CF3 C—H H CF3 C—CH3 H H H n-PrCO 1 3-243 C—Cl C—Cl C—CF3 C—H HCF3 C—CH3 H H H cyclo-PrCH2CO 1 3-244 C—Cl C—Cl C—CF3 C—H H CF3 C—CH3 HH H CH3SCH2CO 1 3-245 C—Cl C—Cl C—CF3 C—H H CF3 C—CH3 H H H CH3S(O)CH2CO1 3-246 C—Cl C—Cl C—CF3 C—H H CF3 C—CH3 H H H CH3SO2CH2CO 1 3-247 C—ClC—H C—Cl C—H H CF3 C—Cl H H H n-PrCO 1 3-248 C—Cl C—H C—Cl C—H H CF3C—Cl H H H cyclo-PrCH2CO 1 3-249 C—Cl C—H C—Cl C—H H CF3 C—Cl H H HCH3SCH2CO 1 3-250 C—Cl C—H C—Cl C—H H CF3 C—Cl H H H CH3S(O)CH2CO 13-251 C—Cl C—H C—Cl C—H H CF3 C—Cl H H H CH3SO2CH2CO 1 3-252 C—Cl C—ClC—Cl C—H H CF3 C—Cl H H H n-PrCO 1 3-253 C—Cl C—Cl C—Cl C—H H CF3 C—Cl HH H cyclo-PrCH2CO 1 3-254 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H H CH3SCH2CO1 3-255 C—Cl C—Cl C—Cl C—H H CF3 C—Cl H H H CH3S(O)CH2CO 1 3-256 C—ClC—Cl C—Cl C—H H CF3 C—Cl H H H CH3SO2CH2CO 1 3-257 C—CF3 C—H C—CF3 C—H HCF3 C—Cl H H H n-PrCO 1 3-258 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H Hcyclo-PrCH2CO 1 3-259 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H H CH3SCH2CO 13-260 C—CF3 C—H C—CF3 C—H H CF3 C—Cl H H H CH3S(O)CH2CO 1 3-261 C—CF3C—H C—CF3 C—H H CF3 C—Cl H H H CH3SO2CH2CO 1 3-262 C—Cl C—Cl C—CF3 C—H HCF3 C—Cl H H H n-PrCO 1 3-263 C—Cl C—Cl C—CF3 C—H H CF3 C—Cl H H Hcyclo-PrCH2CO 1 3-264 C—Cl C—Cl C—CF3 C—H H CF3 C—Cl H H H CH3SCH2CO 13-265 C—Cl C—Cl C—CF3 C—H H CF3 C—Cl H H H CH3S(O)CH2CO 1 3-266 C—ClC—Cl C—CF3 C—H H CF3 C—Cl H H H CH3SO2CH2CO 1 3-267 C—Cl C—H C—Cl C—H HCF3 C—Br H H H CH3CO 1 3-268 C—Cl C—H C—Cl C—H H CF3 C—Br H H H CH3CH2CO1 3-269 C—Cl C—H C—Cl C—H H CF3 C—Br H H H n-PrCO 1 3-270 C—Cl C—H C—ClC—H H CF3 C—Br H H H cyclo-PrCO 1 3-271 C—Cl C—H C—Cl C—H H CF3 C—Br H HH cyclo-PrCH2CO 1 3-272 C—Cl C—H C—Cl C—H H CF3 C—Br H H H CF3CH2CO 13-273 C—Cl C—H C—Cl C—H H CF3 C—Br H H H CH3SCH2CO 1 3-274 C—Cl C—H C—ClC—H H CF3 C—Br H H H CH3S(O)CH2CO 1 3-275 C—Cl C—H C—Cl C—H H CF3 C—Br HH H CH3SO2CH2CO 1 3-276 C—Cl C—H C—Cl C—H H CF3 C—Br H H H CH3CH2NHCO 13-277 C—Cl C—Cl C—Cl C—H H CF3 C—Br H H H CH3CO 1 3-278 C—Cl C—Cl C—ClC—H H CF3 C—Br H H H CH3CH2CO 1 3-279 C—Cl C—Cl C—Cl C—H H CF3 C—Br H HH n-PrCO 1 3-280 C—Cl C—Cl C—Cl C—H H CF3 C—Br H H H cyclo-PrCO 1 3-281C—Cl C—Cl C—Cl C—H H CF3 C—Br H H H cyclo-PrCH2CO 1 3-282 C—Cl C—Cl C—ClC—H H CF3 C—Br H H H CF3CH2CO 1 3-283 C—Cl C—Cl C—Cl C—H H CF3 C—Br H HH CH3SCH2CO 1 3-284 C—Cl C—Cl C—Cl C—H H CF3 C—Br H H H CH3S(O)CH2CO 13-285 C—Cl C—Cl C—Cl C—H H CF3 C—Br H H H CH3SO2CH2CO 1 3-286 C—Cl C—ClC—Cl C—H H CF3 C—Br H H H CH3CH2NHCO 1 3-287 C—CF3 C—H C—CF3 C—H H CF3C—Br H H H CH3CO 1 3-288 C—CF3 C—H C—CF3 C—H H CF3 C—Br H H H CH3CH2CO 13-289 C—CF3 C—H C—CF3 C—H H CF3 C—Br H H H n-PrCO 1 3-290 C—CF3 C—HC—CF3 C—H H CF3 C—Br H H H cyclo-PrCO 1 3-291 C—CF3 C—H C—CF3 C—H H CF3C—Br H H H cyclo-PrCH2CO 1 3-292 C—CF3 C—H C—CF3 C—H H CF3 C—Br H H HCF3CH2CO 1 3-293 C—CF3 C—H C—CF3 C—H H CF3 C—Br H H H CH3SCH2CO 1 3-294C—CF3 C—H C—CF3 C—H H CF3 C—Br H H H CH3S(O)CH2CO 1 3-295 C—CF3 C—HC—CF3 C—H H CF3 C—Br H H H CH3SO2CH2CO 1 3-296 C—CF3 C—H C—CF3 C—H H CF3C—Br H H H CH3CH2NHCO 1 3-297 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H H CH3CO1 3-298 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H H CH3CH2CO 1 3-299 C—Cl C—ClC—CF3 C—H H CF3 C—Br H H H n-PrCO 1 3-300 C—Cl C—Cl C—CF3 C—H H CF3 C—BrH H H cyclo-PrCO 1 3-301 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H Hcyclo-PrCH2CO 1 3-302 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H H CF3CH2CO 13-303 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H H CH3SCH2CO 1 3-304 C—Cl C—ClC—CF3 C—H H CF3 C—Br H H H CH3S(O)CH2CO 1 3-305 C—Cl C—Cl C—CF3 C—H HCF3 C—Br H H H CH3SO2CH2CO 1 3-306 C—Cl C—Cl C—CF3 C—H H CF3 C—Br H H HCH3CH2NHCO 1 3-307 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3CH2OCH2CO 13-308 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H H CH3OCH2CH2CO 1 3-309 C—Cl C—HC—Cl C—H H CF3 C—CF3 H H H CH3CH2OCH2CH2CO 1 3-310 C—Cl C—H C—Cl C—H HCF3 C—CF3 H H H CH3S(O)CH2CO 1 3-311 C—Cl C—H C—Cl C—H H CF3 C—CF3 H H HCH3SO2CH2CO 1 3-312 C—Cl C—H C—Br C—H H CF3 C—CF3 H H H CH3CO 1 3-313C—Cl C—H C—Br C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-314 C—Cl C—H C—Br C—H HCF3 C—CF3 H H H n-PrCO 1 3-315 C—Cl C—H C—Br C—H H CF3 C—CF3 H H Hcyclo-PrCO 1 3-316 C—Cl C—H C—Br C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 13-317 C—Cl C—H C—Br C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-318 C—Cl C—H C—BrC—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-319 C—Cl C—H C—Br C—H H CF3 C—CF3 HH H CH3S(O)CH2CO 1 3-320 C—Cl C—H C—Br C—H H CF3 C—CF3 H H H CH3SO2CH2CO1 3-321 C—Cl C—H C—Br C—H H CF3 C—CF3 H H H CH3CH2NHCO 1 3-322 C—Br C—HC—Br C—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-323 C—Br C—H C—Br C—H H CF3C—CF3 H H H CH3S(O)CH2CO 1 3-324 C—Br C—H C—Br C—H H CF3 C—CF3 H H HCH3SO2CH2CO 1 3-325 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H CH3CO 1 3-326C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-327 C—Cl C—F C—Cl C—H HCF3 C—CF3 H H H n-PrCO 1 3-328 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H Hcyclo-PrCO 1 3-329 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 13-330 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-331 C—Cl C—F C—ClC—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-332 C—Cl C—F C—Cl C—H H CF3 C—CF3 HH H CH3S(O)CH2CO 1 3-333 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H CH3SO2CH2CO1 3-334 C—Cl C—F C—Cl C—H H CF3 C—CF3 H H H CH3CH2NHCO 1 3-335 C—Cl C—ClC—Cl C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-336 C—Cl C—Cl C—Cl C—H HCF3 C—CF3 H H H tert-BuCH2CO 1 3-337 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H HH CH3OCH2CH2CO 1 3-338 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H HCH3CH2OCH2CH2CO 1 3-339 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H H CH3SCH2CO 13-340 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-341 C—ClC—Cl C—Cl C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-342 C—Cl C—Cl C—Cl C—H HCF3 C—CF3 H H H CH3CONHCH(CH3)CO 1 3-343 C—Cl C—Br C—Cl C—H H CF3 C—CF3H H H CH3CO 1 3-344 C—Cl C—Br C—Cl C—H H CF3 C—CF3 H H H CH3CH2CO 13-345 C—Cl C—Br C—Cl C—H H CF3 C—CF3 H H H n-PrCO 1 3-346 C—Cl C—Br C—ClC—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-347 C—Cl C—Br C—Cl C—H H CF3 C—CF3H H H cyclo-PrCH2CO 1 3-348 C—Cl C—Br C—Cl C—H H CF3 C—CF3 H H HCF3CH2CO 1 3-349 C—Cl C—Br C—Cl C—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-350C—Cl C—Br C—Cl C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-351 C—Cl C—Br C—ClC—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-352 C—Cl C—Br C—Cl C—H H CF3 C—CF3H H H CH3CH2NHCO 1 3-353 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H H CH3CO 13-354 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-355 C—Cl C—ClC—Br C—H H CF3 C—CF3 H H H n-PrCO 1 3-356 C—Cl C—Cl C—Br C—H H CF3 C—CF3H H H cyclo-PrCO 1 3-357 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H Hcyclo-PrCH2CO 1 3-358 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H H CF3CH2CO 13-359 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H H CH3SCH2CO 1 3-360 C—Cl C—ClC—Br C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-361 C—Cl C—Cl C—Br C—H H CF3C—CF3 H H H CH3SO2CH2CO 1 3-362 C—Cl C—Cl C—Br C—H H CF3 C—CF3 H H HCH3CH2NHCO 1 3-363 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H CH3CO 1 3-364C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H CH3CH2CO 1 3-365 C—Cl C—F C—Cl C—H FCF3 C—CF3 H H H n-PrCO 1 3-366 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H Hcyclo-PrCO 1 3-367 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H cyclo-PrCH2CO 13-368 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H CF3CH2CO 1 3-369 C—Cl C—F C—ClC—H F CF3 C—CF3 H H H CH3SCH2CO 1 3-370 C—Cl C—F C—Cl C—H F CF3 C—CF3 HH H CH3S(O)CH2CO 1 3-371 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H CH3SO2CH2CO1 3-372 C—Cl C—F C—Cl C—H F CF3 C—CF3 H H H CH3CH2NHCO 1 3-373 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H H H CH3CO 1 3-374 C—Cl C—H C—CF3 C—H H CF3 C—CF3H H H CH3CH2CO 1 3-375 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H H n-PrCO 13-376 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-377 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-378 C—Cl C—H C—CF3 C—H HCF3 C—CF3 H H H CF3CH2CO 1 3-379 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H HCH3OCH2CH2CO 1 3-380 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H HCH3CH2OCH2CH2CO 1 3-381 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H H CH3SCH2CO 13-382 C—Cl C—H C—CF3 C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-383 C—Cl C—HC—CF3 C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-384 C—Cl C—H C—CF3 C—H H CF3C—CF3 H H H CH3CH2NHCO 1 3-385 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H HCH3OCH2CH2CO 1 3-386 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H HCH3CH2OCH2CH2CO 1 3-387 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H CH3SCH2CO1 3-388 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-389 C—CF3C—H C—CF3 C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-390 C—Cl C—Cl C—CF3 C—HH CF3 C—CF3 H H H CH3SCH2CO 1 3-391 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H HH CH3S(O)CH2CO 1 3-392 C—Cl C—Cl C—CF3 C—H H CF3 C—CF3 H H H CH3SO2CH2CO1 3-393 C—Cl N C—Cl C—H H CF3 C—CF3 H H H CH3CO 1 3-394 C—Cl N C—Cl C—HH CF3 C—CF3 H H H CH3CH2CO 1 3-395 C—Cl N C—Cl C—H H CF3 C—CF3 H H Hn-PrCO 1 3-396 C—Cl N C—Cl C—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-397 C—ClN C—Cl C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-398 C—Cl N C—Cl C—H H CF3C—CF3 H H H CF3CH2CO 1 3-399 C—Cl N C—Cl C—H H CF3 C—CF3 H H H CH3SCH2CO1 3-400 C—Cl N C—Cl C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-401 C—Cl NC—Cl C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-402 C—Cl N C—Cl C—H H CF3C—CF3 H H H CH3CH2NHCO 1 3-403 C—CF3 N C—H C—H H CF3 C—CF3 H H H CH3CO 13-404 C—CF3 N C—H C—H H CF3 C—CF3 H H H CH3CH2CO 1 3-405 C—CF3 N C—H C—HH CF3 C—CF3 H H H n-PrCO 1 3-406 C—CF3 N C—H C—H H CF3 C—CF3 H H Hcyclo-PrCO 1 3-407 C—CF3 N C—H C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 13-408 C—CF3 N C—H C—H H CF3 C—CF3 H H H CF3CH2CO 1 3-409 C—CF3 N C—H C—HH CF3 C—CF3 H H H CH3SCH2CO 1 3-410 C—CF3 N C—H C—H H CF3 C—CF3 H H HCH3S(O)CH2CO 1 3-411 C—CF3 N C—H C—H H CF3 C—CF3 H H H CH3SO2CH2CO 13-412 C—CF3 N C—H C—H H CF3 C—CF3 H H H CH3CH2NHCO 1 3-413 C—CF3 N C—CF3C—H H CF3 C—CF3 H H H CH3CO 1 3-414 C—CF3 N C—CF3 C—H H CF3 C—CF3 H H HCH3CH2CO 1 3-415 C—CF3 N C—CF3 C—H H CF3 C—CF3 H H H n-PrCO 1 3-416C—CF3 N C—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCO 1 3-417 C—CF3 N C—CF3 C—HH CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-418 C—CF3 N C—CF3 C—H H CF3 C—CF3 HH H CF3CH2CO 1 3-419 C—CF3 N C—CF3 C—H H CF3 C—CF3 H H H CH3SCH2CO 13-420 C—CF3 N C—CF3 C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-421 C—CF3 NC—CF3 C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-422 C—CF3 N C—CF3 C—H H CF3C—CF3 H H H CH3CH2NHCO 1 3-423 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H H CH3CO1 3-424 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H H CH3CH2CO 1 3-425 C—CF3 C—HC—CF3 N H CF3 C—CF3 H H H n-PrCO 1 3-426 C—CF3 C—H C—CF3 N H CF3 C—CF3 HH H cyclo-PrCO 1 3-427 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H H cyclo-PrCH2CO1 3-428 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H H CF3CH2CO 1 3-429 C—CF3 C—HC—CF3 N H CF3 C—CF3 H H H CH3SCH2CO 1 3-430 C—CF3 C—H C—CF3 N H CF3C—CF3 H H H CH3S(O)CH2CO 1 3-431 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H HCH3SO2CH2CO 1 3-432 C—CF3 C—H C—CF3 N H CF3 C—CF3 H H H CH3CH2NHCO 13-433 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H cyclo-PrCH2CO 1 3-434 C—CF3C—H C—CF3 C—H H CF3 C—CF3 H H H tert-BuCH2CO 1 3-435 C—Cl C—Cl C—Cl C—HH CF3 C—CF3 H H H CH3SO2 1 3-436 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H HCH3SO2 1 3-437 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H CF3CF2CO 1 3-438C—CF3 C—H C—CF3 C—H H CF3 C—CF3 H H H PhSCH2CH2CO 1 3-439 C—CF3 C—H C—HC—H H CF3 C—CF3 H H H CH3CH2CO 1 3-440 C—CF3 C—H C—H C—H H CF3 C—CF3 H HH cyclo-PrCH2CO 1 3-441 C—CF3 C—H C—H C—H H CF3 C—CF3 H H H CH3SCH2CO 13-442 C—CF3 C—H C—H C—H H CF3 C—CF3 H H H CH3S(O)CH2CO 1 3-443 C—CF3 C—HC—H C—H H CF3 C—CF3 H H H CH3SO2CH2CO 1 3-444 C—Br C—H C—Br C—H H CF3C—CF3 H H H cyclo-PrCH2CO 1

TABLE 4

Table 4- Ex.-No. B¹ B² B³ B⁴ X¹ R Y R¹ R² 4-1 C—Cl C—H C—Cl C—H H CF3CF3 H H 4-2 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3 4-3 C—Cl C—H C—Cl C—H HCF3 CF3 H CH3CH2 4-4 C—Cl C—H C—Cl C—H H CF3 CF3 H n-Pr 4-5 C—Cl C—HC—Cl C—H H CF3 CF3 H cyclo-Pr 4-6 C—Cl C—H C—Cl C—H H CF3 CF3 H n-Bu 4-7C—Cl C—H C—Cl C—H H CF3 CF3 H tert-Bu 4-8 C—Cl C—H C—Cl C—H H CF3 CF3 HCF3CH2 4-9 C—Cl C—H C—Cl C—H H CF3 CF3 H 2-PyridylCH2 4-10 C—Cl C—H C—ClC—H H CF3 CF3 H Ph 4-11 C—Cl C—H C—Cl C—H H CF3 CF3 H PhCH2 4-12 C—ClC—H C—Cl C—H H CF3 CF3 H MeO2CCH2 4-13 C—Cl C—H C—Cl C—H H CF3 CF3 Hcyclo-PrCH2 4-14 C—Cl C—Cl C—Cl C—H H CF3 CF3 H H 4-15 C—Cl C—Cl C—ClC—H H CF3 CF3 H CH3 4-16 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3CH2 4-17 C—ClC—Cl C—Cl C—H H CF3 CF3 H n-Pr 4-18 C—Cl C—Cl C—Cl C—H H CF3 CF3 Hcyclo-Pr 4-19 C—Cl C—Cl C—Cl C—H H CF3 CF3 H n-Bu 4-20 C—Cl C—Cl C—ClC—H H CF3 CF3 H tert-Bu 4-21 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CF3CH2 4-22C—Cl C—Cl C—Cl C—H H CF3 CF3 H 2-PyridylCH2 4-23 C—Cl C—Cl C—Cl C—H HCF3 CF3 H Ph 4-24 C—Cl C—Cl C—Cl C—H H CF3 CF3 H PhCH2 4-25 C—Cl C—ClC—Cl C—H H CF3 CF3 H MeO2CCH2 4-26 C—Cl C—Cl C—Cl C—H H CF3 CF3 Hcyclo-PrCH2 4-27 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H 4-28 C—CF3 C—H C—CF3C—H H CF3 CF3 H CH3 4-29 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3CH2 4-30C—CF3 C—H C—CF3 C—H H CF3 CF3 H n-Pr 4-31 C—CF3 C—H C—CF3 C—H H CF3 CF3H cyclo-Pr 4-32 C—CF3 C—H C—CF3 C—H H CF3 CF3 H n-Bu 4-33 C—CF3 C—HC—CF3 C—H H CF3 CF3 H tert-Bu 4-34 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCF3CH2 4-35 C—CF3 C—H C—CF3 C—H H CF3 CF3 H 2-PyridylCH2 4-36 C—CF3 C—HC—CF3 C—H H CF3 CF3 H Ph 4-37 C—CF3 C—H C—CF3 C—H H CF3 CF3 H PhCH2 4-38C—CF3 C—H C—CF3 C—H H CF3 CF3 H MeO2CCH2 4-39 C—CF3 C—H C—CF3 C—H H CF3CF3 H cyclo-PrCH2 4-40 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H H 4-41 C—Cl C—ClC—CF3 C—H H CF3 CF3 H CH3 4-42 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3CH24-43 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H n-Pr 4-44 C—Cl C—Cl C—CF3 C—H H CF3CF3 H cyclo-Pr 4-45 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H n-Bu 4-46 C—Cl C—ClC—CF3 C—H H CF3 CF3 H tert-Bu 4-47 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCF3CH2 4-48 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H 2-PyridylCH2 4-49 C—Cl C—ClC—CF3 C—H H CF3 CF3 H Ph 4-50 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H PhCH2 4-51C—Cl C—Cl C—CF3 C—H H CF3 CF3 H MeO2CCH2 4-52 C—Cl C—Cl C—CF3 C—H H CF3CF3 H cyclo-PrCH2 4-53 C—Cl C—H C—Cl C—H H CF3 H H CH3 4-54 C—Cl C—HC—Cl C—H H CF3 H H CF3CH2 4-55 C—Cl C—H C—Cl C—H H CF3 H H 2-PyridylCH24-56 C—Cl C—H C—Cl C—H H CF3 H H PhCH2 4-57 C—Cl C—H C—Cl C—H H CF3 H HMeO2CCH2 4-58 C—Cl C—Cl C—Cl C—H H CF3 H H CH3 4-59 C—Cl C—Cl C—Cl C—H HCF3 H H CF3CH2 4-60 C—Cl C—Cl C—Cl C—H H CF3 H H 2-PyridylCH2 4-61 C—ClC—Cl C—Cl C—H H CF3 H H PhCH2 4-62 C—Cl C—Cl C—Cl C—H H CF3 H H MeO2CCH24-63 C—CF3 C—Cl C—CF3 C—H H CF3 H H CH3 4-64 C—CF3 C—Cl C—CF3 C—H H CF3H H CF3CH2 4-65 C—CF3 C—Cl C—CF3 C—H H CF3 H H 2-PyridylCH2 4-66 C—CF3C—Cl C—CF3 C—H H CF3 H H PhCH2 4-67 C—CF3 C—Cl C—CF3 C—H H CF3 H HMeO2CCH2 4-68 C—Cl C—H C—Cl C—H H CF3 CH3 H CH3 4-69 C—Cl C—H C—Cl C—H HCF3 CH3 H CF3CH2 4-70 C—Cl C—H C—Cl C—H H CF3 CH3 H 2-PyridylCH2 4-71C—Cl C—H C—Cl C—H H CF3 CH3 H PhCH2 4-72 C—Cl C—H C—Cl C—H H CF3 CH3 HMeO2CCH2 4-73 C—Cl C—Cl C—Cl C—H H CF3 CH3 H CH3 4-74 C—Cl C—Cl C—Cl C—HH CF3 CH3 H CF3CH2 4-75 C—Cl C—Cl C—Cl C—H H CF3 CH3 H 2-PyridylCH2 4-76C—Cl C—Cl C—Cl C—H H CF3 CH3 H PhCH2 4-77 C—Cl C—Cl C—Cl C—H H CF3 CH3 HMeO2CCH2 4-78 C—CF3 C—Cl C—CF3 C—H H CF3 CH3 H CH3 4-79 C—CF3 C—Cl C—CF3C—H H CF3 CH3 H CF3CH2 4-80 C—CF3 C—Cl C—CF3 C—H H CF3 CH3 H2-PyridylCH2 4-81 C—CF3 C—Cl C—CF3 C—H H CF3 CH3 H PhCH2 4-82 C—CF3 C—ClC—CF3 C—H H CF3 CH3 H MeO2CCH2 4-83 C—Cl C—H C—Cl C—H H CF3 Cl H CH34-84 C—Cl C—H C—Cl C—H H CF3 Cl H CF3CH2 4-85 C—Cl C—H C—Cl C—H H CF3 ClH 2-PyridylCH2 4-86 C—Cl C—H C—Cl C—H H CF3 Cl H PhCH2 4-87 C—Cl C—HC—Cl C—H H CF3 Cl H MeO2CCH2 4-88 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3 4-89C—Cl C—Cl C—Cl C—H H CF3 Cl H CF3CH2 4-90 C—Cl C—Cl C—Cl C—H H CF3 Cl H2-PyridylCH2 4-91 C—Cl C—Cl C—Cl C—H H CF3 Cl H PhCH2 4-92 C—Cl C—ClC—Cl C—H H CF3 Cl H MeO2CCH2 4-93 C—CF3 C—Cl C—CF3 C—H H CF3 Cl H CH34-94 C—CF3 C—Cl C—CF3 C—H H CF3 Cl H CF3CH2 4-95 C—CF3 C—Cl C—CF3 C—H HCF3 Cl H 2-PyridylCH2 4-96 C—CF3 C—Cl C—CF3 C—H H CF3 Cl H PhCH2 4-97C—CF3 C—Cl C—CF3 C—H H CF3 Cl H MeO2CCH2 4-98 C—CF3 C—H C—CF3 C—H H CF3H H CF3CH2 4-99 C—CF3 C—H C—CF3 C—H H CF3 H H 2-PyridylCH2 4-100 C—CF3C—H C—CF3 C—H H CF3 CH3 H CF3CH2 4-101 C—CF3 C—H C—CF3 C—H H CF3 CH3 H2-PyridylCH2 4-102 C—Cl C—H C—Cl C—H H CF3 Cl H CH3OCH2 4-103 C—Cl C—HC—Cl C—H H CF3 Cl CH3CO CH3OCH2 4-104 C—Cl C—H C—Cl C—H H CF3 Cl HCH3CH2OCH2 4-105 C—Cl C—H C—Cl C—H H CF3 Cl H CH3OCH2CH2 4-106 C—Cl C—HC—Cl C—H H CF3 Cl H CH3CH2OCH2CH2 4-107 C—Cl C—H C—Cl C—H H CF3 Cl Htetrahydrofuran-2-yl 4-108 C—Cl C—H C—Cl C—H H CF3 Cl H CH3CH2CH2 4-109C—Cl C—H C—Cl C—H H CF3 Cl H CH3S(O)CH2CH2 4-110 C—Cl C—H C—Cl C—H H CF3Cl H CH3SO2CH2CH2 4-111 C—Cl C—H C—Cl C—H H CF3 Cl H CH3SCH2CH(CH3)4-112 C—Cl C—H C—Cl C—H H CF3 Cl H CH3S(O)CH2CH(CH3) 4-113 C—Cl C—H C—ClC—H H CF3 Cl H CH3SO2CH2CH(CH3) 4-114 C—Cl C—H C—Cl C—H H CF3 Cl HCH3SCH2C(CH3)2 4-115 C—Cl C—H C—Cl C—H H CF3 Cl H CH3S(O)CH2C(CH3)24-116 C—Cl C—H C—Cl C—H H CF3 Cl H CH3SO2CH2C(CH3)2 4-117 C—Cl C—H C—ClC—H H CF3 Cl H (Methoxyimino)methyl 4-118 C—Cl C—H C—Cl C—H H CF3 Cl H(Ethoxyimino)methyl 4-119 C—Cl C—H C—Cl C—H H CF3 Cl H[1-(1,3-thiazol-4-yl)]CH2 4-120 C—Cl C—H C—Cl C—H H CF3 Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-121 C—Cl C—H C—Cl C—H H CF3 Cl H5-chloropyrimidin-2-yl 4-122 C—Cl C—H C—Cl C—H H CF3 Cl H5-bromopyrimidin-2-yl 4-123 C—Cl C—H C—Cl C—H H CF3 Cl H5-cyanopyrimidin-2-yl 4-124 C—Cl C—H C—Cl C—H H CF3 Cl H CH3NHC(O)CH24-125 C—Cl C—H C—Cl C—H H CF3 Cl H CH3CH2NHC(O)CH2 4-126 C—Cl C—H C—ClC—H H CF3 Cl H iso-PrNHC(O)CH2 4-127 C—Cl C—H C—Cl C—H H CF3 Cl Hcyclo-PrNHC(O)CH2 4-128 C—Cl C—H C—Cl C—H H CF3 Cl H CF3CH2NHC(O)CH24-129 C—Cl C—H C—Cl C—H H CF3 Cl H CH3NHC(O)CH(CH3) 4-130 C—Cl C—H C—ClC—H H CF3 Cl H CH3CH2NHC(O)CH(CH3) 4-131 C—Cl C—H C—Cl C—H H CF3 Cl Hiso-PrNHC(O)CH(CH3) 4-132 C—Cl C—H C—Cl C—H H CF3 Cl Hcyclo-PrNHC(O)CH(CH3) 4-133 C—Cl C—H C—Cl C—H H CF3 Cl HCF3CH2NHC(O)CH(CH3) 4-134 C—Cl C—H C—Cl C—H H CF3 Cl H CH3NHC(O)C(CH3)24-135 C—Cl C—H C—Cl C—H H CF3 Cl H CH3CH2NHC(O)C(CH3)2 4-136 C—Cl C—HC—Cl C—H H CF3 Cl H iso-PrNHC(O)C(CH3)2 4-137 C—Cl C—H C—Cl C—H H CF3 ClH cyclo-PrNHC(O)C(CH3)2 4-138 C—Cl C—H C—Cl C—H H CF3 Cl HCF3CH2NHC(O)C(CH3)2 4-139 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3OCH2 4-140C—Cl C—Cl C—Cl C—H H CF3 Cl CH3CO CH3OCH2 4-141 C—Cl C—Cl C—Cl C—H H CF3Cl H CH3CH2OCH2 4-142 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3OCH2CH2 4-143C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3CH2OCH2CH2 4-144 C—Cl C—Cl C—Cl C—H HCF3 Cl H tetrahydrofuran-2-yl 4-145 C—Cl C—Cl C—Cl C—H H CF3 Cl HCH3SCH2CH2 4-146 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3S(O)CH2CH2 4-147 C—ClC—Cl C—Cl C—H H CF3 Cl H CH3SO2CH2CH2 4-148 C—Cl C—Cl C—Cl C—H H CF3 ClH CH3SCH2CH(CH3) 4-149 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3S(O)CH2CH(CH3)4-150 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3SO2CH2CH(CH3) 4-151 C—Cl C—ClC—Cl C—H H CF3 Cl H CH3SCH2C(CH3)2 4-152 C—Cl C—Cl C—Cl C—H H CF3 Cl HCH3S(O)CH2C(CH3)2 4-153 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3SO2CH2C(CH3)24-154 C—Cl C—Cl C—Cl C—H H CF3 Cl H (Methoxyimino)methyl 4-155 C—Cl C—ClC—Cl C—H H CF3 Cl H (Ethoxyimino)methyl 4-156 C—Cl C—Cl C—Cl C—H H CF3Cl H [1-(1,3-thiazol-4-yl)]CH2 4-157 C—Cl C—Cl C—Cl C—H H CF3 Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-158 C—Cl C—Cl C—Cl C—H H CF3 Cl H5-chloropyrimidin-2-yl 4-159 C—Cl C—Cl C—Cl C—H H CF3 Cl H5-bromopyrimidin-2-yl 4-160 C—Cl C—Cl C—Cl C—H H CF3 Cl H5-cyanopyrimidin-2-yl 4-161 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3NHC(O)CH24-162 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3CH2NHC(O)CH2 4-163 C—Cl C—Cl C—ClC—H H CF3 Cl H iso-PrNHC(O)CH2 4-164 C—Cl C—Cl C—Cl C—H H CF3 Cl Hcyclo-PrNHC(O)CH2 4-165 C—Cl C—Cl C—Cl C—H H CF3 Cl H CF3CH2NHC(O)CH24-166 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3NHC(O)CH(CH3) 4-167 C—Cl C—ClC—Cl C—H H CF3 Cl H CH3CH2NHC(O)CH(CH3) 4-168 C—Cl C—Cl C—Cl C—H H CF3Cl H iso-PrNHC(O)CH(CH3) 4-169 C—Cl C—Cl C—Cl C—H H CF3 Cl Hcyclo-PrNHC(O)CH(CH3) 4-170 C—Cl C—Cl C—Cl C—H H CF3 Cl HCF3CH2NHC(O)CH(CH3) 4-171 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3NHC(O)C(CH3)24-172 C—Cl C—Cl C—Cl C—H H CF3 Cl H CH3CH2NHC(O)C(CH3)2 4-173 C—Cl C—ClC—Cl C—H H CF3 Cl H iso-PrNHC(O)C(CH3)2 4-174 C—Cl C—Cl C—Cl C—H H CF3Cl H cyclo-PrNHC(O)C(CH3)2 4-175 C—Cl C—Cl C—Cl C—H H CF3 Cl HCF3CH2NHC(O)C(CH3)2 4-176 C—Cl C—H C—CF3 C—H H CF3 Cl H CF3CH2 4-177C—Cl C—H C—CF3 C—H H CF3 Cl H CH3OCH2 4-178 C—Cl C—H C—CF3 C—H H CF3 ClCH3CO CH3OCH2 4-179 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3CH2OCH2 4-180 C—ClC—H C—CF3 C—H H CF3 Cl H CH3OCH2CH2 4-181 C—Cl C—H C—CF3 C—H H CF3 Cl HCH3CH2OCH2CH2 4-182 C—Cl C—H C—CF3 C—H H CF3 Cl H tetrahydrofuran-2-yl4-183 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3SCH2CH2 4-184 C—Cl C—H C—CF3 C—HH CF3 Cl H CH3S(O)CH2CH2 4-185 C—Cl C—H C—CF3 C—H H CF3 Cl HCH3SO2CH2CH2 4-186 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3SCH2CH(CH3) 4-187C—Cl C—H C—CF3 C—H H CF3 Cl H CH3S(O)CH2CH(CH3) 4-188 C—Cl C—H C—CF3 C—HH CF3 Cl H CH3SO2CH2CH(CH3) 4-189 C—Cl C—H C—CF3 C—H H CF3 Cl HCH3SCH2C(CH3)2 4-190 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3S(O)CH2C(CH3)24-191 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3SO2CH2C(CH3)2 4-192 C—Cl C—HC—CF3 C—H H CF3 Cl H (Methoxyimino)methyl 4-193 C—Cl C—H C—CF3 C—H H CF3Cl H (Ethoxyimino)methyl 4-194 C—Cl C—H C—CF3 C—H H CF3 Cl H2-PyridylCH2 4-195 C—Cl C—H C—CF3 C—H H CF3 Cl H[1-(1,3-thiazol-4-yl)]CH2 4-196 C—Cl C—H C—CF3 C—H H CF3 Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-197 C—Cl C—H C—CF3 C—H H CF3 Cl H5-chloropyrimidin-2-yl 4-198 C—Cl C—H C—CF3 C—H H CF3 Cl H5-bromopyrimidin-2-yl 4-199 C—Cl C—H C—CF3 C—H H CF3 Cl H5-cyanopyrimidin-2-yl 4-200 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3NHC(O)CH24-201 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3CH2NHC(O)CH2 4-202 C—Cl C—H C—CF3C—H H CF3 Cl H iso-PrNHC(O)CH2 4-203 C—Cl C—H C—CF3 C—H H CF3 Cl Hcyclo-PrNHC(O)CH2 4-204 C—Cl C—H C—CF3 C—H H CF3 Cl H CF3CH2NHC(O)CH24-205 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3NHC(O)CH(CH3) 4-206 C—Cl C—HC—CF3 C—H H CF3 Cl H CH3CH2NHC(O)CH(CH3) 4-207 C—Cl C—H C—CF3 C—H H CF3Cl H iso-PrNHC(O)CH(CH3) 4-208 C—Cl C—H C—CF3 C—H H CF3 Cl Hcyclo-PrNHC(O)CH(CH3) 4-209 C—Cl C—H C—CF3 C—H H CF3 Cl HCF3CH2NHC(O)CH(CH3) 4-210 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3NHC(O)C(CH3)24-211 C—Cl C—H C—CF3 C—H H CF3 Cl H CH3CH2NHC(O)C(CH3)2 4-212 C—Cl C—HC—CF3 C—H H CF3 Cl H iso-PrNHC(O)C(CH3)2 4-213 C—Cl C—H C—CF3 C—H H CF3Cl H cyclo-PrNHC(O)C(CH3)2 4-214 C—Cl C—H C—CF3 C—H H CF3 Cl HCF3CH2NHC(O)C(CH3)2 4-215 C—CF3 C—H C—CF3 C—H H CF3 Cl H CF3CH2 4-216C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3OCH2 4-217 C—CF3 C—H C—CF3 C—H H CF3Cl CH3CO CH3OCH2 4-218 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3CH2OCH2 4-219C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3OCH2CH2 4-220 C—CF3 C—H C—CF3 C—H HCF3 Cl H CH3CH2OCH2CH2 4-221 C—CF3 C—H C—CF3 C—H H CF3 Cl Htetrahydrofuran-2-yl 4-222 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3SCH2CH24-223 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3S(O)CH2CH2 4-224 C—CF3 C—H C—CF3C—H H CF3 Cl H CH3SO2CH2CH2 4-225 C—CF3 C—H C—CF3 C—H H CF3 Cl HCH3SCH2CH(CH3) 4-226 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3S(O)CH2CH(CH3)4-227 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3SO2CH2CH(CH3) 4-228 C—CF3 C—HC—CF3 C—H H CF3 Cl H CH3SCH2C(CH3)2 4-229 C—CF3 C—H C—CF3 C—H H CF3 Cl HCH3S(O)CH2C(CH3)2 4-230 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3SO2CH2C(CH3)24-231 C—CF3 C—H C—CF3 C—H H CF3 Cl H (Methoxyimino)methyl 4-232 C—CF3C—H C—CF3 C—H H CF3 Cl H (Ethoxyimino)methyl 4-233 C—CF3 C—H C—CF3 C—H HCF3 Cl H 2-PyridylCH2 4-234 C—CF3 C—H C—CF3 C—H H CF3 Cl H[1-(1,3-thiazol-4-yl)]CH2 4-235 C—CF3 C—H C—CF3 C—H H CF3 Cl H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-236 C—CF3 C—H C—CF3 C—H H CF3 Cl H5-chloropyrimidin-2-yl 4-237 C—CF3 C—H C—CF3 C—H H CF3 Cl H5-bromopyrimidin-2-yl 4-238 C—CF3 C—H C—CF3 C—H H CF3 Cl H5-cyanopyrimidin-2-yl 4-239 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3NHC(O)CH24-240 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3CH2NHC(O)CH2 4-241 C—CF3 C—HC—CF3 C—H H CF3 Cl H iso-PrNHC(O)CH2 4-242 C—CF3 C—H C—CF3 C—H H CF3 ClH cyclo-PrNHC(O)CH2 4-243 C—CF3 C—H C—CF3 C—H H CF3 Cl H CF3CH2NHC(O)CH24-244 C—CF3 C—H C—CF3 C—H H CF3 Cl H CH3NHC(O)CH(CH3) 4-245 C—CF3 C—HC—CF3 C—H H CF3 Cl H CH3CH2NHC(O)CH(CH3) 4-246 C—CF3 C—H C—CF3 C—H H CF3Cl H iso-PrNHC(O)CH(CH3) 4-247 C—CF3 C—H C—CF3 C—H H CF3 Cl Hcyclo-PrNHC(O)CH(CH3) 4-248 C—CF3 C—H C—CF3 C—H H CF3 Cl HCF3CH2NHC(O)CH(CH3) 4-249 C—CF3 C—H C—CF3 C—H H CF3 Cl HCH3NHC(O)C(CH3)2 4-250 C—CF3 C—H C—CF3 C—H H CF3 Cl HCH3CH2NHC(O)C(CH3)2 4-251 C—CF3 C—H C—CF3 C—H H CF3 Cl Hiso-PrNHC(O)C(CH3)2 4-252 C—CF3 C—H C—CF3 C—H H CF3 Cl Hcyclo-PrNHC(O)C(CH3)2 4-253 C—CF3 C—H C—CF3 C—H H CF3 Cl HCF3CH2NHC(O)C(CH3)2 4-254 C—Cl C—H C—Cl C—H H CF3 Br H CF3CH2 4-255 C—ClC—H C—Cl C—H H CF3 Br H 2-PyridylCH2 4-256 C—Cl C—Cl C—Cl C—H H CF3 Br HCF3CH2 4-257 C—Cl C—Cl C—Cl C—H H CF3 Br H 2-PyridylCH2 4-258 C—Cl C—HC—CF3 C—H H CF3 Br H CF3CH2 4-259 C—Cl C—H C—CF3 C—H H CF3 Br H2-PyridylCH2 4-260 C—CF3 C—H C—CF3 C—H H CF3 Br H CF3CH2 4-261 C—CF3 C—HC—CF3 C—H H CF3 Br H 2-PyridylCH2 4-262 C—Cl C—H C—Cl C—H H CF3 I HCF3CH2 4-263 C—Cl C—H C—Cl C—H H CF3 I H 2-PyridylCH2 4-264 C—Cl C—ClC—Cl C—H H CF3 I H CF3CH2 4-265 C—Cl C—Cl C—Cl C—H H CF3 I H2-PyridylCH2 4-266 C—Cl C—H C—CF3 C—H H CF3 I H CF3CH2 4-267 C—Cl C—HC—CF3 C—H H CF3 I H 2-PyridylCH2 4-268 C—CF3 C—H C—CF3 C—H H CF3 I HCF3CH2 4-269 C—CF3 C—H C—CF3 C—H H CF3 I H 2-PyridylCH2 4-270 C—Cl C—HC—Cl C—H H CF3 CF3 H CH3OCH2 4-271 C—Cl C—H C—Cl C—H H CF3 CF3 CH3COCH3OCH2 4-272 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3CH2OCH2 4-273 C—Cl C—HC—Cl C—H H CF3 CF3 H CH3OCH2CH2 4-274 C—Cl C—H C—Cl C—H H CF3 CF3 HCH3CH2OCH2CH2 4-275 C—Cl C—H C—Cl C—H H CF3 CF3 H tetrahydrofuran-2-yl4-276 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3SCH2CH2 4-277 C—Cl C—H C—Cl C—H HCF3 CF3 H CH3S(O)CH2CH2 4-278 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3SO2CH2CH24-279 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-280 C—Cl C—H C—ClC—H H CF3 CF3 H CH3S(O)CH2CH(CH3) 4-281 C—Cl C—H C—Cl C—H H CF3 CF3 HCH3SO2CH2CH(CH3) 4-282 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3SCH2C(CH3)24-283 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-284 C—Cl C—HC—Cl C—H H CF3 CF3 H CH3SO2CH2C(CH3)2 4-285 C—Cl C—H C—Cl C—H H CF3 CF3H (Methoxyimino)methyl 4-286 C—Cl C—H C—Cl C—H H CF3 CF3 H(Ethoxyimino)methyl 4-287 C—Cl C—H C—Cl C—H H CF3 CF3 H[1-(1,3-thiazol-4-yl)]CH2 4-288 C—Cl C—H C—Cl C—H H CF3 CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-289 C—Cl C—H C—Cl C—H H CF3 CF3 H5-chloropyrimidin-2-yl 4-290 C—Cl C—H C—Cl C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-291 C—Cl C—H C—Cl C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-292 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3NHC(O)CH24-293 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-294 C—Cl C—H C—ClC—H H CF3 CF3 H iso-PrNHC(O)CH2 4-295 C—Cl C—H C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)CH2 4-296 C—Cl C—H C—Cl C—H H CF3 CF3 H CF3CH2NHC(O)CH24-297 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3NHC(O)CH(CH3) 4-298 C—Cl C—H C—ClC—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-299 C—Cl C—H C—Cl C—H H CF3 CF3 Hiso-PrNHC(O)CH(CH3) 4-300 C—Cl C—H C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)CH(CH3) 4-301 C—Cl C—H C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-302 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3NHC(O)C(CH3)24-303 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3CH2NHC(O)C(CH3)2 4-304 C—Cl C—HC—Cl C—H H CF3 CF3 H iso-PrNHC(O)C(CH3)2 4-305 C—Cl C—H C—Cl C—H H CF3CF3 H cyclo-PrNHC(O)C(CH3)2 4-306 C—Cl C—H C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-307 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3OCH2 4-308C—Cl C—Cl C—Cl C—H H CF3 CF3 CH3CO CH3OCH2 4-309 C—Cl C—Cl C—Cl C—H HCF3 CF3 H CH3CH2OCH2 4-310 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3OCH2CH24-311 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3CH2OCH2CH2 4-312 C—Cl C—Cl C—ClC—H H CF3 CF3 H tetrahydrofuran-2-yl 4-313 C—Cl C—Cl C—Cl C—H H CF3 CF3H CH3SCH2CH2 4-314 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3S(O)CH2CH2 4-315C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3SO2CH2CH2 4-316 C—Cl C—Cl C—Cl C—H HCF3 CF3 H CH3SCH2CH(CH3) 4-317 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCH3S(O)CH2CH(CH3) 4-318 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3SO2CH2CH(CH3)4-319 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-320 C—Cl C—Cl C—ClC—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-321 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCH3SO2CH2C(CH3)2 4-322 C—Cl C—Cl C—Cl C—H H CF3 CF3 H(Methoxyimino)methyl 4-323 C—Cl C—Cl C—Cl C—H H CF3 CF3 H(Ethoxyimino)methyl 4-324 C—Cl C—Cl C—Cl C—H H CF3 CF3 H[1-(1,3-thiazol-4-yl)]CH2 4-325 C—Cl C—Cl C—Cl C—H H CF3 CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-326 C—Cl C—Cl C—Cl C—H H CF3 CF3 H5-chloropyrimidin-2-yl 4-327 C—Cl C—Cl C—Cl C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-328 C—Cl C—Cl C—Cl C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-329 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3NHC(O)CH24-330 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-331 C—Cl C—ClC—Cl C—H H CF3 CF3 H iso-PrNHC(O)CH2 4-332 C—Cl C—Cl C—Cl C—H H CF3 CF3H cyclo-PrNHC(O)CH2 4-333 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CF3CH2NHC(O)CH24-334 C—Cl C—Cl C—Cl C—H H CF3 CF3 H CH3NHC(O)CH(CH3) 4-335 C—Cl C—ClC—Cl C—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-336 C—Cl C—Cl C—Cl C—H H CF3CF3 H iso-PrNHC(O)CH(CH3) 4-337 C—Cl C—Cl C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)CH(CH3) 4-338 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-339 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCH3NHC(O)C(CH3)2 4-340 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCH3CH2NHC(O)C(CH3)2 4-341 C—Cl C—Cl C—Cl C—H H CF3 CF3 Hiso-PrNHC(O)C(CH3)2 4-342 C—Cl C—Cl C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-343 C—Cl C—Cl C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-344 C—Cl C—H C—CF3 C—H H CF3 CF3 H CF3CH2 4-345C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3OCH2 4-346 C—Cl C—H C—CF3 C—H H CF3CF3 CH3CO CH3OCH2 4-347 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3CH2OCH2 4-348C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3OCH2CH2 4-349 C—Cl C—H C—CF3 C—H H CF3CF3 H CH3CH2OCH2CH2 4-350 C—Cl C—H C—CF3 C—H H CF3 CF3 Htetrahydrofuran-2-yl 4-351 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3SCH2CH24-352 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3S(O)CH2CH2 4-353 C—Cl C—H C—CF3C—H H CF3 CF3 H CH3SO2CH2CH2 4-354 C—Cl C—H C—CF3 C—H H CF3 CF3 HCH3SCH2CH(CH3) 4-355 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3S(O)CH2CH(CH3)4-356 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH(CH3) 4-357 C—Cl C—HC—CF3 C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-358 C—Cl C—H C—CF3 C—H H CF3 CF3H CH3S(O)CH2C(CH3)2 4-359 C—Cl C—H C—CF3 C—H H CF3 CF3 HCH3SO2CH2C(CH3)2 4-360 C—Cl C—H C—CF3 C—H H CF3 CF3 H(Methoxyimino)methyl 4-361 C—Cl C—H C—CF3 C—H H CF3 CF3 H(Ethoxyimino)methyl 4-362 C—Cl C—H C—CF3 C—H H CF3 CF3 H 2-PyridylCH24-363 C—Cl C—H C—CF3 C—H H CF3 CF3 H [1-(1,3-thiazol-4-yl)]CH2 4-364C—Cl C—H C—CF3 C—H H CF3 CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 4-365C—Cl C—H C—CF3 C—H H CF3 CF3 H 5-chloropyrimidin-2-yl 4-366 C—Cl C—HC—CF3 C—H H CF3 CF3 H 5-bromopyrimidin-2-yl 4-367 C—Cl C—H C—CF3 C—H HCF3 CF3 H 5-cyanopyrimidin-2-yl 4-368 C—Cl C—H C—CF3 C—H H CF3 CF3 HCH3NHC(O)CH2 4-369 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-370C—Cl C—H C—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH2 4-371 C—Cl C—H C—CF3 C—HH CF3 CF3 H cyclo-PrNHC(O)CH2 4-372 C—Cl C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH2 4-373 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH(CH3)4-374 C—Cl C—H C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-375 C—Cl C—HC—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH(CH3) 4-376 C—Cl C—H C—CF3 C—H H CF3CF3 H cyclo-PrNHC(O)CH(CH3) 4-377 C—Cl C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-378 C—Cl C—H C—CF3 C—H H CF3 CF3 HCH3NHC(O)C(CH3)2 4-379 C—Cl C—H C—CF3 C—H H CF3 CF3 HCH3CH2NHC(O)C(CH3)2 4-380 C—Cl C—H C—CF3 C—H H CF3 CF3 Hiso-PrNHC(O)C(CH3)2 4-381 C—Cl C—H C—CF3 C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-382 C—Cl C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-383 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3OCH2 4-384C—CF3 C—H C—CF3 C—H H CF3 CF3 CH3CO CH3OCH2 4-385 C—CF3 C—H C—CF3 C—H HCF3 CF3 H CH3CH2OCH2 4-386 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3OCH2CH24-387 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3CH2OCH2CH2 4-388 C—CF3 C—HC—CF3 C—H H CF3 CF3 H tetrahydrofuran-2-yl 4-389 C—CF3 C—H C—CF3 C—H HCF3 CF3 H CH3SCH2CH2 4-390 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3S(O)CH2CH24-391 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH2 4-392 C—CF3 C—H C—CF3C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-393 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCH3S(O)CH2CH(CH3) 4-394 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH(CH3)4-395 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-396 C—CF3 C—HC—CF3 C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-397 C—CF3 C—H C—CF3 C—H H CF3CF3 H CH3SO2CH2C(CH3)2 4-398 C—CF3 C—H C—CF3 C—H H CF3 CF3 H(Methoxyimino)methyl 4-399 C—CF3 C—H C—CF3 C—H H CF3 CF3 H(Ethoxyimino)methyl 4-400 C—CF3 C—H C—CF3 C—H H CF3 CF3 H[1-(1,3-thiazol-4-yl)]CH2 4-401 C—CF3 C—H C—CF3 C—H H CF3 CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-402 C—CF3 C—H C—CF3 C—H H CF3 CF3 H5-chloropyrimidin-2-yl 4-403 C—CF3 C—H C—CF3 C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-404 C—CF3 C—H C—CF3 C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-405 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH24-406 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-407 C—CF3 C—HC—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH2 4-408 C—CF3 C—H C—CF3 C—H H CF3CF3 H cyclo-PrNHC(O)CH2 4-409 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH2 4-410 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH(CH3)4-411 C—CF3 C—H C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-412 C—CF3C—H C—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH(CH3) 4-413 C—CF3 C—H C—CF3 C—HH CF3 CF3 H cyclo-PrNHC(O)CH(CH3) 4-414 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-415 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCH3NHC(O)C(CH3)2 4-416 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCH3CH2NHC(O)C(CH3)2 4-417 C—CF3 C—H C—CF3 C—H H CF3 CF3 Hiso-PrNHC(O)C(CH3)2 4-418 C—CF3 C—H C—CF3 C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-419 C—CF3 C—H C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-420 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3OCH2 4-421C—Cl C—Cl C—CF3 C—H H CF3 CF3 CH3CO CH3OCH2 4-422 C—Cl C—Cl C—CF3 C—H HCF3 CF3 H CH3CH2OCH2 4-423 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3OCH2CH24-424 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3CH2OCH2CH2 4-425 C—Cl C—ClC—CF3 C—H H CF3 CF3 H tetrahydrofuran-2-yl 4-426 C—Cl C—Cl C—CF3 C—H HCF3 CF3 H CH3SCH2CH2 4-427 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3S(O)CH2CH24-428 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH2 4-429 C—Cl C—Cl C—CF3C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-430 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCH3S(O)CH2CH(CH3) 4-431 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH(CH3)4-432 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-433 C—Cl C—ClC—CF3 C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-434 C—Cl C—Cl C—CF3 C—H H CF3CF3 H CH3SO2CH2C(CH3)2 4-435 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H(Methoxyimino)methyl 4-436 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H(Ethoxyimino)methyl 4-437 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H[1-(1,3-thiazol-4-yl)]CH2 4-438 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H[1-(1-methyl-1H-pyrazol-5-yl]CH2 4-439 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H5-chloropyrimidin-2-yl 4-440 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-441 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-442 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH24-443 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-444 C—Cl C—ClC—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH2 4-445 C—Cl C—Cl C—CF3 C—H H CF3CF3 H cyclo-PrNHC(O)CH2 4-446 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH2 4-447 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH(CH3)4-448 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-449 C—ClC—Cl C—CF3 C—H H CF3 CF3 H iso-PrNHC(O)CH(CH3) 4-450 C—Cl C—Cl C—CF3 C—HH CF3 CF3 H cyclo-PrNHC(O)CH(CH3) 4-451 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-452 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCH3NHC(O)C(CH3)2 4-453 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCH3CH2NHC(O)C(CH3)2 4-454 C—Cl C—Cl C—CF3 C—H H CF3 CF3 Hiso-PrNHC(O)C(CH3)2 4-455 C—Cl C—Cl C—CF3 C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-456 C—Cl C—Cl C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-457 C—Cl N C—Cl C—H H CF3 CF3 H CF3CH2 4-458 C—ClN C—Cl C—H H CF3 CF3 H CH3OCH2 4-459 C—Cl N C—Cl C—H H CF3 CF3 CH3COCH3OCH2 4-460 C—Cl N C—Cl C—H H CF3 CF3 H CH3CH2OCH2 4-461 C—Cl N C—ClC—H H CF3 CF3 H CH3OCH2CH2 4-462 C—Cl N C—Cl C—H H CF3 CF3 HCH3CH2OCH2CH2 4-463 C—Cl N C—Cl C—H H CF3 CF3 H tetrahydrofuran-2-yl4-464 C—Cl N C—Cl C—H H CF3 CF3 H CH3SCH2CH2 4-465 C—Cl N C—Cl C—H H CF3CF3 H CH3S(O)CH2CH2 4-466 C—Cl N C—Cl C—H H CF3 CF3 H CH3SO2CH2CH2 4-467C—Cl N C—Cl C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-468 C—Cl N C—Cl C—H H CF3CF3 H CH3S(O)CH2CH(CH3) 4-469 C—Cl N C—Cl C—H H CF3 CF3 HCH3SO2CH2CH(CH3) 4-470 C—Cl N C—Cl C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-471C—Cl N C—Cl C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-472 C—Cl N C—Cl C—H HCF3 CF3 H CH3SO2CH2C(CH3)2 4-473 C—Cl N C—Cl C—H H CF3 CF3 H(Methoxyimino)methyl 4-474 C—Cl N C—Cl C—H H CF3 CF3 H(Ethoxyimino)methyl 4-475 C—Cl N C—Cl C—H H CF3 CF3 H 2-PyridylCH2 4-476C—Cl N C—Cl C—H H CF3 CF3 H [1-(1,3-thiazol-4-yl)]CH2 4-477 C—Cl N C—ClC—H H CF3 CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 4-478 C—Cl N C—Cl C—H HCF3 CF3 H 5-chloropyrimidin-2-yl 4-479 C—Cl N C—Cl C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-480 C—Cl N C—Cl C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-481 C—Cl N C—Cl C—H H CF3 CF3 H CH3NHC(O)CH24-482 C—Cl N C—Cl C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-483 C—Cl N C—Cl C—HH CF3 CF3 H iso-PrNHC(O)CH2 4-484 C—Cl N C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)CH2 4-485 C—Cl N C—Cl C—H H CF3 CF3 H CF3CH2NHC(O)CH24-486 C—Cl N C—Cl C—H H CF3 CF3 H CH3NHC(O)CH(CH3) 4-487 C—Cl N C—Cl C—HH CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-488 C—Cl N C—Cl C—H H CF3 CF3 Hiso-PrNHC(O)CH(CH3) 4-489 C—Cl N C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)CH(CH3) 4-490 C—Cl N C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-491 C—Cl N C—Cl C—H H CF3 CF3 H CH3NHC(O)C(CH3)24-492 C—Cl N C—Cl C—H H CF3 CF3 H CH3CH2NHC(O)C(CH3)2 4-493 C—Cl N C—ClC—H H CF3 CF3 H iso-PrNHC(O)C(CH3)2 4-494 C—Cl N C—Cl C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-495 C—Cl N C—Cl C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-496 C—CF3 N C—H C—H H CF3 CF3 H CF3CH2 4-497 C—CF3N C—H C—H H CF3 CF3 H CH3OCH2 4-498 C—CF3 N C—H C—H H CF3 CF3 CH3COCH3OCH2 4-499 C—CF3 N C—H C—H H CF3 CF3 H CH3CH2OCH2 4-500 C—CF3 N C—HC—H H CF3 CF3 H CH3OCH2CH2 4-501 C—CF3 N C—H C—H H CF3 CF3 HCH3CH2OCH2CH2 4-502 C—CF3 N C—H C—H H CF3 CF3 H tetrahydrofuran-2-yl4-503 C—CF3 N C—H C—H H CF3 CF3 H CH3SCH2CH2 4-504 C—CF3 N C—H C—H H CF3CF3 H CH3S(O)CH2CH2 4-505 C—CF3 N C—H C—H H CF3 CF3 H CH3SO2CH2CH2 4-506C—CF3 N C—H C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-507 C—CF3 N C—H C—H H CF3CF3 H CH3S(O)CH2CH(CH3) 4-508 C—CF3 N C—H C—H H CF3 CF3 HCH3SO2CH2CH(CH3) 4-509 C—CF3 N C—H C—H H CF3 CF3 H CH3SCH2C(CH3)2 4-510C—CF3 N C—H C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-511 C—CF3 N C—H C—H HCF3 CF3 H CH3SO2CH2C(CH3)2 4-512 C—CF3 N C—H C—H H CF3 CF3 H(Methoxyimino)methyl 4-513 C—CF3 N C—H C—H H CF3 CF3 H(Ethoxyimino)methyl 4-514 C—CF3 N C—H C—H H CF3 CF3 H 2-PyridylCH2 4-515C—CF3 N C—H C—H H CF3 CF3 H [1-(1,3-thiazol-4-yl)]CH2 4-516 C—CF3 N C—HC—H H CF3 CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 4-517 C—CF3 N C—H C—H HCF3 CF3 H 5-chloropyrimidin-2-yl 4-518 C—CF3 N C—H C—H H CF3 CF3 H5-bromopyrimidin-2-yl 4-519 C—CF3 N C—H C—H H CF3 CF3 H5-cyanopyrimidin-2-yl 4-520 C—CF3 N C—H C—H H CF3 CF3 H CH3NHC(O)CH24-521 C—CF3 N C—H C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-522 C—CF3 N C—H C—HH CF3 CF3 H iso-PrNHC(O)CH2 4-523 C—CF3 N C—H C—H H CF3 CF3 Hcyclo-PrNHC(O)CH2 4-524 C—CF3 N C—H C—H H CF3 CF3 H CF3CH2NHC(O)CH24-525 C—CF3 N C—H C—H H CF3 CF3 H CH3NHC(O)CH(CH3) 4-526 C—CF3 N C—H C—HH CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-527 C—CF3 N C—H C—H H CF3 CF3 Hiso-PrNHC(O)CH(CH3) 4-528 C—CF3 N C—H C—H H CF3 CF3 Hcyclo-PrNHC(O)CH(CH3) 4-529 C—CF3 N C—H C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-530 C—CF3 N C—H C—H H CF3 CF3 H CH3NHC(O)C(CH3)24-531 C—CF3 N C—H C—H H CF3 CF3 H CH3CH2NHC(O)C(CH3)2 4-532 C—CF3 N C—HC—H H CF3 CF3 H iso-PrNHC(O)C(CH3)2 4-533 C—CF3 N C—H C—H H CF3 CF3 Hcyclo-PrNHC(O)C(CH3)2 4-534 C—CF3 N C—H C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-535 C—CF3 N C—CF3 C—H H CF3 CF3 H CF3CH2 4-536C—CF3 N C—CF3 C—H H CF3 CF3 H CH3OCH2 4-537 C—CF3 N C—CF3 C—H H CF3 CF3CH3CO CH3OCH2 4-538 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3CH2OCH2 4-539 C—CF3N C—CF3 C—H H CF3 CF3 H CH3OCH2CH2 4-540 C—CF3 N C—CF3 C—H H CF3 CF3 HCH3CH2OCH2CH2 4-541 C—CF3 N C—CF3 C—H H CF3 CF3 H tetrahydrofuran-2-yl4-542 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3SCH2CH2 4-543 C—CF3 N C—CF3 C—H HCF3 CF3 H CH3S(O)CH2CH2 4-544 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3SO2CH2CH24-545 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3SCH2CH(CH3) 4-546 C—CF3 N C—CF3C—H H CF3 CF3 H CH3S(O)CH2CH(CH3) 4-547 C—CF3 N C—CF3 C—H H CF3 CF3 HCH3SO2CH2CH(CH3) 4-548 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3SCH2C(CH3)24-549 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-550 C—CF3 NC—CF3 C—H H CF3 CF3 H CH3SO2CH2C(CH3)2 4-551 C—CF3 N C—CF3 C—H H CF3 CF3H (Methoxyimino)methyl 4-552 C—CF3 N C—CF3 C—H H CF3 CF3 H(Ethoxyimino)methyl 4-553 C—CF3 N C—CF3 C—H H CF3 CF3 H 2-PyridylCH24-554 C—CF3 N C—CF3 C—H H CF3 CF3 H [1-(1,3-thiazol-4-yl)]CH2 4-555C—CF3 N C—CF3 C—H H CF3 CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 4-556C—CF3 N C—CF3 C—H H CF3 CF3 H 5-chloropyrimidin-2-yl 4-557 C—CF3 N C—CF3C—H H CF3 CF3 H 5-bromopyrimidin-2-yl 4-558 C—CF3 N C—CF3 C—H H CF3 CF3H 5-cyanopyrimidin-2-yl 4-559 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH24-560 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)CH2 4-561 C—CF3 N C—CF3C—H H CF3 CF3 H iso-PrNHC(O)CH2 4-562 C—CF3 N C—CF3 C—H H CF3 CF3 Hcyclo-PrNHC(O)CH2 4-563 C—CF3 N C—CF3 C—H H CF3 CF3 H CF3CH2NHC(O)CH24-564 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3NHC(O)CH(CH3) 4-565 C—CF3 N C—CF3C—H H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-566 C—CF3 N C—CF3 C—H H CF3 CF3 Hiso-PrNHC(O)CH(CH3) 4-567 C—CF3 N C—CF3 C—H H CF3 CF3 Hcyclo-PrNHC(O)CH(CH3) 4-568 C—CF3 N C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-569 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3NHC(O)C(CH3)24-570 C—CF3 N C—CF3 C—H H CF3 CF3 H CH3CH2NHC(O)C(CH3)2 4-571 C—CF3 NC—CF3 C—H H CF3 CF3 H iso-PrNHC(O)C(CH3)2 4-572 C—CF3 N C—CF3 C—H H CF3CF3 H cyclo-PrNHC(O)C(CH3)2 4-573 C—CF3 N C—CF3 C—H H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-574 C—CF3 C—H C—CF3 N H CF3 CF3 H CF3CH2 4-575C—CF3 C—H C—CF3 N H CF3 CF3 H CH3OCH2 4-576 C—CF3 C—H C—CF3 N H CF3 CF3CH3CO CH3OCH2 4-577 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3CH2OCH2 4-578 C—CF3C—H C—CF3 N H CF3 CF3 H CH3OCH2CH2 4-579 C—CF3 C—H C—CF3 N H CF3 CF3 HCH3CH2OCH2CH2 4-580 C—CF3 C—H C—CF3 N H CF3 CF3 H tetrahydrofuran-2-yl4-581 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3SCH2CH2 4-582 C—CF3 C—H C—CF3 N HCF3 CF3 H CH3S(O)CH2CH2 4-583 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3SO2CH2CH24-584 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3SCH2CH(CH3) 4-585 C—CF3 C—H C—CF3N H CF3 CF3 H CH3S(O)CH2CH(CH3) 4-586 C—CF3 C—H C—CF3 N H CF3 CF3 HCH3SO2CH2CH(CH3) 4-587 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3SCH2C(CH3)24-588 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3S(O)CH2C(CH3)2 4-589 C—CF3 C—HC—CF3 N H CF3 CF3 H CH3SO2CH2C(CH3)2 4-590 C—CF3 C—H C—CF3 N H CF3 CF3 H(Methoxyimino)methyl 4-591 C—CF3 C—H C—CF3 N H CF3 CF3 H(Ethoxyimino)methyl 4-592 C—CF3 C—H C—CF3 N H CF3 CF3 H 2-PyridylCH24-593 C—CF3 C—H C—CF3 N H CF3 CF3 H [1-(1,3-thiazol-4-yl)]CH2 4-594C—CF3 C—H C—CF3 N H CF3 CF3 H [1-(1-methyl-1H-pyrazol-5-yl]CH2 4-595C—CF3 C—H C—CF3 N H CF3 CF3 H 5-chloropyrimidin-2-yl 4-596 C—CF3 C—HC—CF3 N H CF3 CF3 H 5-bromopyrimidin-2-yl 4-597 C—CF3 C—H C—CF3 N H CF3CF3 H 5-cyanopyrimidin-2-yl 4-598 C—CF3 C—H C—CF3 N H CF3 CF3 HCH3NHC(O)CH2 4-599 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3CH2NHC(O)CH2 4-600C—CF3 C—H C—CF3 N H CF3 CF3 H iso-PrNHC(O)CH2 4-601 C—CF3 C—H C—CF3 N HCF3 CF3 H cyclo-PrNHC(O)CH2 4-602 C—CF3 C—H C—CF3 N H CF3 CF3 HCF3CH2NHC(O)CH2 4-603 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3NHC(O)CH(CH3)4-604 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3CH2NHC(O)CH(CH3) 4-605 C—CF3 C—HC—CF3 N H CF3 CF3 H iso-PrNHC(O)CH(CH3) 4-606 C—CF3 C—H C—CF3 N H CF3CF3 H cyclo-PrNHC(O)CH(CH3) 4-607 C—CF3 C—H C—CF3 N H CF3 CF3 HCF3CH2NHC(O)CH(CH3) 4-608 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3NHC(O)C(CH3)24-609 C—CF3 C—H C—CF3 N H CF3 CF3 H CH3CH2NHC(O)C(CH3)2 4-610 C—CF3 C—HC—CF3 N H CF3 CF3 H iso-PrNHC(O)C(CH3)2 4-611 C—CF3 C—H C—CF3 N H CF3CF3 H cyclo-PrNHC(O)C(CH3)2 4-612 C—CF3 C—H C—CF3 N H CF3 CF3 HCF3CH2NHC(O)C(CH3)2 4-613 C—Cl C—H C—Cl C—H H CF3 CF3 H(pyrimidin-2-yl)CH2 4-614 C—Cl C—H C—Cl C—H H CF3 CF3 H(pyridin-2-yl)CH2NHC(O)CH2 4-615 C—Cl C—H C—Cl C—H H CF3 CF3 HClCH2CH2NHC(O)CH2 4-616 C—Cl C—H C—Cl C—H H CF3 CF3 H CH3OCO 4-617 C—ClC—H C—Cl C—H H CF3 CF3 (dimethylamino)methylene prop-2-yn-1-yl 4-618C—Cl C—H C—Cl C—H H CF3 CF3 H

TABLE 5

Ex.-No. B¹ B² B³ B⁴ X¹ R Y R³ R⁴ R⁵ R⁶ 1 5-1 C—Cl C—H C—Cl C—H H CF3 CF3H H H H 1 5-2 C—Cl C—H C—Cl C—H H CF3 CF3 H H H HCO 1 5-3 C—Cl C—H C—ClC—H H CF3 CF3 H H H CH3CO 1 5-4 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3CH2CO 1 5-5 C—Cl C—H C—Cl C—H H CF3 CF3 H H H n-PrCO 1 5-6 C—Cl C—HC—Cl C—H H CF3 CF3 H H H iso-PrCO 1 5-7 C—Cl C—H C—Cl C—H H CF3 CF3 H HH cyclo-PrCO 1 5-8 C—Cl C—H C—Cl C—H H CF3 CF3 H H H n-BuCO 1 5-9 C—ClC—H C—Cl C—H H CF3 CF3 H H H tert-BuCO 1 5-10 C—Cl C—H C—Cl C—H H CF3CF3 H H H iso-BuCO 1 5-11 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-BuCO 15-12 C—Cl C—H C—Cl C—H H CF3 CF3 H H H (CH3)3CCH2CO 1 5-13 C—Cl C—H C—ClC—H H CF3 CF3 H H H cyclo-PenCO 1 5-14 C—Cl C—H C—Cl C—H H CF3 CF3 H H Hcyclo-HexCO 1 5-15 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-PrCH2CO 15-16 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3CO 1 5-17 C—Cl C—H C—Cl C—H HCF3 CF3 H H H CCl3CO 1 5-18 C—Cl C—H C—Cl C—H H CF3 CF3 H H H ClCH2CO 15-19 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF2ClCO 1 5-20 C—Cl C—H C—Cl C—HH CF3 CF3 H H H ClCH2CH2CO 1 5-21 C—Cl C—H C—Cl C—H H CF3 CF3 H H HHCF2CF2CO 1 5-22 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3CH2CO 1 5-23 C—ClC—H C—Cl C—H H CF3 CF3 H H H (CF3)2CHCO 1 5-24 C—Cl C—H C—Cl C—H H CF3CF3 H H H HCF2CO 1 5-25 C—Cl C—H C—Cl C—H H CF3 CF3 H H H ClCH2CO 1 5-26C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-27 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-28 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-29 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-30 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-31 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-32 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH2═CH—CO 1 5-33 C—Cl C—H C—ClC—H H CF3 CF3 H H H CH3CH═CH—CO 1 5-34 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH2═C(CH3)—CO 1 5-35 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH═C(CH3)—CO 15-36 C—Cl C—H C—Cl C—H H CF3 CF3 H H H (CH3)2C═CH—CO 1 5-37 C—Cl C—HC—Cl C—H H CF3 CF3 H H H CH2═C(Cl)—CO 1 5-38 C—Cl C—H C—Cl C—H H CF3 CF3H H H ClCH═C(CH3)—CO 1 5-39 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH2═CHCH2—CO 1 5-40 C—Cl C—H C—Cl C—H H CF3 CF3 H H H HCC—CO 1 5-41 C—ClC—H C—Cl C—H H CF3 CF3 H H H CH3CC—CO 1 5-42 C—Cl C—H C—Cl C—H H CF3 CF3H H H NCCH2—CO 1 5-43 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3OCH2CO 1 5-44C—Cl C—H C—Cl C—H H CF3 CF3 H H H C2H5OCH2—CO 1 5-45 C—Cl C—H C—Cl C—H HCF3 CF3 H H H CH3SCH2CO 1 5-46 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3O(CO)CH2—CO 1 5-47 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3(CO)OCH2—CO 15-48 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3O(CO)—CO 1 5-49 C—Cl C—H C—ClC—H H CF3 CF3 H H H CF3O(CO)—CO 1 5-50 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3(CO)CH2—CO 1 5-51 C—Cl C—H C—Cl C—H H CF3 CF3 H H H (CH3)2NCH2—CO 15-52 C—Cl C—H C—Cl C—H H CF3 CF3 H H H PhCO 1 5-53 C—Cl C—H C—Cl C—H HCF3 CF3 H H H PhCH2CO 1 5-54 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-py-CO 15-55 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 3-py-CO 1 5-56 C—Cl C—H C—Cl C—HH CF3 CF3 H H H 4-py-CO 1 5-57 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-58 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-F—PhCO 1 5-59 C—Cl C—H C—ClC—H H CF3 CF3 H H H 3-F—PhCO 1 5-60 C—Cl C—H C—Cl C—H H CF3 CF3 H H H4-F—PhCO 1 5-61 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-Cl—PhCO 1 5-62 C—ClC—H C—Cl C—H H CF3 CF3 H H H 3-Cl—PhCO 1 5-63 C—Cl C—H C—Cl C—H H CF3CF3 H H H 4-Cl—PhCO 1 5-64 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-Br—PhCO 15-65 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-CF3—PhCO 1 5-66 C—Cl C—H C—ClC—H H CF3 CF3 H H H 2-CH3—PhCO 1 5-67 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-68 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-69 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-70 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-71 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-72 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-73 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-74 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-75 C—Cl C—H C—Cl C—H H CF3 CF3 H H CH3 CH3CO 1 5-76 C—Cl C—H C—ClC—H H CF3 CF3 H H CH3 cyclo-PrCO 1 5-77 C—Cl C—H C—Cl C—H H CF3 CF3 H HH CH3NHCO 1 5-78 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH2NHCO 1 5-79C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3CH2NHCO 1 5-80 C—Cl C—H C—Cl C—H HCF3 CF3 H H H n-PrNHCO 1 5-81 C—Cl C—H C—Cl C—H H CF3 CF3 H H Hiso-PrNHCO 1 5-82 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-PrNHCO 1 5-83C—Cl C—H C—Cl C—H H CF3 CF3 H H H n-BuNHCO 1 5-84 C—Cl C—H C—Cl C—H HCF3 CF3 H H H tert-BuNHCO 1 5-85 C—Cl C—H C—Cl C—H H CF3 CF3 H H Hcyclo-BuNHCO 1 5-86 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-PenNHCO 15-87 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-HexNHCO 1 5-88 C—Cl C—HC—Cl C—H H CF3 CF3 H H H CH2═CHCH2NHCO 1 5-89 C—Cl C—H C—Cl C—H H CF3CF3 H H H HCCCH2NHCO 1 5-90 C—Cl C—H C—Cl C—H H CF3 CF3 H H Hcyclo-PrCH2NHCO 1 5-91 C—Cl C—H C—Cl C—H H CF3 CF3 H H H NCCH2NHCO 15-92 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3(CH3)CHNHCO 1 5-93 C—Cl C—HC—Cl C—H H CF3 CF3 H H H CF3(CH3)2CNCO 1 5-95 C—Cl C—H C—Cl C—H H CF3CF3 H H H FCH2CH2NHCO 1 5-96 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCF3CH2CH2NHCO 1 5-97 C—Cl C—H C—Cl C—H H CF3 CF3 H H H HCF2CF2CH2NHCO 15-98 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-99 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-100 C—Cl C—H C—Cl C—H H CF3 CF3 H H H EtO2CCH2NHCO 1 5-101 C—Cl C—HC—Cl C—H H CF3 CF3 H H H 2-CF3—PhNHCO 1 5-102 C—Cl C—H C—Cl C—H H CF3CF3 H H H 3-CF3—PhNHCO 1 5-103 C—Cl C—H C—Cl C—H H CF3 CF3 H H H4-CF3—PhNHCO 1 5-104 C—Cl C—H C—Cl C—H H CF3 CF3 H H H 2-py-NHCO 1 5-105C—Cl C—H C—Cl C—H H CF3 CF3 H H H 3-py-NHCO 1 5-106 C—Cl C—H C—Cl C—H HCF3 CF3 H H H 4-py-NHCO 1 5-107 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-108 C—Cl C—H C—Cl C—H H CF3 CF3 H H H

1 5-109 C—Cl C—H C—Cl C—H H CF3 CF3 H H H PhCH2HNCO 1 5-110 C—Cl C—HC—Cl C—H H CF3 CF3 H H H

1 5-111 C—Cl C—H C—Cl C—H H CF3 CF3 H H H (CH3)2NCO 1 5-112 C—Cl C—HC—Cl C—H H CF3 CF3 H H CH3 CH3NHCO 1 5-113 C—Cl C—H C—Cl C—H H CF3 CF3 HH CH3 CH3CH2NHCO 1 5-114 C—Cl C—H C—Cl C—H H CF3 CF3 H H CH3cyclo-PrNHCO 1 5-115 C—Cl C—H C—Cl C—H H CF3 CF3 H H H pyrrolidineCO 15-116 C—Cl C—H C—Cl C—H H CF3 CF3 H H H piperidineCO 1 5-117 C—Cl C—HC—Cl C—H H CF3 CF3 H H H morpholineCO 1 5-118 C—Cl C—H C—Cl C—H H CF3CF3 H H H CH3OCO 1 5-119 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH2OCO 15-120 C—Cl C—H C—Cl C—H H CF3 CF3 H H H n-PrOCO 1 5-121 C—Cl C—H C—ClC—H H CF3 CF3 H H H cyclo-PrOCO 1 5-122 C—Cl C—H C—Cl C—H H CF3 CF3 H HH CF3CH2OCO 1 5-123 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH2═CHCH2OCO 15-124 C—Cl C—H C—Cl C—H H CF3 CF3 H H H HCCCH2OCO 1 5-125 C—Cl C—H C—ClC—H H CF3 CF3 H H H PhOCO 1 5-126 C—Cl C—H C—Cl C—H H CF3 CF3 H H HPhCH2OCO 1 5-127 C—Cl C—H C—Cl C—H H CF3 CF3 H H H tert-BuOCO 1 5-128C—Cl C—H C—Cl C—H H CF3 CF3 H H CH3 tert-BuOCO 1 5-129 C—Cl C—H C—Cl C—HH CF3 CF3 H H H CH3SO2 1 5-130 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3CH2SO2 1 5-131 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3SO2 1 5-132 C—ClC—H C—Cl C—H H CF3 CF3 H H H CF3CH2SO2 1 5-133 C—Cl C—H C—Cl C—H H CF3CF3 H H H PhSO2 1 5-134 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3NHCONHSO2 15-135 C—Cl C—H C—Cl C—H H CF3 CF3 H H H (CH3)2NCONHSO2 1 5-136 C—Cl C—HC—Cl C—H H CF3 CF3 H H H CH3CS 1 5-137 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3CH2CS 1 5-138 C—Cl C—H C—Cl C—H H CF3 CF3 H H H cyclo-PrCS 1 5-139C—Cl C—H C—Cl C—H H CF3 CF3 H H H CF3CH2CS 1 5-140 C—Cl C—H C—Cl C—H HCF3 CF3 H H H H 1 5-141 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CO 1 5-142C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH2CO 1 5-143 C—Cl C—H C—Cl C—H HCF3 CF3 H H H cyclo-PrCO 1 5-144 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCF3CH2CO 1 5-145 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH2NHCO 1 5-146C—CF3 C—H C—CF3 C—H H CF3 CF3 H H H H 1 5-147 C—CF3 C—H C—CF3 C—H H CF3CF3 H H H CH3CO 1 5-148 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H H CH3CH2CO 15-149 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H H cyclo-PrCO 1 5-150 C—CF3 C—HC—CF3 C—H H CF3 CF3 H H H CF3CH2CO 1 5-151 C—CF3 C—H C—CF3 C—H H CF3 CF3H H H CH3CH2NHCO 1 5-152 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H H H CH3CO 15-153 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H H H CH3CH2CO 1 5-154 C—Cl C—ClC—CF3 C—H H CF3 CF3 H H H cyclo-PrCO 1 5-155 C—Cl C—Cl C—CF3 C—H H CF3CF3 H H H CF3CH2CO 1 5-156 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H H HCH3CH2NHCO 1 5-157 C—Br C—H C—Br C—H H CF3 CF3 H H H CH3CO 1 5-158 C—BrC—H C—Br C—H H CF3 CF3 H H H CH3CH2CO 1 5-159 C—Br C—H C—Br C—H H CF3CF3 H H H cyclo-PrCO 1 5-160 C—Br C—H C—Br C—H H CF3 CF3 H H H CF3CH2CO1 5-161 C—Br C—H C—Br C—H H CF3 CF3 H H H CH3CH2NHCO 1 5-162 C—Cl C—HC—Cl C—H H CF3 H H H H CH3CO 1 5-163 C—Cl C—H C—Cl C—H H CF3 H H H HCH3CH2CO 1 5-164 C—Cl C—H C—Cl C—H H CF3 H H H H cyclo-PrCO 1 5-165 C—ClC—H C—Cl C—H H CF3 H H H H CF3CH2CO 1 5-166 C—Cl C—H C—Cl C—H H CF3 H HH H CH3CH2NHCO 1 5-167 C—Cl C—Cl C—Cl C—H H CF3 H H H H CH3CO 1 5-168C—Cl C—Cl C—Cl C—H H CF3 H H H H CH3CH2CO 1 5-169 C—Cl C—Cl C—Cl C—H HCF3 H H H H cyclo-PrCO 1 5-170 C—Cl C—Cl C—Cl C—H H CF3 H H H H CF3CH2CO1 5-171 C—Cl C—Cl C—Cl C—H H CF3 H H H H CH3CH2NHCO 1 5-172 C—CF3 C—HC—CF3 C—H H CF3 H H H H CH3CO 1 5-173 C—CF3 C—H C—CF3 C—H H CF3 H H H HCH3CH2CO 1 5-174 C—CF3 C—H C—CF3 C—H H CF3 H H H H cyclo-PrCO 1 5-175C—CF3 C—H C—CF3 C—H H CF3 H H H H CF3CH2CO 1 5-176 C—CF3 C—H C—CF3 C—H HCF3 H H H H CH3CH2NHCO 1 5-177 C—Cl C—H C—Cl C—H H CF3 CH3 H H H CH3CO 15-178 C—Cl C—H C—Cl C—H H CF3 CH3 H H H CH3CH2CO 1 5-179 C—Cl C—H C—ClC—H H CF3 CH3 H H H cyclo-PrCO 1 5-180 C—Cl C—H C—Cl C—H H CF3 CH3 H H HCF3CH2CO 1 5-181 C—Cl C—H C—Cl C—H H CF3 CH3 H H H CH3CH2NHCO 1 5-182C—Cl C—Cl C—Cl C—H H CF3 CH3 H H H CH3CO 1 5-183 C—Cl C—Cl C—Cl C—H HCF3 CH3 H H H CH3CH2CO 1 5-184 C—Cl C—Cl C—Cl C—H H CF3 CH3 H H Hcyclo-PrCO 1 5-185 C—Cl C—Cl C—Cl C—H H CF3 CH3 H H H CF3CH2CO 1 5-186C—Cl C—Cl C—Cl C—H H CF3 CH3 H H H CH3CH2NHCO 1 5-187 C—CF3 C—H C—CF3C—H H CF3 CH3 H H H CH3CO 1 5-188 C—CF3 C—H C—CF3 C—H H CF3 CH3 H H HCH3CH2CO 1 5-189 C—CF3 C—H C—CF3 C—H H CF3 CH3 H H H cyclo-PrCO 1 5-190C—CF3 C—H C—CF3 C—H H CF3 CH3 H H H CF3CH2CO 1 5-191 C—CF3 C—H C—CF3 C—HH CF3 CH3 H H H CH3CH2NHCO 1 5-192 C—Cl C—H C—Cl C—H H CF3 Cl H H HCH3CO 1 5-193 C—Cl C—H C—Cl C—H H CF3 Cl H H H CH3CH2CO 1 5-194 C—Cl C—HC—Cl C—H H CF3 Cl H H H cyclo-PrCO 1 5-195 C—Cl C—H C—Cl C—H H CF3 Cl HH H CF3CH2CO 1 5-196 C—Cl C—H C—Cl C—H H CF3 Cl H H H CH3CH2NHCO 1 5-197C—Cl C—Cl C—Cl C—H H CF3 Cl H H H CH3CO 1 5-198 C—Cl C—Cl C—Cl C—H H CF3Cl H H H CH3CH2CO 1 5-199 C—Cl C—Cl C—Cl C—H H CF3 Cl H H H cyclo-PrCO 15-200 C—Cl C—Cl C—Cl C—H H CF3 Cl H H H CF3CH2CO 1 5-201 C—Cl C—Cl C—ClC—H H CF3 Cl H H H CH3CH2NHCO 1 5-202 C—CF3 C—H C—CF3 C—H H CF3 Cl H H HCH3CO 1 5-203 C—CF3 C—H C—CF3 C—H H CF3 Cl H H H CH3CH2CO 1 5-204 C—CF3C—H C—CF3 C—H H CF3 Cl H H H cyclo-PrCO 1 5-205 C—CF3 C—H C—CF3 C—H HCF3 Cl H H H CF3CH2CO 1 5-206 C—CF3 C—H C—CF3 C—H H CF3 Cl H H HCH3CH2NHCO 1 5-207 C—Cl C—H C—Cl C—H H CF3 H H H H n-PrCO 1 5-208 C—ClC—H C—Cl C—H H CF3 H H H H cyclo-PrCH2CO 1 5-209 C—Cl C—H C—Cl C—H H CF3H H H H CH3SCH2CO 1 5-210 C—Cl C—H C—Cl C—H H CF3 H H H H CH3S(O)CH2CO 15-211 C—Cl C—H C—Cl C—H H CF3 H H H H CH3SO2CH2CO 1 5-212 C—Cl C—Cl C—ClC—H H CF3 H H H H n-PrCO 1 5-213 C—Cl C—Cl C—Cl C—H H CF3 H H H Hcyclo-PrCH2CO 1 5-214 C—Cl C—Cl C—Cl C—H H CF3 H H H H CH3SCH2CO 1 5-215C—Cl C—Cl C—Cl C—H H CF3 H H H H CH3S(O)CH2CO 1 5-216 C—Cl C—Cl C—Cl C—HH CF3 H H H H CH3SO2CH2CO 1 5-217 C—CF3 C—H C—CF3 C—H H CF3 H H H Hn-PrCO 1 5-218 C—CF3 C—H C—CF3 C—H H CF3 H H H H cyclo-PrCH2CO 1 5-219C—CF3 C—H C—CF3 C—H H CF3 H H H H CH3SCH2CO 1 5-220 C—CF3 C—H C—CF3 C—HH CF3 H H H H CH3S(O)CH2CO 1 5-221 C—CF3 C—H C—CF3 C—H H CF3 H H H HCH3SO2CH2CO 1 5-222 C—Cl C—Cl C—CF3 C—H H CF3 H H H H n-PrCO 1 5-223C—Cl C—Cl C—CF3 C—H H CF3 H H H H cyclo-PrCH2CO 1 5-224 C—Cl C—Cl C—CF3C—H H CF3 H H H H CH3SCH2CO 1 5-225 C—Cl C—Cl C—CF3 C—H H CF3 H H H HCH3S(O)CH2CO 1 5-226 C—Cl C—Cl C—CF3 C—H H CF3 H H H H CH3SO2CH2CO 15-227 C—Cl C—H C—Cl C—H H CF3 CH3 H H H n-PrCO 1 5-228 C—Cl C—H C—Cl C—HH CF3 CH3 H H H cyclo-PrCH2CO 1 5-229 C—Cl C—H C—Cl C—H H CF3 CH3 H H HCH3SCH2CO 1 5-230 C—Cl C—H C—Cl C—H H CF3 CH3 H H H CH3S(O)CH2CO 1 5-231C—Cl C—H C—Cl C—H H CF3 CH3 H H H CH3SO2CH2CO 1 5-232 C—Cl C—Cl C—Cl C—HH CF3 CH3 H H H n-PrCO 1 5-233 C—Cl C—Cl C—Cl C—H H CF3 CH3 H H Hcyclo-PrCH2CO 1 5-234 C—Cl C—Cl C—Cl C—H H CF3 CH3 H H H CH3SCH2CO 15-235 C—Cl C—Cl C—Cl C—H H CF3 CH3 H H H CH3S(O)CH2CO 1 5-236 C—Cl C—ClC—Cl C—H H CF3 CH3 H H H CH3SO2CH2CO 1 5-237 C—CF3 C—H C—CF3 C—H H CF3CH3 H H H n-PrCO 1 5-238 C—CF3 C—H C—CF3 C—H H CF3 CH3 H H Hcyclo-PrCH2CO 1 5-239 C—CF3 C—H C—CF3 C—H H CF3 CH3 H H H CH3SCH2CO 15-240 C—CF3 C—H C—CF3 C—H H CF3 CH3 H H H CH3S(O)CH2CO 1 5-241 C—CF3 C—HC—CF3 C—H H CF3 CH3 H H H CH3SO2CH2CO 1 5-242 C—Cl C—Cl C—CF3 C—H H CF3CH3 H H H n-PrCO 1 5-243 C—Cl C—Cl C—CF3 C—H H CF3 CH3 H H Hcyclo-PrCH2CO 1 5-244 C—Cl C—Cl C—CF3 C—H H CF3 CH3 H H H CH3SCH2CO 15-245 C—Cl C—Cl C—CF3 C—H H CF3 CH3 H H H CH3S(O)CH2CO 1 5-246 C—Cl C—ClC—CF3 C—H H CF3 CH3 H H H CH3SO2CH2CO 1 5-247 C—Cl C—H C—Cl C—H H CF3 ClH H H n-PrCO 1 5-248 C—Cl C—H C—Cl C—H H CF3 Cl H H H cyclo-PrCH2CO 15-249 C—Cl C—H C—Cl C—H H CF3 Cl H H H CH3SCH2CO 1 5-250 C—Cl C—H C—ClC—H H CF3 Cl H H H CH3S(O)CH2CO 1 5-251 C—Cl C—H C—Cl C—H H CF3 Cl H H HCH3SO2CH2CO 1 5-252 C—Cl C—Cl C—Cl C—H H CF3 Cl H H H n-PrCO 1 5-253C—Cl C—Cl C—Cl C—H H CF3 Cl H H H cyclo-PrCH2CO 1 5-254 C—Cl C—Cl C—ClC—H H CF3 Cl H H H CH3SCH2CO 1 5-255 C—Cl C—Cl C—Cl C—H H CF3 Cl H H HCH3S(O)CH2CO 1 5-256 C—Cl C—Cl C—Cl C—H H CF3 Cl H H H CH3SO2CH2CO 15-257 C—CF3 C—H C—CF3 C—H H CF3 Cl H H H n-PrCO 1 5-258 C—CF3 C—H C—CF3C—H H CF3 Cl H H H cyclo-PrCH2CO 1 5-259 C—CF3 C—H C—CF3 C—H H CF3 Cl HH H CH3SCH2CO 1 5-260 C—CF3 C—H C—CF3 C—H H CF3 Cl H H H CH3S(O)CH2CO 15-261 C—CF3 C—H C—CF3 C—H H CF3 Cl H H H CH3SO2CH2CO 1 5-262 C—Cl C—ClC—CF3 C—H H CF3 Cl H H H n-PrCO 1 5-263 C—Cl C—Cl C—CF3 C—H H CF3 Cl H HH cyclo-PrCH2CO 1 5-264 C—Cl C—Cl C—CF3 C—H H CF3 Cl H H H CH3SCH2CO 15-265 C—Cl C—Cl C—CF3 C—H H CF3 Cl H H H CH3S(O)CH2CO 1 5-266 C—Cl C—ClC—CF3 C—H H CF3 Cl H H H CH3SO2CH2CO 1 5-267 C—Cl C—H C—Cl C—H H CF3 BrH H H CH3CO 1 5-268 C—Cl C—H C—Cl C—H H CF3 Br H H H CH3CH2CO 1 5-269C—Cl C—H C—Cl C—H H CF3 Br H H H n-PrCO 1 5-270 C—Cl C—H C—Cl C—H H CF3Br H H H cyclo-PrCO 1 5-271 C—Cl C—H C—Cl C—H H CF3 Br H H Hcyclo-PrCH2CO 1 5-272 C—Cl C—H C—Cl C—H H CF3 Br H H H CF3CH2CO 1 5-273C—Cl C—H C—Cl C—H H CF3 Br H H H CH3SCH2CO 1 5-274 C—Cl C—H C—Cl C—H HCF3 Br H H H CH3S(O)CH2CO 1 5-275 C—Cl C—H C—Cl C—H H CF3 Br H H HCH3SO2CH2CO 1 5-276 C—Cl C—H C—Cl C—H H CF3 Br H H H CH3CH2NHCO 1 5-277C—Cl C—Cl C—Cl C—H H CF3 Br H H H CH3CO 1 5-278 C—Cl C—Cl C—Cl C—H H CF3Br H H H CH3CH2CO 1 5-279 C—Cl C—Cl C—Cl C—H H CF3 Br H H H n-PrCO 15-280 C—Cl C—Cl C—Cl C—H H CF3 Br H H H cyclo-PrCO 1 5-281 C—Cl C—ClC—Cl C—H H CF3 Br H H H cyclo-PrCH2CO 1 5-282 C—Cl C—Cl C—Cl C—H H CF3Br H H H CF3CH2CO 1 5-283 C—Cl C—Cl C—Cl C—H H CF3 Br H H H CH3SCH2CO 15-284 C—Cl C—Cl C—Cl C—H H CF3 Br H H H CH3S(O)CH2CO 1 5-285 C—Cl C—ClC—Cl C—H H CF3 Br H H H CH3SO2CH2CO 1 5-286 C—Cl C—Cl C—Cl C—H H CF3 BrH H H CH3CH2NHCO 1 5-287 C—CF3 C—H C—CF3 C—H H CF3 Br H H H CH3CO 15-288 C—CF3 C—H C—CF3 C—H H CF3 Br H H H CH3CH2CO 1 5-289 C—CF3 C—HC—CF3 C—H H CF3 Br H H H n-PrCO 1 5-290 C—CF3 C—H C—CF3 C—H H CF3 Br H HH cyclo-PrCO 1 5-291 C—CF3 C—H C—CF3 C—H H CF3 Br H H H cyclo-PrCH2CO 15-292 C—CF3 C—H C—CF3 C—H H CF3 Br H H H CF3CH2CO 1 5-293 C—CF3 C—HC—CF3 C—H H CF3 Br H H H CH3SCH2CO 1 5-294 C—CF3 C—H C—CF3 C—H H CF3 BrH H H CH3S(O)CH2CO 1 5-295 C—CF3 C—H C—CF3 C—H H CF3 Br H H HCH3SO2CH2CO 1 5-296 C—CF3 C—H C—CF3 C—H H CF3 Br H H H CH3CH2NHCO 15-297 C—Cl C—Cl C—CF3 C—H H CF3 Br H H H CH3CO 1 5-298 C—Cl C—Cl C—CF3C—H H CF3 Br H H H CH3CH2CO 1 5-299 C—Cl C—Cl C—CF3 C—H H CF3 Br H H Hn-PrCO 1 5-300 C—Cl C—Cl C—CF3 C—H H CF3 Br H H H cyclo-PrCO 1 5-301C—Cl C—Cl C—CF3 C—H H CF3 Br H H H cyclo-PrCH2CO 1 5-302 C—Cl C—Cl C—CF3C—H H CF3 Br H H H CF3CH2CO 1 5-303 C—Cl C—Cl C—CF3 C—H H CF3 Br H H HCH3SCH2CO 1 5-304 C—Cl C—Cl C—CF3 C—H H CF3 Br H H H CH3S(O)CH2CO 15-305 C—Cl C—Cl C—CF3 C—H H CF3 Br H H H CH3SO2CH2CO 1 5-306 C—Cl C—ClC—CF3 C—H H CF3 Br H H H CH3CH2NHCO 1 5-307 C—Cl C—H C—Cl C—H H CF3 CF3H H H CH3CH2OCH2CO 1 5-308 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3OCH2CH2CO 1 5-309 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3CH2OCH2CH2CO 15-310 C—Cl C—H C—Cl C—H H CF3 CF3 H H H CH3S(O)CH2CO 1 5-311 C—Cl C—HC—Cl C—H H CF3 CF3 H H H CH3SO2CH2CO 1 5-312 C—Cl C—H C—Br C—H H CF3 CF3H H H CH3CO 1 5-313 C—Cl C—H C—Br C—H H CF3 CF3 H H H CH3CH2CO 1 5-314C—Cl C—H C—Br C—H H CF3 CF3 H H H n-PrCO 1 5-315 C—Cl C—H C—Br C—H H CF3CF3 H H H cyclo-PrCO 1 5-316 C—Cl C—H C—Br C—H H CF3 CF3 H H Hcyclo-PrCH2CO 1 5-317 C—Cl C—H C—Br C—H H CF3 CF3 H H H CF3CH2CO 1 5-318C—Cl C—H C—Br C—H H CF3 CF3 H H H CH3SCH2CO 1 5-319 C—Cl C—H C—Br C—H HCF3 CF3 H H H CH3S(O)CH2CO 1 5-320 C—Cl C—H C—Br C—H H CF3 CF3 H H HCH3SO2CH2CO 1 5-321 C—Cl C—H C—Br C—H H CF3 CF3 H H H CH3CH2NHCOOCO 15-322 C—Br C—H C—Br C—H H CF3 CF3 H H H CH3SCH2CO 1 5-323 C—Br C—H C—BrC—H H CF3 CF3 H H H CH3S(O)CH2CO 1 5-324 C—Br C—H C—Br C—H H CF3 CF3 H HH CH3SO2CH2CO 1 5-325 C—Cl C—F C—Cl C—H H CF3 CF3 H H H CH3CO 1 5-326C—Cl C—F C—Cl C—H H CF3 CF3 H H H CH3CH2CO 1 5-327 C—Cl C—F C—Cl C—H HCF3 CF3 H H H n-PrCO 1 5-328 C—Cl C—F C—Cl C—H H CF3 CF3 H H Hcyclo-PrCO 1 5-329 C—Cl C—F C—Cl C—H H CF3 CF3 H H H cyclo-PrCH2CO 15-330 C—Cl C—F C—Cl C—H H CF3 CF3 H H H CF3CH2CO 1 5-331 C—Cl C—F C—ClC—H H CF3 CF3 H H H CH3SCH2CO 1 5-332 C—Cl C—F C—Cl C—H H CF3 CF3 H H HCH3S(O)CH2CO 1 5-333 C—Cl C—F C—Cl C—H H CF3 CF3 H H H CH3SO2CH2CO 15-334 C—Cl C—F C—Cl C—H H CF3 CF3 H H H CH3CH2NHCOOCO 1 5-335 C—Cl C—ClC—Cl C—H H CF3 CF3 H H H n-PrCH2CO 1 5-336 C—Cl C—Cl C—Cl C—H H CF3 CF3H H H cyclo-PrCH2CO 1 5-337 C—Cl C—Cl C—Cl C—H H CF3 CF3 H H Htert-BuCH2CO 1 5-338 C—Cl C—Cl C—Cl C—H H CF3 CF3 H H H CH3OCH2CH2CO 15-339 C—Cl C—Cl C—Cl C—H H CF3 CF3 H H H CH3CH2OCH2CH2CO 1 5-340 C—ClC—Cl C—Cl C—H H CF3 CF3 H H H CH3SCH2CO 1 5-341 C—Cl C—Cl C—Cl C—H H CF3CF3 H H H CH3S(O)CH2CO 1 5-342 C—Cl C—Cl C—Cl C—H H CF3 CF3 H H HCH3SO2CH2CO 1 5-343 C—Cl C—Br C—Cl C—H H CF3 CF3 H H H CH3CO 1 5-344C—Cl C—Br C—Cl C—H H CF3 CF3 H H H CH3CH2CO 1 5-345 C—Cl C—Br C—Cl C—H HCF3 CF3 H H H n-PrCO 1 5-346 C—Cl C—Br C—Cl C—H H CF3 CF3 H H Hcyclo-PrCO 1 5-347 C—Cl C—Br C—Cl C—H H CF3 CF3 H H H cyclo-PrCH2CO 15-348 C—Cl C—Br C—Cl C—H H CF3 CF3 H H H CF3CH2CO 1 5-349 C—Cl C—Br C—ClC—H H CF3 CF3 H H H CH3SCH2CO 1 5-350 C—Cl C—Br C—Cl C—H H CF3 CF3 H H HCH3S(O)CH2CO 1 5-351 C—Cl C—Br C—Cl C—H H CF3 CF3 H H H CH3SO2CH2CO 15-352 C—Cl C—Br C—Cl C—H H CF3 CF3 H H H CH3CH2NHCOOCO 1 5-353 C—Cl C—ClC—Br C—H H CF3 CF3 H H H CH3CO 1 5-354 C—Cl C—Cl C—Br C—H H CF3 CF3 H HH CH3CH2CO 1 5-355 C—Cl C—Cl C—Br C—H H CF3 CF3 H H H n-PrCO 1 5-356C—Cl C—Cl C—Br C—H H CF3 CF3 H H H cyclo-PrCO 1 5-357 C—Cl C—Cl C—Br C—HH CF3 CF3 H H H cyclo-PrCH2CO 1 5-358 C—Cl C—Cl C—Br C—H H CF3 CF3 H H HCF3CH2CO 1 5-359 C—Cl C—Cl C—Br C—H H CF3 CF3 H H H CH3SCH2CO 1 5-360C—Cl C—Cl C—Br C—H H CF3 CF3 H H H CH3S(O)CH2CO 1 5-361 C—Cl C—Cl C—BrC—H H CF3 CF3 H H H CH3SO2CH2CO 1 5-362 C—Cl C—Cl C—Br C—H H CF3 CF3 H HH CH3CH2NHCOOCO 1 5-363 C—Cl C—F C—Cl C—H F CF3 CF3 H H H CH3CO 1 5-364C—Cl C—F C—Cl C—H F CF3 CF3 H H H CH3CH2CO 1 5-365 C—Cl C—F C—Cl C—H FCF3 CF3 H H H n-PrCO 1 5-366 C—Cl C—F C—Cl C—H F CF3 CF3 H H Hcyclo-PrCO 1 5-367 C—Cl C—F C—Cl C—H F CF3 CF3 H H H cyclo-PrCH2CO 15-368 C—Cl C—F C—Cl C—H F CF3 CF3 H H H CF3CH2CO 1 5-369 C—Cl C—F C—ClC—H F CF3 CF3 H H H CH3SCH2CO 1 5-370 C—Cl C—F C—Cl C—H F CF3 CF3 H H HCH3S(O)CH2CO 1 5-371 C—Cl C—F C—Cl C—H F CF3 CF3 H H H CH3SO2CH2CO 15-372 C—Cl C—F C—Cl C—H F CF3 CF3 H H H CH3CH2NHCOOCO 1 5-373 C—Cl C—HC—CF3 C—H H CF3 CF3 H H H CH3CO 1 5-374 C—Cl C—H C—CF3 C—H H CF3 CF3 H HH CH3CH2CO 1 5-375 C—Cl C—H C—CF3 C—H H CF3 CF3 H H H n-PrCO 1 5-376C—Cl C—H C—CF3 C—H H CF3 CF3 H H H cyclo-PrCO 1 5-377 C—Cl C—H C—CF3 C—HH CF3 CF3 H H H cyclo-PrCH2CO 1 5-378 C—Cl C—H C—CF3 C—H H CF3 CF3 H H HCF3CH2CO 1 5-379 C—Cl C—H C—CF3 C—H H CF3 CF3 H H H CH3OCH2CH2CO 1 5-380C—Cl C—H C—CF3 C—H H CF3 CF3 H H H CH3CH2OCH2CH2CO 1 5-381 C—Cl C—HC—CF3 C—H H CF3 CF3 H H H CH3SCH2CO 1 5-382 C—Cl C—H C—CF3 C—H H CF3 CF3H H H CH3S(O)CH2CO 1 5-383 C—Cl C—H C—CF3 C—H H CF3 CF3 H H HCH3SO2CH2CO 1 5-384 C—Cl C—H C—CF3 C—H H CF3 CF3 H H H CH3CH2NHCOOCO 15-385 C—Cl C—H C—CF3 C—H H CF3 CF3 H H H CH3OCH2CH2CO 1 5-386 C—Cl C—HC—CF3 C—H H CF3 CF3 H H H CH3CH2OCH2CH2CO 1 5-387 C—CF3 C—H C—CF3 C—H HCF3 CF3 H H H CH3SCH2CO 1 5-388 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H HCH3S(O)CH2CO 1 5-389 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H H CH3SO2CH2CO 15-390 C—Cl C—Cl C—CF3 C—H H CF3 CF3 H H H CH3SCH2CO 1 5-391 C—Cl C—ClC—CF3 C—H H CF3 CF3 H H H CH3S(O)CH2CO 1 5-392 C—Cl C—Cl C—CF3 C—H H CF3CF3 H H H CH3SO2CH2CO 1 5-393 C—Cl N C—Cl C—H H CF3 CF3 H H H CH3CO 15-394 C—Cl N C—Cl C—H H CF3 CF3 H H H CH3CH2CO 1 5-395 C—Cl N C—Cl C—H HCF3 CF3 H H H n-PrCO 1 5-396 C—Cl N C—Cl C—H H CF3 CF3 H H H cyclo-PrCO1 5-397 C—Cl N C—Cl C—H H CF3 CF3 H H H cyclo-PrCH2CO 1 5-398 C—Cl NC—Cl C—H H CF3 CF3 H H H CF3CH2CO 1 5-399 C—Cl N C—Cl C—H H CF3 CF3 H HH CH3SCH2CO 1 5-400 C—Cl N C—Cl C—H H CF3 CF3 H H H CH3S(O)CH2CO 1 5-401C—Cl N C—Cl C—H H CF3 CF3 H H H CH3SO2CH2CO 1 5-402 C—Cl N C—Cl C—H HCF3 CF3 H H H CH3CH2NHCOOCO 1 5-403 C—CF3 N C—H C—H H CF3 CF3 H H HCH3CO 1 5-404 C—CF3 N C—H C—H H CF3 CF3 H H H CH3CH2CO 1 5-405 C—CF3 NC—H C—H H CF3 CF3 H H H n-PrCO 1 5-406 C—CF3 N C—H C—H H CF3 CF3 H H Hcyclo-PrCO 1 5-407 C—CF3 N C—H C—H H CF3 CF3 H H H cyclo-PrCH2CO 1 5-408C—CF3 N C—H C—H H CF3 CF3 H H H CF3CH2CO 1 5-409 C—CF3 N C—H C—H H CF3CF3 H H H CH3SCH2CO 1 5-410 C—CF3 N C—H C—H H CF3 CF3 H H H CH3S(O)CH2CO1 5-411 C—CF3 N C—H C—H H CF3 CF3 H H H CH3SO2CH2CO 1 5-412 C—CF3 N C—HC—H H CF3 CF3 H H H CH3CH2NHCOOCO 1 5-413 C—CF3 N C—CF3 C—H H CF3 CF3 HH H CH3CO 1 5-414 C—CF3 N C—CF3 C—H H CF3 CF3 H H H CH3CH2CO 1 5-415C—CF3 N C—CF3 C—H H CF3 CF3 H H H n-PrCO 1 5-416 C—CF3 N C—CF3 C—H H CF3CF3 H H H cyclo-PrCO 1 5-417 C—CF3 N C—CF3 C—H H CF3 CF3 H H Hcyclo-PrCH2CO 1 5-418 C—CF3 N C—CF3 C—H H CF3 CF3 H H H CF3CH2CO 1 5-419C—CF3 N C—CF3 C—H H CF3 CF3 H H H CH3SCH2CO 1 5-420 C—CF3 N C—CF3 C—H HCF3 CF3 H H H CH3S(O)CH2CO 1 5-421 C—CF3 N C—CF3 C—H H CF3 CF3 H H HCH3SO2CH2CO 1 5-422 C—CF3 N C—CF3 C—H H CF3 CF3 H H H CH3CH2NHCOOCO 15-423 C—CF3 C—H C—CF3 N H CF3 CF3 H H H CH3CO 1 5-424 C—CF3 C—H C—CF3 NH CF3 CF3 H H H CH3CH2CO 1 5-425 C—CF3 C—H C—CF3 N H CF3 CF3 H H Hn-PrCO 1 5-426 C—CF3 C—H C—CF3 N H CF3 CF3 H H H cyclo-PrCO 1 5-427C—CF3 C—H C—CF3 N H CF3 CF3 H H H cyclo-PrCH2CO 1 5-428 C—CF3 C—H C—CF3N H CF3 CF3 H H H CF3CH2CO 1 5-429 C—CF3 C—H C—CF3 N H CF3 CF3 H H HCH3SCH2CO 1 5-430 C—CF3 C—H C—CF3 N H CF3 CF3 H H H CH3S(O)CH2CO 1 5-431C—CF3 C—H C—CF3 N H CF3 CF3 H H H CH3SO2CH2CO 1 5-432 C—CF3 C—H C—CF3 NH CF3 CF3 H H H CH3CH2NHCOOCO 1 5-433 C—CF3 C—H C—CF3 C—H H CF3 CF3 H HH cyclo-PrCH2CO 1 5-434 C—CF3 C—H C—CF3 C—H H CF3 CF3 H H H tert-BuCH2CO1 5-435 C—Cl C—H C—Cl C—H H CF3 Cl H H H CH3SCO 1 5-436 C—Cl C—H C—ClC—H H CF3 CH3 H H H CH3SCO 1 5-437 C—Cl C—H C—Cl C—H H CF3 CF3 H H HCH3SCO 1

TABLE 6

Ex.-No. B¹ B² B³ B⁴ X¹ R W¹ R⁵ R⁶ 6-1 C—Cl C—H C—Cl C—H H CF3 — H H 6-2C—Cl C—H C—Cl C—H H CF3 — H HCO 6-3 C—Cl C—H C—Cl C—H H CF3 — H CH3CO6-4 C—Cl C—H C—Cl C—H H CF3 — H CH3CH2CO 6-5 C—Cl C—H C—Cl C—H H CF3 — Hn-PrCO 6-6 C—Cl C—H C—Cl C—H H CF3 — H iso-PrCO 6-7 C—Cl C—H C—Cl C—H HCF3 — H cyclo-PrCO 6-8 C—Cl C—H C—Cl C—H H CF3 — H n-BuCO 6-9 C—Cl C—HC—Cl C—H H CF3 — H tert-BuCO 6-10 C—Cl C—H C—Cl C—H H CF3 — H iso-BuCO6-11 C—Cl C—H C—Cl C—H H CF3 — H cyclo-BuCO 6-12 C—Cl C—H C—Cl C—H H CF3— H (CH3)3CCH2CO 6-13 C—Cl C—H C—Cl C—H H CF3 — H cyclo-PenCO 6-14 C—ClC—H C—Cl C—H H CF3 — H cyclo-HexCO 6-15 C—Cl C—H C—Cl C—H H CF3 — Hcyclo-PrCH2CO 6-16 C—Cl C—H C—Cl C—H H CF3 — H CF3CO 6-17 C—Cl C—H C—ClC—H H CF3 — H CCl3CO 6-18 C—Cl C—H C—Cl C—H H CF3 — H ClCH2CO 6-19 C—ClC—H C—Cl C—H H CF3 — H CF2ClCO 6-20 C—Cl C—H C—Cl C—H H CF3 — HClCH2CH2CO 6-21 C—Cl C—H C—Cl C—H H CF3 — H HCF2CF2CO 6-22 C—Cl C—H C—ClC—H H CF3 — H CF3CH2CO 6-23 C—Cl C—H C—Cl C—H H CF3 — H (CF3)2CHCO 6-24C—Cl C—H C—Cl C—H H CF3 — H HCF2CO 6-25 C—Cl C—H C—Cl C—H H CF3 — HClCH2CO 6-26 C—Cl C—H C—Cl C—H H CF3 — H

6-27 C—Cl C—H C—Cl C—H H CF3 — H

6-28 C—Cl C—H C—Cl C—H H CF3 — H

6-29 C—Cl C—H C—Cl C—H H CF3 — H

6-30 C—Cl C—H C—Cl C—H H CF3 — H

6-31 C—Cl C—H C—Cl C—H H CF3 — H

6-32 C—Cl C—H C—Cl C—H H CF3 — H CH2═CH—CO 6-33 C—Cl C—H C—Cl C—H H CF3— H CH3CH═CH—CO 6-34 C—Cl C—H C—Cl C—H H CF3 — H CH2═C(CH3)—CO 6-35 C—ClC—H C—Cl C—H H CF3 — H CH3CH═C(CH3)—CO 6-36 C—Cl C—H C—Cl C—H H CF3 — H(CH3)2C═CH—CO 6-37 C—Cl C—H C—Cl C—H H CF3 — H CH2═C(Cl)—CO 6-38 C—ClC—H C—Cl C—H H CF3 — H ClCH═C(CH3)—CO 6-39 C—Cl C—H C—Cl C—H H CF3 — HCH2═CHCH2—CO 6-40 C—Cl C—H C—Cl C—H H CF3 — H HCC—CO 6-41 C—Cl C—H C—ClC—H H CF3 — H CH3CC—CONH 6-42 C—Cl C—H C—Cl C—H H CF3 — H NCCH2—CO 6-43C—Cl C—H C—Cl C—H H CF3 — H CH3OCH2—CO 6-44 C—Cl C—H C—Cl C—H H CF3 — HC2H5OCH2—CO 6-45 C—Cl C—H C—Cl C—H H CF3 — H CH3SCH2CO 6-46 C—Cl C—HC—Cl C—H H CF3 — H CH3O(CO)CH2—CO 6-47 C—Cl C—H C—Cl C—H H CF3 — HCH3(CO)OCH2—CO 6-48 C—Cl C—H C—Cl C—H H CF3 — H CH3O(CO)—CO 6-49 C—ClC—H C—Cl C—H H CF3 — H CF3O(CO)—CO 6-50 C—Cl C—H C—Cl C—H H CF3 — HCH3(CO)CH2—CO 6-51 C—Cl C—H C—Cl C—H H CF3 — H (CH3)2NCH2—CO 6-52 C—ClC—H C—Cl C—H H CF3 — H PhCO 6-53 C—Cl C—H C—Cl C—H H CF3 — H PhCH2CO6-54 C—Cl C—H C—Cl C—H H CF3 — H 2-py-CO 6-55 C—Cl C—H C—Cl C—H H CF3 —H 3-py-CO 6-56 C—Cl C—H C—Cl C—H H CF3 — H 4-py-CO 6-57 C—Cl C—H C—ClC—H H CF3 — H

6-58 C—Cl C—H C—Cl C—H H CF3 — H 2-F—PhCO 6-59 C—Cl C—H C—Cl C—H H CF3 —H 3-F—PhCO 6-60 C—Cl C—H C—Cl C—H H CF3 — H 4-F—PhCO 6-61 C—Cl C—H C—ClC—H H CF3 — H 2-Cl—PhCO 6-62 C—Cl C—H C—Cl C—H H CF3 — H 3-Cl—PhCO 6-63C—Cl C—H C—Cl C—H H CF3 — H 4-Cl—PhCO 6-64 C—Cl C—H C—Cl C—H H CF3 — H2-Br-PhCO 6-65 C—Cl C—H C—Cl C—H H CF3 — H 2-CF3—PhCO 6-66 C—Cl C—H C—ClC—H H CF3 — H 2-CF3—PhCO 6-67 C—Cl C—H C—Cl C—H H CF3 — H

6-68 C—Cl C—H C—Cl C—H H CF3 — H

6-69 C—Cl C—H C—Cl C—H H CF3 — H

6-70 C—Cl C—H C—Cl C—H H CF3 — H

6-71 C—Cl C—H C—Cl C—H H CF3 — H

6-72 C—Cl C—H C—Cl C—H H CF3 — H

6-73 C—Cl C—H C—Cl C—H H CF3 — H

6-74 C—Cl C—H C—Cl C—H H CF3 — H

6-75 C—Cl C—H C—Cl C—H H CF3 — H CH3NHCO 6-76 C—Cl C—H C—Cl C—H H CF3 —H CH3CH2NHCO 6-77 C—Cl C—H C—Cl C—H H CF3 — H CF3CH2NHCO 6-78 C—Cl C—HC—Cl C—H H CF3 — H n-PrNHCO 6-79 C—Cl C—H C—Cl C—H H CF3 — H iso-PrNHCO6-80 C—Cl C—H C—Cl C—H H CF3 — H cyclo-PrNHCO 6-81 C—Cl C—H C—Cl C—H HCF3 — H n-BuNHCO 6-82 C—Cl C—H C—Cl C—H H CF3 — H tert-BuNHCO 6-83 C—ClC—H C—Cl C—H H CF3 — H cyclo-BuNHCO 6-84 C—Cl C—H C—Cl C—H H CF3 — Hcyclo-PenNHCO 6-85 C—Cl C—H C—Cl C—H H CF3 — H cyclo-HexNHCO 6-86 C—ClC—H C—Cl C—H H CF3 — H CH2═CHCH2NHCO 6-87 C—Cl C—H C—Cl C—H H CF3 — HHCCCH2NHCO 6-88 C—Cl C—H C—Cl C—H H CF3 — H cyclo-PrCH2NHCO 6-89 C—ClC—H C—Cl C—H H CF3 — H NCCH2NHCO 6-90 C—Cl C—H C—Cl C—H H CF3 — HCF3(CH3)CHNHCO 6-91 C—Cl C—H C—Cl C—H H CF3 — H CF3(CH3)2CNCO 6-93 C—ClC—H C—Cl C—H H CF3 — H FCH2CH2NHCO 6-94 C—Cl C—H C—Cl C—H H CF3 — HCF3CH2CH2NHCO 6-95 C—Cl C—H C—Cl C—H H CF3 — H HCF2CF2CH2NHCO 6-96 C—ClC—H C—Cl C—H H CF3 — H

6-97 C—Cl C—H C—Cl C—H H CF3 — H

6-98 C—Cl C—H C—Cl C—H H CF3 — H EtO2CCH2NHCO 6-99 C—Cl C—H C—Cl C—H HCF3 — H 2-CF3—PhNHCO 6-100 C—Cl C—H C—Cl C—H H CF3 — H 3-CF3—PhNHCO6-101 C—Cl C—H C—Cl C—H H CF3 — H 4-CF3—PhNHCO 6-102 C—Cl C—H C—Cl C—H HCF3 — H 2-py-NHCO 6-103 C—Cl C—H C—Cl C—H H CF3 — H 3-py-NHCO 6-104 C—ClC—H C—Cl C—H H CF3 — H 4-py-NHCO 6-105 C—Cl C—H C—Cl C—H H CF3 — H

6-106 C—Cl C—H C—Cl C—H H CF3 — H

6-107 C—Cl C—H C—Cl C—H H CF3 — H PhCH2HNCO 6-108 C—Cl C—H C—Cl C—H HCF3 — H

6-109 C—Cl C—H C—Cl C—H H CF3 — H (CH3)2NCO 6-100 C—Cl C—H C—Cl C—H HCF3 — H pyrrolidineCO 6-111 C—Cl C—H C—Cl C—H H CF3 — H piperidineCO6-112 C—Cl C—H C—Cl C—H H CF3 — H morpholineCO 6-113 C—Cl C—H C—Cl C—H HCF3 — H CH3OCO 6-114 C—Cl C—H C—Cl C—H H CF3 — H CH3CH2OCO 6-115 C—ClC—H C—Cl C—H H CF3 — H n-PrOCO 6-116 C—Cl C—H C—Cl C—H H CF3 — Hcyclo-PrOCO 6-117 C—Cl C—H C—Cl C—H H CF3 — H CF3CH2OCO 6-118 C—Cl C—HC—Cl C—H H CF3 — H CH2═CHCH2OCO 6-119 C—Cl C—H C—Cl C—H H CF3 — HHCCCH2OCO 6-120 C—Cl C—H C—Cl C—H H CF3 — H PhOCO 6-121 C—Cl C—H C—ClC—H H CF3 — H PhCH2OCO 6-122 C—Cl C—H C—Cl C—H H CF3 — H tert-BuOCO6-123 C—Cl C—H C—Cl C—H H CF3 — H CH3SO2 6-124 C—Cl C—H C—Cl C—H H CF3 —H CH3CH2SO2 6-125 C—Cl C—H C—Cl C—H H CF3 — H CF3SO2NH 6-126 C—Cl C—HC—Cl C—H H CF3 — H CF3CH2SO2 6-127 C—Cl C—H C—Cl C—H H CF3 — H PhSO26-128 C—Cl C—H C—Cl C—H H CF3 — H CH3NHCONHSO2 6-129 C—Cl C—H C—Cl C—H HCF3 — H (CH3)2NCONHSO2 6-130 C—Cl C—H C—Cl C—H H CF3 — H CH3CS 6-131C—Cl C—H C—Cl C—H H CF3 — H CH3CH2CS 6-132 C—Cl C—H C—Cl C—H H CF3 — Hcyclo-PrCS 6-133 C—Cl C—H C—Cl C—H H CF3 — H CF3CH2CS 6-134 C—Cl C—HC—Cl C—H H CF3 CH2 H H 6-135 C—Cl C—H C—Cl C—H H CF3 CH2 H HCO 6-136C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CO 6-137 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3CH2CO 6-138 C—Cl C—H C—Cl C—H H CF3 CH2 H n-PrCO 6-139 C—Cl C—H C—ClC—H H CF3 CH2 H iso-PrCO 6-140 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-PrCO6-141 C—Cl C—H C—Cl C—H H CF3 CH2 H n-BuCO 6-142 C—Cl C—H C—Cl C—H H CF3CH2 H tert-BuCO 6-143 C—Cl C—H C—Cl C—H H CF3 CH2 H iso-BuCO 6-144 C—ClC—H C—Cl C—H H CF3 CH2 H cyclo-BuCO 6-145 C—Cl C—H C—Cl C—H H CF3 CH2 H(CH3)3CCH2CO 6-146 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-PenCO 6-147 C—ClC—H C—Cl C—H H CF3 CH2 H cyclo-HexCO 6-148 C—Cl C—H C—Cl C—H H CF3 CH2 Hcyclo-PrCH2CO 6-149 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CO 6-150 C—Cl C—HC—Cl C—H H CF3 CH2 H CCl3CO 6-151 C—Cl C—H C—Cl C—H H CF3 CH2 H ClCH2CO6-152 C—Cl C—H C—Cl C—H H CF3 CH2 H CF2ClCO 6-153 C—Cl C—H C—Cl C—H HCF3 CH2 H ClCH2CH2CO 6-154 C—Cl C—H C—Cl C—H H CF3 CH2 H HCF2CF2CO 6-155C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CH2CO 6-156 C—Cl C—H C—Cl C—H H CF3 CH2H (CF3)2CHCO 6-157 C—Cl C—H C—Cl C—H H CF3 CH2 H HCF2CO 6-158 C—Cl C—HC—Cl C—H H CF3 CH2 H ClCH2CO 6-159 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-160 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-161 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-162 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-163 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-164 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-165 C—Cl C—H C—Cl C—H H CF3 CH2 H CH2═CH—CO 6-166 C—Cl C—H C—Cl C—H HCF3 CH2 H CH3CH═CH—CO 6-167 C—Cl C—H C—Cl C—H H CF3 CH2 H CH2═C(CH3)—CO6-168 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CH═C(CH3)—CO 6-169 C—Cl C—H C—ClC—H H CF3 CH2 H (CH3)2C═CH—CO 6-170 C—Cl C—H C—Cl C—H H CF3 CH2 HCH2═C(Cl)—CO 6-171 C—Cl C—H C—Cl C—H H CF3 CH2 H ClCH═C(CH3)—CO 6-172C—Cl C—H C—Cl C—H H CF3 CH2 H CH2═CHCH2—CO 6-173 C—Cl C—H C—Cl C—H H CF3CH2 H HCC—CO 6-174 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CC—CONH 6-175 C—ClC—H C—Cl C—H H CF3 CH2 H NCCH2—CO 6-176 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3OCH2CO 6-177 C—Cl C—H C—Cl C—H H CF3 CH2 H C2H5OCH2—CO 6-178 C—Cl C—HC—Cl C—H H CF3 CH2 H CH3SCH2CO 6-179 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3O(CO)CH2—CO 6-180 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3(CO)OCH2—CO 6-181C—Cl C—H C—Cl C—H H CF3 CH2 H CH3O(CO)—CO 6-182 C—Cl C—H C—Cl C—H H CF3CH2 H CF3O(CO)—CO 6-183 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3(CO)CH2—CO6-184 C—Cl C—H C—Cl C—H H CF3 CH2 H (CH3)2NCH2—CO 6-185 C—Cl C—H C—ClC—H H CF3 CH2 H PhCO 6-186 C—Cl C—H C—Cl C—H H CF3 CH2 H PhCH2CO 6-187C—Cl C—H C—Cl C—H H CF3 CH2 H 2-py-CO 6-188 C—Cl C—H C—Cl C—H H CF3 CH2H 3-py-CO 6-189 C—Cl C—H C—Cl C—H H CF3 CH2 H 4-py-CO 6-190 C—Cl C—HC—Cl C—H H CF3 CH2 H

6-191 C—Cl C—H C—Cl C—H H CF3 CH2 H 2-F—PhCO 6-192 C—Cl C—H C—Cl C—H HCF3 CH2 H 3-F—PhCO 6-193 C—Cl C—H C—Cl C—H H CF3 CH2 H 4-F—PhCO 6-194C—Cl C—H C—Cl C—H H CF3 CH2 H 2-Cl—PhCO 6-195 C—Cl C—H C—Cl C—H H CF3CH2 H 3-Cl—PhCO 6-196 C—Cl C—H C—Cl C—H H CF3 CH2 H 4-Cl—PhCO 6-197 C—ClC—H C—Cl C—H H CF3 CH2 H 2-Br—PhCO 6-198 C—Cl C—H C—Cl C—H H CF3 CH2 H2-CF3—PhCO 6-199 C—Cl C—H C—Cl C—H H CF3 CH2 H 2-CH3—PhCO 6-200 C—Cl C—HC—Cl C—H H CF3 CH2 H

6-201 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-202 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-203 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-204 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-205 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-206 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-207 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-208 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3NHCO 6-209 C—Cl C—H C—Cl C—H HCF3 CH2 H CH3CH2NHCO 6-210 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CH2NHCO6-211 C—Cl C—H C—Cl C—H H CF3 CH2 H n-PrNHCO 6-212 C—Cl C—H C—Cl C—H HCF3 CH2 H iso-PrNHCO 6-213 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-PrNHCO6-214 C—Cl C—H C—Cl C—H H CF3 CH2 H n-BuNHCO 6-215 C—Cl C—H C—Cl C—H HCF3 CH2 H tert-BuNHCO 6-216 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-BuNHCO6-217 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-PenNHCO 6-218 C—Cl C—H C—ClC—H H CF3 CH2 H cyclo-HexNHCO 6-219 C—Cl C—H C—Cl C—H H CF3 CH2 HCH2═CHCH2NHCO 6-220 C—Cl C—H C—Cl C—H H CF3 CH2 H HCCCH2NHCO 6-221 C—ClC—H C—Cl C—H H CF3 CH2 H cyclo-PrCH2NHCO 6-222 C—Cl C—H C—Cl C—H H CF3CH2 H NCCH2NHCO 6-223 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3(CH3)CHNHCO 6-224C—Cl C—H C—Cl C—H H CF3 CH2 H CF3(CH3)2CNCO 6-226 C—Cl C—H C—Cl C—H HCF3 CH2 H FCH2CH2NHCO 6-227 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CH2CH2NHCO6-228 C—Cl C—H C—Cl C—H H CF3 CH2 H HCF2CF2CH2NHCO 6-229 C—Cl C—H C—ClC—H H CF3 CH2 H

6-230 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-231 C—Cl C—H C—Cl C—H H CF3 CH2 H EtO2CCH2NHCO 6-232 C—Cl C—H C—Cl C—HH CF3 CH2 H 2-CF3—PhNHCO 6-233 C—Cl C—H C—Cl C—H H CF3 CH2 H3-CF3—PhNHCO 6-234 C—Cl C—H C—Cl C—H H CF3 CH2 H 4-CF3—PhNHCO 6-235 C—ClC—H C—Cl C—H H CF3 CH2 H 2-py-NHCO 6-236 C—Cl C—H C—Cl C—H H CF3 CH2 H3-py-NHCO 6-237 C—Cl C—H C—Cl C—H H CF3 CH2 H 4-py-NHCO 6-238 C—Cl C—HC—Cl C—H H CF3 CH2 H

6-239 C—Cl C—H C—Cl C—H H CF3 CH2 H

6-240 C—Cl C—H C—Cl C—H H CF3 CH2 H PhCH2HNCO 6-241 C—Cl C—H C—Cl C—H HCF3 CH2 H

6-242 C—Cl C—H C—Cl C—H H CF3 CH2 H (CH3)2NCO 6-243 C—Cl C—H C—Cl C—H HCF3 CH2 H pyrrolidineCO 6-244 C—Cl C—H C—Cl C—H H CF3 CH2 H piperidineCO6-245 C—Cl C—H C—Cl C—H H CF3 CH2 H morpholineCO 6-246 C—Cl C—H C—Cl C—HH CF3 CH2 H CH3OCO 6-247 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CH2OCO 6-248C—Cl C—H C—Cl C—H H CF3 CH2 H n-PrOCO 6-249 C—Cl C—H C—Cl C—H H CF3 CH2H cyclo-PrOCO 6-250 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CH2OCO 6-251 C—ClC—H C—Cl C—H H CF3 CH2 H CH2═CHCH2OCO 6-252 C—Cl C—H C—Cl C—H H CF3 CH2H HCCCH2OCO 6-253 C—Cl C—H C—Cl C—H H CF3 CH2 H PhOCO 6-254 C—Cl C—HC—Cl C—H H CF3 CH2 H PhCH2OCO 6-255 C—Cl C—H C—Cl C—H H CF3 CH2 Htert-BuOCO 6-256 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3SO2 6-257 C—Cl C—HC—Cl C—H H CF3 CH2 H CH3CH2SO2 6-258 C—Cl C—H C—Cl C—H H CF3 CH2 HCF3SO2NH 6-259 C—Cl C—H C—Cl C—H H CF3 CH2 H CF3CH2SO2 6-260 C—Cl C—HC—Cl C—H H CF3 CH2 H PhSO2 6-261 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3NHCONHSO2 6-262 C—Cl C—H C—Cl C—H H CF3 CH2 H (CH3)2NCONHSO2 6-263C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CS 6-264 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3CH2CS 6-265 C—Cl C—H C—Cl C—H H CF3 CH2 H cyclo-PrCS 6-266 C—Cl C—HC—Cl C—H H CF3 CH2 H CF3CH2CS 6-267 C—Cl C—Cl C—Cl C—H H CF3 — H CH3CO6-268 C—Cl C—Cl C—Cl C—H H CF3 — H CH3CH2CO 6-269 C—Cl C—Cl C—Cl C—H HCF3 — H cyclo-PrCO 6-270 C—Cl C—Cl C—Cl C—H H CF3 — H CF3CH2CO 6-271C—Cl C—Cl C—Cl C—H H CF3 — H CH3CH2NHCO 6-272 C—CF3 C—H C—CF3 C—H H CF3— H CH3CO 6-273 C—CF3 C—H C—CF3 C—H H CF3 — H CH3CH2CO 6-274 C—CF3 C—HC—CF3 C—H H CF3 — H cyclo-PrCO 6-275 C—CF3 C—H C—CF3 C—H H CF3 — HCF3CH2CO 6-276 C—CF3 C—H C—CF3 C—H H CF3 — H CH3CH2NHCO 6-277 C—Cl C—ClC—CF3 C—H H CF3 — H CH3CO 6-278 C—Cl C—Cl C—CF3 C—H H CF3 — H CH3CH2CO6-279 C—Cl C—Cl C—CF3 C—H H CF3 — H cyclo-PrCO 6-280 C—Cl C—Cl C—CF3 C—HH CF3 — H CF3CH2CO 6-281 C—Cl C—Cl C—CF3 C—H H CF3 — H CH3CH2NHCO 6-282C—Br C—H C—Br C—H H CF3 — H CH3CO 6-283 C—Br C—H C—Br C—H H CF3 — HCH3CH2CO 6-284 C—Br C—H C—Br C—H H CF3 — H cyclo-PrCO 6-285 C—Br C—HC—Br C—H H CF3 — H CF3CH2CO 6-286 C—Br C—H C—Br C—H H CF3 — H CH3CH2NHCO6-287 C—Cl C—Cl C—Cl C—H H CF3 CH2 H CH3CO 6-288 C—Cl C—Cl C—Cl C—H HCF3 CH2 H CH3CH2CO 6-289 C—Cl C—Cl C—Cl C—H H CF3 CH2 H cyclo-PrCO 6-290C—Cl C—Cl C—Cl C—H H CF3 CH2 H CF3CH2CO 6-291 C—Cl C—Cl C—Cl C—H H CF3CH2 H CH3CH2NHCO 6-292 C—CF3 C—H C—CF3 C—H H CF3 CH2 H CH3CO 6-293 C—CF3C—H C—CF3 C—H H CF3 CH2 H CH3CH2CO 6-294 C—CF3 C—H C—CF3 C—H H CF3 CH2 Hcyclo-PrCO 6-295 C—CF3 C—H C—CF3 C—H H CF3 CH2 H CF3CH2CO 6-296 C—CF3C—H C—CF3 C—H H CF3 CH2 H CH3CH2NHCO 6-297 C—Cl C—Cl C—CF3 C—H H CF3 CH2H CH3CO 6-298 C—Cl C—Cl C—CF3 C—H H CF3 CH2 H CH3CH2CO 6-299 C—Cl C—ClC—CF3 C—H H CF3 CH2 H cyclo-PrCO 6-300 C—Cl C—Cl C—CF3 C—H H CF3 CH2 HCF3CH2CO 6-301 C—Cl C—Cl C—CF3 C—H H CF3 CH2 H CH3CH2NHCO 6-302 C—Cl C—HC—H C—H H CF3 — H CH3CO 6-303 C—Cl C—H C—H C—H H CF3 — H CH3CH2CO 6-304C—Cl C—H C—H C—H H CF3 — H n-PrCO 6-305 C—Cl C—H C—H C—H H CF3 — Hcyclo-PrCO 6-306 C—Cl C—H C—H C—H H CF3 — H cyclo-PrCH2CO 6-307 C—Cl C—HC—H C—H H CF3 — H CF3CH2CO 6-308 C—Cl C—H C—H C—H H CF3 — H CH3SCH2CO6-309 C—Cl C—H C—H C—H H CF3 — H CH3S(O)CH2CO 6-310 C—Cl C—H C—H C—H HCF3 — H CH3SO2CH2CO 6-311 C—Cl C—H C—H C—H H CF3 — H CH3CH2NHCO 6-312C—Cl C—H C—H C—H F CF3 — H CH3CO 6-313 C—Cl C—H C—H C—H F CF3 — HCH3CH2CO 6-314 C—Cl C—H C—H C—H F CF3 — H n-PrCO 6-315 C—Cl C—H C—H C—HF CF3 — H cyclo-PrCO 6-316 C—Cl C—H C—H C—H F CF3 — H cyclo-PrCH2CO6-317 C—Cl C—H C—H C—H F CF3 — H CF3CH2CO 6-318 C—Cl C—H C—H C—H F CF3 —H CH3SCH2CO 6-319 C—Cl C—H C—H C—H F CF3 — H CH3S(O)CH2CO 6-320 C—Cl C—HC—H C—H F CF3 — H CH3SO2CH2CO 6-321 C—Cl C—H C—H C—H F CF3 — HCH3CH2NHCO 6-322 C—H C—H C—Cl C—H F CF3 — H CH3CO 6-323 C—H C—H C—Cl C—HF CF3 — H CH3CH2CO 6-324 C—H C—H C—Cl C—H F CF3 — H n-PrCO 6-325 C—H C—HC—Cl C—H F CF3 — H cyclo-PrCO 6-326 C—H C—H C—Cl C—H F CF3 — Hcyclo-PrCH2CO 6-327 C—H C—H C—Cl C—H F CF3 — H CF3CH2CO 6-328 C—H C—HC—Cl C—H F CF3 — H CH3SCH2CO 6-329 C—H C—H C—Cl C—H F CF3 — HCH3S(O)CH2CO 6-330 C—H C—H C—Cl C—H F CF3 — H CH3SO2CH2CO 6-331 C—H C—HC—Cl C—H F CF3 — H CH3CH2NHCO 6-332 C—Cl C—H C—Cl C—H H CF3 — HCH3OCH2CH2CO 6-333 C—Cl C—H C—Cl C—H H CF3 — H CH3CH2OCH2CH2CO 6-334C—Cl C—H C—Cl C—H H CF3 — H CH3S(O)CH2CO 6-335 C—Cl C—H C—Cl C—H H CF3 —H CH3SO2CH2CO 6-336 C—Cl C—H C—Br C—H H CF3 — H CH3CO 6-337 C—Cl C—HC—Br C—H H CF3 — H CH3CH2CO 6-338 C—Cl C—H C—Br C—H H CF3 — H n-PrCO6-339 C—Cl C—H C—Br C—H H CF3 — H cyclo-PrCO 6-340 C—Cl C—H C—Br C—H HCF3 — H cyclo-PrCH2CO 6-341 C—Cl C—H C—Br C—H H CF3 — H CF3CH2CO 6-342C—Cl C—H C—Br C—H H CF3 — H CH3SCH2CO 6-343 C—Cl C—H C—Br C—H H CF3 — HCH3S(O)CH2CO 6-344 C—Cl C—H C—Br C—H H CF3 — H CH3SO2CH2CO 6-345 C—ClC—H C—Br C—H H CF3 — H CH3CH2NHCO 6-346 C—Br C—H C—Br C—H H CF3 — Hn-PrCO 6-347 C—Br C—H C—Br C—H H CF3 — H cyclo-PrCH2CO 6-348 C—Br C—HC—Br C—H H CF3 — H CH3SCH2CO 6-349 C—Br C—H C—Br C—H H CF3 — HCH3S(O)CH2CO 6-350 C—Br C—H C—Br C—H H CF3 — H CH3SO2CH2CO 6-351 C—ClC—F C—Cl C—H H CF3 — H CH3CO 6-352 C—Cl C—F C—Cl C—H H CF3 — H CH3CH2CO6-353 C—Cl C—F C—Cl C—H H CF3 — H n-PrCO 6-354 C—Cl C—F C—Cl C—H H CF3 —H cyclo-PrCO 6-355 C—Cl C—F C—Cl C—H H CF3 — H cyclo-PrCH2CO 6-356 C—ClC—F C—Cl C—H H CF3 — H CF3CH2CO 6-357 C—Cl C—F C—Cl C—H H CF3 — HCH3SCH2CO 6-358 C—Cl C—F C—Cl C—H H CF3 — H CH3S(O)CH2CO 6-359 C—Cl C—FC—Cl C—H H CF3 — H CH3SO2CH2CO 6-360 C—Cl C—F C—Cl C—H H CF3 — HCH3CH2NHCO 6-361 C—Cl C—Cl C—Cl C—H H CF3 — H n-PrCO 6-362 C—Cl C—ClC—Cl C—H H CF3 — H cyclo-PrCH2CO 6-363 C—Cl C—Cl C—Cl C—H H CF3 — HCH3OCH2CH2CO 6-364 C—Cl C—Cl C—Cl C—H H CF3 — H CH3CH2OCH2CH2CO 6-365C—Cl C—Cl C—Cl C—H H CF3 — H CH3SCH2CO 6-366 C—Cl C—Cl C—Cl C—H H CF3 —H CH3S(O)CH2CO 6-367 C—Cl C—Cl C—Cl C—H H CF3 — H CH3SO2CH2CO 6-368 C—ClC—Br C—Cl C—H H CF3 — H CH3CO 6-369 C—Cl C—Br C—Cl C—H H CF3 — HCH3CH2CO 6-370 C—Cl C—Br C—Cl C—H H CF3 — H n-PrCO 6-371 C—Cl C—Br C—ClC—H H CF3 — H cyclo-PrCO 6-372 C—Cl C—Br C—Cl C—H H CF3 — Hcyclo-PrCH2CO 6-373 C—Cl C—Br C—Cl C—H H CF3 — H CF3CH2CO 6-374 C—ClC—Br C—Cl C—H H CF3 — H CH3SCH2CO 6-375 C—Cl C—Br C—Cl C—H H CF3 — HCH3S(O)CH2CO 6-376 C—Cl C—Br C—Cl C—H H CF3 — H CH3SO2CH2CO 6-377 C—ClC—Br C—Cl C—H H CF3 — H CH3CH2NHCO 6-378 C—Cl C—Cl C—Br C—H H CF3 — HCH3CO 6-379 C—Cl C—Cl C—Br C—H H CF3 — H CH3CH2CO 6-380 C—Cl C—Cl C—BrC—H H CF3 — H n-PrCO 6-381 C—Cl C—Cl C—Br C—H H CF3 — H cyclo-PrCO 6-382C—Cl C—Cl C—Br C—H H CF3 — H cyclo-PrCH2CO 6-383 C—Cl C—Cl C—Br C—H HCF3 — H CF3CH2CO 6-384 C—Cl C—Cl C—Br C—H H CF3 — H CH3SCH2CO 6-385 C—ClC—Cl C—Br C—H H CF3 — H CH3S(O)CH2CO 6-386 C—Cl C—Cl C—Br C—H H CF3 — HCH3SO2CH2CO 6-387 C—Cl C—Cl C—Br C—H H CF3 — H CH3CH2NHCO 6-388 C—Cl C—FC—Cl C—H F CF3 — H CH3CO 6-389 C—Cl C—F C—Cl C—H F CF3 — H CH3CH2CO6-390 C—Cl C—F C—Cl C—H F CF3 — H n-PrCO 6-391 C—Cl C—F C—Cl C—H F CF3 —H cyclo-PrCO 6-392 C—Cl C—F C—Cl C—H F CF3 — H cyclo-PrCH2CO 6-393 C—ClC—F C—Cl C—H F CF3 — H CF3CH2CO 6-394 C—Cl C—F C—Cl C—H F CF3 — HCH3SCH2CO 6-395 C—Cl C—F C—Cl C—H F CF3 — H CH3S(O)CH2CO 6-396 C—Cl C—FC—Cl C—H F CF3 — H CH3SO2CH2CO 6-397 C—Cl C—F C—Cl C—H F CF3 — HCH3CH2NHCO 6-398 C—CF3 C—H C—H C—H H CF3 — H CH3CO 6-399 C—CF3 C—H C—HC—H H CF3 — H CH3CH2CO 6-400 C—CF3 C—H C—H C—H H CF3 — H n-PrCO 6-401C—CF3 C—H C—H C—H H CF3 — H cyclo-PrCO 6-402 C—CF3 C—H C—H C—H H CF3 — Hcyclo-PrCH2CO 6-403 C—CF3 C—H C—H C—H H CF3 — H CF3CH2CO 6-404 C—CF3 C—HC—H C—H H CF3 — H CH3SCH2CO 6-405 C—CF3 C—H C—H C—H H CF3 — HCH3S(O)CH2CO 6-406 C—CF3 C—H C—H C—H H CF3 — H CH3SO2CH2CO 6-407 C—CF3C—H C—H C—H H CF3 — H CH3CH2NHCO 6-408 C—CF3 C—F C—H C—H H CF3 — H CH3CO6-409 C—CF3 C—F C—H C—H H CF3 — H CH3CH2CO 6-410 C—CF3 C—F C—H C—H H CF3— H n-PrCO 6-411 C—CF3 C—F C—H C—H H CF3 — H cyclo-PrCO 6-412 C—CF3 C—FC—H C—H H CF3 — H cyclo-PrCH2CO 6-413 C—CF3 C—F C—H C—H H CF3 — HCF3CH2CO 6-414 C—CF3 C—F C—H C—H H CF3 — H CH3SCH2CO 6-415 C—CF3 C—F C—HC—H H CF3 — H CH3S(O)CH2CO 6-416 C—CF3 C—F C—H C—H H CF3 — H CH3SO2CH2CO6-417 C—CF3 C—F C—H C—H H CF3 — H CH3CH2NHCO 6-418 C—CF3 C—H C—H C—H FCF3 — H CH3CO 6-419 C—CF3 C—H C—H C—H F CF3 — H CH3CH2CO 6-420 C—CF3 C—HC—H C—H F CF3 — H n-PrCO 6-421 C—CF3 C—H C—H C—H F CF3 — H cyclo-PrCO6-422 C—CF3 C—H C—H C—H F CF3 — H cyclo-PrCH2CO 6-423 C—CF3 C—H C—H C—HF CF3 — H CF3CH2CO 6-424 C—CF3 C—H C—H C—H F CF3 — H CH3SCH2CO 6-425C—CF3 C—H C—H C—H F CF3 — H CH3S(O)CH2CO 6-426 C—CF3 C—H C—H C—H F CF3 —H CH3SO2CH2CO 6-427 C—CF3 C—H C—H C—H F CF3 — H CH3CH2NHCO 6-428 C—H C—HC—CF3 C—H F CF3 — H CH3CO 6-429 C—H C—H C—CF3 C—H F CF3 — H CH3CH2CO6-430 C—H C—H C—CF3 C—H F CF3 — H n-PrCO 6-431 C—H C—H C—CF3 C—H F CF3 —H cyclo-PrCO 6-432 C—H C—H C—CF3 C—H F CF3 — H cyclo-PrCH2CO 6-433 C—HC—H C—CF3 C—H F CF3 — H CF3CH2CO 6-434 C—H C—H C—CF3 C—H F CF3 — HCH3SCH2CO 6-435 C—H C—H C—CF3 C—H F CF3 — H CH3S(O)CH2CO 6-436 C—H C—HC—CF3 C—H F CF3 — H CH3SO2CH2CO 6-437 C—H C—H C—CF3 C—H F CF3 — HCH3CH2NHCO 6-438 C—Cl C—H C—CF3 C—H H CF3 — H CH3CO 6-439 C—Cl C—H C—CF3C—H H CF3 — H CH3CH2CO 6-440 C—Cl C—H C—CF3 C—H H CF3 — H n-PrCO 6-441C—Cl C—H C—CF3 C—H H CF3 — H cyclo-PrCO 6-442 C—Cl C—H C—CF3 C—H H CF3 —H cyclo-PrCH2CO 6-443 C—Cl C—H C—CF3 C—H H CF3 — H CF3CH2CO 6-444 C—ClC—H C—CF3 C—H H CF3 — H CH3OCH2CH2CO 6-445 C—Cl C—H C—CF3 C—H H CF3 — HCH3CH2OCH2CH2CO 6-446 C—Cl C—H C—CF3 C—H H CF3 — H CH3SCH2CO 6-447 C—ClC—H C—CF3 C—H H CF3 — H CH3S(O)CH2CO 6-448 C—Cl C—H C—CF3 C—H H CF3 — HCH3SO2CH2CO 6-449 C—Cl C—H C—CF3 C—H H CF3 — H CH3CH2NHCO 6-450 C—CF3C—H C—CF3 C—H H CF3 — H n-PrCO 6-451 C—CF3 C—H C—CF3 C—H H CF3 — Hcyclo-PrCH2CO 6-452 C—CF3 C—H C—CF3 C—H H CF3 — H CH3OCH2CH2CO 6-453C—CF3 C—H C—CF3 C—H H CF3 — H CH3CH2OCH2CH2CO 6-454 C—CF3 C—H C—CF3 C—HH CF3 — H CH3SCH2CO 6-455 C—CF3 C—H C—CF3 C—H H CF3 — H CH3S(O)CH2CO6-456 C—CF3 C—H C—CF3 C—H H CF3 — H CH3SO2CH2CO 6-457 C—Cl C—Cl C—CF3C—H H CF3 — H n-PrCO 6-458 C—Cl C—Cl C—CF3 C—H H CF3 — H cyclo-PrCH2CO6-459 C—Cl C—Cl C—CF3 C—H H CF3 — H CH3SCH2CO 6-460 C—Cl C—Cl C—CF3 C—HH CF3 — H CH3S(O)CH2CO 6-461 C—Cl C—Cl C—CF3 C—H H CF3 — H CH3SO2CH2CO6-462 C—Cl N C—H C—H H CF3 — H CH3CO 6-463 C—Cl N C—H C—H H CF3 — HCH3CH2CO 6-464 C—Cl N C—H C—H H CF3 — H n-PrCO 6-465 C—Cl N C—H C—H HCF3 — H cyclo-PrCO 6-466 C—Cl N C—H C—H H CF3 — H cyclo-PrCH2CO 6-467C—Cl N C—H C—H H CF3 — H CF3CH2CO 6-468 C—Cl N C—H C—H H CF3 — HCH3SCH2CO 6-469 C—Cl N C—H C—H H CF3 — H CH3S(O)CH2CO 6-470 C—Cl N C—HC—H H CF3 — H CH3SO2CH2CO 6-471 C—Cl N C—H C—H H CF3 — H CH3CH2NHCO6-472 C—Cl N C—Cl C—H H CF3 — H CH3CO 6-473 C—Cl N C—Cl C—H H CF3 — HCF3CH2CO 6-474 C—Cl N C—Cl C—H H CF3 — H n-PrCO 6-475 C—Cl N C—Cl C—H HCF3 — H cyclo-PrCO 6-476 C—Cl N C—Cl C—H H CF3 — H cyclo-PrCH2CO 6-477C—Cl N C—Cl C—H H CF3 — H CF3CH2CO 6-478 C—Cl N C—Cl C—H H CF3 — HCH3SCH2CO 6-479 C—Cl N C—Cl C—H H CF3 — H CH3S(O)CH2CO 6-480 C—Cl N C—ClC—H H CF3 — H CH3SO2CH2CO 6-481 C—Cl N C—Cl C—H H CF3 — H CH3CH2NHCO6-482 C—CF3 N C—H C—H H CF3 — H CH3CO 6-483 C—CF3 N C—H C—H H CF3 — HCF3CH2CO 6-484 C—CF3 N C—H C—H H CF3 — H n-PrCO 6-485 C—CF3 N C—H C—H HCF3 — H cyclo-PrCO 6-486 C—CF3 N C—H C—H H CF3 — H cyclo-PrCH2CO 6-487C—CF3 N C—H C—H H CF3 — H CF3CH2CO 6-488 C—CF3 N C—H C—H H CF3 — HCH3SCH2CO 6-489 C—CF3 N C—H C—H H CF3 — H CH3S(O)CH2CO 6-490 C—CF3 N C—HC—H H CF3 — H CH3SO2CH2CO 6-491 C—CF3 N C—H C—H H CF3 — H CH3CH2NHCO6-492 C—CF3 N C—CF3 C—H H CF3 — H CH3CO 6-493 C—CF3 N C—CF3 C—H H CF3 —H CF3CH2CO 6-494 C—CF3 N C—CF3 C—H H CF3 — H n-PrCO 6-495 C—CF3 N C—CF3C—H H CF3 — H cyclo-PrCO 6-496 C—CF3 N C—CF3 C—H H CF3 — H cyclo-PrCH2CO6-497 C—CF3 N C—CF3 C—H H CF3 — H CF3CH2CO 6-498 C—CF3 N C—CF3 C—H H CF3— H CH3SCH2CO 6-499 C—CF3 N C—CF3 C—H H CF3 — H CH3S(O)CH2CO 6-500 C—CF3N C—CF3 C—H H CF3 — H CH3SO2CH2CO 6-501 C—CF3 N C—CF3 C—H H CF3 — HCH3CH2NHCO 6-502 C—CF3 C—H C—H N H CF3 — H CH3CO 6-503 C—CF3 C—H C—H N HCF3 — H CF3CH2CO 6-504 C—CF3 C—H C—H N H CF3 — H n-PrCO 6-505 C—CF3 C—HC—H N H CF3 — H cyclo-PrCO 6-506 C—CF3 C—H C—H N H CF3 — H cyclo-PrCH2CO6-507 C—CF3 C—H C—H N H CF3 — H CF3CH2CO 6-508 C—CF3 C—H C—H N H CF3 — HCH3SCH2CO 6-509 C—CF3 C—H C—H N H CF3 — H CH3S(O)CH2CO 6-510 C—CF3 C—HC—H N H CF3 — H CH3SO2CH2CO 6-511 C—CF3 C—H C—H N H CF3 — H CH3CH2NHCO6-512 C—H C—H C—CF3 N H CF3 — H CH3CO 6-513 C—H C—H C—CF3 N H CF3 — HCF3CH2CO 6-514 C—H C—H C—CF3 N H CF3 — H n-PrCO 6-515 C—H C—H C—CF3 N HCF3 — H cyclo-PrCO 6-516 C—H C—H C—CF3 N H CF3 — H cyclo-PrCH2CO 6-517C—H C—H C—CF3 N H CF3 — H CF3CH2CO 6-518 C—H C—H C—CF3 N H CF3 — HCH3SCH2CO 6-519 C—H C—H C—CF3 N H CF3 — H CH3S(O)CH2CO 6-520 C—H C—HC—CF3 N H CF3 — H CH3SO2CH2CO 6-521 C—H C—H C—CF3 N H CF3 — H CH3CH2NHCO6-522 C—CF3 C—H C—Cl N H CF3 — H CH3CO 6-523 C—CF3 C—H C—Cl N H CF3 — HCF3CH2CO 6-524 C—CF3 C—H C—Cl N H CF3 — H n-PrCO 6-525 C—CF3 C—H C—Cl NH CF3 — H cyclo-PrCO 6-526 C—CF3 C—H C—Cl N H CF3 — H cyclo-PrCH2CO6-527 C—CF3 C—H C—Cl N H CF3 — H CF3CH2CO 6-528 C—CF3 C—H C—Cl N H CF3 —H CH3SCH2CO 6-529 C—CF3 C—H C—Cl N H CF3 — H CH3S(O)CH2CO 6-530 C—CF3C—H C—Cl N H CF3 — H CH3SO2CH2CO 6-531 C—CF3 C—H C—Cl N H CF3 — HCH3CH2NHCO 6-532 C—CF3 C—H C—Br N H CF3 — H CH3CO 6-533 C—CF3 C—H C—Br NH CF3 — H CF3CH2CO 6-534 C—CF3 C—H C—Br N H CF3 — H n-PrCO 6-535 C—CF3C—H C—Br N H CF3 — H cyclo-PrCO 6-536 C—CF3 C—H C—Br N H CF3 — Hcyclo-PrCH2CO 6-537 C—CF3 C—H C—Br N H CF3 — H CF3CH2CO 6-538 C—CF3 C—HC—Br N H CF3 — H CH3SCH2CO 6-539 C—CF3 C—H C—Br N H CF3 — H CH3S(O)CH2CO6-540 C—CF3 C—H C—Br N H CF3 — H CH3SO2CH2CO 6-541 C—CF3 C—H C—Br N HCF3 — H CH3CH2NHCO 6-542 C—CF3 C—H C—CF3 N H CF3 — H CH3CO 6-543 C—CF3C—H C—CF3 N H CF3 — H CF3CH2CO 6-544 C—CF3 C—H C—CF3 N H CF3 — H n-PrCO6-545 C—CF3 C—H C—CF3 N H CF3 — H cyclo-PrCO 6-546 C—CF3 C—H C—CF3 N HCF3 — H cyclo-PrCH2CO 6-547 C—CF3 C—H C—CF3 N H CF3 — H CF3CH2CO 6-548C—CF3 C—H C—CF3 N H CF3 — H CH3SCH2CO 6-549 C—CF3 C—H C—CF3 N H CF3 — HCH3S(O)CH2CO 6-550 C—CF3 C—H C—CF3 N H CF3 — H CH3SO2CH2CO 6-551 C—CF3C—H C—CF3 N H CF3 — H CH3CH2NHCO 6-552 C—Cl C—H C—H C—H H CF3 CH2 HCH3CO 6-553 C—Cl C—H C—H C—H H CF3 CH2 H CF3CH2CO 6-554 C—Cl C—H C—H C—HH CF3 CH2 H n-PrCO 6-555 C—Cl C—H C—H C—H H CF3 CH2 H cyclo-PrCO 6-556C—Cl C—H C—H C—H H CF3 CH2 H cyclo-PrCH2CO 6-557 C—Cl C—H C—H C—H H CF3CH2 H CF3CH2CO 6-558 C—Cl C—H C—H C—H H CF3 CH2 H CH3SCH2CO 6-559 C—ClC—H C—H C—H H CF3 CH2 H CH3S(O)CH2CO 6-560 C—Cl C—H C—H C—H H CF3 CH2 HCH3SO2CH2CO 6-561 C—Cl C—H C—H C—H H CF3 CH2 H CH3CH2NHCO 6-562 C—Cl C—HC—H C—H F CF3 CH2 H CH3CO 6-563 C—Cl C—H C—H C—H F CF3 CH2 H CF3CH2CO6-564 C—Cl C—H C—H C—H F CF3 CH2 H n-PrCO 6-565 C—Cl C—H C—H C—H F CF3CH2 H cyclo-PrCO 6-566 C—Cl C—H C—H C—H F CF3 CH2 H cyclo-PrCH2CO 6-567C—Cl C—H C—H C—H F CF3 CH2 H CF3CH2CO 6-568 C—Cl C—H C—H C—H F CF3 CH2 HCH3SCH2CO 6-569 C—Cl C—H C—H C—H F CF3 CH2 H CH3S(O)CH2CO 6-570 C—Cl C—HC—H C—H F CF3 CH2 H CH3SO2CH2CO 6-571 C—Cl C—H C—H C—H F CF3 CH2 HCH3CH2NHCO 6-572 C—H C—H C—Cl C—H F CF3 CH2 H CH3CO 6-573 C—H C—H C—ClC—H F CF3 CH2 H CF3CH2CO 6-574 C—H C—H C—Cl C—H F CF3 CH2 H n-PrCO 6-575C—H C—H C—Cl C—H F CF3 CH2 H cyclo-PrCO 6-576 C—H C—H C—Cl C—H F CF3 CH2H cyclo-PrCH2CO 6-577 C—H C—H C—Cl C—H F CF3 CH2 H CF3CH2CO 6-578 C—HC—H C—Cl C—H F CF3 CH2 H CH3SCH2CO 6-579 C—H C—H C—Cl C—H F CF3 CH2 HCH3S(O)CH2CO 6-580 C—H C—H C—Cl C—H F CF3 CH2 H CH3SO2CH2CO 6-581 C—HC—H C—Cl C—H F CF3 CH2 H CH3CH2NHCO 6-582 C—Cl C—H C—Cl C—H H CF3 CH2 HCH3OCH2CH2CO 6-583 C—Cl C—H C—Cl C—H H CF3 CH2 H CH3CH2OCH2CH2CO 6-584C—Cl C—H C—Cl C—H H CF3 CH2 H CH3S(O)CH2CO 6-585 C—Cl C—H C—Cl C—H H CF3CH2 H CH3SO2CH2CO 6-586 C—Cl C—H C—Br C—H H CF3 CH2 H CH3CO 6-587 C—ClC—H C—Br C—H H CF3 CH2 H CF3CH2CO 6-588 C—Cl C—H C—Br C—H H CF3 CH2 Hn-PrCO 6-589 C—Cl C—H C—Br C—H H CF3 CH2 H cyclo-PrCO 6-590 C—Cl C—HC—Br C—H H CF3 CH2 H cyclo-PrCH2CO 6-591 C—Cl C—H C—Br C—H H CF3 CH2 HCF3CH2CO 6-592 C—Cl C—H C—Br C—H H CF3 CH2 H CH3SCH2CO 6-593 C—Cl C—HC—Br C—H H CF3 CH2 H CH3S(O)CH2CO 6-594 C—Cl C—H C—Br C—H H CF3 CH2 HCH3SO2CH2CO 6-595 C—Cl C—H C—Br C—H H CF3 CH2 H CH3CH2NHCO 6-596 C—BrC—H C—Br C—H H CF3 CH2 H n-PrCO 6-597 C—Br C—H C—Br C—H H CF3 CH2 Hcyclo-PrCH2CO 6-598 C—Br C—H C—Br C—H H CF3 CH2 H CH3SCH2CO 6-599 C—BrC—H C—Br C—H H CF3 CH2 H CH3S(O)CH2CO 6-600 C—Br C—H C—Br C—H H CF3 CH2H CH3SO2CH2CO 6-601 C—Cl C—F C—Cl C—H H CF3 CH2 H CH3CO 6-602 C—Cl C—FC—Cl C—H H CF3 CH2 H CF3CH2CO 6-603 C—Cl C—F C—Cl C—H H CF3 CH2 H n-PrCO6-604 C—Cl C—F C—Cl C—H H CF3 CH2 H cyclo-PrCO 6-605 C—Cl C—F C—Cl C—H HCF3 CH2 H cyclo-PrCH2CO 6-606 C—Cl C—F C—Cl C—H H CF3 CH2 H CF3CH2CO6-607 C—Cl C—F C—Cl C—H H CF3 CH2 H CH3SCH2CO 6-608 C—Cl C—F C—Cl C—H HCF3 CH2 H CH3S(O)CH2CO 6-609 C—Cl C—F C—Cl C—H H CF3 CH2 H CH3SO2CH2CO6-610 C—Cl C—F C—Cl C—H H CF3 CH2 H CH3CH2NHCO 6-611 C—Cl C—Cl C—Cl C—HH CF3 CH2 H n-PrCO 6-612 C—Cl C—Cl C—Cl C—H H CF3 CH2 H cyclo-PrCH2CO6-613 C—Cl C—Cl C—Cl C—H H CF3 CH2 H CH3OCH2CH2CO 6-614 C—Cl C—Cl C—ClC—H H CF3 CH2 H CH3CH2OCH2CH2CO 6-615 C—Cl C—Cl C—Cl C—H H CF3 CH2 HCH3SCH2CO 6-616 C—Cl C—Cl C—Cl C—H H CF3 CH2 H CH3S(O)CH2CO 6-617 C—ClC—Cl C—Cl C—H H CF3 CH2 H CH3SO2CH2CO 6-618 C—Cl C—Br C—Cl C—H H CF3 CH2H CH3CO 6-619 C—Cl C—Br C—Cl C—H H CF3 CH2 H CH3CH2CO 6-620 C—Cl C—BrC—Cl C—H H CF3 CH2 H n-PrCO 6-621 C—Cl C—Br C—Cl C—H H CF3 CH2 Hcyclo-PrCO 6-622 C—Cl C—Br C—Cl C—H H CF3 CH2 H cyclo-PrCH2CO 6-623 C—ClC—Br C—Cl C—H H CF3 CH2 H CF3CH2CO 6-624 C—Cl C—Br C—Cl C—H H CF3 CH2 HCH3SCH2CO 6-625 C—Cl C—Br C—Cl C—H H CF3 CH2 H CH3S(O)CH2CO 6-626 C—ClC—Br C—Cl C—H H CF3 CH2 H CH3SO2CH2CO 6-627 C—Cl C—Br C—Cl C—H H CF3 CH2H CH3CH2NHCO 6-628 C—Cl C—Cl C—Br C—H H CF3 CH2 H CH3CO 6-629 C—Cl C—ClC—Br C—H H CF3 CH2 H CH3CH2CO 6-630 C—Cl C—Cl C—Br C—H H CF3 CH2 Hn-PrCO 6-631 C—Cl C—Cl C—Br C—H H CF3 CH2 H cyclo-PrCO 6-632 C—Cl C—ClC—Br C—H H CF3 CH2 H cyclo-PrCH2CO 6-633 C—Cl C—Cl C—Br C—H H CF3 CH2 HCF3CH2CO 6-634 C—Cl C—Cl C—Br C—H H CF3 CH2 H CH3SCH2CO 6-635 C—Cl C—ClC—Br C—H H CF3 CH2 H CH3S(O)CH2CO 6-636 C—Cl C—Cl C—Br C—H H CF3 CH2 HCH3SO2CH2CO 6-637 C—Cl C—Cl C—Br C—H H CF3 CH2 H CH3CH2NHCO 6-638 C—ClC—F C—Cl C—H F CF3 CH2 H CH3CO 6-639 C—Cl C—F C—Cl C—H F CF3 CH2 HCH3CH2CO 6-640 C—Cl C—F C—Cl C—H F CF3 CH2 H n-PrCO 6-641 C—Cl C—F C—ClC—H F CF3 CH2 H cyclo-PrCO 6-642 C—Cl C—F C—Cl C—H F CF3 CH2 Hcyclo-PrCH2CO 6-643 C—Cl C—F C—Cl C—H F CF3 CH2 H CF3CH2CO 6-644 C—ClC—F C—Cl C—H F CF3 CH2 H CH3SCH2CO 6-645 C—Cl C—F C—Cl C—H F CF3 CH2 HCH3S(O)CH2CO 6-646 C—Cl C—F C—Cl C—H F CF3 CH2 H CH3SO2CH2CO 6-647 C—ClC—F C—Cl C—H F CF3 CH2 H CH3CH2NHCO 6-648 C—CF3 C—H C—H C—H H CF3 CH2 HCH3CO 6-649 C—CF3 C—H C—H C—H H CF3 CH2 H CH3CH2CO 6-650 C—CF3 C—H C—HC—H H CF3 CH2 H n-PrCO 6-651 C—CF3 C—H C—H C—H H CF3 CH2 H cyclo-PrCO6-652 C—CF3 C—H C—H C—H H CF3 CH2 H cyclo-PrCH2CO 6-653 C—CF3 C—H C—HC—H H CF3 CH2 H CF3CH2CO 6-654 C—CF3 C—H C—H C—H H CF3 CH2 H CH3SCH2CO6-655 C—CF3 C—H C—H C—H H CF3 CH2 H CH3S(O)CH2CO 6-656 C—CF3 C—H C—H C—HH CF3 CH2 H CH3SO2CH2CO 6-657 C—CF3 C—H C—H C—H H CF3 CH2 H CH3CH2NHCO6-658 C—CF3 C—F C—H C—H H CF3 CH2 H CH3CO 6-659 C—CF3 C—F C—H C—H H CF3CH2 H CH3CH2CO 6-660 C—CF3 C—F C—H C—H H CF3 CH2 H n-PrCO 6-661 C—CF3C—F C—H C—H H CF3 CH2 H cyclo-PrCO 6-662 C—CF3 C—F C—H C—H H CF3 CH2 Hcyclo-PrCH2CO 6-663 C—CF3 C—F C—H C—H H CF3 CH2 H CF3CH2CO 6-664 C—CF3C—F C—H C—H H CF3 CH2 H CH3SCH2CO 6-665 C—CF3 C—F C—H C—H H CF3 CH2 HCH3S(O)CH2CO 6-666 C—CF3 C—F C—H C—H H CF3 CH2 H CH3SO2CH2CO 6-667 C—CF3C—F C—H C—H H CF3 CH2 H CH3CH2NHCO 6-668 C—CF3 C—H C—H C—H F CF3 CH2 HCH3CO 6-669 C—CF3 C—H C—H C—H F CF3 CH2 H CH3CH2CO 6-670 C—CF3 C—H C—HC—H F CF3 CH2 H n-PrCO 6-671 C—CF3 C—H C—H C—H F CF3 CH2 H cyclo-PrCO6-672 C—CF3 C—H C—H C—H F CF3 CH2 H cyclo-PrCH2CO 6-673 C—CF3 C—H C—HC—H F CF3 CH2 H CF3CH2CO 6-674 C—CF3 C—H C—H C—H F CF3 CH2 H CH3SCH2CO6-675 C—CF3 C—H C—H C—H F CF3 CH2 H CH3S(O)CH2CO 6-676 C—CF3 C—H C—H C—HF CF3 CH2 H CH3SO2CH2CO 6-677 C—CF3 C—H C—H C—H F CF3 CH2 H CH3CH2NHCO6-678 C—H C—H C—CF3 C—H F CF3 CH2 H CH3CO 6-679 C—H C—H C—CF3 C—H F CF3CH2 H CH3CH2CO 6-680 C—H C—H C—CF3 C—H F CF3 CH2 H n-PrCO 6-681 C—H C—HC—CF3 C—H F CF3 CH2 H cyclo-PrCO 6-682 C—H C—H C—CF3 C—H F CF3 CH2 Hcyclo-PrCH2CO 6-683 C—H C—H C—CF3 C—H F CF3 CH2 H CF3CH2CO 6-684 C—H C—HC—CF3 C—H F CF3 CH2 H CH3SCH2CO 6-685 C—H C—H C—CF3 C—H F CF3 CH2 HCH3S(O)CH2CO 6-686 C—H C—H C—CF3 C—H F CF3 CH2 H CH3SO2CH2CO 6-687 C—HC—H C—CF3 C—H F CF3 CH2 H CH3CH2NHCO 6-688 C—Cl C—H C—CF3 C—H H CF3 CH2H CH3CO 6-689 C—Cl C—H C—CF3 C—H H CF3 CH2 H CH3CH2CO 6-690 C—Cl C—HC—CF3 C—H H CF3 CH2 H n-PrCO 6-691 C—Cl C—H C—CF3 C—H H CF3 CH2 Hcyclo-PrCO 6-692 C—Cl C—H C—CF3 C—H H CF3 CH2 H cyclo-PrCH2CO 6-693 C—ClC—H C—CF3 C—H H CF3 CH2 H CF3CH2CO 6-694 C—Cl C—H C—CF3 C—H H CF3 CH2 HCH3OCH2CH2CO 6-695 C—Cl C—H C—CF3 C—H H CF3 CH2 H CH3CH2OCH2CH2CO 6-696C—Cl C—H C—CF3 C—H H CF3 CH2 H CH3SCH2CO 6-697 C—Cl C—H C—CF3 C—H H CF3CH2 H CH3S(O)CH2CO 6-698 C—Cl C—H C—CF3 C—H H CF3 CH2 H CH3SO2CH2CO6-699 C—Cl C—H C—CF3 C—H H CF3 CH2 H CH3CH2NHCO 6-700 C—CF3 C—H C—CF3C—H H CF3 CH2 H n-PrCO 6-701 C—CF3 C—H C—CF3 C—H H CF3 CH2 Hcyclo-PrCH2CO 6-702 C—CF3 C—H C—CF3 C—H H CF3 CH2 H CH3OCH2CH2CO 6-703C—CF3 C—H C—CF3 C—H H CF3 CH2 H CH3CH2OCH2CH2CO 6-704 C—CF3 C—H C—CF3C—H H CF3 CH2 H CH3SCH2CO 6-705 C—CF3 C—H C—CF3 C—H H CF3 CH2 HCH3S(O)CH2CO 6-706 C—CF3 C—H C—CF3 C—H H CF3 CH2 H CH3SO2CH2CO 6-707C—Cl C—Cl C—CF3 C—H H CF3 CH2 H n-PrCO 6-708 C—Cl C—Cl C—CF3 C—H H CF3CH2 H cyclo-PrCH2CO 6-709 C—Cl C—Cl C—CF3 C—H H CF3 CH2 H CH3SCH2CO6-710 C—Cl C—Cl C—CF3 C—H H CF3 CH2 H CH3S(O)CH2CO 6-711 C—Cl C—Cl C—CF3C—H H CF3 CH2 H CH3SO2CH2CO 6-712 C—Cl N C—H C—H H CF3 CH2 H CH3CO 6-713C—Cl N C—H C—H H CF3 CH2 H CH3CH2CO 6-714 C—Cl N C—H C—H H CF3 CH2 Hn-PrCO 6-715 C—Cl N C—H C—H H CF3 CH2 H cyclo-PrCO 6-716 C—Cl N C—H C—HH CF3 CH2 H cyclo-PrCH2CO 6-717 C—Cl N C—H C—H H CF3 CH2 H CF3CH2CO6-718 C—Cl N C—H C—H H CF3 CH2 H CH3SCH2CO 6-719 C—Cl N C—H C—H H CF3CH2 H CH3S(O)CH2CO 6-720 C—Cl N C—H C—H H CF3 CH2 H CH3SO2CH2CO 6-721C—Cl N C—H C—H H CF3 CH2 H CH3CH2NHCO 6-722 C—Cl N C—Cl C—H H CF3 CH2 HCH3CO 6-723 C—Cl N C—Cl C—H H CF3 CH2 H CH3CH2CO 6-724 C—Cl N C—Cl C—H HCF3 CH2 H n-PrCO 6-725 C—Cl N C—Cl C—H H CF3 CH2 H cyclo-PrCO 6-726 C—ClN C—Cl C—H H CF3 CH2 H cyclo-PrCH2CO 6-727 C—Cl N C—Cl C—H H CF3 CH2 HCF3CH2CO 6-728 C—Cl N C—Cl C—H H CF3 CH2 H CH3SCH2CO 6-729 C—Cl N C—ClC—H H CF3 CH2 H CH3S(O)CH2CO 6-730 C—Cl N C—Cl C—H H CF3 CH2 HCH3SO2CH2CO 6-731 C—Cl N C—Cl C—H H CF3 CH2 H CH3CH2NHCO 6-732 C—CF3 NC—H C—H H CF3 CH2 H CH3CO 6-733 C—CF3 N C—H C—H H CF3 CH2 H CH3CH2CO6-734 C—CF3 N C—H C—H H CF3 CH2 H n-PrCO 6-735 C—CF3 N C—H C—H H CF3 CH2H cyclo-PrCO 6-736 C—CF3 N C—H C—H H CF3 CH2 H cyclo-PrCH2CO 6-737 C—CF3N C—H C—H H CF3 CH2 H CF3CH2CO 6-738 C—CF3 N C—H C—H H CF3 CH2 HCH3SCH2CO 6-739 C—CF3 N C—H C—H H CF3 CH2 H CH3S(O)CH2CO 6-740 C—CF3 NC—H C—H H CF3 CH2 H CH3SO2CH2CO 6-741 C—CF3 N C—H C—H H CF3 CH2 HCH3CH2NHCO 6-742 C—CF3 N C—CF3 C—H H CF3 CH2 H CH3CO 6-743 C—CF3 N C—CF3C—H H CF3 CH2 H CH3CH2CO 6-744 C—CF3 N C—CF3 C—H H CF3 CH2 H n-PrCO6-745 C—CF3 N C—CF3 C—H H CF3 CH2 H cyclo-PrCO 6-746 C—CF3 N C—CF3 C—H HCF3 CH2 H cyclo-PrCH2CO 6-747 C—CF3 N C—CF3 C—H H CF3 CH2 H CF3CH2CO6-748 C—CF3 N C—CF3 C—H H CF3 CH2 H CH3SCH2CO 6-749 C—CF3 N C—CF3 C—H HCF3 CH2 H CH3S(O)CH2CO 6-750 C—CF3 N C—CF3 C—H H CF3 CH2 H CH3SO2CH2CO6-751 C—CF3 N C—CF3 C—H H CF3 CH2 H CH3CH2NHCO 6-752 C—CF3 C—H C—H N HCF3 CH2 H CH3CO 6-753 C—CF3 C—H C—H N H CF3 CH2 H CH3CH2CO 6-754 C—CF3C—H C—H N H CF3 CH2 H n-PrCO 6-755 C—CF3 C—H C—H N H CF3 CH2 Hcyclo-PrCO 6-756 C—CF3 C—H C—H N H CF3 CH2 H cyclo-PrCH2CO 6-757 C—CF3C—H C—H N H CF3 CH2 H CF3CH2CO 6-758 C—CF3 C—H C—H N H CF3 CH2 HCH3SCH2CO 6-759 C—CF3 C—H C—H N H CF3 CH2 H CH3S(O)CH2CO 6-760 C—CF3 C—HC—H N H CF3 CH2 H CH3SO2CH2CO 6-761 C—CF3 C—H C—H N H CF3 CH2 HCH3CH2NHCO 6-762 C—H C—H C—CF3 N H CF3 CH2 H CH3CO 6-763 C—H C—H C—CF3 NH CF3 CH2 H CH3CH2CO 6-764 C—H C—H C—CF3 N H CF3 CH2 H n-PrCO 6-765 C—HC—H C—CF3 N H CF3 CH2 H cyclo-PrCO 6-766 C—H C—H C—CF3 N H CF3 CH2 Hcyclo-PrCH2CO 6-767 C—H C—H C—CF3 N H CF3 CH2 H CF3CH2CO 6-768 C—H C—HC—CF3 N H CF3 CH2 H CH3SCH2CO 6-769 C—H C—H C—CF3 N H CF3 CH2 HCH3S(O)CH2CO 6-770 C—H C—H C—CF3 N H CF3 CH2 H CH3SO2CH2CO 6-771 C—H C—HC—CF3 N H CF3 CH2 H CH3CH2NHCO 6-772 C—CF3 C—H C—Cl N H CF3 CH2 H CH3CO6-773 C—CF3 C—H C—Cl N H CF3 CH2 H CH3CH2CO 6-774 C—CF3 C—H C—Cl N H CF3CH2 H n-PrCO 6-775 C—CF3 C—H C—Cl N H CF3 CH2 H cyclo-PrCO 6-776 C—CF3C—H C—Cl N H CF3 CH2 H cyclo-PrCH2CO 6-777 C—CF3 C—H C—Cl N H CF3 CH2 HCF3CH2CO 6-778 C—CF3 C—H C—Cl N H CF3 CH2 H CH3SCH2CO 6-779 C—CF3 C—HC—Cl N H CF3 CH2 H CH3S(O)CH2CO 6-780 C—CF3 C—H C—Cl N H CF3 CH2 HCH3SO2CH2CO 6-781 C—CF3 C—H C—Cl N H CF3 CH2 H CH3CH2NHCO 6-782 C—CF3C—H C—Br N H CF3 CH2 H CH3CO 6-783 C—CF3 C—H C—Br N H CF3 CH2 H CH3CH2CO6-784 C—CF3 C—H C—Br N H CF3 CH2 H n-PrCO 6-785 C—CF3 C—H C—Br N H CF3CH2 H cyclo-PrCO 6-786 C—CF3 C—H C—Br N H CF3 CH2 H cyclo-PrCH2CO 6-787C—CF3 C—H C—Br N H CF3 CH2 H CF3CH2CO 6-788 C—CF3 C—H C—Br N H CF3 CH2 HCH3SCH2CO 6-789 C—CF3 C—H C—Br N H CF3 CH2 H CH3S(O)CH2CO 6-790 C—CF3C—H C—Br N H CF3 CH2 H CH3SO2CH2CO 6-791 C—CF3 C—H C—Br N H CF3 CH2 HCH3CH2NHCO 6-792 C—CF3 C—H C—CF3 N H CF3 CH2 H CH3CO 6-793 C—CF3 C—HC—CF3 N H CF3 CH2 H CH3CH2CO 6-794 C—CF3 C—H C—CF3 N H CF3 CH2 H n-PrCO6-795 C—CF3 C—H C—CF3 N H CF3 CH2 H cyclo-PrCO 6-796 C—CF3 C—H C—CF3 N HCF3 CH2 H cyclo-PrCH2CO 6-797 C—CF3 C—H C—CF3 N H CF3 CH2 H CF3CH2CO6-798 C—CF3 C—H C—CF3 N H CF3 CH2 H CH3SCH2CO 6-799 C—CF3 C—H C—CF3 N HCF3 CH2 H CH3S(O)CH2CO 6-800 C—CF3 C—H C—CF3 N H CF3 CH2 H CH3SO2CH2CO6-801 C—CF3 C—H C—CF3 N H CF3 CH2 H CH3CH2NHCO 6-802 C—Cl C—Cl C—Cl C—HH CF3 — H tert-BuOCO 6-803 C—Cl C—H C—Cl C—H H CF3 — H 2-py-NHCO 6-804C—Cl C—H C—Cl C—H H CF3 — H 3-py-NHCO 6-805 C—Cl C—H C—Cl C—H H CF3 — H4-py-NHCO 6-806 C—Cl C—H C—Cl C—H H CF3 — H

6-807 C—Cl C—H C—Cl C—H H CF3 — H

6-808 C—Cl C—H C—Cl C—H H CF3 — H PhCH2HNCO 6-809 C—Cl C—H C—Cl C—H HCF3 — H

6-810 C—Cl C—H C—Cl C—H H CF3 — H (CH3)2NCO 6-811 C—Cl C—H C—Cl C—H HCF3 — H pyrrolidineCO 6-812 C—Cl C—H C—Cl C—H H CF3 — H piperidineCO6-813 C—Cl C—H C—Cl C—H H CF3 — H morpholineCO

TABLE 7

Table 7- Ex.-No. B¹ B² B³ B⁴ X¹ R A¹ A² A³ A⁴ R′ 7-1 C—Cl C—H C—Cl C—H HCF3 CH CH C—CF3 CH CN 7-2 C—Cl C—H C—Cl C—H H CF3 CH CH CH CH CN 7-3C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CH CN 7-4 C—Cl C—H C—Cl C—H H CF3 CHCH C—F CH CN 7-5 C—Cl C—H C—Cl C—H H CF3 CH CH C—CH3 CH CN 7-6 C—Cl C—HC—Cl C—H H CF3 CH CH C—SCF3 CH CN 7-7 C—Cl C—H C—Cl C—H H CF3 CH CHC—S(O)CF3 CH CN 7-8 C—Cl C—H C—Cl C—H H CF3 CH CH C—S(O)2CF3 CH CN 7-9C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH2CF3 CH CN 7-10 C—Cl C—H C—Cl C—H HCF3 CH CH C—S(O)CH2CF3 CH CN 7-11 C—Cl C—H C—Cl C—H H CF3 CH CHC—S(O)2CH2CF3 CH CN 7-12 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 CH CN 7-13C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl CH CN 7-14 C—Cl C—Cl C—Cl C—H H CF3CH CH C—Br CH CN 7-15 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—F CH CN 7-16 C—ClC—Cl C—Cl C—H H CF3 CH CH C—CH3 CH CN 7-17 C—Cl C—Cl C—Cl C—H H CF3 CHCH C—SCF3 CH CN 7-18 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—S(O)CF3 CH CN 7-19C—Cl C—Cl C—Cl C—H H CF3 CH CH C—S(O)2CF3 CH CN 7-20 C—Cl C—Cl C—Cl C—HH CF3 CH CH C—SCH2CF3 CH CN 7-21 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—S(O)CH2CF3 CH CN 7-22 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—S(O)2CH2CF3 CHCN 7-23 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 CH CN 7-24 C—CF3 C—H C—CF3C—H H CF3 CH CH C—Cl CH CN 7-25 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Br CHCN 7-26 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F CH CN 7-27 C—CF3 C—H C—CF3C—H H CF3 CH CH C—CH3 CH CN 7-28 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—NO2CH CN 7-29 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCF3 CH CN 7-30 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—S(O)CF3 CH CN 7-31 C—CF3 C—H C—CF3 C—H H CF3 CHCH C—S(O)2CF3 CH CN 7-32 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH CN7-33 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH CN 7-34 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—S(O)2CH2CF3 CH CN 7-35 C—Cl C—Cl C—CF3 C—H H CF3CH CH C—CF3 CH CN 7-36 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Cl CH CN 7-37C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—Br CH CN 7-38 C—Cl C—Cl C—CF3 C—H HCF3 CH CH C—F CH CN 7-39 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—CH3 CH CN7-40 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—SCF3 CH CN 7-41 C—Cl C—Cl C—CF3C—H H CF3 CH CH C—S(O)CF3 CH CN 7-42 C—Cl C—Cl C—CF3 C—H H CF3 CH CHC—S(O)2CF3 CH CN 7-43 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—SCH2CF3 CH CN7-44 C—Cl C—Cl C—CF3 C—H H CF3 CH CH C—S(O)CH2CF3 CH CN 7-45 C—Cl C—ClC—CF3 C—H H CF3 CH CH C—S(O)2CH2CF3 CH CN 7-46 C—Cl C—H C—Cl C—H H CF3CH CH C—SCH3 CH CN 7-47 C—Cl C—H C—Cl C—H H CF3 CH CH C—SCH3 CH CH2OH7-49 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br N CH2OH 7-51 C—Cl C—H C—CF3 C—HH CF3 CH CH C—Br CH CH2OH 7-53 C—Cl C—H C—Cl C—H H CF3 CH CH C—Br CHCH2OH 7-55 C—Cl C—H C—Cl C—H H CF3 CH CH C—I CH CH2OH 7-57 C—Cl C—ClC—Cl C—H H CF3 CH CH C—Br CH CH2OH 7-59 C—Cl C—H C—Cl C—H H CF3 CH CHC—Cl C—F CH2OH 7-61 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl CH CH2OH 7-63C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl C—F CH2OH 7-65 C—CF3 C—H C—CF3 C—HH CF3 CH CH C—Br CH CH2OH 7-67 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—I CHCH2OH 7-69 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—F C—F CH2OH 7-71 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—F C—F CN 7-72 C—Cl C—Cl C—Cl C—H H CF3 CH CHC—Cl C—F CH2OH 7-74 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CH3 C—F CH2OH 7-76C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CH3 C—F CH2OH 7-78 C—Br C—H C—Br C—H HCF3 CH CH C—CF3 CH CH2OH 7-86 C—Cl C—H C—Cl C—H H CF3 CH CH C—Cl N CH2OH7-87 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl N CO2CH3 7-88 C—Cl C—Cl C—ClC—H H CF3 CH CH C—Cl N CO2H 7-89 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Cl NCH2OH 7-90 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—Cl N CO2CH3 7-91 C—CF3 C—HC—CF3 C—H H CF3 CH CH C—Cl N CO2H 7-92 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—Cl N CH2OH 7-93 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—Br N CH2OH 7-95 C—CF3C—H C—CF3 C—H H CF3 CH CH C—Br N CH2OH 7-97 C—Cl C—H C—Cl C—H H CF3 C—FCH C—Cl N CN 7-98 C—Cl C—Cl C—Cl C—H H CF3 C—F CH C—Cl N CN 7-99 C—CF3C—H C—CF3 C—H H CF3 C—F CH C—Cl N CN 7-100 C—Cl C—H C—Cl C—H H CF3 CH CHC—OCH3 CH CH2OH 7-102 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—OCF3 CH CN 7-103C—Br C—H C—Br C—H H CF3 CH CH C—CF3 CH CN 7-104 C—Cl C—H C—Cl C—H H CF3CH CH CH N CH2OH 7-105 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 CH CO2Et7-106 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 CH CO2H 7-107 C—Cl C—Cl C—ClC—H H CF3 N CH C—CF3 CH CH2OH 7-108 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3CH CO2Et 7-109 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3 CH CO2H 7-110 C—CF3C—H C—CF3 C—H H CF3 N CH C—CF3 CH CH2OH 7-111 C—Cl C—H C—Cl C—H H CF3 CHCH C—CF3 N CH2OH 7-112 C—Cl C—Cl C—Cl C—H H CF3 CH CH C—CF3 N CH2OH7-113 C—Cl C—H C—CF3 C—H H CF3 CH CH C—CF3 N CO2Et 7-114 C—Cl C—H C—CF3C—H H CF3 CH CH C—CF3 N CH2OH 7-115 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3N CO2Et 7-116 C—CF3 C—H C—H C—H H CF3 CH CH C—CF3 N CO2H 7-117 C—CF3 C—HC—H C—H H CF3 CH CH C—CF3 N CH2OH 7-118 C—CF3 C—H C—CF3 C—H H CF3 CH CHC—CF3 N CO2H 7-119 C—CF3 C—H C—CF3 C—H H CF3 CH CH C—CF3 N CH2OH 7-120C—Br C—H C—Br C—H H CF3 CH CH C—CF3 N CO2Et 7-121 C—Br C—H C—Br C—H HCF3 CH CH C—CF3 N CH2OH 7-122 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 NCO2Et 7-123 C—Cl C—H C—Cl C—H H CF3 CH CH C—CF3 N OO2H 7-124 C—Cl C—HC—Cl C—H H CF3 CH CH C—CF3 N CH2OH 7-125 C—Cl C—H C—Cl C—H H CF3 CH CHC-cyclo-Pr N CO2Et 7-126 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N CO2H7-127 C—Cl C—H C—Cl C—H H CF3 CH CH C-cyclo-Pr N CH2OH 7-128 C—CF3 C—HC—CF3 C—H H CF3 CH CH C-cyclo-Pr N CO2Et 7-129 C—CF3 C—H C—CF3 C—H H CF3CH CH C-cyclo-Pr N CH2OH 7-130 C—Cl C—H C—Cl C—H H CF3 N CH CH N CO2CH37-131 C—Cl C—H C—Cl C—H H CF3 N CH CH N CO2H 7-132 C—Cl C—H C—Cl C—H HCF3 N CH C—CF3 N CO2Et 7-133 C—Cl C—H C—Cl C—H H CF3 N CH C—CF3 N CO2H7-134 C—Cl C—H C—Cl C—H H CF3 N CH C—CF3 N CH2OH 7-135 C—Cl C—Cl C—ClC—H H CF3 N CH C—CF3 N CO2Et 7-136 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 NCO2H 7-137 C—Cl C—Cl C—Cl C—H H CF3 N CH C—CF3 N CH2OH 7-138 C—Cl C—ClC—Cl C—H H CF3 N CH C—CF3 N CH2OSO23CH3 7-139 C—CF3 C—H C—H C—H H CF3 NCH C—CF3 N CO2Et 7-140 C—CF3 C—H C—H C—H H CF3 N CH C—CF3 N CO2H 7-141C—CF3 C—H C—H C—H H CF3 N CH C—CF3 N CH2OH 7-142 C—CF3 C—H C—CF3 C—H HCF3 N CH C—CF3 N CO2Et 7-143 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3 N CO2H7-144 C—CF3 C—H C—CF3 C—H H CF3 N CH C—CF3 N CH2OH 7-145 C—CF3 C—H C—CF3C—H H CF3 N CH C—CF3 N CH2OSO2CH3 7-146 C—Br C—H C—Br C—H H CF3 N CHC—CF3 N CO2Et 7-147 C—Br C—H C—Br C—H H CF3 N CH C—CF3 N CH2OH

TABLE 7a

Table 7a- Ex.- No. B1 B2 B3 B4 X1 R Y R′ 7a-1 C—Cl C—H C—Cl C—H H CF3C—Cl CHO 7a-2 C—Cl C—H C—Cl C—H H CF3 C—Cl CH2OH 7a-3 C—Cl C—H C—Cl C—HH CF3 C—CH3 CO2Et 7a-4 C—Cl C—H C—Cl C—H H CF3 C—CH3 CO2CH3 7a-5 C—ClC—H C—Cl C—H H CF3 C—CH3 CH2OH 7a-6 C—Cl C—H C—Cl C—H H CF3 C—CF3 CO2Et7a-7 C—Cl C—H C—Cl C—H H CF3 C—CF3 CO2H 7a-8 C—Cl C—H C—Cl C—H H CF3C—CF3 CH2OH 7a-9 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 CO2Et 7a-10 C—Cl C—ClC—Cl C—H H CF3 C—CF3 CO2H 7a-11 C—Cl C—Cl C—Cl C—H H CF3 C—CF3 CH2OH7a-12 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 CO2Et 7a-13 C—CF3 C—H C—CF3 C—H HCF3 C—CF3 CO2H 7a-14 C—CF3 C—H C—CF3 C—H H CF3 C—CF3 CH2OH

TABLE 8 Table 8 - Ex.-No. 1H-NMR 1-3 1H-NMR (CDCl3) δ: 1.14 (6H, d),2.30-2.39 (1H, m), 2.53-2.55 (1H, m), 2.82-2.86 (1H, m), 3.45-3.52 (2H,m), 3.74 (1H), 4.02 (1H, d), 4.42 (2H, d), 5.79 (1H, s), 6.45 (1H, dd),6.59 (1H, d), 7.25-7.27 (3H, m), 7.39 (1H, t) 1-4 1H-NMR (CDCl3) δ:0.70-0.74 (2H, m), 0.88-1.00 (2H, m), 1.26-1.32 (1H, m), 2.51-2.55 (1H,m), 2.81-2.84 (1H, m), 3.45-3.52 (2H, m), 3.74 (1H, d), 4.02 (1H, d),4.45 (2H, d), 5.98 (1H, s), 6.45 (1H, dd), 6.60 (1H, d), 7.27-7.28 (4H,m), 7.39 (1H, t) 1-7 1H-NMR (CDCl3) δ: 0.92 (6H, d), 2.07-2.18 (3H, m),2.51-2.54 (1H, m), 2.81-2.89 (1H, m), 3.45-3.52 (2H, m), 3.74 (1H, d),4.02 (1H, d), 4.43 (2H, d), 5.75 (1H, s), 6.45 (1H, dd), 6.59 (1H, d),7.26-7.29 (3H, m), 7.39 (1H, t) 1-8 1H-NMR (CDCl3) δ: 1.83-2.36 (6H, m),2.53-2.55 (1H, m), 2.80-2.89 (1H, m), 2.97-3.00 (1H, m), 3.47-3.51 (2H,m), 3.74 (1H, d), 4.02 (1H, d), 4.43 (2H, d), 5.67 (1H, s), 6.45 (1H,dd), 6.59 (1H, d), 7.26-7.27 (3H, m), 7.39 (1H, t) 1-12 1H-NMR (CDCl3)δ: 0.18-0.19 (2H, m), 0.58-0.61 (3H, m), 0.90-0.97 (1H, m), 2.16 (2H,d), 2.53-2.56 (1H, m), 2.81-2.89 (1H, m), 3.45-3.54 (2H, m), 3.75 (1H,d), 4.03 (1H, d), 4.46 (2H, d), 6.31 (1H, s), 6.46 (1H, dd), 6.60 (1H,d), 7.27-7.29 (3H, m), 7.39 (1H, t) 1-15 1H-NMR (CDCl3) δ: 2.51-2.56(1H, m), 2.83-2.84 (1H, m), 3.44-3.55 (2H, m), 3.75 (1H, d), 4.01-4.05(3H, m), 4.49 (2H, d), 6.46 (1H, dd), 6.61 (1H, d), 6.93 (1H, br s),7.28 (2H, s), 7.39 (1H, t). 1-19 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m),2.82-2.87 (1H, m), 3.06 (2H, q), 3.48-3.51 (2H, m), 3.75 (1H, d), 4.03(1H, d), 4.47 (2H, d), 6.04 (1H, s), 6.46 (1H, dd), 6.60 (1H, d),7.24-7.26 (3H, m), 7.39 (1H, t) 1-20 1H-NMR (CDCl3) δ: 2.53-2.57 (1H,m), 2.86-2.88 (1H, m), 3.47-3.52 (2H, m), 3.73-3.85 (2H, m), 4.04 (1H,d), 4.51 (2H, d), 6.21 (1H, s), 6.46 (1H, dd), 6.61 (1H, d), 7.22-7.26(3H, m), 7.39 (1H, t) 1-21 1H-NMR (CDCl3) δ: 2.51-2.59 (1H, m),2.82-2.90 (1H, m), 3.44-3.55 (2H, m), 3.75 (1H, d), 4.03 (1H, d), 4.51(2H, d), 5.89 (1H, t), 6.46 (1H, dd), 6.61-6.62 (2H, m), 7.26-7.27 (3H,m), 7.39 (1H, s) 1-23 1H-NMR (CDCl3) δ: 0.54-0.56 (2H, m), 1.18-1.21(2H, m), 1.30 (3H, s), 2.51-2.58 (1H, m), 2.80-2.89 (1H, m), 3.46-3.52(2H, m), 3.75 (1H, d), 4.02 (1H, d), 4.44 (2H, d), 6.13 (1H, s), 6.46(1H, dd), 6.60 (1H, d), 7.26-7.28 (3H, m), 7.39 (1H, t). 1-24 1H-NMR(CDCl3) δ: 1.77-1.81 (1H, m), 2.12-2.14 (1H, m), 2.32-2.36 (1H, m),2.52-2.54 (1H, m), 2.82-2.87 (1H, m), 3.45-3.52 (2H, m), 3.74 (1H, d),4.02 (1H, d), 4.50-4.51 (2H, m), 6.25 (1H, s), 6.46 (1H, dd), 6.60 (1H,d), 7.27-7.30 (3H, m), 7.39 (1H, t) 1-25 1H-NMR (CDCl3) δ: 1.59-1.71(1H, m), 2.07-2.28 (2H, m), 2.53-2.56 (1H, m), 2.81-2.89 (1H, m),3.44-3.54 (3H, m), 3.75 (1H, d), 4.02 (1H, d), 4.45-4.52 (2H, m), 6.03(1H, s), 6.46 (1H, dd), 6.60 (1H, d), 7.26-7.27 (3H, m), 7.39 (1H, t)1-28 1H-NMR (CDCl3) δ: 1.47-1.48 (2H, m), 1.67-1.70 (2H, m), 2.53-2.55(1H, m), 2.82-2.90 (1H, m), 3.47-3.53 (2H, m), 3.75 (1H, d), 4.04 (1H,d), 4.48 (2H, d), 6.46 (1H, dd), 6.62 (1H, d), 6.74 (1H, s), 7.23-7.28(3H, m), 7.39 (1H, t) 1-30 1H-NMR (CDCl3) δ: 1.84 (3H, dd), 2.51-2.55(1H, m), 2.83-2.84 (1H, m), 3.47-3.50 (2H, m), 3.74 (1H, d), 4.02 (1H,d), 4.49 (2H, d), 5.78 (2H, dd), 6.45 (1H, dd), 6.59 (1H, d), 6.85 (1H,dd), 7.27-7.30 (3H, m), 7.39 (1H, t). 1-31 1H-NMR (CDCl3) δ: 1.55 (3H,s), 2.30-2.37 (1H, m), 2.52-2.54 (1H, m), 2.81-2.93 (2H, m), 3.49 (2H,d), 3.74 (1H, d), 4.02 (1H, d), 4.36-4.38 (2H, m), 6.44 (1H, dd), 6.59(1H, d), 7.16 (1H, d), 7.27-7.28 (2H, m), 7.39 (1H, t). 1-32 1H-NMR(CDCl3) δ: 1.74 (3H, d), 1.83 (3H, s), 2.51-2.55 (1H, m), 2.83-2.87 (1H,m), 3.46-3.52 (2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.49 (2H, d), 6.06(1H, s), 6.42-6.47 (2H, m), 6.59 (1H, d), 7.27-7.30 (3H, m), 7.39 (1H,t). 1-36 1H-NMR (CDCl3) δ: 2.51-2.55 (1H, m), 2.82-2.84 (1H, m), 3.01(2H, d), 3.46-3.52 (2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.43 (2H, d),5.17-5.24 (2H, m), 5.88-5.97 (2H, m), 6.45 (1H, dd), 6.59 (1H, d),7.25-7.27 (3H, m), 7.39 (1H, t). 1-39 1H-NMR (CDCl3) δ: 2.54-2.58 (1H,m), 2.84-2.86 (1H, m), 3.36 (2H, s), 3.48-3.51 (2H, m), 3.75 (1H, d),4.03 (1H, d), 4.47 (2H, d), 6.45-6.47 (2H, m), 6.61 (1H, d), 7.25-7.27(3H, m), 7.39 (1H, t). 1-40 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m),2.81-2.89 (1H, m), 3.42-3.54 (5H, m), 3.75 (1H, d), 3.90 (2H, s), 4.02(1H, d), 4.48 (2H, d), 6.46 (1H, dd), 6.60 (1H, d), 6.84 (1H, s), 7.27(3H, t), 7.39 (1H, dd). 1-42 1H-NMR (CDCl3) δ: 2.09 (3H, s), 2.51-2.58(1H, m), 2.81-2.89 (1H, m), 3.22 (2H, s), 3.46-3.52 (2H, m), 3.75 (1H,d), 4.03 (1H, d), 4.47 (2H, d), 6.46 (1H, dd), 6.60 (1H, d), 7.24-7.27(4H, m), 7.39 (1H, t). 1-50 1H-NMR (CDCl3) δ: 2.51-2.55 (1H, m),2.81-2.86 (1H, m), 3.43-3.60 (5H, m), 3.73 (1H, d), 4.00 (1H, d), 4.38(2H, d), 5.79 (1H, s), 6.42 (1H, dd), 6.55 (1H, d), 7.17-7.40 (8H, m)1-51 1H-NMR (CDCl3) δ: 2.52-2.55 (1H, m), 2.80-2.88 (1H, m), 3.45-3.51(2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.67 (2H, d), 6.46 (1H, dd), 6.62(1H, d), 7.26-7.27 (2H, m), 7.34-7.43 (3H, m), 7.83 (1H, td), 8.20 (1H,dt), 8.38 (1H, s), 8.53 (1H, dq) 1-52 1H-NMR (CDCl3) δ: 2.51-2.56 (1H,m), 2.84-2.87 (1H, m), 3.48-3.52 (2H, m), 3.75 (1H, d), 4.03 (1H, d),4.65 (2H, d), 6.46-6.62 (3H, m), 7.26-7.39 (4H, m), 8.10 (1H, ddd), 8.71(1H, dd), 8.96 (1H, dd) 1-53 1H-NMR (CDCl3) δ: 2.51-2.56 (1H, m),2.83-2.87 (1H, m), 3.46-3.53 (2H, m), 3.75 (1H, d), 4.03 (1H, d), 4.63(2H, d), 6.47 (1H, dd), 6.61-6.62 (2H, m), 7.27 (3H, s), 7.34 (1H, d),7.39 (1H, t), 7.59 (2H, dd), 8.71 (2H, dd) 1-72 1H-NMR (CDCl3) δ: 2.14(3H, d), 2.51-2.55 (1H, m), 2.82-2.88 (1H, m), 2.93 (3H, s), 3.46-3.53(2H, m), 3.74 (1H, d,), 4.03 (1H, dd), 4.58 (2H, d), 6.46-6.49 (1H, m),6.60 (1H, dd), 7.09 (1H, dd), 7.26-7.28 (2H, m), 7.39 (1H, m). 1-731H-NMR (CDCl3) δ: 1.13-1.21 (3H, m), 2.35-2.40 (2H, m), 2.50-2.56 (1H,m), 2.86-2.91 (4H, m), 3.46-3.51 (2H, m), 3.74 (1H, d), 4.01-4.04 (1H,m), 4.59 (2H, d), 6.44-6.50 (1H, m), 6.60 (1H, dd), 7.07 (1H, dd),7.26-7.28 (3H, m), 7.39 (1H, t). 1-74 1H-NMR (CDCl3) δ: 0.83-0.97 (4H,m), 1.57-1.80 (1H, m), 2.52-2.55 (1H, m), 2.84-2.86 (1H, m), 3.04 (3H,t), 3.46-3.55 (2H, m), 3.76 (1H, d), 4.03 (1H, dd), 4.69 (2H, d),6.51-6.58 (2H, m), 7.16-7.27 (4H, m). 1-75 1H-NMR (CDCl3) δ: 2.53-2.55(1H, m), 2.84-2.86 (1H, m), 2.96 (3H, s), 3.27 (2H, q), 3.45-3.53 (2H,m), 3.75 (1H, dd), 4.03 (1H, dd), 4.51 (1H, s), 4.69 (1H, s), 6.49 (1H,dt), 6.61 (1H, dd), 7.08 (1H, dd), 7.28 (2H, s), 7.39-7.40 (1H, m). 1-771H-NMR (CDCl3) δ: 1.12 (3H, t), 2.50-2.55 (1H, m), 2.82-2.83 (1H, m),3.17-3.22 (2H, m), 3.46-3.50 (2H, m), 3.74 (1H, d), 4.01 (1H, d), 4.36(2H, d), 4.64 (1H, s), 6.46 (1H, dd), 6.58 (1H, d), 7.26-7.31 (3H, m),7.39 (1H, t). 1-78 1H-NMR (CDCl3) δ: 2.51-2.55 (1H, m), 2.83-2.86 (1H,m), 3.46-3.51 (2H, m), 3.74 (1H, d), 3.82-3.88 (2H, m), 4.02 (1H, d),4.38 (2H, d), 4.87 (1H, s), 6.46 (1H, dd), 6.58 (1H, d), 7.23-7.27 (3H,m), 7.39 (1H, t). 1-79 1H-NMR (CDCl3) δ: 0.90 (3H, t), 1.46-1.53 (2H,m), 2.50-2.55 (1H, m), 2.80-2.88 (1H, m), 3.08-3.15 (2H, m), 3.47-3.50(2H, m), 3.74 (1H, d), 4.01 (1H, d), 4.36 (2H, d), 4.64 (1H, s), 6.46(1H, dd), 6.58 (1H, d), 7.23-7.31 (3H, m), 7.39 (1H, t). 1-80 1H-NMR(CDCl3) δ: 1.12 (6H, d), 2.52-2.55 (1H, m), 2.80-2.88 (1H, m), 3.45-3.51(2H, m), 3.75-3.83 (2H, m), 4.01 (1H, d), 4.34 (2H, d), 4.63 (1H, q),6.45 (1H, dd), 6.57 (1H, d), 7.27-7.29 (3H, m), 7.39 (1H, t). 1-811H-NMR (CDCl3) δ: 0.53-0.58 (2H, m), 0.69-0.75 (2H, m), 2.45-2.50 (2H,m), 2.80-2.88 (1H, m), 3.48-3.51 (2H, m), 3.74 (1H, d), 4.02 (1H, d),4.42 (2H, d), 5.44 (1H, d), 6.46 (1H, dd), 6.60 (1H, d), 7.26-7.32 (3H,m), 7.39 (1H, t). 1-83 1H-NMR (acetone-d6) δ: 1.27 (9H, s), 2.73-2.79(1H, m), 2.98-3.02 (1H, m), 3.50-3.53 (3H, m), 3.93 (1H, d), 4.22-4.24(3H, m), 5.57 (1H, s), 6.61 (1H, dd), 6.69 (1H, d), 7.25 (1H, d), 7.54(1H, t), 7.62 (3H, d). 1-86 1H-NMR (CDCl3) δ: 1.24-1.74 (10H, m),2.50-2.55 (1H, m), 2.82-2.83 (1H, m), 3.45-3.52 (3H, m), 3.74 (1H, d),4.01 (1H, d), 4.35 (2H, d), 4.60 (1H, d), 6.46 (1H, dd), 6.58 (1H, d),7.27-7.28 (3H, m), 7.39 (1H, t). 1-87 1H-NMR (acetone-d6) δ: 2.63-2.91(2H, m), 3.39-3.42 (2H, m), 3.62-3.64 (2H, m), 3.81 (1H, d), 4.10-4.19(3H, m), 4.86 (1H, d), 5.01 (1H, d), 5.68-5.75 (1H, m), 6.50-6.58 (3H,m), 7.41-7.51 (4H, m). 1-88 1H-NMR (CDCl3) δ: 2.21 (1H, t,), 2.50-2.54(1H, m), 2.82-2.85 (1H, m), 3.46-3.50 (3H, m), 3.73 (1H, d), 3.96-4.03(3H, m), 4.36 (2H, d), 4.86 (1H, t), 6.45 (1H, dd), 6.57 (1H, d),7.27-7.29 (3H, m), 7.39 (1H, t). 1-89 1H-NMR (CDCl3) δ: 0.14-0.17 (2H,m), 0.45-0.49 (2H, m), 0.86-0.96 (1H, m), 2.52-2.55 (1H, m), 2.80-2.88(1H, m), 3.02 (2H, dd), 3.47-3.50 (2H, m), 3.74 (1H, d), 4.01 (1H, d),4.36 (2H, d), 4.69 (1H, s), 6.45 (1H, dd), 6.58 (1H, d), 7.25-7.31 (3H,m), 7.39 (1H, t). 1-97 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m), 2.81-2.89(1H, m), 3.42-3.54 (5H, m), 3.75 (1H, d), 3.90 (2H, s), 4.02 (1H, d),4.48 (2H, d), 6.46 (1H, dd), 6.60 (1H, d), 6.84 (1H, s), 7.27 (3H, t),7.39 (1H, dd). 1-98 1H-NMR (CDCl3) δ: 2.07 (3H, s), 2.52-2.60 (3H, m),2.81-2.87 (1H, m), 3.38-3.48 (4H, m), 3.72 (1H, d), 4.01 (1H, d), 4.34(2H, d), 4.94-4.96 (2H, m), 6.44 (1H, dd), 6.56 (1H, d), 7.26-7.29 (3H,m), 7.38 (1H, t). 1-99 1H-NMR (CDCl3) δ: 0.92-0.96 (1H, m), 1.28-1.42(1H, m), 2.52-2.56 (1H, m), 2.82-2.85 (2H, m), 3.48-3.51 (2H, m), 3.75(1H, d), 4.02 (1H, d), 4.39-4.65 (4H, m), 5.29 (1H, t), 6.45 (1H, dd),6.60 (1H, d), 7.28 (3H, t), 7.39 (1H, t). 1-101 1H-NMR (CDCl3) δ: 1.27(3H, t), 2.52 (1H, d), 2.82-2.83 (1H, m), 3.46-3.49 (2H, m), 3.73 (1H,d), 3.99-4.01 (3H, m), 4.19 (2H, q), 4.37 (2H, d), 4.88 (1H, s), 6.45(1H, dd), 6.57 (1H, d), 7.27-7.29 (3H, m), 7.39 (1H, t). 1-110 1H-NMR(CDCl3) δ: 2.52-2.56 (1H, m), 2.82-2.83 (1H, m), 3.44-3.49 (2H, m), 3.72(1H, d), 4.00 (1H, d), 4.33-4.36 (4H, m), 4.75 (2H, br s), 6.42 (1H,dd), 6.55 (1H, d), 7.22-7.33 (8H, m), 7.39 (1H, t). 1-113 1H-NMR (CDCl3)δ: 1.12 (3H, t), 2.52-2.57 (1H, m), 2.78-2.90 (4H, m), 3.24-3.35 (2H,m), 3.48-3.51 (2H, m), 3.75 (1H, d), 4.02 (1H, d), 4.34 (1H, s), 4.49(2H, s), 6.48 (1H, dd), 6.59 (1H, d), 7.15 (1H, d), 7.27-7.28 (2H, m),7.39 (1H, t). 1-115 1H-NMR (CDCl3) δ: 1.85-1.90 (4H, m), 2.51-2.53 (1H,m), 2.81-2.85 (1H, m), 3.30-3.33 (4H, m), 3.45-3.51 (2H, m), 3.74 (1H,d), 4.01 (1H, d), 4.41 (2H, d), 4.64 (1H, t), 6.45 (1H, dd), 6.58 (1H,d), 7.27-7.28 (3H, m), 7.35 (1H, d), 7.38 (1H, t). 1-116 1H-NMR (CDCl3)δ: 1.52-1.55 (6H, m), 2.47-2.57 (1H, m), 2.80-2.88 (1H, m), 3.29-3.31(4H, m), 3.45-3.51 (2H, m), 3.74 (1H, d), 4.01 (1H, d), 4.40 (2H, d),4.85 (1H, t), 6.45 (1H, dd), 6.58 (1H, d), 7.26-7.33 (3H, m), 7.38 (1H,t). 1-117 1H-NMR (CDCl3) δ: 2.50-2.55 (1H, m), 2.81-2.83 (1H, m), 3.33(4H, t), 3.45-3.51 (2H, m), 3.66 (4H, t), 3.74 (1H, d), 4.02 (1H, d),4.41 (2H, d), 4.88 (1H, t), 6.45 (1H, dd), 6.59 (1H, d), 7.26-7.32 (3H,m), 7.39 (1H, t). 1-118 1H-NMR (CDCl3) δ: 2.51-2.53 (1H, m), 2.80-2.92(7H, m), 3.45-3.51 (2H, m), 3.74 (1H, d), 4.01 (1H, d), 4.40 (2H, d),4.82 (1H, t), 6.45 (1H, dd), 6.58 (1H, d), 7.27-7.28 (2H, m), 7.33 (1H,d), 7.38 (1H, t). 1-123 1H-NMR (CDCl3) δ: 2.53-2.56 (1H, m), 2.81-2.89(1H, m), 3.46-3.52 (2H, m), 3.75 (1H, d), 4.03 (1H, d), 4.38 (2H, d),4.45 (2H), 5.30 (1H, s), 6.46 (1H, dd), 6.60 (1H, d), 7.24-7.28 (3H, m),7.39 (1H, t) 1-128 1H-NMR (CDCl3) δ: 1.44 (9H, s), 2.72-2.87 (1H, m),3.45-3.52 (2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.30 (2H, d), 4.92 (1H,br s), 6.45 (1H, dd), 6.58 (1H, d), 7.25-7.27 (3H, m), 7.38-7.39 (1H,m). 1-129 1H-NMR (CDCl3) δ: 1.48 (9H, s), 2.53-2.55 (1H, m), 2.83-2.87(4H, m), 3.43-3.51 (2H, m), 3.75 (1H, d), 4.02 (1H, d), 4.47 (2H, s),6.48 (1H, dd), 6.58 (1H, d), 7.12 (1H, s), 7.26-7.28 (3H, m), 7.39 (1H,t). 1-141 H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.48-3.61 (2H, m), 3.79 (1H, d), 3.91 (2H, s), 4.06 (1H, d), 6.74 (1H,d), 6.80 (1H, d), 7.30 (2H, d), 7.40 (2H, dd) 1-143 1H-NMR (CDCl3) δ:1.15 (3H, t), 2.20 (2H, q), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.46-3.61 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.50 (2H, d), 5.68 (1H,t), 6.70 (1H, dd), 6.79 (1H, d), 7.29 (2H, d), 7.40 (1H, t), 7.45 (1H,d). 1-145 1H-NMR (CDCl3) δ: 0.92 (6H, d), 2.03-2.17 (1H, m), 2.50-2.60(1H, m), 2.83-2.91 (1H, m), 3.48-3.60 (2H, m), 3.78 (1H, d), 4.06 (1H,d), 4.49 (2H, d), 5.65 (1H, bt), 6.67-6.80 (2H, m), 7.28-7.46 (3H, m)1-146 1H-NMR (CDCl3) δ: 0.72 (2H, dt), 0.97 (2H, dt), 1.28-1.36 (1H, m),2.50-2.60 (1H, m), 2.83-2.91 (1H, m), 3.45-3.61 (2H, m), 3.78 (1H, d),4.06 (1H, d), 4.51 (2H, d), 5.95 (1H, br s), 6.70 (1H, dd), 6.80 (1H,d), 7.29 (2H, d), 7.39 (1H, t), 7.44 (1H, d). 1-150 1H-NMR (CDCl3) δ:1.86-1.98 (2H, m), 2.10-2.32 (4H, m), 2.50-2.60 (1H, m), 2.83-3.00 (2H,m), 3.48-3.59 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.49 (2H, d), 5.59(1H, bt), 6.68-6.80 (2H, m), 7.26-7.46 (4H, m) 1-151 1H-NMR (CDCl3) δ:1.00 (9H, s), 2.04 (2H, s), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.48-3.60 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.49 (2H, d), 5.60 (1H,bt), 6.67-6.80 (2H, m), 7.28-7.48 (3H, m) 1-154 1H-NMR (CDCl3) δ:1.93-2.02 (2H, m), 2.43-2.57 (5H, m), 2.82-2.90 (1H, m), 3.45-3.59 (2H,m), 3.78 (1H, d), 4.05 (1H, d), 4.56 (2H, d), 5.92 (1H, b), 6.51-6.81(3H, m), 7.29-7.49 (4H, m) 1-155 1H-NMR (CDCl3) δ: 0.14-0.19 (2H, m),0.55-0.61 (2H, m), 0.88-0.93 (1H, m), 2.16 (2H, d), 2.50-2.60 (1H, m),2.82-2.90 (1H, m), 3.46-3.59 (2H, m), 3.78 (1H, d), 4.12 (1H, d), 4.14(2H, d), 6.21 (1H, b), 6.67-6.81 (2H, m), 7.29-7.48 (4H, m) 1-162 1H-NMR(acetone-d6) δ: 2.72-2.82 (1H, m), 2.99-3.09 (1H, m), 3.28 (2H, q),3.54-3.66 (2H, m), 4.02 (1H, d), 4.34 (1H, d), 4.48 (2H, d), 6.92 (1H,dd), 6.96 (1H, d), 7.42 (1H, d), 7.55 (1H, t), 7.63 (2H, d), 7.70 (1H,br s). 1-164 1H-NMR (CDCl3) δ: 2.50-2.61 (1H, m), 2.84-2.92 (1H, m),3.50-3.60 (2H, m), 3.78 (1H, d), 4.08 (1H, d), 4.58 (2H, d), 5.89 (1H,t), 6.51 (1H, b), 6.69-6.83 (3H, m), 7.27-7.44 (3H, m) 1-166 1H-NMR(CDCl3) δ: 1.45-1.70 (2H, m), 1.71-1.80 (3H, m), 1.95-2.05 (4H, m),2.38-2.42 (1H, m), 2.50-2.60 (1H, m), 3.45-3.59 (2H, m), 3.78 (1H, d),4.09 (1H, d), 4.48 (2H, d), 5.84 (1H, d), 6.68-6.80 (2H, m), 7.29-7.42(4H, m) 1-167 1H-NMR (CDCl3) δ: 0.53-0.58 (2H, m), 1.17-1.21 (2H, m),1.26 (3H, s), 2.50-2.61 (1H, m), 2.82-2.89 (1H, m), 3.47-3.60 (2H, m),3.78 (1H, d), 4.06 (1H, d), 4.51 (2H, d), 6.02 (1H, bt), 6.68-6.81 (2H,m), 7.28-7.45 (4H, m) 1-173 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m),2.83-2.89 (1H, m), 3.48-3.60 (2H, m), 3.78 (1H, d), 4.08 (1H, d), 4.58(2H, d), 5.62-5.67 (1H, m), 5.82 (1H, bt), 6.01-6.27 (1H, m), 6.26-6.33(1H, m), 6.70-6.83 (2H, m), 7.28-7.51 (3H, m) 1-174 1H-NMR (CDCl3) δ:1.84 (3H, dd), 2.50-2.60 (1H, m), 2.82-2.91 (1H, m), 3.47-3.60 (2H, m),3.78 (1H, d), 4.06 (1H, d), 4.56 (2H, d), 5.65 (1H, bt), 5.73-5.79 (1H,m), 6.68-6.89 (3H, m), 7.28-7.48 (3H, m) 1-176 1H-NMR (CDCl3) δ: 1.73(3H, d), 1.82 (3H, s), 2.50-2.64 (1H, m), 2.83-2.91 (1H, m), 3.49-3.61(2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.56 (2H, d), 5.97 (1H, bt), 6.01(1H, q), 6.68-6.81 (2H, m), 7.26-7.48 (4H, m) 1-180 1H-NMR (CDCl3) δ:2.50-2.60 (1H, m), 2.83-2.89 (1H, m), 3.00 (2H, d), 3.48-3.60 (2H, m),3.78 (1H, d), 4.06 (1H, d), 4.49 (2H, d), 5.15-5.24 (2H, m), 5.83-6.68(2H, m), 6.33 (1H, m), 6.67-6.80 (2H, m), 7.28-7.45 (3H, m) 1-182 1H-NMR(CDCl3) δ: 1.92 (3H, s), 2.50-2.60 (1H, m), 2.83-2.92 (1H, m), 3.48-3.61(2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.52 (2H, d), 5.96 (1H, bt),6.68-6.81 (2H, m), 7.29-7.46 (3H, m) 1-183 1H-NMR (CDCl3) δ: 2.50-2.64(1H, m), 2.83-2.91 (1H, m), 3.36 (2H, s), 3.49-3.61 (2H, m), 3.79 (1H,d), 4.08 (1H, d), 4.54 (2H, d), 6.30 (1H, bt), 6.01 (1H, q), 6.68-6.83(2H, m), 7.28-7.43 (4H, m) 1-185 1H-NMR (CDCl3) δ: 1.18 (3H, t),2.50-2.61 (1H, m), 2.83-2.92 (1H, m), 3.50-3.60 (4H, m), 3.78 (1H, d),3.94 (2H, s), 4.07 (1H, d), 4.55 (2H, d), 6.68-6.89 (3H, m), 7.28-7.45(3H, m) 1-186 1H-NMR (CDCl3) δ: 2.06 (3H, s), 2.50-2.61 (1H, m),2.84-2.92 (1H, m), 3.50-3.62 (2H, m), 3.78 (1H, d), 4.07 (1H, d), 4.54(2H, d), 6.68-6.82 (2H, m), 7.13 (1H, b), 7.28-7.45 (4H, m) 1-188 1H-NMR(CDCl3) δ: 2.12 (3H, s), 2.54-2.63 (1H, m), 2.84-2.92 (1H, m), 3.54-3.60(2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.56 (4H, m), 6.40 (1H, b),6.68-6.82 (2H, m), 7.26-7.46 (4H, m) 1-198 1H-NMR (CDCl3) δ: 2.50-2.64(1H, m), 2.83-2.88 (1H, m), 3.36 (2H, s), 3.49-3.60 (2H, m), 3.79 (1H,d), 4.08 (1H, d), 4.70 (2H, d), 6.30 (1H, bt), 6.70-6.83 (2H, m),7.26-7.51 (5H, m), 8.01-8.71 (2H, m) 1-210 1H-NMR (CDCl3) δ: 2.53-2.60(1H, m), 2.83-2.91 (1H, m), 3.48-3.59 (2H, m), 3.78 (1H, d), 4.06 (1H,d), 4.68 (2H, d), 6.25 (1H, bt), 6.68-7.07 (3H, m), 7.28-7.55 (6H, m)1-211 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.45-3.59(2H, m), 3.78 (1H, d), 3.95 (3H, s), 4.06 (1H, d), 4.62 (2H, d),6.04-6.82 (6H, m), 7.29-7.50 (4H, m) 1-216 1H-NMR (CDCl3) δ: 2.50-2.60(1H, m), 2.82-2.90 (1H, m), 3.45-3.59 (2H, m), 3.78 (1H, d), 4.06 (1H,d), 4.63 (2H, d), 5.88 (1H, b), 6.36 (1H, d), 6.69-6.81 (2H, m),7.29-7.53 (9H, m), 7.64 (1H, d) 1-220 1H-NMR (CDCl3) δ: 1.11 (3H, t),2.50-2.60 (1H, m), 2.83-2.91 (1H, m), 3.15-3.24 (2H, m), 3.44-3.58 (3H,m), 3.78 (1H, d), 4.06 (1H, d), 4.52-4.44 (4H, m), 6.71 (1H, d), 6.79(1H, d), 7.29 (2H, s), 7.39 (1H, t), 7.50 (1H, d). 1-222 1H-NMR (CDCl3)δ: 0.88 (3H, t), 1.42-1.52 (2H, m), 2.50-2.60 (1H, m), 2.82-2.90 (1H,m), 3.13 (2H, q), 3.46-3.59 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.25(1H, b), 4.44 (2H, d), 4.57 (1H, b), 6.68-6.78 (2H, m), 7.28-7.51 (4H,m) 1-224 1H-NMR (CDCl3) δ: 0.50-0.56 (2H, m), 0.67-0.73 (2H, m),2.37-2.41 (1H, m), 2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.46-3.59 (2H,m), 3.74 (1H, d), 4.50 (1H, d), 4.63 (1H, bs), 5.32 (1H, bt), 6.68-6.81(2H, m), 7.29-7.51 (4H, m) 1-227 1H-NMR (CDCl3) δ: 1.62-1.82 (4H, m),2.26-2.31 (3H, m), 2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.46-3.59 (2H,m), 3.78 (1H, d), 4.12 (1H, d), 4.35-4.44 (3H, m), 6.68-6.79 (2H, m),7.29-7.50 (4H, m) 1-228 1H-NMR (CDCl3) δ: 1.25-1.40 (2H, m), 1.50-1.65(4H, m), 1.89-2.00 (2H, m), 2.50-2.60 (1H, m), 2.75-2.89 (1H, m),3.40-3.60 (2H, m), 3.78 (1H, d), 3.91-3.96 (1H, m), 4.09 (1H, d), 4.23(1H, b), 4.44 (2H, d), 4.56 (1H, b), 6.68-6.80 (2H, m), 7.29-7.51 (4H,m) 1-230 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.82-2.90 (1H, m),3.46-3.62 (2H, m), 3.76-3.81 (3H, m), 4.08 (1H, d), 4.32 (1H, b), 4.45(2H, d), 4.63 (1H, b), 6.68-6.79 (2H, m), 7.28-7.51 (4H, m) 1-231 1H-NMR(CDCl3) δ: 2.21 (1H, t), 2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.46-3.58(2H, m), 3.78 (1H, d), 3.97-4.00 (2H, m), 4.45 (3H, m), 4.71 (1H, b),6.68-6.78 (2H, m), 7.28-7.50 (4H, m) 1-232 1H-NMR (CDCl3) δ: 0.12-0.18(2H, m), 0.43-0.50 (2H, m), 0.86-0.95 (1H, m), 2.50-2.60 (1H, m),2.82-2.90 (1H, m), 3.00-3.04 (2H, m), 3.46-3.59 (2H, m), 3.78 (1H, d),4.12 (1H, d), 4.36 (1H, t), 4.44 (2H, d), 4.58 (1H, t), 6.68-6.78 (2H,m), 7.29-7.52 (4H, m) 1-238 1H-NMR (CDCl3) δ: 2.24-2.40 (2H, m),2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.46-3.57 (4H, m), 3.77 (1H, d),4.07 (1H, d), 4.41 (2H, d), 4.65 (1H, b), 4.78 (1H, b), 6.68-6.83 (2H,m), 7.29-7.46 (4H, m) 1-243 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 3.30(3H, s), 3.30-3.60 (6H, m), 3.78 (1H, d), 4.09 (1H, d), 4.44 (2H, d),4.60 (1H, b), 4.84 (1H, b), 6.68-6.80 (2H, m), 7.29-7.51 (4H, m) 1-2441H-NMR (CDCl3) δ: 2.12 (3H, s), 2.50-2.64 (2H, m), 2.82-2.91 (1H, m),3.36-3.79 (4H, m), 3.78 (1H, d), 4.08 (1H, d), 4.44 (2H, d), 4.72 (2H,b), 6.68-6.80 (2H, m), 7.29-7.50 (4H, m) 1-253 1H-NMR (CDCl3) δ:2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.46-3.60 (2H, m), 3.76 (1H, d),4.04 (1H, d), 4.33 (2H, d), 4.43 (2H, d), 4.70 (2H, b), 6.66-6.77 (2H,m), 7.14-7.48 (9H, m) 1-254 1H-NMR (CDCl3) δ: 2.49-2.59 (1H, m),2.81-2.90 (1H, m), 3.46-3.57 (2H, m), 3.76 (1H, d), 4.04 (1H, d), 4.47(4H, d), 5.14 (1H, b), 5.59 (1H, b), 6.66-6.77 (2H, m), 7.14-7.66 (7H,m), 8.45-8.48 (1H, m) 1-255 1H-NMR (CDCl3) δ: 1.85-1.92 (4H, m),2.50-2.60 (1H, m), 2.82-2.90 (1H, m), 3.32-3.49 (4H, m), 3.50-3.62 (2H,m), 3.78 (1H, d), 4.08 (1H, d), 4.50 (3H, s), 6.71-6.80 (2H, m),7.29-7.56 (4H, m) 1-257 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.82-2.90(1H, m), 3.31 (4H, t), 3.50-3.62 (2H, m), 3.66 (4H, t), 3.78 (1H, d),4.08 (1H, d), 4.50 (2H, d), 4.74 (1H, b), 6.68-6.80 (2H, m), 7.28-7.45(4H, m) 1-258 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.83-3.00 (1H, m),2.86 (6H, s), 3.48-3.58 (2H, m), 3.78 (1H, d), 4.08 (1H, d), 4.48 (2H,d), 4.68 (1H, bt), 6.68-6.80 (2H, m), 7.26-7.46 (4H, m) 1-260 1H-NMR(CDCl3) δ: 0.61-0.80 (4H, m), 2.36-2.42 (1H, m), 2.50-2.60 (1H, m),2.82-3.00 (1H, m), 2.89 (3H, s), 3.47-3.58 (2H, m), 3.78 (1H, d), 4.06(1H, d), 4.50 (2H, d), 5.62 (1H, bt), 6.67-6.80 (2H, m), 7.28-7.62 (4H,m) 1-270 1H-NMR (CDCl3) δ: 1.45 (9H, s), 2.50-2.60 (1H, m), 2.83-2.91(1H, m), 3.45-3.61 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.38 (2H, d),4.83 (1H, br s), 6.71 (1H, dd), 6.79 (1H, d), 7.29 (2H, d), 7.39 (1H,t), 7.44 (1H, d). 1-274 1H-NMR (CDCl3) δ: 2.55-2.60 (1H, m), 2.88-2.92(1H, m), 3.52-3.61 (2H, m), 3.80-3.87 (1H, m), 4.09-4.11 (1H, m), 4.50(2H, d,), 5.06 (1H, t), 6.73-6.76 (1H, m), 7.30-7.37 (4H, m). 1-2751H-NMR (CDCl3) δ: 2.55-2.60 (1H, m), 2.87-2.92 (1H, m), 3.51-3.82 (5H,m), 4.12-4.19 (1H, m), 4.42 (2H, d), 4.88 (1H, t), 6.72-6.75 (1H, m),7.26-7.69 (5H, m). 1-276 1H-NMR (CDCl3) δ: 2.52-2.57 (1H, m), 2.85-2.89(1H, m), 3.47-3.55 (2H, m), 3.69-3.86 (1H, m), 3.98-4.27 (3H, m), 4.79(1H, t), 6.61-6.76 (2H, m), 7.20-7.95 (9H, m). 1-285 1H-NMR (CDCl3) δ:1.16 (3H, t), 2.22 (2H, q), 2.42-2.53 (1H, m), 2.81-2.89 (1H, m),3.44-3.56 (2H, m), 3.69-3.76 (1H, m), 4.00-4.04 (1H, m), 4.42-4.44 (2H,m), 5.81 (1H, br s), 6.49-6.51 (1H, m), 6.77-6.78 (1H, m), 7.27-7.29(3H, m), 7.39-7.39 (1H, m). 1-286 1H-NMR (CDCl3) δ: 0.68-0.75 (2H, m),0.95-1.00 (2H, m), 1.30-1.35 (1H, m), 2.50-2.56 (1H, m), 3.42-3.54 (2H,m), 3.74 (1H, d), 4.02 (1H, d), 4.44 (2H, d), 5.99 (1H, b), 6.48-7.40(6H, m) 1-287 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.81-2.90 (1H, m),3.03 (1H, d), 3.00 (1H, d), 3.43-3.54 (1H, m), 3.74 (1H, d), 4.02 (1H,d), 4.47 (2H, d), 6.07 (1H, b), 6.48-6.70 (2H, m), 7.22-7.40 (4H, m)1-291 1H-NMR (CDCl3) δ: 1.10 (3H, t), 2.14 (2H, q), 2.25 (3H, s),2.41-2.51 (1H, m), 2.73-2.80 (1H, m), 3.36-3.52 (2H, m), 3.70 (1H, d),3.97 (1H, d), 4.29 (2H, d), 5.40 (1H, s), 6.33-6.37 (2H, m), 7.06 (1H,d), 7.24 (2H, d), 7.32 (1H, t). 1-295 1H-NMR (CDCl3) δ: 2.62-2.66 (1H,m), 2.97-3.05 (1H, m), 3.57-3.62 (2H, m), 3.86-3.89 (3H, m), 4.19 (1H,d), 6.77-6.82 (2H, m), 7.42 (1H, d), 7.85-7.93 (3H, m) 1-296 1H-NMR(CDCl3) δ: 2.58-2.68 (1H, m), 2.97-3.05 (1H, m), 3.24 (2H, q), 3.51-3.68(2H, m), 3.85 (1H, d), 4.20 (1H, d), 4.55 (2H, d), 5.99 (1H, t), 6.79(2H, dd), 7.44 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 1-297 1H-NMR (CDCl3)δ: 2.58-2.68 (3H, m), 2.97-3.05 (1H, m), 3.50-3.66 (2H, m), 3.78-3.87(3H, m), 4.19 (1H, d), 4.53 (2H, d), 5.94 (1H, t), 6.74 (1H, dd), 6.83(1H, d), 7.46 (1H, d), 7.85 (2H, s), 7.93 (1H, s). 1-298 1H-NMR (CDCl3)δ: 2.58-2.67 (1H, m), 2.97-3.05 (1H, m), 3.53-3.68 (4H, m), 3.84 (1H,d), 4.19 (1H, d), 4.43 (2H, d), 4.98 (1H, br s), 6.74 (1H, dd), 6.83(1H, d), 7.48 (1H, d), 7.84 (2H, s), 7.93 (1H, s) 1-299 1H-NMR (CDCl3)δ: 1.24 (3H, t), 2.58-2.68 (1H, m), 2.97-3.05 (1H, m), 3.50-3.67 (2H,m), 3.85 (1H, d), 4.09-4.21 (3H, m), 4.43 (2H, d), 4.96 (1H, br s), 6.74(1H, dd), 6.83 (1H, d), 7.85 (2H, s), 7.93 (1H, s). 1-300 1H-NMR (CDCl3)δ: 1.57 (9H, s), 2.58-2.68 (1H, m), 2.96-3.05 (1H, m), 3.50-3.63 (2H,m), 3.85 (1H, d), 4.19 (1H, d), 4.38 (2H, d), 4.83 (1H, br s), 6.74 (1H,dd), 6.82 (1H, d), 7.46 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 1-3011H-NMR (CDCl3) δ: 2.57-2.67 (1H, m), 2.74 (3H, d), 2.96-3.04 (1H, m),3.49-3.65 (2H, m), 3.84 (1H, d), 4.18 (1H, d), 4.44-4.39 (3H, m), 4.75(1H, t), 6.73 (1H, dd), 6.81 (1H, d), 7.50 (1H, d), 7.84 (2H, s), 7.93(1H, s). 1-302 1H-NMR (CDCl3) δ: 1.11 (3H, t), 2.57-2.68 (1H, m),2.96-3.04 (1H, m), 3.14-3.23 (2H, m), 3.49-3.66 (2H, m), 3.84 (1H, d),4.18 (1H, d), 4.27 (1H, br s), 4.44 (2H, d), 4.63 (1H, t), 6.73 (1H,dd), 6.81 (1H, d), 7.51 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 1-3031H-NMR (CDCl3) δ: 0.86 (3H, t), 1.39-1.51 (2H, m), 2.56-2.67 (1H, m),2.95-3.10 (3H, m), 3.48-3.64 (2H, m), 3.82 (1H, d), 4.17 (1H, d), 4.40(2H, d), 4.75 (1H, br s), 5.01 (1H, t), 6.71 (1H, dd), 6.79 (1H, d),7.47 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 1-304 1H-NMR (CDCl3) δ: 1.11(6H, d), 2.57-2.67 (1H, m), 2.96-3.04 (1H, m), 3.49-3.65 (2H, m),3.78-3.88 (2H, m), 4.15-4.20 (2H, m), 4.43 (2H, d), 4.60 (1H, t), 6.73(1H, dd), 6.81 (1H, d), 7.50 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 1-3051H-NMR (CDCl3) δ: 0.53 (2H, td), 0.70 (2H, td), 2.36-2.43 (1H, m),2.58-2.68 (1H, m), 2.96-3.05 (1H, m), 3.50-3.67 (2H, m), 3.85 (1H, d),4.19 (1H, d), 4.51 (2H, d), 4.67 (1H, s), 5.34 (1H, t), 6.74 (1H, dd),6.83 (1H, d), 7.51 (1H, d), 7.85 (2H, s), 7.93 (1H, s). 1-306 1H-NMR(CDCl3) δ: 2.59-2.62 (1H, m), 2.96-3.00 (1H, m), 3.46-3.62 (2H, m),3.82-3.88 (3H, m), 4.10-4.16 (1H, m), 6.49-6.53 (1H, m), 6.64-6.65 (1H,m), 7.21-7.24 (1H, m), 7.85 (2H, s), 7.92 (1H, s) 1-307 1H-NMR (CDCl3)δ: 1.15 (3H, t), 2.21 (2H, q), 2.55-2.65 (1H, m), 2.94-3.02 (1H, m),3.45-3.62 (2H, m), 3.80 (1H, d), 4.15 (1H, d), 4.44 (2H, d), 5.79 (1H,br s), 6.49 (1H, dd), 6.62 (1H, d), 7.29 (1H, d), 7.83 (2H, s), 7.92(1H, s). 1-308 1H-NMR (CDCl3) δ: 0.72 (2H, dt), 0.97 (2H, dt), 1.29-1.38(1H, m), 2.55-2.66 (1H, m), 2.94-3.02 (1H, m), 3.46-3.62 (2H, m), 3.81(1H, d), 4.15 (2H, d), 4.45 (2H, d), 6.01 (1H, t), 6.49 (1H, dd), 6.63(1H, d), 7.29 (1H, d), 7.92 (2H, s), 7.88 (1H, s). 1-309 1H-NMR (CDCl3)δ: 2.56-2.66 (1H, m), 2.95-3.11 (3H, m), 3.45-3.62 (2H, m), 3.81 (1H,d), 4.16 (1H, d), 4.46 (2H, d), 6.20 (1H, br s), 6.49 (1H, dd), 6.63(1H, d), 7.26 (1H, d), 7.83 (2H, s), 7.93 (1H, s). 1-312 1H-NMR (CDCl3)δ: 1.16 (3H, t), 2.21 (3H, q), 2.60-2.63 (1H, m), 2.94-3.02 (1H, m),3.48-3.59 (2H, m), 3.80 (1H, d), 4.09-4.16 (1H, m), 4.43 (2H, d), 5.81(1H, br s), 6.52-6.55 (1H, m), 6.81 (1H, d), 7.28-7.30 (1H, m),7.83-7.92 (3H, m) 1-313 1H-NMR (CDCl3) δ: 0.71-0.74 (2H, m), 0.96-0.99(2H, m), 1.25-1.36 (1H, m), 2.59-2.61 (1H, m), 2.96-3.00 (1H, m),3.48-3.59 (1H, m), 3.78-3.82 (2H, m), 4.13-4.16 (1H, m), 4.44-4.46 (2H,m), 5.96-5.99 (1H, m), 6.52-6.55 (1H, m), 6.83-6.89 (1H, m), 7.25-7.21-314 H-NMR (CDCl3) δ: 2.57-2.63 (1H, m), 2.95-3.26 (3H, m), 3.52-3.58(2H, m), 3.80 (1H, d), 4.15 (1H, d), 4.46 (2H, d), 6.24 (1H, br s),6.52-6.55 (1H, m), 6.81 (1H, d), 7.26-7.27 (1H, m), 7.83-7.93 (3H, m)1-317 1H-NMR (CDCl3) δ: 1.97 (3H, s), 2.61-2.70 (1H, m), 3.00-3.08 (1H,m), 3.53-3.70 (2H, m), 3.87 (1H, d), 4.23 (1H, d), 4.53 (2H, d), 6.34(1H, t), 6.83 (1H, dd), 7.23 (1H, d), 7.55 (1H, d), 7.84 (2H, s), 7.94(1H, s). 1-319 1H-NMR (CDCl3) δ: 0.72 (2H, dt), 0.95 (2H, dt), 1.30-1.39(1H, m), 2.59-2.70 (1H, m), 3.00-3.08 (1H, m), 3.53-3.69 (2H, m), 3.86(1H, d), 4.23 (1H, d), 4.56 (2H, d), 6.49 (1H, t), 6.82 (1H, dd), 7.24(1H, d), 7.53 (1H, d), 7.84 (2H, s), 7.94 (1H, s). 1-321 1H-NMR (CDCl3)δ: 2.59-2.69 (1H, m), 2.88 (3H, s), 2.99-3.07 (1H, m), 3.69-3.51 (2H,m), 3.86 (1H, d), 4.21 (1H, d), 4.39 (2H, d), 4.53 (1H, t), 6.77 (1H,dd), 6.85 (1H, d), 7.49 (1H, d), 7.84 (2H, s), 7.94 (1H, s). 1-3221H-NMR (CDCl3) δ: 1.33 (3H, t), 2.59-2.69 (1H, m), 2.96-3.07 (3H, m),3.52-3.69 (2H, m), 3.86 (1H, d), 4.22 (1H, d), 4.37 (2H, d), 4.49 (1H,t), 6.78 (1H, dd), 6.84 (1H, d), 7.50 (1H, d), 7.85 (2H, s), 7.94 (1H,s). 1-323 1H-NMR (CDCl3) δ: 2.60-2.73 (1H, m), 3.00-3.13 (1H, m),3.61-3.70 (2H, m), 3.87-3.93 (1H, m), 4.19-4.32 (1H, m), 4.50-4.58 (2H,m), 5.10 (1H, br s), 6.80-6.84 (2H, m), 7.39-7.48 (1H, m), 7.78-7.94(3H, m). 1-324 1H-NMR (CDCl3) δ: 2.62-2.67 (1H, m), 3.01-3.05 (1H, m),3.56-3.88 (5H, m), 4.16-4.21 (1H, m), 4.43-4.50 (2H, m), 4.85 (1H, t),6.78-6.84 (2H, m), 7.47 (1H, d), 7.84-7.94 (3H, m). 1-325 1H-NMR (CDCl3)δ: 2.57-2.71 (1H, m), 2.99-3.03 (1H, m), 3.56-3.63 (2H, m), 3.81-3.84(1H, m), 4.13-4.26 (4H, m), 4.69 (1H, t), 6.68-6.75 (2H, m), 7.28-7.61(4H, m), 7.87-7.90 (5H, m). 1-327 1H-NMR (CDCl3) δ: 2.49-2.59 (1H, m),2.83-2.91 (1H, m), 3.05 (2H, q), 3.46-3.62 (2H, m), 3.78 (1H, d), 4.06(1H, d), 4.53 (2H, d), 6.04 (1H, br s), 6.70 (1H, dd), 6.80 (1H, d),7.43-7.40 (3H, m). 1-328 1H-NMR (CDCl3) δ: 0.92 (3H, t), 1.60-1.71 (3H,m), 2.14 (2H, t), 2.49-2.59 (1H, m), 2.82-2.90 (1H, m), 3.47-3.62 (2H,m), 3.77 (1H, d), 4.05 (1H, d), 4.50 (2H, d), 5.70 (1H, t), 6.70 (1H,dd), 6.79 (1H, d), 7.46-7.43 (3H, m). 1-329 1H-NMR (CDCl3) δ: 1.14 (6H,d), 2.29-2.38 (1H, m), 2.49-2.59 (1H, m), 2.82-2.90 (1H, m), 3.45-3.61(2H, m), 3.77 (1H, d), 4.05 (1H, d), 4.49 (2H, d), 5.71 (1H, t), 6.70(1H, dd), 6.79 (1H, d), 7.44-7.42 (3H, m). 1-330 1H-NMR (CDCl3) δ: 1.11(3H, t), 2.49-2.58 (1H, m), 2.82-2.91 (1H, m), 3.18 (2H, q), 3.45-3.60(2H, m), 3.77 (1H, d), 4.04 (1H, d), 4.23 (1H, br s), 4.44 (2H, d), 4.59(1H, br s), 6.70 (1H, dd), 6.78 (1H, d), 7.43 (2H, s), 7.50 (1H, d).1-333 1H-NMR (CDCl3) δ: 2.54-2.61 (1H, m), 2.81-2.94 (1H, m), 3.50-3.60(2H, m), 3.82-3.88 (1H, m), 4.02-4.10 (1H, m), 4.50 (2H, d,), 5.04 (1H,t), 6.73-6.75 (1H, m), 7.30-7.42 (3H, m). 1-334 1H-NMR (CDCl3) δ:2.53-2.60 (1H, m), 2.85-2.91 (1H, m), 3.50-3.80 (5H, m), 4.11-4.18 (1H,m), 4.40 (2H, d), 4.86 (1H, t), 6.72-6.76 (1H, m), 7.21-7.70 (4H, m).1-335 1H-NMR (CDCl3) δ: 2.52-2.58 (1H, m), 2.85-2.90 (1H, m), 3.47-3.60(2H, m), 3.70-3.87 (1H, m), 3.98-4.29 (3H, m), 4.80 (1H, t), 6.60-6.77(2H, m), 7.11-7.80 (8H, m). 1-336 1H-NMR (CDCl3) δ: 2.46-2.56 (1H, m),2.79-2.87 (1H, m), 3.48-3.51 (2H, m), 3.74 (1H, d), 3.83 (1H, s), 4.01(1H, d), 6.47 (1H, dd), 6.60 (1H, d), 7.21 (1H, d), 7.42 (2H, s) 1-3371H-NMR (CDCl3) δ: 1.98 (3H, s), 2.47-2.57 (1H, m), 2.80-2.88 (1H, m),3.42-3.57 (2H, m), 3.73 (1H, d), 4.01 (1H, d), 4.41 (2H, d), 5.86 (1H,br s), 6.45 (1H, dd,), 6.59 (1H, d), 7.27 (1H, d), 7.41 (2H, s). 1-3381H-NMR (CDCl3) δ: 1.15 (4H, t), 2.47-2.57 (1H, m), 2.80-2.88 (1H, m),3.40-3.56 (2H, m), 3.73 (1H, d), 4.01 (1H, d), 4.43 (2H, d), 5.81 (1H,s), 6.45 (1H, dd), 6.59 (1H, d), 7.27 (1H, d), 7.42 (2H, s). 1-3391H-NMR (CDCl3) δ: 0.72 (2H, dt), 0.97 (2H, dt), 1.29-1.37 (1H, m),2.46-2.57 (1H, m), 2.79-2.88 (1H, m), 3.41-3.56 (2H, m), 3.74 (1H, d),4.01 (1H, d), 4.45 (2H, d), 5.99 (1H, br s), 6.45 (1H, dd), 6.59 (1H,d), 7.28 (1H, d), 7.42 (2H, s). 1-340 1H-NMR (CDCl3) δ: 2.46-2.56 (1H,m), 2.79-2.88 (1H, m), 3.07 (2H, q), 3.40-3.56 (2H, m), 3.72 (1H, d),4.01 (1H, d), 4.44 (2H, d), 6.32 (1H, br s), 6.44 (1H, dd), 6.58 (1H,d), 7.23 (1H, d), 7.41 (2H, s). 1-341 1H-NMR (CDCl3) δ: 1.10 (3H, t),2.45-2.56 (1H, m), 2.79-2.87 (1H, m), 3.13-3.22 (2H, m), 3.39-3.55 (2H,m), 3.72 (1H, d), 3.99 (1H, d), 4.33-4.38 (3H, m), 4.78 (1H, t), 6.44(1H, dd), 6.57 (1H, d), 7.28 (2H, d), 7.41 (2H, s). 1-344 1H-NMR (CDCl3)δ: 1.98 (3H, s), 2.45-2.56 (1H, m), 2.80-2.87 (1H, m), 3.40-3.60 (2H,m), 3.73 (1H, d), 4.01 (1H, d), 4.41 (2H, d), 5.82 (1H, b), 6.48-7.46(5H, m) 1-345 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.21 (2H, q), 2.44-2.52(1H, m), 2.79-2.88 (1H, m), 3.43-3.56 (2H, m), 3.71-3.74 (1H, m),3.99-4.02 (1H, m), 4.42-4.44 (2H, m), 5.81 (1H, br s), 6.50 (1H, dd),6.77 (1H, d), 7.29 (1H, d), 7.40 (2H, s). 1-346 1H-NMR (CDCl3) δ:0.69-1.37 (5H, m), 2.46-2.56 (1H, m), 2.79-2.88 (1H, m), 3.43-3.56 (2H,m), 3.72-3.74 (1H, m), 3.99-4.02 (1H, m), 4.43-4.45 (2H, m), 6.00 (1H,br s), 6.50 (1H, dd), 6.78 (1H, d), 7.26-7.41 (3H, m). 1-347 1H-NMR(CDCl3) δ: 2.47-2.57 (1H, m), 2.80-2.89 (1H, m), 3.07 (2H, q), 3.47-3.55(2H, m), 3.72-3.74 (1H, m), 4.00-4.03 (1H, m), 4.46-4.48 (2H, m), 6.12(1H, br s), 6.50 (1H, dd), 6.78 (1H, d), 7.26-7.30 (1H, m), 7.43 (2H, s)1-355 1H-NMR (CDCl3) δ: 1.98 (3H, s), 2.54-2.64 (1H, m), 2.90-2.98 (1H,m), 3.47-3.64 (2H, m), 3.82 (1H, d), 4.13 (1H, d), 4.49 (2H, d), 5.75(1H, br s), 6.72 (1H, dd), 6.81 (1H, d), 7.46 (1H, d), 7.54 (1H, s),7.59 (1H, s), 7.65 (1H, s). 1-356 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.20(2H, q), 2.54-2.64 (1H, m), 2.89-2.98 (1H, m), 3.48-3.64 (2H, m), 3.81(1H, d), 4.12 (1H, d), 4.50 (2H, d), 5.71 (1H, br s), 6.72 (1H, dd),6.81 (1H, d), 7.45 (1H, d), 7.54 (1H, s), 7.59 (1H, s), 7.65 (1H, s).1-357 1H-NMR (CDCl3) δ: 0.70-0.76 (2H, m), 0.96-1.01 (2H, m), 1.27-1.34(1H, m), 2.54-2.67 (1H, m), 2.90-2.98 (1H, m), 3.48-3.64 (2H, m), 3.81(1H, d), 4.12 (1H, d), 4.52 (1H, d), 5.89 (1H, br s), 6.72 (1H, dd),6.81 (1H, d), 7.46 (1H, d), 7.54 (1H, s), 7.59 (1 1-377 1H-NMR (CDCl3)δ: 2.00 (3H, s), 2.54-2.59 (1H, m), 2.87-2.95 (1H, m), 3.61-3.72 (2H,m), 3.94-3.98 (1H, m), 4.43-4.46 (3H, m), 5.73 (1H, br s), 6.61 (1H, s),7.44 (2H, s), 8.37 (1H, s). 1-378 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.22(2H, q), 2.54-2.59 (1H, m), 2.87-2.95 (1H, m), 3.62-3.68 (2H, m),3.94-3.98 (1H, m), 4.41-4.66 (3H, m), 5.70 (1H, br s), 6.57 (1H, s),7.42 (2H, s), 8.37 (1H, s). 1-379 1H-NMR (CDCl3) δ: 0.71-1.36 (5H, m),2.51-2.61 (1H, m), 2.87-2.95 (1H, m), 3.60-3.73 (2H, m), 3.94-3.98 (1H,m), 4.42-4.49 (3H, m), 5.88 (1H, br s), 6.57 (1H, s), 7.44 (2H, s), 8.37(1H, s). 1-380 1H-NMR (CDCl3) δ: 2.54-2.59 (1H, m), 2.87-2.96 (1H, m),3.05-3.09 (2H, m), 3.61-3.73 (2H, m), 3.94-3.98 (1H, m), 4.43-4.51 (3H,m), 5.99 (1H, br s), 6.58 (1H, s), 7.45 (2H, d), 8.36 (1H, s) 1-3811H-NMR (CDCl3) δ: 1.14 (3H, t), 2.50-2.61 (1H, m), 2.86-2.94 (1H, m),3.17-3.21 (2H, m), 3.60-3.71 (2H, m), 3.93-3.97 (1H, m), 4.29-4.30 (1H,m), 4.41-4.43 (3H, m), 4.58-4.60 (1H, m), 6.55 (1H, s), 7.44 (2H, s),8.40 (1H, s). 1-386 1H-NMR (CDCl3) δ: 2.61-2.69 (1H, m), 3.02-3.12 (3H,m), 3.69-3.72 (2H, m), 4.03-4.07 (1H, m), 4.53-4.61 (3H, m), 5.98 (1H,br s), 6.61 (1H, s), 7.85 (2H, s), 7.93 (1H, s), 8.38 (1H, s). 1-3901H-NMR (CDCl3) δ: 1.18 (3H, t), 2.15 (2H, q,), 2.49-2.59 (1H, m),2.83-2.92 (1H, m), 3.57-3.70 (2H, m), 3.95 (1H, d), 4.38-4.45 (3H, m),5.76 (1H, br s), 6.51 (1H, d), 7.30 (2H, s), 7.39 (1H, t), 7.72 (1H, d).1-391 1H-NMR (CDCl3) δ: 0.71-0.82 (2H, m), 0.95-1.05 (2H, m), 1.24-1.40(1H, m), 2.52-2.57 (1H, m), 2.83-2.92 (1H, m), 3.61-3.64 (2H, m), 3.95(1H, d), 4.38-4.47 (3H, m), 5.95 (1H, br s), 6.51 (1H, d), 7.26-7.39(3H, m), 7.72 (1H, d). 1-398 1H-NMR (CDCl3) δ: 2.49-2.59 (1H, m),2.83-2.92 (1H, m), 3.01-3.12 (2H, m), 3.61-3.68 (2H, m), 3.96 (1H, d),4.38 (1H, d), 4.49-4.51 (2H, m), 6.08 (1H, br s), 6.52 (1H, d), 7.43(2H, s), 7.69 (1H, d). 1-404 1H-NMR (CDCl3) δ: 2.57-2.67 (1H, m),3.02-3.07 (3H, m), 3.63-3.70 (2H, m), 4.08-4.10 (1H, m), 4.50-4.51 (3H,m), 6.06 (1H, br s), 6.55 (1H, dz), 7.71 (1H, d), 7.85 (2H, s), 7.92(1H, s). 1-408 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.20 (2H, q), 2.50-2.58(1H, m), 2.81-2.90 (1H, m), 3.42-3.60 (2H, m), 3.76 (1H, d), 4.02 (1H,d), 4.58 (2H, d), 5.73 (1H, b), 6.67-7.44 (5H, m) 1-442 1H-NMR (CDCl3)δ: 1.27 (3H, d), 2.52-2.54 (1H, m), 2.80-2.88 (1H, m), 3.43-3.52 (2H,m), 3.73 (1H, d), 4.01 (1H, d), 4.35 (2H, dd), 4.50-4.54 (2H, m), 4.90(1H, t), 6.44 (1H, dd), 6.57 (1H, d), 7.25-7.27 (3H, m), 7.39 (1H, t)1-443 1H-NMR (CDCl3) δ: 2.51-2.60 (5H, m), 2.80-2.89 (1H, m), 3.47-3.50(2H, m), 3.66 (4H, dd), 3.74 (1H, d), 4.02 (1H, d), 4.41 (2H, d), 4.81(1H, t), 6.46 (1H, dd), 6.59 (1H, d), 7.27-7.31 (3H, m), 7.39 (1H, t).1-444 1H-NMR (CDCl3) δ: 2.51-2.56 (1H, m), 2.80-2.88 (1H, m), 3.29-3.53(10H, m), 3.74 (1H, d), 4.01 (1H, d), 4.34-4.36 (3H, m), 4.50 (1H, t),4.89 (1H, t), 6.45 (1H, dd), 6.58 (1H, d), 7.27-7.29 (3H, m), 7.39 (1H,t). 1-445 1H-NMR (CDCl3) δ: 1.85-1.93 (4H, m), 2.50-2.55 (1H, m),2.80-2.88 (1H, m), 3.03-3.12 (1H, m), 3.45-3.50 (3H, m), 3.73-3.81 (4H,m), 3.91-4.03 (2H, m), 4.36 (2H, d), 4.62 (1H, s), 5.07 (1H, br s), 6.45(1H, dd), 6.58 (1H, d), 7.28 (3H, t), 7.38-7.39 (1H, m). 1-446 1H-NMR(CDCl3) δ: 1.55 (3H, d), 2.51-2.53 (1H, m), 2.81-2.85 (1H, m), 3.43-3.48(2H, m), 3.71 (1H, d), 3.99 (1H, d), 4.34 (2H, d), 5.28-5.43 (3H, m),6.41 (1H, d), 6.54 (1H, d), 7.21-7.26 (4H, m), 7.38 (1H, d), 7.64 (1H,d). 1-448 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.20 (2H, q), 2.48-2.57 (1H,m), 2.80-2.88 (1H, m), 3.39-3.55 (2H, m), 3.74 (1H, d), 4.01 (1H, d),4.37 (2H, d), 5.77 (1H, s), 6.30 (2H, dd), 7.21 (1H, dd), 7.28 (2H, d),7.38 (1H, t). 1-457 1H-NMR (CDCl3) δ: 2.43-2.55 (3H, m), 2.82-2.83 (1H,m), 3.43-3.54 (2H, m), 3.76 (3H, t), 4.02 (1H, d), 6.47 (1H, dd), 6.60(1H, d), 7.24-7.39 (4H, m). 1-458 1H-NMR (CDCl3) δ: 1.74 (3H, d),2.51-2.64 (1H, m), 2.81-2.89 (1H, m), 3.46-3.53 (2H, m), 3.75 (1H, d),4.03 (1H, d),, 4.43-4.47 (3H, m), 6.46 (1H, dd), 6.61 (1H, d), 7.25-7.27(3H, m), 7.39 (1H, t). 1-461 1H-NMR (CDCl3) δ: 1.23 (3H, t), 2.51-2.53(3H, m), 2.82-2.86 (1H, m), 3.24 (2H, s), 3.44-3.54 (2H, m), 3.75 (1H,d), 4.03 (1H, d), 4.46 (2H, d), 6.45 (1H, dd), 6.60 (1H, d), 7.26-7.28(3H, m), 7.39 (1H, t). 1-464 1H-NMR (CDCl3) δ: 1.23 (6H, dd), 2.54-2.57(1H, m), 2.82-2.89 (2H, m), 3.25 (2H, s), 3.46-3.51 (2H, m), 3.75 (1H,d), 4.03 (1H, d), 4.45 (2H, d), 6.45 (1H, dd), 6.60 (1H, d), 7.26-7.27(3H, m), 7.39 (1H, t). 1-467 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.45-2.89(6H, m), 3.44-3.54 (2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.45 (2H, d),6.03 (1H, br s), 6.45 (1H, dd), 6.59 (1H, d), 7.26-7.30 (3H, m), 7.39(1H, t). 1-468 1H-NMR (CDCl3) δ: 0.66-0.68 (2H, m), 0.78-0.81 (2H, m),2.49-2.59 (2H, m), 2.84-2.85 (1H, m), 3.47-3.53 (2H, m), 3.75 (1H, d),4.03 (1H, d), 4.85 (2H, d), 6.25 (1H, s), 6.47 (1H, dd), 6.61 (1H, d),6.68 (1H, s), 7.28-7.28 (2H, m), 7.39-7.42 (2H, m). 1-469 1H-NMR (CDCl3)δ: 2.51-2.53 (1H, m), 2.81-2.85 (1H, m), 3.43-3.62 (6H, m), 3.73 (1H,d), 4.01 (1H, d), 4.35 (2H, d), 4.86-4.93 (1H, m), 6.45 (1H, dd), 6.57(1H, d), 7.26-7.29 (3H, m), 7.39 (1H, t). 1-471 1H-NMR (CDCl3) δ: 2.09(3H, s), 2.48-2.58 (4H, m), 2.79-2.88 (1H, m), 3.26 (2H, s), 3.40-3.57(2H, m), 3.74 (1H, d), 4.02 (1H, d), 4.46 (2H, d), 6.48-7.40 (7H, m)1-472 1H-NMR (CDCl3) δ: 2.48-2.60 (1H, m), 2.66 (3H, s), 2.80-2.88 (1H,m), 3.29 (1H, d), 3.40-3.54 (2H, m), 3.66 (1H, d), 3.74 (1H, d), 4.02(1H, d), 4.47-4.50 (2H, m), 6.47-7.39 (7H, m) 1-473 1H-NMR (CDCl3) δ:2.48-2.60 (1H, m), 2.80-2.88 (1H, m), 3.05 (3H, s), 3.40-3.60 (2H, m),3.74 (1H, d), 3.86 (2H, s), 4.02 (1H, d) 4.49 (2H, d), 6.48-7.40 (7H, m)1-474 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.22 (2H, q), 2.47-2.57 (1H, m),2.80-2.88 (1H, m), 3.40-3.56 (2H, m), 3.73 (1H, d), 4.00 (1H, d), 4.40(2H, d), 5.76 (1H, br s), 6.54 (1H, dd), 7.03 (1H, d), 7.25 (1H, d),7.28 (2H, d), 7.39 (1H, t). 1-490 1H-NMR (CDCl3) δ: 2.48 (3H, s),2.54-2.64 (1H, m), 2.86-2.92 (1H, m), 3.50-3.58 (2H, m), 3.78 (1H, d),4.07 (1H, d), 4.53 (2H, d), 6.68-6.85 (2H, m), 7.15-7.43 (5H, m) 1-4911H-NMR (CDCl3) δ: 2.48 (2H, t), 2.50-2.63 (1H, m), 2.82-2.91 (1H, m),3.34 (3H, s), 3.48-3.59 (5H, m), 3.75 (1H, d), 4.06 (1H, d), 4.50 (2H,d), 6.55 (1H, b), 6.67-6.80 (2H, m), 7.29-7.46 (4H, m) 1-493 1H-NMR(CDCl3) δ: 2.48-2.63 (1H, m), 2.80-2.90 (1H, m), 3.24 (2H, d), 3.47-3.60(2H, m), 3.58 (1H, d), 4.07 (1H, d), 4.53 (2H, d), 6.69-6.95 (3H, m),7.23-7.45 (4H, m) 1-494 1H-NMR (CDCl3) δ: 2.50-2.63 (1H, m), 2.65 (3H,s), 2.83-2.91 (1H, m), 3.28 (1H, d), 3.51-3.61 (2H, m), 3.65 (1H, d),3.78 (1H, d), 4.06 (1H, d), 4.58 (2H, d), 6.67-6.81 (2H, m), 7.11 (1H,b), 7.26-7.47 (4H, m) 1-495 1H-NMR (CDCl3) δ: 2.50-2.63 (1H, m),2.83-2.91 (1H, m), 3.05 (3H, s), 3.48-3.61 (2H, m), 3.78 (1H, d), 3.85(2H, s), 4.06 (1H, d), 4.57 (2H, d), 6.56 (1H, b), 6.69-6.82 (2H, m),7.26-7.47 (4H, m) 1-496 1H-NMR (CDCl3) δ: 2.50-2.61 (1H, m), 2.83-2.91(1H, m), 3.49-3.62 (2H, m), 3.59 (2H, s), 3.78 (1H, d), 4.06 (1H, d),4.54 (2H, d), 6.58 (1H, b), 6.68-6.81 (2H, m), 7.26-7.42 (4H, m) 1-4981H-NMR (CDCl3) δ: 2.50-2.61 (1H, m), 2.86-2.91 (1H, m), 3.49-3.65 (2H,m), 3.75-3.80 (3H, m), 4.06 (1H, d), 4.57 (2H, d), 6.46 (1H, b),6.68-6.81 (2H, m), 7.26-7.44 (4H, m) 1-499 1H-NMR (CDCl3) δ: 1.20 (3H,t), 2.49 (2H, q), 2.48-2.61 (1H, m), 2.84-2.91 (1H, m), 3.23 (2H, s),3.49-3.60 (2H, m), 3.79 (1H, d), 4.12 (1H, d), 4.53 (2H, d), 6.68-6.81(2H, m), 7.15 (1H, b), 7.27-7.44 (4H, m) 1-500 1H-NMR (CDCl3) δ: 1.24(3H, t), 2.51-2.61 (1H, m), 2.78-2.90 (3H, m), 3.29 (1H, d), 3.49-3.60(2H, m), 3.57 (1H, d), 3.78 (1H, d), 4.06 (1H, d), 4.57 (2H, d),6.67-6.80 (2H, m), 7.11 (1H, b), 7.28-7.46 (4H, m) 1-501 1H-NMR (CDCl3)δ: 1.26 (3H, t), 2.51-2.61 (1H, m), 2.83-2.92 (1H, m), 3.15 (2H, q),3.49-3.62 (2H, m), 3.78 (1H, d), 3.83 (2H, s), 4.07 (1H, d), 4.55 (2H,d), 6.68-6.81 (3H, m), 7.28-7.44 (4H, m) 1-502 1H-NMR (CDCl3) δ: 2.38(3H, s), 2.50-2.60 (1H, m), 2.83-2.92 (1H, m), 3.48-3.58 (2H, m), 3.56(2H, s), 3.78 (1H, d), 4.06 (1H, d), 4.47 (2H, d), 6.44 (1H, b),6.67-6.80 (2H, m), 7.28-7.40 (4H, m) 1-503 1H-NMR (CDCl3) δ: 2.50-2.61(1H, m), 2.83-2.92 (1H, m), 3.07 (2H, d), 3.18 (2H, s), 3.49-3.60 (2H,m), 3.79 (1H, d), 4.07 (1H, d), 4.52 (2H, d), 5.02-5.09 (2H, m),5.61-5.72 (1H, m), 6.68-6.82 (2H, m), 7.04 (1H, b), 7.28-7.45 (4H, m)1-504 1H-NMR (CDCl3) δ: 2.50-2.62 (1H, m), 2.83-2.92 (1H, m), 3.33 (1H,d), 3.52-3.63 (5H, m), 3.78 (1H, d), 4.07 (1H, d), 4.56 (2H, d),5.35-5.47 (2H, m), 5.79-5.86 (1H, m), 6.67-6.80 (2H, m), 7.03 (1H, b),7.28-7.47 (4H, m) 1-505 1H-NMR (CDCl3) δ: 2.50-2.61 (1H, m), 2.83-2.92(1H, m), 3.49-3.60 (2H, m), 3.80-3.87 (5H, m), 4.07 (1H, d), 4.55 (2H,d), 5.51-5.57 (2H, m), 6.63 (1H, b), 6.68-6.82 (2H, m), .28-7.45 (4H, m)1-506 1H-NMR (CDCl3) δ: 1.45 (3H, d), 2.01 (3H, s), 2.50-2.60 (1H, m),2.83-2.91 (1H, m), 3.32 (1H, q), 3.49-3.59 (2H, m), 3.78 (1H, d), 4.07(1H, d), 4.51 (2H, d), 6.68-6.82 (2H, m), 6.95 (1H, b), 7.28-7.44 (4H,m) 1-507 1H-NMR (CDCl3) δ: 1.30, 1.60 (3H, d), 2.42-2.57 (3H, s),2.53-2.63 (1H, m), 2.83-2.91 (1H, m), 3.18, 3.56 (1H, q), 3.48-3.80 (2H,m), 3.78 (1H, d), 4.06 (1H, d), 4.55-4.60 (2H, m), 6.68-6.80 (2H, m),6.98-7.10 (1H, b), 7.28-7.45 (4H, m) 1-508 1H-NMR (CDCl3) δ: 1.60 (3H,d), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m), 2.90 (3H, s), 3.48-3.80 (4H,m), 3.38 (1H, d), 4.07 (1H, d), 4.56 (2H, d), 6.57 (1H, b), 6.68-6.82(2H, m), 7.28-7.43 (4H, m) 1-509 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.46(2H, t), 2.50-2.60 (1H, m), 2.80 (2H, t), 2.83-2.91 (1H, m), 3.49-3.59(2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.52 (2H, d), 5.90 (1H, b),6.68-6.80 (2H, m), 7.28-7.47 (4H, m) 1-513 1H-NMR (CDCl3) δ: 2.01 (3H,s), 2.51-2.60 (1H, m), 2.83-2.91 (1H, m), 3.48-3.60 (2H, m), 3.77 (1H,d), 3.90 (2H, d), 4.05 (1H, d), 4.50 (2H, d), 6.40 (2H, b), 6.67-6.80(2H, m), 7.29-7.40 (4H, m) 1-515 1H-NMR (CDCl3) δ: 0.75-0.80 (2H, m),0.92-0.97 (2H, m), 1.39-1.44 (1H, m), 2.51-2.60 (1H, m), 2.83-2.91 (1H,m), 3.48-3.60 (2H, m), 3.77 (1H, d), 3.93 (2H, d), 4.06 (1H, d), 4.51(2H, d), 6.43 (1H, b), 6.60 (1H, b), 6.67-6.80 (2H, m), 7.28-7.41 (4H,m) 1-516 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.84-2.91 (1H, m), 3.10(2H, q), 3.48-3.60 (2H, m), 3.77 (1H, d), 3.95 (2H, d), 4.05 (1H, d),4.50 (2H, d), 6.66 (1H, b), 6.66-6.80 (2H, m), 6.86 (1H, b), 7.28-7.40(4H, m) 1-517 1H-NMR (CDCl3) δ: 2.17 (3H, s), 2.50-2.63 (1H, m),2.83-2.92 (1H, m), 3.20 (2H, s), 3.48-3.60 (2H, m), 3.78 (1H, d), 3.95(2H, d), 4.06 (1H, d), 4.51 (2H, d), 6.27 (1H, b), 6.67-6.80 (2H, m),7.28-7.42 (4H, m) 1-520 1H-NMR (CDCl3) δ: 1.45 (9H, s), 2.50-2.60 (1H,m), 2.83-2.92 (1H, m), 3.48-3.60 (2H, m), 3.76-3.79 (3H, m), 4.06 (1H,d), 4.52 (2H, d), 5.02 (1H, b), 6.29 (1H, b), 6.67-6.80 (2H, m),7.26-7.43 (4H, m) 1-521 1H-NMR (CDCl3) δ: 1.34 (3H, d), 1.98 (3H, s),2.52-2.57 (1H, m), 2.83-2.91 (1H, m), 3.47-3.60 (2H, m), 3.72-3.77 (1H,m), 4.05-4.07 (1H, m), 4.44-4.51 (3H, m), 6.21-6.24 (1H, m), 6.45-6.47(1H, m), 6.69-6.77 (2H, m), 7.27-7.28 (1H, m), 7.34-7.38 (2H, m). 1-5221H-NMR (CDCl3) δ: 1.11 (3H, t), 1.34 (3H, d), 2.21 (2H, q), 2.47-2.59(1H, m), 2.84-2.89 (1H, m), 3.47-3.60 (2H, m), 3.74-3.77 (2H, m),4.03-4.13 (1H, m), 4.46-4.53 (2H, m), 6.30-6.33 (1H, m), 6.69-6.75 (3H,m), 7.27-7.28 (1H, m), 7.34-7.46 (2H, m). 1-523 1H-NMR (CDCl3) δ:0.69-0.98 (4H, m), 1.23-1.46 (3H, m), 2.49-2.57 (1H, m), 2.82-2.90 (1H,m), 3.46-3.59 (2H, m), 3.75-3.77 (2H, m), 4.04-4.11 (1H, m), 4.40-4.64(3H, m), 6.35-6.38 (1H, m), 6.70-6.87 (3H, m), 7.16-7.45 (3H, m). 1-5251H-NMR (CDCl3) δ: 1.38-1.46 (3H, m), 2.01-2.08 (3H, m), 2.50-2.60 (1H,m), 2.83-2.91 (1H, m), 3.14-3.20 (2H, m), 3.49-3.61 (2H, m), 3.77-3.79(1H, m), 4.04-4.13 (1H, m), 4.41-4.65 (3H, m), 6.36-6.38 (1H, m),6.69-6.77 (2H, m), 7.29-7.39 (3H, m). 1-528 1H-NMR (CDCl3) δ: 1.55 (6H,s), 2.07 (3H, s), 2.49-2.60 (1H, m), 2.82-2.90 (1H, m), 3.48-3.61 (2H,m), 3.78 (1H, d), 4.06 (1H, d), 4.50 (2H, d), 6.17 (1H, b), 6.69-6.80(3H, m), 7.26-7.43 (4H, m) 1-530 1H-NMR (CDCl3) δ: 0.68-0.74 (2H, m),0.88-0.93 (2H, m), 1.32-1.63 (1H, m), 1.55 (6H, s), 2.50-2.60 (1H, m),2.82-2.90 (1H, m), 3.48-3.61 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.50(2H, d), 6.19 (1H, s), 6.67-6.83 (3H, m), 7.26-7.41 (4H, m) 1-532 1H-NMR(CDCl3) δ: 1.57 (6H, s), 2.11 (3H, s), 2.50-2.61 (1H, m), 2.82-2.91 (1H,m), 3.55 (2H, s), 3.47-3.59 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.51(2H, d), 6.64-6.80 (3H, m), 7.26-7.44 (4H, m) 1-543 1H-NMR (CDCl3) δ:2.50-2.63 (1H, m), 2.83-2.91 (1H, m), 3.50-3.61 (2H, m), 3.77 (1H, d),4.06 (1H, d), 4.47 (2H, d), 4.64 (2H, s), 5.71 (1H, b), 6.65-7.48 (9H,m) 1-544 1H-NMR (CDCl3) δ: 2.52-2.60 (1H, m), 2.82-2.90 (1H, m),3.47-3.60 (2H, m), 3.77 (1H, d), 4.05 (1H, d), 4.47 (2H, d), 4.83 (2H,s), 6.31-6.77 (4H, m), 7.26-7.61 (6H, m) 1-547 1H-NMR (CDCl3) δ:2.50-2.63 (1H, m), 2.83-2.91 (1H, m), 3.45-3.78 (2H, m), 3.77 (1H, d),4.09 (1H, d), 4.48 (2H, d), 4.74 (2H, s), 6.45 (1H, b), 6.65-6.78 (2H,m), 7.26-7.50 (6H, m) 1-553 1H-NMR (CDCl3) δ: 2.50-2.63 (1H, m),2.84-2.92 (1H, m), 3.48-3.61 (2H, m), 3.77 (1H, d), 4.06 (1H, d), 4.49(2H, d), 4.82 (2H, s), 6.40 (1H, b), 6.65-6.79 (2H, m), 7.26-7.95 (6H,m) 1-555 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.84-2.91 (1H, m),3.45-3.58 (2H, m), 3.77 (1H, d), 4.06 (1H, d), 4.49 (2H, d), 4.84 (2H,s), 6.41 (1H, b), 6.58-6.78 (3H, m), 7.28-7.52 (5H, m) 1-558 1H-NMR(CDCl3) δ: 2.50-2.61 (1H, m), 2.83-2.91 (1H, m), 3.48-3.58 (2H, m), 3.77(1H, d), 4.06 (1H, d), 4.50 (2H, d), 4.86 (2H, s), 6.54 (1H, b),6.65-6.78 (2H, m), 7.26-8.15 (6H, m) 1-574 1H-NMR (CDCl3) δ: 2.50-2.61(1H, m), 2.80-2.93 (7H, m), 3.49-3.63 (2H, m), 3.79 (1H, d), 4.08 (1H,d), 4.28 (2H, s), 6.71-6.80 (2H, m), 7.29-7.47 (4H, m) 1-586 1H-NMR(CDCl3) δ: 1.15 (3H, t), 2.19 (2H, q), 2.50-2.56 (4H, m), 2.79-2.88 (1H,m), 3.50-3.57 (1H, m), 3.77 (1H, d), 4.04 (1H, d), 4.45 (2H, d), 5.75(1H, b), 6.37-6.46 (2H, m), 7.20-7.40 (4H, m) 1-587 1H-NMR (CDCl3) δ:0.68-0.75 (2H, m), 0.95-1.00 (2H, m), 1.58-1.61 (1H, m), 2.45-2.55 (4H,m), 2.78-2.90 (1H, m), 3.42-3.60 (2H, m), 3.77 (1H, d), 4.03 (1H, d),4.46 (2H, d), 5.97 (1H, b), 6.37-6.47 (2H, m), 7.20-7.40 (4H, m) 1-5881H-NMR (CDCl3) δ: 2.49-2.60 (4H, m), 2.76-2.91 (1H, m), 2.99-3.10 (2H,m), 3.45-3.55 (2H, m), 3.78 (1H, d), 4.04 (1H, d), 4.48 (2H, d), 6.04(1H, b), 6.35-6.47 (2H, m), 7.18-7.40 (4H, m) 1-597 1H-NMR (CDCl3) δ:2.60-2.64 (1H, m), 2.85-3.02 (3H, m), 3.14 (3H, s), 3.50-3.61 (2H, m),3.78 (1H, d), 4.09 (1H, d), 4.61 (2H, d), 6.74-6.78 (2H, m), 7.15-7.54(5H, m) 1-598 1H-NMR (CDCl3) δ: 1.17 (3H, t), 2.22 (2H, q), 2.49-2.60(1H, m), 2.83-2.91 (1H, m), 3.42-3.60 (2H, m), 3.77 (1H, d), 4.04 (1H,d), 4.58 (2H, d), 5.74 (1H, b), 6.67-7.43 (6H, m) 1-645 1H-NMR (CDCl3)δ: 1.14 (3H, t), 2.20 (2H, q), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.46-3.61 (2H, m), 3.77 (1H, d), 4.06 (1H, d), 4.50 (2H, d), 5.76 (1H,br s), 6.70 (1H, dd), 6.80 (1H, d), 7.44 (1H, d), 7.48 (2H, d), 7.70(1H, t). 1-647 1H-NMR (CDCl3) δ: 0.69-0.75 (2H, m), 0.96-1.00 (2H, m),1.28-1.35 (1H, m), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m), 3.46-3.61 (3H,m), 3.77 (1H, d), 4.06 (1H, d), 4.52 (2H, d), 5.88 (1H, t), 6.70 (1H,dd), 6.80 (1H, d), 7.45 (1H, d), 7.48 (2H, d), 7.70 (1H, t). 1-6501H-NMR (CDCl3) δ: 2.06 (3H, s), 2.50-2.60 (1H, m), 2.83-2.91 (1H, m),3.20 (2H, s), 3.46-3.62 (2H, m), 3.77 (1H, d), 4.07 (1H, d), 4.54 (2H,d), 6.70 (1H, dd), 6.81 (1H, d), 7.14 (1H, t), 7.43 (1H, d), 7.48 (2H,d), 7.70 (1H, t). 1-651 1H-NMR (CDCl3) δ: 2.50-2.59 (1H, m), 2.65 (3H,s), 2.83-2.91 (1H, m), 3.28 (1H, d), 3.46-3.61 (2H, m), 3.66 (1H, d),3.75-3.78 (2H, m), 4.06 (1H, d), 4.58 (2H, d), 6.70 (1H, dd), 6.80 (1H,d), 7.11 (1H, t), 7.46 (1H, d), 7.47 (2H, d), 7.70 (1H, t). 1-652 1H-NMR(DMSO-d6) δ: 2.60-2.68 (1H, m), 2.89-2.98 (1H, m), 3.12 (3H, s),3.42-3.47 (2H, m), 3.80 (1H, d), 4.14 (2H, s), 4.24 (1H, d), 4.37 (2H,d), 6.90-6.92 (2H, m), 7.39 (1H, d), 7.83 (2H, s), 7.92 (1H, s), 8.72(1H, t). 1-675 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.20 (2H, q), 2.48-2.59(1H, m), 2.83-2.91 (1H, m), 3.46-3.61 (2H, m), 3.77 (1H, d), 4.06 (1H,d), 4.49 (2H, d), 5.76 (1H, s), 6.70 (1H, dd), 6.79 (1H, d), 7.37 (2H,d), 7.45 (1H, d). 1-694 1H-NMR (CDCl3) δ: 1.44 (9H, s), 2.47-2.56 (1H,m), 2.79-2.88 (1H, m), 3.41-3.56 (2H, m), 3.73 (1H), 4.01 (1H, d), 4.30(2H, d), 4.90 (1H, br s), 6.45 (1H, dd), 6.58 (1H, d), 7.26 (2H, d),7.41 (2H, s). 1-698 1H-NMR (CDCl3) δ: 2.09 (3H, s), 2.47-2.57 (1H, m),2.80-2.88 (1H, m), 3.20 (2H, s), 3.42-3.57 (2H, m), 3.74 (1H, d), 4.02(1H, d), 4.47 (2H, d), 6.46 (1H, dd), 6.60 (1H, d), 7.28 (1H, d), 7.42(2H, s). 1-699 1H-NMR (acetone-d6) δ: 2.63 (3H, s), 2.70-2.78 (1H, m),2.95-3.04 (1H, m), 3.49-3.58 (3H, m), 3.70 (1H, d), 3.94 (1H, d), 4.24(1H, d), 4.40 (2H, dd), 6.59 (1H, dd), 6.71 (1H, d), 7.23 (1H, br s),7.31 (1H, d), 7.76 (1H, br s), 7.82 (2H, s). 1-700 1H-NMR (acetone-d6)δ: 2.69-2.80 (1H, m), 2.97-3.05 (1H, m), 3.10 (3H, s), 3.47-3.59 (2H,m), 3.95 (1H, d), 4.05 (2H, s), 4.25 (1H, d), 4.41 (2H, d), 6.61 (1H,dd), 6.72 (1H, d), 7.31 (1H, d), 7.82 (2H, s), 7.84 (1H, br s). 1-7081H-NMR (CDCl3) δ: 2.09 (3H, s), 2.46-2.56 (1H, m), 2.80-2.88 (1H, m),3.20 (2H, s), 3.41-3.57 (2H, m), 3.73 (1H, d), 4.01 (1H, d), 4.46 (2H,d), 6.50 (1H, dd), 6.78 (1H, d), 7.28 (1H, d), 7.41 (2H, s). 1-7091H-NMR (CDCl3) δ: 2.45-2.63 (1H, m), 3.27 (1H, d), 3.40-3.54 (2H, m),3.64-3.74 (2H, m), 4.01 (1H, d), 4.48-4.51 (2H, m), 6.47-7.41 (6H, m)1-710 1H-NMR (CDCl3) δ: 2.46-2.60 (1H, m), 2.80-2.93 (1H, m), 3.05 (3H,s), 3.40-3.60 (2H, m), 3.76 (1H, d), 3.86 (2H, s), 4.01 (1H, d), 4.48(2H, d), 6.48-7.41 (6H, m) 1-723 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m),2.83-2.92 (1H, m), 3.49-3.60 (2H, m), 3.78 (1H, d), 4.04-4.08 (3H, m),4.55 (2H, d), 6.68-6.82 (3H, m), 7.42-7.45 (3H, m) 1-725 1H-NMR (CDCl3)δ: 2.44-2.59 (4H, m), 2.85-2.90 (1H, m), 3.34 (3H, s), 3.50-3.63 (4H,m), 3.77 (1H, d), 4.05 (1H, d), 4.51 (2H, d), 6.57 (1H, b), 6.67-6.80(2H, m), 7.43-7.48 (3H, m) 1-727 1H-NMR (CDCl3) δ: 2.49-2.60 (1H, m),2.83-2.91 (1H, m), 3.24 (2H, d), 3.50-3.62 (2H, m), 3.78 (1H, d), 4.06(1H, d), 4.53 (2H, d), 6.68-7.05 (4H, m), 7.26-7.45 (3H, m) 1-728 1H-NMR(CDCl3) δ: 2.06 (3H, s), 2.49-2.59 (1H, m), 2.82-2.91 (1H, m), 3.20 (2H,s), 3.50-3.60 (2H, m), 3.78 (1H, d), 4.06 (1H, d), 4.54 (2H, d),6.69-6.81 (2H, m), 7.13 (1H, b), 7.42-7.45 (3H, m) 1-729 1H-NMR (CDCl3)δ: 2.49-2.60 (1H, m), 2.65 (3H, s), 2.82-2.91 (1H, m), 3.26, 3.66 (2H,d), 3.49-3.61 (2H, m), 3.77 (1H, d), 4.05 (1H, d), 4.58 (2H, d),6.67-6.81 (2H, m), 7.08 (1H, b), 7.42-7.47 (3H, m) 1-730 1H-NMR (CDCl3)δ: 2.49-2.59 (1H, m), 2.83-2.91 (1H, m), 3.04 (3H, s), 3.50-3.60 (2H,m), 3.78 (1H, d), 3.86 (2H, s), 4.06 (1H, d), 4.56 (2H, d), 6.60 (1H,b), 6.69-6.81 (2H, m), 7.42-7.45 (3H, m) 1-731 1H-NMR (CDCl3) δ:2.49-2.59 (1H, m), 2.83-2.91 (1H, m), 3.50-3.59 (4H, m), 3.78 (1H, d),4.06 (1H, d), 4.54 (2H, d), 6.55 (1H, b), 6.68-6.81 (2H, m), 7.40-7.45(3H, m) 1-732 1H-NMR (CDCl3) δ: 2.49-2.59 (1H, m), 2.83-2.90 (1H, m),3.07 (2H, d), 3.18 (2H, s), 3.50-3.60 (2H, m), 3.78 (1H, d), 4.06 (1H,d), 4.53 (2H, d), 5.02-5.09 (2H, m), 5.63-5.72 (1H, m), 6.68-6.81 (2H,m), 7.04 (1H, b), 7.42-7.45 (3H, m) 1-733 1H-NMR (CDCl3) δ: 2.50-2.59(1H, m), 2.82-2.90 (1H, m), 3.32-3.62 (6H, m), 3.77 (1H, d), 4.05 (1H,d), 4.57 (2H, d), 5.37-5.5.47 (2H, m), 5.77-5.89-5.72 (1H, m), 6.67-6.81(2H, m), 7.07 (1H, b), 7.42-7.47 (3H, m) 1-734 1H-NMR (CDCl3) δ:2.50-2.59 (1H, m), 2.83-2.91 (1H, m), 3.50-3.62 (2H, m), 3.76-3.87 (5H,m), 4.06 (1H, d), 4.55 (2H, d), 5.51-5.57 (2H, m), 5.83-5.97 (1H, m),6.64-6.81 (3H, m), 7.42-7.45 (3H, m) 1-735 1H-NMR (CDCl3) δ: 2.38 (3H,s), 2.50-2.59 (1H, m), 2.83-2.91 (1H, m), 3.50-3.62 (4H, m), 3.77 (1H,d), 4.05 (1H, d), 4.57 (2H, d), 6.43 (1H, b), 6.68-6.79 (3H, m),7.38-7.43 (3H, m) 1-856 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.20 (2H, q),2.51-2.61 (1H, m), 2.99-3.07 (1H, m), 3.49-3.61 (2H, m), 3.76 (1H, d),4.25 (1H, dd), 4.50 (2H, d), 5.72 (1H, s), 6.71 (1H, dd), 6.81 (1H, d),7.32 (1H, dd), 7.45 (1H, d). 1-866 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.20(2H, q), 2.57-2.66 (1H, m), 2.91-2.99 (1H, m), 3.46-3.64 (2H, m), 3.85(1H, d), 4.14 (1H, d), 4.50 (2H, d), 5.67 (1H, s), 6.71 (1H, dd), 6.81(1H, d), 7.45 (1H, d), 7.52-7.64 (4H, m). 1-907 1H-NMR (CDCl3) δ: 2.46(2H, t), 2.54-2.64 (1H, m), 2.89-2.98 (1H, m), 3.34 (3H, s), 3.48-3.63(4H, m), 3.81 (1H, d), 4.12 (1H, d), 4.51 (2H, d), 6.57 (1H, b),6.69-6.81 (2H, m), 7.44-7.65 (4H, m) 1-912 1H-NMR (CDCl3) δ: 1.99 (3H,s), 2.51-2.62 (1H, m), 2.87-2.96 (1H, m), 3.40-3.58 (2H, m), 3.77 (1H,d), 4.08 (1H, d), 4.42 (2H, d), 5.82 (1H, b), 6.50-6.79 (2H, m),7.26-7.65 (4H, m) 1-913 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.21 (2H, q),2.50-2.62 (1H, m), 2.87-2.95 (1H, m), 3.77 (1H, d), 4.08 (1H, d), 4.43(2H, d), 5.80 (1H, b), 6.50-6.79 (2H, m), 6.27-7.65 (4H, m) 1-915 1H-NMR(CDCl3) δ: 0.69-0.75 (2H, m), 0.95-0.98 (2H, m), 1.25-1.35 (1H, m),2.50-2.60 (1H, m), 2.87-2.94 (1H, m), 3.40-3.57 (2H, m), 3.77 (1H, d),4.08 (1H, d), 4.45 (2H, d), 5.98 (1H, d), 6.49-7.65 (6H, m) 1-917 1H-NMR(CDCl3) δ: 2.50-2.62 (1H, m), 2.87-2.96 (1H, m), 3.03 (1H, d), 3.10 (1H,d), 3.40-3.57 (2H, m), 3.78 (1H, d), 4.09 (1H, d), 4.47 (2H, d), 6.09(1H, b), 6.50-6.80 (2H, m), 7.26-7.65 (4H, m) 1-918 1H-NMR (CDCl3) δ:2.09 (3H, s), 2.51-2.62 (1H, m), 2.87-2.96 (1H, m), 3.21 (2H, s),3.40-3.60 (2H, m), 3.78 (1H, d), 4.09 (1H, d), 4.46 (2H, d), 6.50-6.81(2H, m), 7.26-7.65 (5H, m) 1-924 1H-NMR (CDCl3) δ: 2.07 (3H, s),2.55-2.64 (1H, m), 2.90-3.00 (1H, m), 3.20 (2H, s), 3.82 (1H, d), 4.13(1H, d), 4.55 (2H, d), 6.70-7.66 (7H, m) 1-925 1H-NMR (CDCl3) δ:2.54-2.65 (4H, m), 2.90-2.98 (1H, m), 3.27 (1H, d), 3.51-3.69 (3H, m),3.81 (1H, d), 4.13 (1H, d), 4.59 (2H, d), 6.69-7.66 (7H, m) 1-926 1H-NMR(CDCl3) δ: 2.54-2.65 (1H, m), 2.91-3.00 (1H, m), 3.05 (3H, s), 3.50-3.63(2H, m), 3.81 (1H, d), 3.86 (2H, s), 4.13 (1H, d), 4.57 (2H, d),6.58-6.83 (3H, m), 7.42-7.66 (4H, m) 1-939 1H-NMR (CDCl3) δ: 2.09 (3H,s), 2.56-2.66 (1H, m), 2.95-3.03 (1H, m), 3.20 (1H, s), 3.46-3.63 (2H,m), 3.82 (1H, d), 4.17 (1H, d), 4.47 (2H, d), 6.50 (1H, dd), 6.65 (1H,d), 7.85 (2H, s), 7.93 (1H, s), 7.30-7.23 (1H, m). 1-940 1H-NMR(acetone-d6) δ: 2.63 (3H, s), 2.79-2.91 (1H, m), 3.13-3.21 (1H, m),3.54-3.64 (2H, m), 4.06 (1H, d), 4.39-4.45 (3H, m), 6.64 (1H, dd), 6.74(1H, d), 7.33 (1H, d), 7.72 (1H, br s), 8.13 (1H, s), 8.26 (2H, s).1-941 1H-NMR (acetone-d6) δ: 2.66-2.80 (1H, m), 2.98 (3H, s), 3.02-3.10(1H, m), 3.40-3.52 (2H, m), 3.91-3.96 (3H, m), 4.29-4.33 (3H, m), 6.52(1H, dd), 6.62 (1H, d), 7.20 (1H, d), 7.72 (1H, br s), 8.00 (1H, s),8.14 (2H, s). 1-945 1H-NMR (CDCl3) δ: 2.10 (3H, s), 2.55-2.67 (1H, m),2.94-3.03 (1H, m), 3.80 (1H, d), 4.15 (1H, d), 4.47 (2H, d), 6.51-7.92(7H, m) 1-946 1H-NMR (CDCl3) δ: 2.55-2.66 (4H, m), 2.94-3.02 (1H, m),3.27 (1H, d), 3.45-3.53 (2H, m), 3.57 (1H, d), 3.63 (1H, d), 3.80 (1H,d), 4.48-4.51 (2H, m), 6.51-7.92 (7H, m) 1-947 1H-NMR (CDCl3) δ:2.55-2.65 (1H, m), 2.94-3.05 (4H, m), 3.40-3.62 (2H, m), 3.80 (1H, d),3.86 (2H, s), 4.15 (1H, d), 4.48 (2H, d), 6.51-7.92 (7H, m) 1-963 1H-NMR(CDCl3) δ: 2.25 (3H, s), 2.60-2.68 (1H, m), 2.96-3.05 (1H, m), 3.42 (2H,s), 3.50-3.62 (2H, m), 3.84 (1H, d), 4.19 (1H, d), 4.54 (2H, d),6.70-6.84 (2H, m), 7.19 (1H, b), 7.27-7.93 (4H, m) 1-966 1H-NMR (CDCl3)δ: 2.06 (3H, s), 2.60-2.68 (1H, m), 2.96-3.05 (1H, m), 3.20 (2H, s),3.53-3.63 (2H, m), 3.85 (1H, d), 4.19 (1H, d), 4.55 (2H, d), 6.70-6.85(2H, m), 7.13 (1H, b), 7.27-7.93 (4H, m) 1-967 1H-NMR (CDCl3) δ:2.61-2.68 (4H, m), 2.97-3.05 (1H, m), 3.29 (1H, d), 3.50-3.68 (3H, m),3.84 (1H, d), 4.19 (1H, d), 4.58 (2H, d), 6.71-6.84 (2H, m), 7.16 (1H,b), 7.46-7.93 (4H, m) 1-968 1H-NMR (CDCl3) δ: 2.60-2.68 (1H, m),2.97-3.05 (4H, m), 3.52-3.65 (2H, m), 3.83-3.86 (3H, m), 4.19 (1H, d),4.57 (2H, d), 6.61 (1H, b), 6.72-6.85 (2H, m), 7.16 (1H, b), 7.43-7.93(4H, m) 1-969 1H-NMR (CDCl3) δ: 2.62-2.68 (1H, m), 2.97-3.18 (3H, m),3.57 (2H, s), 3.53-3.65 (2H, m), 3.85 (1H, d), 4.20 (1H, d), 4.53 (2H,d), 5.02-5.09 (2H, m), 5.61-5.75 (1H, m), 6.72-6.83 (2H, m), 6.75 (1H,b), 7.44-7.93 (4H, m) 1-970 1H-NMR (CDCl3) δ: 2.62-2.68 (1H, m),2.97-3.18 (1H, m), 3.34 (1H, d), 3.50-3.65 (3H, m), 3.84 (1H, d), 4.19(1H, d), 4.59 (2H, d), 5.37-5.47 (2H, m), 5.78-5.87 (1H, m), 6.72-6.83(2H, m), 7.03 (1H, b), 7.46-7.93 (4H, m) 1-971 1H-NMR (CDCl3) δ:2.63-2.68 (1H, m), 2.97-3.05 (1H, m), 3.52-3.62 (2H, m), 3.83-3.85 (5H,m), 4.20 (1H, d), 4.56 (2H, d), 5.51-5.57 (2H, m), 5.83-5.98 (1H, m),6.62 (1H, b), 6.72-6.85 (2H, m), 7.44-7.93 (4H, m) 1-996 1H-NMR (CDCl3)δ: 1.15 (3H, t), 2.21 (2H, q), 2.54-2.68 (1H, m), 2.95-3.06 (1H, m),3.45-3.60 (2H, m), 3.83 (1H, d), 4.16 (1H, d), 4.59 (2H, d), 5.72 (1H,b), 6.71-7.93 (6H, m) 1-1066 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.20 (3H,q), 2.49-2.61 (1H, m), 2.80-2.92 (1H, m), 3.45-3.59 (2H, m), 3.79 (1H,d), 4.04 (1H, d), 4.50 (2H, d), 5.76 (1H, s), 6.71 (1H, dd), 6.80 (1H,d), 7.32 (2H, s), 7.46 (1H, d). 1-1169 1H-NMR (CDCl3) δ: 1.58-1.68 (1H,m), 2.10-2.30 (2H, m), 2.50-2.56 (1H, m), 2.83-2.89 (1H, m), 3.50-3.63(2H, m), 3.91 (1H, d), 4.36-4.44 (3H, m), 6.14 (1H, b), 6.27 (1H, d),7.30-7.55 (4H, m) 1-1171 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m), 2.83-2.91(1H, m), 3.07 (2H, q), 3.53-3.64 (2H, m), 3.92 (1H, d), 4.37-4.43 (3H,m), 6.16 (1H, b), 6.27 (1H, d), 7.29-7.55 (4H, m) 1-1172 1H-NMR (CDCl3)δ: 2.09 (3H, s), 2.48-2.58 (1H, m), 2.83-2.90 (1H, m), 3.20 (2H, s),3.53-3.66 (2H, m), 3.92 (1H, d), 4.37-4.43 (3H, m), 6.27 (1H, d),7.29-7.56 (5H, m) 1-1174 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m), 2.83-2.92(1H, m), 3.06 (3H, s), 3.53-3.65 (2H, m), 3.87-3.93 (3H, m), 4.37-4.45(3H, m), 6.27 (1H, d), 6.82 (1H, b), 7.29-7.61 (4H, m) 1-1179 1H-NMR(CDCl3) δ: 0.68-0.77 (2H, m), 0.95-1.00 (2H, m), 1.30-1.35 (1H, m),2.47-2.58 (1H, m), 2.81-2.92 (1H, m), 3.50-3.66 (2H, m), 3.91 (1H, d),4.37-4.40 (3H, m), 6.10 (1H, b), 6.25-7.57 (5H, m) 1-1181 1H-NMR (CDCl3)δ: 2.48-2.59 (1H, m), 2.84-2.91 (1H, m), 3.03 (1H, d), 3.10 (1H, d),3.52-3.66 (2H, m), 3.91 (1H, d), 4.40-4.48 (3H, m), 6.26-6.29 (2H, m),7.29-7.54 (4H, m) 1-1182 1H-NMR (CDCl3) δ: 2.10 (3H, s), 2.45-2.60 (1H,m), 2.80-2.90 (1H, m), 3.20 (2H, s), 3.50-3.65 (2H, m), 3.92 (1H, d),4.37-4.43 (3H, m), 6.27 (1H, d), 7.26-7.57 (5H, m) 1-1183 1H-NMR (CDCl3)δ: 2.48-2.58 (1H, m), 2.67 (3H, s), 2.82-2.91 (1H, m), 3.24-3.30 (1H,m), 3.52-3.70 (3H, m), 3.91 (1H, d), 4.41-4.47 (3H, m), 6.25-7.58 (6H,m) 1-1184 1H-NMR (CDCl3) δ: 2.48-2.59 (1H, m), 2.83-2.91 (1H, m), 3.06(3H, s), 3.50-3.66 (2H, m), 3.87-3.92 (3H, m), 4.41-4.65 (3H, m),6.24-7.61 (6H, m) 1-1192 1H-NMR (CDCl3) δ: 2.08 (3H, s), 2.52-2.58 (1H,m), 2.87-2.94 (1H, m), 3.22 (2H, s), 3.52-3.62 (2H, m), 3.95 (1H, d),4.39 (1H, d), 4.49-4.51 (2H, m), 6.52 (1H, d), 7.26-7.34 (4H, m), 7.70(1H, d). 1-1196 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.45-2.77 (7H, m),3.48-3.51 (1H, m), 3.68-3.75 (1H, m), 4.08 (1H, d), 4.30 (1H, d), 4.38(2H, d), 5.59 (1H, b), 6.67 (1H, d), 7.25-7.39 (4H, m) 1-1198 1H-NMR(CDCl3) δ: 2.46-2.55 (1H, m), 2.54 (3H, s), 2.63-2.76 (1H, m), 3.06 (2H,q), 3.45-3.50 (1H, m), 3.68-3.73 (1H, m), 4.07 (1H, d), 4.30 (1H, d),4.48 (2H, d), 5.93 (1H, b), 6.70 (1H, d), 7.25-7.40 (4H, m) 1-12791H-NMR (CDCl3) δ: 1.15 (3H, t), 2.22 (2H, q), 2.46-2.57 (1H, m),2.82-2.90 (1H, m), 3.54-3.66 (2H, m), 3.92 (1H, d), 4.35-4.40 (3H, m),5.92 (1H, b), 6.27 (1H, d), 7.43-7.58 (3H, m) 1-1283 1H-NMR (CDCl3) δ:2.47-2.57 (1H, m), 2.82-2.90 (1H, m), 3.04 (1H, d), 3.11 (1H, d),3.50-3.67 (2H, m), 3.91 (1H, d), 4.36-4.48 (3H, m), 6.22 (1H, b), 4.47(1H, d), 7.39-7.55 (3H, m) 1-1284 1H-NMR (CDCl3) δ: 2.13 (3H, s),2.47-2.57 (1H, m), 2.82-2.90 (1H, m), 3.20 (2H, s), 3.50-3.67 (2H, m),3.92 (1H, d), 4.36-4.43 (3H, m), 6.27 (1H, d), 7.35-7.57 (4H, m) 1-12891H-NMR (CDCl3) δ: 0.14-0.24 (2H, m), 0.57-0.59 (2H, m), 0.85-0.98 (1H,m), 2.12-2.18 (2H, m), 2.49-2.58 (1H, m), 2.83-2.91 (1H, m), 3.57-3.70(2H, m), 3.96 (1H, d), 4.37 (1H, d), 4.48-4.50 (2H, m), 6.29 (1H, br s),6.51 (1H, d), 7.45 (2H, s), 7.74 (1H, d). 1-1290 1H-NMR (CDCl3) δ: 2.05(3H, s), 2.49-2.59 (1H, m), 2.83-2.91 (1H, m), 3.19 (2H, s), 3.58-3.71(2H, m), 3.97 (1H, d), 4.37 (1H, d), 4.50-4.51 (2H, m), 6.51 (1H, d),7.44 (2H, s), 7.71 (1H, d). 1-1291 1H-NMR (CDCl3) δ: 2.49-2.61 (1H, m),2.65 (3H, s), 2.83-2.89 (1H, m), 3.28 (1H, d), 3.57-3.69 (3H, m), 3.96(1H, d), 4.37 (1H, d), 4.54-4.55 (2H, m), 6.52 (1H, d), 7.23-7.28 (1H,m), 7.48 (2H, s), 7.73 (1H, d). 1-1292 1H-NMR (CDCl3) δ: 2.51-2.56 (1H,m), 2.83-2.92 (1H, m), 3.08 (3H, s), 3.57-3.70 (2H, m), 3.89-3.96 (3H,m), 4.37 (1H, d), 4.51-4.53 (2H, m), 6.52 (1H, d), 6.84 (1H, br s), 7.43(2H, s), 7.69 (1H, d). 1-1427 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.10-2.27(2H, m), 2.54-2.63 (1H, m), 2.91-3.00 (1H, m), 3.55-3.72 (2H, m), 4.05(1H, d), 4.44-4.47 (3H, m), 5.79 (1H, br s), 6.56 (1H, d), 7.51-7.78(5H, m). 1-1431 1H-NMR (CDCl3) δ: 2.59-2.67 (1H, m), 2.92-3.17 (3H, m),3.54-3.67 (2H, m), 4.04 (1H, d), 4.47-4.54 (3H, m), 6.15 (1H, br s),6.56 (1H, d), 7.52-7.77 (5H, m). 1-1432 1H-NMR (CDCl3) δ: 2.06 (3H, s),2.58-2.64 (1H, m), 2.92-3.00 (1H, m), 3.19 (2H, s), 3.62-3.70 (2H, m),4.05 (1H, d), 4.44-4.52 (3H, m), 6.52 (1H, d), 7.23 (1H, br s),7.56-7.67 (5H, m). 1-1433 1H-NMR (CDCl3) δ: 2.59-2.66 (4H, m), 2.88-2.95(1H, m), 3.26 (1H, d), 3.65 (3H, m), 4.03 (1H, d), 4.45 (1H, d),4.54-4.56 (2H, m), 6.52 (1H, d), 7.17 (1H, br s), 7.56-7.69 (5H, m).1-1434 1H-NMR (CDCl3) δ: 2.58-2.64 (1H, m), 2.92-3.00 (1H, m), 3.08 (3H,s), 3.63-3.68 (2H, m), 3.86 (2H, s), 4.02 (1H, d), 4.45-4.52 (3H, m),6.53 (1H, d), 6.71 (1H, br s), 7.52-7.69 (5H, m). 1-1467 1H-NMR (CDCl3)δ: 1.15 (3H, t), 2.22 (2H, q), 2.57-2.66 (1H, m), 2.96-3.05 (1H, m),3.56-3.68 (2H, m), 3.98 (1H, d), 4.38 (2H, d), 4.53 (1H, d), 5.90 (1H,b), 6.29 (1H, d), 7.57-7.91 (4H, m) 1-1471 1H-NMR (CDCl3) δ: 2.55-2.66(1H, m), 2.98-3.13 (3H, m), 3.56-3.68 (2H, m), 3.98 (1H, d), 4.43 (2H,d), 4.54 (1H, d), 6.16 (1H, b), 6.30 (1H, d), 7.54-7.92 (4H, m) 1-14721H-NMR (CDCl3) δ: 2.10 (3H, s), 2.55-2.66 (1H, m), 2.97-3.05 (1H, m),3.18 (2H, s), 3.55-3.68 (2H, m), 3.98 (1H, d), 4.38 (2H, d), 4.53 (1H,d), 6.30 (1H, d), 7.35 (1H, b), 7.56-7.92 (4H, m) 1-1476 1H-NMR (CDCl3)δ: 1.99 (3H, s), 2.55-2.66 (1H, m), 2.96-3.05 (1H, m), 3.56-3.68 (2H,m), 3.98 (1H, d), 4.37 (2H, d), 4.53 (1H, d), 6.05 (1H, b), 6.29 (1H,d), 6.28-7.85 (4H, m) 1-1477 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.22 (2H,q), 2.55-2.66 (1H, m), 2.96-3.00 (1H, m), 3.56-3.68 (2H, m), 3.98 (1H,d), 4.38 (2H, d), 4.53 (1H, d), 6.31 (1H, b), 6.29 (1H, d), 6.28-7.91(4H, m) 1-1479 1H-NMR (CDCl3) δ: 0.70-0.77 (2H, m), 0.94-0.99 (2H, m),1.28-1.38 (1H, m), 2.56-2.71 (1H, m), 2.58-3.05 (1H, m), 3.55-3.68 (2H,m), 3.98 (1H, d), 4.40 (2H, d), 4.54 (1H, d), 6.09 (1H, b), 6.29 (1H,d), 7.56-7.92 (4H, m) 1-1481 1H-NMR (CDCl3) δ: 2.56-2.66 (1H, m),2.98-3.13 (3H, m), 3.56-3.71 (2H, m), 3.99 (1H, d), 4.43 (2H, d), 4.54(1H, d), 6.19 (1H, b), 6.30 (1H, d), 7.54-7.92 (4H, m) 1-1482 1H-NMR(CDCl3) δ: 2.10 (3H, s), 2.58-2.66 (1H, m), 2.97-3.05 (1H, m), 3.20 (2H,s), 3.50-3.68 (2H, m), 3.99 (1H, d), 4.43 (2H, d), 4.54 (1H, d), 6.30(1H, d), 7.35 (1H, b), 7.40-7.92 (4H, m) 1-1483 1H-NMR (CDCl3) δ:2.60-2.67 (4H, m), 2.96-3.07 (1H, m), 3.27 (1H, d), 3.50-3.76 (3H, m),3.98 (1H, d), 4.45-4.56 (3H, m), 6.30 (1H, d), 7.30 (1H, b), 7.57-7.92(4H, m) 1-1484 1H-NMR (CDCl3) δ: 2.55-2.66 (1H, m), 2.97-3.06 (4H, m),3.55-3.71 (2H, m), 3.88-4.00 (3H, m), 4.44-4.56 (3H, m), 6.21 (1H, d),6.85 (1H, b), 7.54-7.92 (4H, m) 1-1487 1H-NMR (CDCl3) δ: 0.16-0.22 (2H,m), 0.52-0.63 (2H, m), 0.85-0.98 (1H, m), 2.15 (2H, d), 2.59-2.64 (1H,m), 2.97-3.05 (1H, m), 3.60-3.72 (2H, m), 4.07 (1H, d), 4.49-4.51 (3H,m), 6.31 (1H, br s), 6.54 (1H, d), 7.76 (1H, d), 7.85-7.91 (3H, m).1-1488 1H-NMR (CDCl3) δ: 2.06 (3H, s), 2.57-2.67 (1H, m), 3.01-3.07 (1H,m), 3.20 (2H, s), 3.63-3.73 (2H, m), 4.08 (1H, d), 4.49-4.51 (3H, m),6.54 (1H, d), 7.24 (1H, br s), 7.73 (1H, d), 7.85 (2H, s), 7.92 (1H, s).1-1489 1H-NMR (CDCl3) δ: 2.60-2.69 (4H, m), 2.97-3.05 (1H, m), 3.30 (1H,d), 3.58-3.75 (3H, m), 4.04-4.07 (1H, m), 4.50-4.55 (3H, m), 6.55 (1H,d), 7.24 (1H, br s), 7.74 (1H, d), 7.85 (2H, s), 7.92 (1H, s). 1-14901H-NMR (CDCl3) δ: 2.59-2.65 (1H, m), 3.00-3.07 (4H, m), 3.58-3.75 (2H,m), 3.88 (2H, s), 4.05-4.13 (1H, m), 4.50-4.53 (3H, m), 6.55 (1H, d),6.80 (1H, br s), 7.70 (1H, d), 7.85 (2H, s), 7.92 (1H, s). 1-1696 1H-NMR(CDCl3) δ: 2.04 (3H, s), 2.45-2.55 (1H, m), 2.50 (3H, s), 2.63-2.76 (1H,m),, 3.15 (2H, s), 3.51-3.59 (1H, m), 3.68-3.75 (1H, m), 4.07 (1H, d),4.30 (1H, d), 4.49 (2H, d), 6.69 (1H, d), 6.94 (1H, b), 7.25-7.39 (4H,m) 1-1730 1H-NMR (CDCl3) δ: 1.17-1.23 (3H, m), 2.09-2.22 (2H, m),2.34-2.59 (4H, m), 2.80-2.89 (1H, m), 3.55-3.63 (2H, m), 3.94 (1H, d),4.34-4.38 (3H, m), 5.48 (1H, br s), 6.20 (1H, dz), 7.29-7.35 (4H, m).1-1733 1H-NMR (CDCl3) δ: 0.19-0.23 (2H, m), 0.51-0.71 (3H, m), 0.88-0.99(1H, m), 2.18 (2H, d), 2.45-2.60 (4H, m), 2.81-2.89 (1H, m), 3.57-3.62(2H, m), 3.95 (1H, d), 4.36-4.39 (3H, m), 5.93 (1H, br s), 6.21 (1H, d),7.26-7.54 (4H, m). 1-1735 1H-NMR (CDCl3) δ: 2.10 (3H, s), 2.42-2.57 (4H,m), 2.81-2.89 (1H, m), 3.24 (2H, s), 3.53-3.63 (2H, m), 3.95 (1H, d),4.38-4.40 (3H, m), 6.21 (1H, d), 6.93 (1H, br s), 7.29-7.32 (4H, m).1-1770 1H-NMR (CDCl3) δ: 0.88-0.92 (2H, m), 1.13-1.17 (5H, m), 2.00-2.05(1H, m), 2.21 (2H, q), 2.44-2.54 (1H, m), 2.76-2.85 (1H, m), 3.49-3.63(2H, m), 3.90 (1H, d), 4.24 (1H, d), 4.46-4.47 (2H, m), 5.53 (1H, br s),6.11 (1H, d), 7.28-7.36 (4H, m). 1-1772 1H-NMR (CDCl3) δ: 0.70-1.36 (9H,m), 2.00-2.09 (1H, m), 2.44-2.54 (1H, m), 2.76-2.85 (1H, m), 3.49-3.63(2H, m), 3.90 (1H, d), 4.24 (1H, d), 4.46-4.51 (2H, m), 5.74 (1H, br s),6.11 (1H, d), 7.38-7.43 (4H, m). 1-1775 1H-NMR (CDCl3) δ: 0.86-0.93 (2H,m), 1.13-1.18 (2H, m), 1.97-2.13 (4H, m), 2.45-2.55 (1H, m), 2.77-2.85(1H, m), 3.24 (2H, s), 3.47-3.64 (2H, m), 3.91 (1H, d), 4.24 (1H, d),4.50-4.52 (2H, m), 6.12 (1H, d), 7.08 (1H, br s), 7.28-7.33 (4H, m).1-1800 1H-NMR (CDCl3) δ: 0.88-0.97 (2H, m), 1.07-1.19 (5H, m), 2.02-2.06(1H, m), 2.22 (2H, q), 2.52-2.61 (1H, m), 2.89-2.97 (1H, m), 3.50-3.67(2H, m), 4.02 (1H, d), 4.33 (1H, d), 4.47 (2H, d), 5.53 (1H, br s), 6.13(1H, d), 7.33 (1H, d), 7.84-7.90 (3H, m). 1-1802 1H-NMR (CDCl3) δ:0.72-0.75 (2H, m), 0.92-0.98 (4H, m), 1.19-1.27 (3H, m), 2.01-2.10 (1H,m), 2.56-2.60 (1H, m), 2.89-2.97 (1H, m), 3.55-3.62 (2H, m), 4.02 (1H,d), 4.34 (1H, d), 4.49 (2H, d), 5.69 (1H, br s), 6.14 (1H, d), 7.33 (1H,d), 7.84-7.90 (3H, m). 1-1803 1H-NMR (CDCl3) δ: 0.15-0.20 (2H, m),0.56-0.58 (2H, m), 0.86-0.99 (3H, m), 1.10-1.19 (2H, m), 2.00-2.09 (1H,m), 2.18 (2H, d), 2.52-2.61 (1H, m), 2.89-2.97 (1H, m), 3.54-3.65 (2H,m), 4.03 (1H, d), 4.33 (1H, d), 4.50 (2H, d), 6.00 (1H, br s), 6.14 (1H,d), 7.33 (1H, d), 7.84-7.90 (3H, m). 1-1804 1H-NMR (CDCl3) δ: 0.87-0.92(2H, m), 1.13-1.15 (2H, m), 1.94-2.02 (1H, m), 2.52-2.62 (1H, m),2.89-2.98 (1H, m), 3.08 (2H, q), 3.54-3.65 (2H, m), 4.02 (1H, d), 4.33(1H, d), 4.51 (2H, d), 5.85 (1H, br s), 6.14 (1H, d), 7.31 (1H, d),7.84-7.90 (3H, m). 1-1805 1H-NMR (CDCl3) δ: 0.88-0.96 (2H, m), 1.10-1.20(2H, m), 2.00-2.05 (1H, m), 2.24 (2H, s), 2.47-2.70 (1H, m), 2.92-2.98(1H, m), 3.24 (3H, s), 3.55-3.62 (2H, m), 4.03 (1H, d), 4.33 (1H, d),4.52 (2H, d), 6.14 (1H, d), 7.04 (1H, br s), 7.34 (1H, d), 7.84 (2H, s),7.90 (1H, s). 1-1969 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.24 (2H, q),2.42-2.52 (1H, m), 2.73-2.82 (1H, m), 3.50 (1H, br s), 3.61 (1H, dd),3.93 (1H, d), 4.10 (1H, dd), 4.39 (2H, d), 5.90 (1H, s), 6.64 (1H, d),7.06 (1H, d), 7.28 (2H, s), 7.38 (1H, t). 1-1981 1H-NMR (CDCl3) δ: 1.15(3H, t, J = 7.5 Hz), 2.22 (2H, q, J = 7.6 Hz), 2.43-2.53 (1H, m),2.73-2.82 (1H, m), 3.51 (1H, br s), 3.63 (1H, dd), 3.96 (1H, d), 4.12(1H, dd), 4.44 (2H, d), 5.80 (1H, s), 6.55 (1H, dd), 7.07 (1H, d), 7.28(2H, s), 7.38 (1H, t). 1-1984 1H-NMR (CDCl3) δ: 2.02 (3H, s), 2.47-2.49(1H, m), 2.73-2.81 (1H, m), 3.54-3.61 (2H, m), 3.97-4.08 (2H, m), 4.43(2H, d, J = 5.9 Hz), 5.94 (1H, br s), 6.55 (1H, t, J = 8.5 Hz), 7.07(1H, dd, J = 8.5, 1.6 Hz), 7.43 (2H, s). 1-1985 1H-NMR (CDCl3) δ: 1.15(3H, t), 2.22 (2H, q), 2.47-2.49 (1H, m), 2.73-2.81 (1H, m), 3.54-3.60(2H, m), 3.92-3.96 (1H, m), 4.07-4.11 (1H, m), 4.44 (2H, d), 5.91 (1H,br s), 6.55 (1H, t), 7.06 (1H, dd), 7.42 (2H, s). 1-1986 1H-NMR (CDCl3)δ: 0.63-0.67 (2H, m), 0.88-0.90 (2H, m), 1.25-1.29 (1H, m), 2.39-2.41(1H, m), 2.65-2.73 (1H, m), 3.47-3.51 (2H, m), 3.89-4.00 (2H, m), 4.37(2H, d), 6.04 (1H, t), 6.47 (1H, t), 6.98 (1H, dd), 7.35 (2H, s). 1-19871H-NMR (CDCl3) δ: 2.47-2.49 (1H, m), 2.73-2.82 (1H, m), 3.07 (2H, q),3.55-3.61 (2H, m), 4.00-4.08 (2H, m), 4.46 (2H, d), 6.29 (1H, br s),6.55 (1H, t), 7.04 (1H, dd), 7.42 (2H, s). 1-1988 1H-NMR (CDCl3) δ: 1.99(3H, s), 2.51-2.60 (1H, m), 2.87-2.95 (1H, m), 3.51-3.71 (2H, m), 4.03(1H, d), 4.21 (1H, dd), 4.43 (2H, d), 6.08 (1H, s), 6.58 (1H, dd), 7.08(1H, dd), 7.85 (2H, s), 7.92 (1H, s). 1-1989 1H-NMR (CDCl3) δ: 1.16 (3H,t), 2.23 (2H, q), 2.51-2.60 (1H, m), 2.87-2.95 (1H, m), 3.54 (1H, br s),3.68 (1H, dd), 4.04 (1H, d), 4.22 (1H, dd), 4.45 (2H, d), 5.90 (1H, s),6.59 (1H, dd), 7.08 (1H, dd), 7.85 (2H, s), 7.92 (1H, s). 1-1990 1H-NMR(CDCl3) δ: 0.70-0.76 (2H, m), 0.94-0.99 (2H, m), 1.32-1.40 (1H, m),2.51-2.60 (1H, m), 2.87-2.95 (1H, m), 3.53 (1H, br s), 3.67 (1H, dd),4.04 (1H, d), 4.21 (1H, dd), 4.46 (2H, d), 6.12 (1H, s), 6.59 (1H, dd),7.08 (1H, dd), 7.85 (2H, s), 7.92 (1H, s). 1-1991 1H-NMR (CDCl3) δ:2.51-2.61 (1H, m), 2.88-2.96 (1H, m), 3.08 (2H, q, J = 10.6 Hz), 3.55(1H, br s), 3.69 (1H, dd, J = 8.4, 4.2 Hz), 4.04 (1H, d, J = 10.6 Hz),4.23 (1H, dd, J = 10.8, 2.4 Hz), 4.48 (2H, d, J = 5.9 Hz), 6.27 (1H, s),6.59 (1H, dd, J = 8.5, 4.3 Hz), 7.06 (1H, dd, J = 8.4, 1.5 Hz), 7.84(2H, s), 7.92 (1H, s). 1-1992 1H-NMR (CDCl3) δ: 2.09 (3H, s), 2.48-2.58(4H, m), 2.79-2.88 (1H, m), 3.20 (3H, s), 3.45-3.55 (2H, m), 3.78 (1H,d), 4.70 (1H, d), 4.48 (2H, d), 6.37-6.48 (2H, m), 7.19-7.45 (4H, m)1-1993 1H-NMR (CDCl3) δ: 2.50-2.56 (4H, m), 2.79-2.88 (1H, m), 3.05 (2H,s), 3.45-3.57 (2H, m), 3.77 (1H, d), 4.04 (1H, d), 4.49 (2H, d),6.36-6.46 (2H, m), 6.71 (1H, b), 7.18-7.40 (4H, m) 1-1995 1H-NMR (CDCl3)δ: 2.50-2.2.63 (1H, m), 2.83-2.91 (1H, m), 3.47-3.60 (2H, m), 3.78 (1H,d), 4.08 (1H, d), 4.54 (2H, d), 4.63 (2H, s), 5.91 (1H, b), 6.67-6.80(2H, m), 7.26-7.81 (6H, m) 1-1996 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m),2.82-2.90 (1H, m), 3.47-3.52 (1H, m), 3.76 (1H, d), 4.04 (1H, d), 4.47(2H, d), 4.82 (2H, s), 6.31-7.64 (9H, m) 1-1997 1H-NMR (CDCl3) δ:2.50-2.61 (1H, m), 2.89-2.97 (1H, m), 3.79 (1H, d), 4.11 (1H, d), 4.47(2H, d), 4.83 (2H, s), 6.31-6.78 (4H, m), 7.34-7.65 (6H, m) 1-19981H-NMR (CDCl3) δ: 1.99 (3H, s), 2.50-2.66 (1H, m), 2.94-3.02 (1H, m),3.45-3.60 (2H, m), 3.80 (1H, d), 4.13 (1H, d), 4.43 (2H, d), 5.81 (1H,b), 6.51-6.81 (2H, m), 7.28-7.92 (4H, m) 1-1999 1H-NMR (CDCl3) δ:2.54-2.64 (1H, m), 2.93-3.01 (1H, m), 3.44-3.60 (2H, m), 3.78 (1H, d),4.12 (1H, d), 4.39 (2H, d), 4.83 (2H, s), 6.32-6.77 (4H, m), 7.17-7.92(6H, m) 1-2000 1H-NMR (CDCl3) δ: 2.47 (2H, t), 2.55-2.65 (1H, m),2.94-3.02 (1H, m), 3.34 (3H, s), 3.47-3.65 (4H, m), 3.80 (1H, d), 4.14(1H, d), 4.43 (2H, d), 6.51-7.92 (7H, m) 1-2001 1H-NMR (CDCl3) δ:2.45-2.60 (3H, m), 2.82-2.91 (1H, m), 3.36 (3H, s), 3.52-3.64 (4H, m),3.91 (1H, d), 4.36-4.40 (3H, m), 6.24-7.60 (6H, m) 1-2002 1H-NMR (CDCl3)δ: 2.44-2.60 (3H, m), 2.80-2.90 (1H, m), 3.36 (3H, s), 3.40-3.65 (4H,m), 3.74 (1H, d), 4.02 (1H, d), 4.44 (2H, d), 6.47-7.40 (6H, m) 1-20031H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.85-2.95 (4H, m), 3.60-3.69 (2H,m), 3.97 (1H, d), 4.37-4.39 (3H, m), 6.56 (1H, d), 7.44 (2H, s), 7.74(1H, d). 1-2004 1H-NMR (CDCl3) δ: 2.58-2.68 (1H, m), 2.90-3.16 (4H, m),3.66-3.74 (2H, m), 4.05-4.16 (1H, m), 4.41-4.57 (4H, m), 6.59 (1H, dz),7.76 (1H, d), 7.85-7.92 (3H, m). 1-2005 1H-NMR (CDCl3) δ: 2.56-2.66 (1H,m), 2.96-3.04 (1H, m), 3.64-3.70 (2H, m), 4.05 (1H, d), 4.50 (1H, d),4.70-4.72 (2H, m), 6.54 (1H, d), 7.41-7.43 (1H, m), 7.82-7.88 (5H, m),8.18-8.21 (1H, m), 8.39 (1H, br s), 8.53-8.54 (1H, m). 1-2007 1H-NMR(CDCl3) δ: 1.99 (3H, s), 2.55-2.66 (1H, m), 2.94-3.02 (1H, m), 3.44-3.61(2H, m), 3.79 (1H, d), 4.14 (1H, d), 4.40 (2H, d), 5.80 (1H, br s), 6.58(1H, dd), 7.06 (1H, d), 7.28 (1H, d), 7.83 (2H, s), 7.92 (1H, s). 1-20081H-NMR (CDCl3) δ: 1.16 (3H, t), 2.22 (2H, q), 2.55-2.65 (1H, m),2.94-3.02 (1H, m), 3.44-3.61 (2H, m), 3.79 (1H, d), 4.14 (1H, d), 4.40(2H, d), 5.78 (1H, br s), 6.58 (1H, dd), 7.06 (1H, d), 7.27 (1H, d),7.83 (2H, s), 7.92 (1H, s). 1-2009 1H-NMR (CDCl3) δ: 0.70-0.78 (2H, m),0.95-1.01 (2H, m), 1.30-1.38 (1H, m), 2.55-2.65 (1H, m), 2.94-3.02 (1H,m), 3.44-3.61 (2H, m), 3.79 (1H, d), 4.14 (1H, d), 4.42 (2H, d), 6.00(1H, br s), 6.58 (1H, dd), 7.07 (1H, d), 7.27 (1H, d), 7.84 (2H, s),7.92 (1H, s). 1-2010 1H-NMR (CDCl3) δ: 2.55-2.65 (1H, m), 2.95-3.12 (3H,m), 3.44-3.61 (2H, m), 3.79 (1H, d), 4.14 (1H, d), 4.44 (2H, d), 6.13(1H, br s), 6.58 (1H, dd), 7.07 (1H, d), 7.25 (1H, d), 7.83 (2H, s),7.93 (1H, s). 1-2011 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.55-2.65 (1H, m),2.95-3.01 (1H, m), 3.21 (2H, s), 3.45-3.62 (2H, m), 3.80 (1H, d), 4.15(1H, d), 4.43 (2H, d), 6.58 (1H, dd), 7.08 (1H, d), 7.27 (2H, d), 7.84(2H, s), 7.93 (1H, s). 1-2012 1H-NMR (CDCl3) δ: 2.54-2.67 (4H, m),2.94-3.02 (1H, m), 3.28 (1H, d, J = 14.3 Hz), 3.42-3.61 (2H, m), 3.68(1H, d), 3.79 (1H, d), 4.14 (1H, d), 4.48 (2H, d), 6.58 (1H, dd), 7.07(1H, d), 7.18 (1H, br s), 7.29 (1H, d), 7.83 (2H, s), 7.92 (1H, s).1-2013 1H-NMR (acetone-d6) δ: 2.79-2.91 (1H, m), 3.11 (3H, s), 3.13-3.21(1H, m), 3.50-3.64 (2H, m), 4.05 (1H, d), 4.07 (1H, d), 4.37 (2H, d),4.43 (1H, d), 6.73 (1H, dd), 7.18 (1H, d), 7.28 (1H, d), 7.84 (1H, brs), 8.12 (1H, s), 8.26 (2H, s). 1-2015 1H-NMR (CDCl3) δ: 1.99 (3H, s),2.50-2.63 (1H, m), 2.87-2.95 (1H, m), 3.55 (1H, br s), 3.64-3.72 (1H,m), 4.03 (1H, d), 4.22 (1H, dd), 4.39 (2H, d), 5.86 (1H, br s),6.45-6.39 (1H, m), 7.02-6.96 (1H, m), 7.85 (2H, s), 7.92 (1H, s). 1-20161H-NMR (CDCl3) δ: 1.15 (3H, t, J = 7.6 Hz), 2.22 (2H, q, J = 7.6 Hz),2.50-2.63 (1H, m), 2.85-2.95 (1H, m), 3.55 (1H, br s), 3.62-3.72 (1H,m), 4.02 (1H, d), 4.21 (1H, dd), 4.39 (2H, d), 5.85 (1H, br s),6.36-6.45 (1H, m), 6.95-7.01 (1H, m), 7.85 (2H, s), 7.92 (1H, s). 1-20171H-NMR (CDCl3) δ: 0.71-0.77 (2H, m), 0.95-1.00 (2H, m), 1.30-1.40 (1H,m), 2.51-2.61 (1H, m), 2.87-2.95 (1H, m), 3.56 (1H, br s), 3.64-3.72(1H, m), 4.03 (1H, d), 4.22 (1H, dd), 4.42 (2H, d), 6.09 (1H, br s),6.46-6.39 (1H, m), 6.96-7.02 (1H, m), 7.85 (2H, s), 7.92 (1H, s). 1-20181H-NMR (CDCl3) δ: 2.51-2.60 (1H, m), 2.87-2.96 (1H, m), 3.06-3.10 (2H,m), 3.57 (1H, br s), 3.65-3.74 (1H, m), 4.03 (1H, d), 4.23 (1H, dd),4.46 (2H, d), 6.03 (1H, br s), 6.46-6.40 (1H, m), 6.94-7.00 (1H, m),7.84 (2H, s), 7.92 (1H, s). 1-2019 1H-NMR (CDCl3) δ: 2.10 (3H, s),2.50-2.63 (1H, m), 2.87-2.95 (1H, m), 3.21 (2H, s), 3.56 (1H, br s),3.65-3.75 (1H, m), 4.03 (1H, d), 4.23 (1H, dd), 4.46 (2H, d), 6.39-6.46(1H, m), 6.96-7.02 (1H, m), 7.17 (1H, br s), 7.84 (2H, s), 7.92 (1H, s).1-2020 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m), 2.66 (3H, s), 2.87-2.95 (1H,m), 3.26 (1H, d), 3.56 (1H, br s), 3.64-3.76 (1H, m), 3.69 (1H, d), 4.02(1H, d), 4.22 (1H, dd), 4.49 (2H, ddd), 6.39-6.45 (1H, m), 6.98-7.04(1H, m), 7.18 (1H, br s), 7.84 (2H, s), 7.92 (1H, s). 1-2021 1H-NMR(CDCl3) δ: 2.50-2.60 (1H, m), 2.87-2.96 (1H, m), 3.06 (3H, s), 3.57 (1H,br s), 3.66-3.76 (1H, m), 3.88 (2H, d), 4.02 (1H, d), 4.23 (1H, dd),4.47 (2H, d), 6.40-6.46 (1H, m), 6.73 (1H, br s), 6.95-7.01 (1H, m),7.84 (2H, s), 7.92 (1H, s). 1-2022 1H-NMR (CDCl3) δ: 1.44 (9H, s),2.50-2.60 (1H, m), 2.86-2.94 (1H, m), 3.55 (1H, br s), 3.68 (1H, dd),4.02 (1H, d), 4.21 (1H, dd), 4.28 (2H, d), 4.84 (1H), 6.39-6.45 (1H, m),7.00-6.94 (1H, m), 7.85 (2H, s), 7.91 (1H, s). 1-2023 1H-NMR (CDCl3) δ:2.09 (3H, s), 2.45-2.52 (1H, m), 2.74-2.82 (1H, m), 3.21 (2H, s),3.54-3.63 (2H, m), 3.94-3.97 (1H, m), 4.09-4.13 (1H, m), 4.49 (2H, d),6.56 (1H, t), 7.08 (1H, dd), 7.43 (2H, s). 1-2024 1H-NMR (CDCl3) δ:2.50-2.60 (1H, m), 2.87-2.96 (1H, m), 3.06 (3H, s), 3.53-3.56 (1H, m),3.67-3.70 (1H, m), 3.89 (2H, s), 4.01-4.05 (1H, m), 4.21-4.25 (1H, m),4.50 (2H, d), 6.59 (1H, t), 6.89-6.91 (1H, m), 7.08 (1H, dd), 7.84 (2H,s), 7.92 (1H, s). 1-2025 1H-NMR (CDCl3) δ: 2.52-2.57 (1H, m), 2.64 (3H,s), 2.84-2.92 (1H, m), 3.37 (1H, d), 3.49-3.52 (1H, m), 3.62-3.67 (2H,m), 3.98-4.01 (1H, m), 4.17-4.21 (1H, m), 4.44-4.46 (2H, m), 6.56 (1H,t), 7.07 (1H, d), 7.57 (1H, t), 7.83 (2H, s), 7.89 (1H, s). 1-20261H-NMR (CDCl3) δ: 2.09 (3H, s), 2.45-2.52 (1H, m), 2.74-2.82 (1H, m),3.21 (2H, s), 3.54-3.63 (2H, m), 3.94-3.97 (1H, m), 4.09-4.13 (1H, m),4.49 (2H, d), 6.56 (1H, t), 7.08 (1H, dd), 7.43 (2H, s). 1-2029 1H-NMR(CDCl3) δ: 2.24-2.25 (3H, m), 2.51-2.53 (1H, m), 2.83-2.87 (1H, m),3.51-3.62 (4H, m), 3.83 (2H, s), 3.99-4.14 (2H, m), 6.57 (1H, t), 7.00(1H, d), 7.87 (2H, s), 7.90 (1H, s). 1-2030 1H-NMR (CDCl3) δ: 1.99 (3H,s), 2.22-2.23 (3H, m), 2.54-2.61 (1H, m), 2.86-2.91 (1H, m), 3.56-3.60(2H, m), 4.05-4.13 (2H, m), 4.36 (2H, d), 5.50 (1H, br s), 6.55 (1H, t),6.93 (1H, d), 7.87 (2H, s), 7.91 (1H, s). 1-2031 1H-NMR (CDCl3) δ: 1.09(3H, t), 2.10-2.18 (5H, m), 2.44-2.48 (1H, m), 2.78-2.80 (1H, m),3.46-3.53 (2H, m), 3.96-4.05 (2H, m), 4.29 (2H, d), 5.47 (1H, s), 6.48(1H, t), 6.85 (1H, d), 7.80 (2H, s), 7.83 (1H, s). 1-2032 1H-NMR (CDCl3)δ: 0.63-0.67 (2H, m), 0.90-0.92 (2H, m), 1.18-1.29 (1H, m), 2.15-2.16(3H, m), 2.41-2.51 (1H, m), 2.76-2.84 (1H, m), 3.47-3.51 (2H, m),3.94-4.08 (2H, m), 4.30 (2H, d), 5.67 (1H, br s), 6.48 (1H, t), 6.87(1H, d), 7.80 (2H, s), 7.83 (1H, s). 1-2033 1H-NMR (CDCl3) δ: 2.21-2.24(3H, m), 2.49-2.59 (1H, m), 2.84-2.93 (1H, m), 3.06 (2H, q), 3.51-3.67(2H, m), 4.01-4.17 (2H, m), 4.39 (2H, d), 5.92 (1H, br s), 6.55 (1H, t),6.91 (1H, d), 7.87 (2H, s), 7.91 (1H, s). 1-2034 1H-NMR (CDCl3) δ: 2.11(3H, s), 2.23-2.24 (3H, m), 2.52-2.57 (1H, m), 2.87-2.90 (1H, m), 3.22(2H, s), 3.55-3.62 (2H, m), 4.05-4.15 (2H, m), 4.41 (2H, d), 6.57 (1H,t), 6.95 (2H, d), 7.88 (2H, s), 7.91 (1H, s). 1-2037 1H-NMR (CDCl3) δ:2.24-2.25 (3H, m), 2.44-2.46 (1H, m), 2.72-2.74 (1H, m), 3.50-3.56 (2H,m), 3.79 (2H, s), 3.93-4.01 (2H, m), 6.55 (1H, t), 6.96 (1H, d), 7.46(2H, s). 1-2038 1H-NMR (CDCl3) δ: 1.99 (3H, s), 2.21-2.22 (3H, m),2.40-2.50 (1H, m), 2.70-2.79 (1H, m), 3.44-3.61 (2H, m), 3.95-4.02 (2H,m), 4.34 (2H, d), 5.62 (1H, br s), 6.51 (1H, t), 6.91 (1H, d), 7.45 (2H,s). 1-2039 1H-NMR (CDCl3) δ: 1.17 (3H, t), 2.20-2.26 (5H, m), 2.41-2.50(1H, m), 2.70-2.79 (1H, m), 3.47-3.59 (2H, m), 3.94-4.03 (2H, m), 4.36(2H, d), 5.52 (1H, br s), 6.51 (1H, t), 6.91 (1H, d), 7.45 (2H, s).1-2040 1H-NMR (CDCl3) δ: 0.69-0.76 (2H, m), 0.97-1.00 (2H, m), 1.30-1.35(1H, m), 2.21-2.22 (3H, m), 2.40-2.50 (1H, m), 2.70-2.79 (1H, m),3.47-3.58 (2H, m), 3.95-4.03 (2H, m), 4.36 (2H, d), 5.77 (1H, br s),6.51 (1H, t), 6.93 (1H, d), 7.45 (2H, s). 1-2041 1H-NMR (CDCl3) δ:2.12-2.13 (3H, m), 2.37-2.39 (1H, m), 2.63-2.72 (1H, m), 2.98 (2H, q),3.45-3.48 (2H, m), 3.87-3.96 (2H, m), 4.30 (2H, d), 5.82 (1H, br s),6.43 (1H, t), 6.82 (1H, d), 7.37 (2H, s). 1-2042 1H-NMR (CDCl3) δ: 2.11(3H, s), 2.22-2.23 (3H, m), 2.45-2.47 (1H, m), 2.71-2.79 (1H, m), 3.22(2H, s), 3.49-3.59 (2H, m), 3.92-3.96 (1H, m), 4.03-4.07 (1H, m), 4.40(2H, d), 6.53 (1H, t), 6.92-6.95 (2H, m), 7.45 (2H, s). 1-2043 1H-NMR(CDCl3) δ: 2.22-2.23 (3H, m), 2.43-2.46 (1H, m), 2.64 (3H, s), 2.72-2.75(1H, m), 3.34 (1H, d), 3.46-3.57 (1H, m), 3.62 (1H, d), 3.93-4.02 (2H,m), 4.38 (2H, d), 6.50 (1H, t), 6.95 (1H, d), 7.30 (1H, br s), 7.45 (2H,s). 1-2046 1H-NMR (CDCl3) δ: 1.17 (3H, t), 2.18-2.23 (2H, m), 2.50-2.52(1H, m), 2.78-2.87 (1H, m), 3.45-3.55 (2H, m), 3.76 (1H, d), 4.01 (1H,d), 4.34 (2H, d), 5.61 (1H, br s), 6.57 (2H, d), 7.20 (2H, d), 7.45 (2H,s). 1-2047 1H-NMR (CDCl3) δ: 1.18 (3H, t), 2.17-2.26 (2H, m), 2.60-2.63(1H, m), 2.93-3.01 (1H, m), 3.52-3.58 (2H, m), 3.83 (1H, d), 4.15 (1H,d), 4.35 (2H, d), 5.57 (1H, br s), 6.60 (2H, d), 7.21 (2H, d), 7.85 (2H,s), 7.91 (1H, s). 1-2048 1H-NMR (CDCl3) δ: 1.10-1.15 (3H, m), 2.12-2.19(2H, m), 2.52-2.54 (1H, m), 2.70-2.87 (3H, m), 3.46-3.52 (4H, m), 3.77(1H, d), 4.02 (1H, d), 5.47 (1H, br s), 6.56 (2H, d), 7.09 (2H, d),7.30-7.38 (3H, m). 1-2049 1H-NMR (CDCl3) δ: 1.13 (3H, t), 2.14-2.17 (2H,m), 2.49-2.52 (1H, m), 2.70-2.86 (3H, m), 3.46-3.52 (4H, m), 3.76 (1H,d), 4.01 (1H, d), 5.47 (1H, br s), 6.56 (2H, d), 7.09 (2H, d), 7.44 (2H,s). 1-2050 1H-NMR (CDCl3) δ: 1.13 (3H, t), 2.14-2.17 (2H, m), 2.57-2.62(1H, m), 2.73-2.75 (2H, m), 2.94-2.96 (1H, m), 3.48-3.57 (4H, m), 3.83(1H, d), 4.14 (1H, d), 5.40 (1H, br s), 6.60 (2H, d), 7.11 (2H, d), 7.85(2H, s), 7.91 (1H, s). 1-2051 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.18 (2H,q), 2.46-2.56 (1H, m), 2.79-2.88 (1H, m), 3.45-3.56 (2H, m), 3.77 (1H,d), 3.88 (3H, s), 4.03 (1H, d), 4.35 (2H, d), 5.82 (1H, b), 6.08-6.16(2H, m), 7.14-7.39 (4H, m) 1-2052 1H-NMR (CDCl3) δ: 2.07 (3H, s),2.48-2.58 (1H, m), 2.79-2.88 (1H, m), 3.18 (2H, s), 3.45-3.60 (2H, m),3.77 (1H, d), 3.89 (3H, s), 4.04 (1H, d), 6.09-6.16 (2H, m), 7.13-7.39(5H, m) 1-2053 1H-NMR (CDCl3) δ: 2.51-2.66 (4H, m), 2.88-2.95 (1H, m),3.27 (1H, d), 3.29-3.59 (2H, m), 3.66 (1H, d), 3.77 (1H, d), 4.48-4.56(2H, m), 6.49-6.80 (2H, m), 7.19 (1H, b), 7.29-7.65 (4H, m) 1-20541H-NMR (CDCl3) δ: 2.50-2.59 (1H, m), 2.80-2.94 (1H, m), 3.05 (3H, s),3.40-3.57 (2H, m), 3.77 (1H.d), 3.79 (2H, s), 4.09 (1H, d), 4.49 (2H,d), 6.50-6.80 (3H, m), 7.26-7.65 (4H, m) 1-2058 1H-NMR (CDCl3) δ: 2.47(2H, t), 2.54-2.65 (1H, m), 2.94-3.02 (1H, m), 3.36 (3H, s), 3.65-3.46(4H, m), 3.81 (1H, d), 4.15 (1H, d), 4.44 (2H, d), 6.48 (1H, dd), 6.62(2H, d), 7.28 (1H, d), 7.84 (2H, s), 7.92 (1H, s). 1-2067 1H-NMR (CDCl3)δ: 2.47 (2H, t), 2.52-2.66 (1H, m), 2.96-3.05 (1H, m), 3.36 (3H, s),3.54-3.70 (4H, m), 3.98 (1H, d), 4.37 (2H, d), 4.53 (1H, d), 6.25-7.85(6H, m) 1-2068 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.14 (2H, q), 2.56-2.61(1H, m), 2.90-2.98 (1H, m), 3.56-3.72 (2H, m), 4.00 (1H, d), 4.44-4.46(3H, m), 5.78 (1H, br s), 6.52 (1H, d), 7.56-7.62 (3H, m), 7.74 (1H, d).1-2069 1H-NMR (CDCl3) δ: 0.74-0.78 (2H, m), 0.82-1.00 (2H, m), 1.28-1.32(1H, m), 2.53-2.63 (1H, m), 2.91-2.96 (1H, m), 3.61-3.70 (2H, m), 4.00(1H, d), 4.44-4.47 (3H, m), 5.95 (1H, br s), 6.52 (1H, d), 7.52-7.62(3H, m), 7.73 (1H, d). 1-2070 1H-NMR (CDCl3) δ: 0.15-0.18 (2H, m),0.56-0.60 (2H, m), 0.87-0.93 (1H, m), 2.16 (2H, d), 2.56-2.61 (1H, m),2.90-2.98 (1H, m), 3.62-3.70 (2H, m), 4.01 (1H, d), 4.44-4.48 (3H, m),6.31 (1H, br s), 6.53 (1H, d), 7.48-7.64 (3H, m), 7.74 (1H, d). 1-20711H-NMR (CDCl3) δ: 2.05 (3H, s), 2.47-2.64 (1H, m), 2.91-2.97 (1H, m),3.22 (2H, s), 3.63-3.71 (2H, m), 4.01 (1H, d), 4.45-4.50 (3H, m), 6.53(1H, d), 7.26 (1H, br s), 7.49-7.73 (4H, m). 1-2074 1H-NMR (CDCl3) δ:1.15 (3H, t), 2.20 (2H, q), 2.48-2.59 (1H, m), 2.83-2.91 (1H, m),3.58-3.70 (2H, m), 3.93 (1H, d), 4.38-4.45 (3H, m), 5.75 (1H, br s),6.51 (1H, d), 7.48 (2H, s), 7.69-7.74 (2H, m). 1-2075 1H-NMR (CDCl3) δ:0.71-0.82 (2H, m), 0.92-0.97 (2H, m), 1.24-1.36 (1H, m), 2.49-2.59 (1H,m), 2.83-2.91 (1H, m), 3.59-3.65 (2H, m), 3.93 (1H, d), 4.38-4.47 (3H,m), 5.94 (1H, br s), 6.51 (1H, d), 7.45 (2H, s), 7.69-7.73 (2H, m).1-2076 1H-NMR (CDCl3) δ: 0.12-0.20 (2H, m), 0.51-0.67 (2H, m), 0.90-0.99(1H, m), 2.15 (2H, d), 2.51-2.56 (1H, m), 2.83-2.91 (1H, m), 3.59-3.67(2H, m), 3.94 (1H, d), 4.38-4.48 (3H, m), 6.31 (1H, br s), 6.52 (1H, d),7.45-7.52 (2H, m), 7.68-7.74 (2H, m). 1-2077 1H-NMR (CDCl3) δ: 2.05 (3H,s), 2.52-2.57 (1H, m), 2.87-2.93 (1H, m), 3.22 (2H, s), 3.59-3.71 (2H,m), 3.94 (1H, d), 4.39 (1H, d), 4.50-4.51 (2H, m), 6.52 (1H, d), 7.24(1H, br s), 7.48-7.49 (2H, m), 7.69-7.71 (2H, m). 1-2082 1H-NMR (CDCl3)δ: 0.74-0.79 (2H, m), 0.96-1.06 (2H, m), 1.23-1.37 (1H, m), 2.51-2.57(1H, m), 2.85-2.90 (1H, m), 3.56-3.67 (2H, m), 3.94 (1H, d), 4.35-4.39(3H, m), 5.88 (1H, br s), 6.38 (1H, d), 7.27-7.50 (4H, m), 8.10 (1H, d).1-2089 1H-NMR (CDCl3) δ: 1.53 (2H, b), 2.42-2.53 (1H, m), 2.75-2.84 (1H,m), 3.75-3.95 (4H, m), 3.79 (1H, d), 4.42 (1H, d), 7.22-7.88 (5H, m)1-2091 1H-NMR (CDCl3) δ: 1.17 (3H, t), 2.23 (2H, q), 2.42-2.53 (1H, m),2.75-2.84 (1H, m), 3.75-3.93 (2H, m), 4.06 (1H, d), 3.30 (2H, d), 4.42(1H, d), 5.67 (1H, b), 7.19-7.86 (5H, m) 1-2094 1H-NMR (CDCl3) δ: 2.11(3H, s), 2.43-2.53 (1H, m), 2.76-2.85 (1H, m), 3.24 (2H, s), 3.75-3.95(2H, m), 4.07 (1H, d), 4.37 (2H, d), 4.43 (1H, d), 7.15-7.89 (6H, m)1-2107 1H-NMR (CDCl3) δ: 1.69 (2H, b), 2.50-2.61 (1H, m), 2.88-2.96 (1H,m), 3.75-3.98 (4H, m), 4.13 (1H, d), 4.54 (1H, d), 7.24-7.30 (1H, m),7.88-7.91 (4H, m) 1-2109 1H-NMR (CDCl3) δ: 1.17 (3H, t), 2.24 (2H, q),2.50-2.60 (1H, m), 2.89-2.97 (1H, m), 3.78-3.98 (2H, m), 4.11 (1H, d),4.33 (2H, d), 4.55 (1H, d), 5.71 (1H, b), 7.21-7.91 (5H, m) 1-21161H-NMR (CDCl3) δ: 1.53 (2H, b), 2.42-2.53 (1H, m), 2.75-2.84 (1H, m),3.75-3.90 (4H, m), 4.05 (1H, d), 4.42 (1H, d), 7.29-7.39 (4H, m) 1-21181H-NMR (CDCl3) δ: 1.16 (3H, t), 2.23 (2H, q), 2.39-2.52 (1H, m),2.74-2.83 (1H, m), 3.75-3.92 (2H, m), 4.03 (1H, d), 4.34 (2H, d), 4.31(1H, d), 5.96 (1H, b), 7.30-7.39 (4H, m) 1-2119 1H-NMR (CDCl3) δ:0.72-0.79 (2H, m), 0.95-0.99 (2H, m), 1.31-1.38 (1H, m), 2.45-2.52 (1H,m), 2.74-2.83 (1H, m), 3.75-3.95 (2H, m), 4.04 (1H, d), 4.36 (2H, d),4.41 (1H, d), 6.13 (1H, b), 7.30-7.39 (4H, m) 1-2120 1H-NMR (CDCl3) δ:2.42-2.53 (1H, m), 2.75-2.84 (1H, m), 3.05 (1H, d), 3.12 (1H, d),3.75-3.93 (2H, m), 4.04 (1H, d), 4.37-4.45 (3H, m), 6.28 (1H, b),7.28-7.40 (4H, m) 1-2121 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.42-2.50 (1H,m), 2.52-2.84 (1H, m), 3.21 (2H, s), 3.75-3.95 (2H, m), 4.04 (1H, d),4.37-4.45 (3H, m), 7.30-7.39 (5H, m) 1-2122 1H-NMR (CDCl3) δ: 2.42-2.50(1H, m), 2.68 (3H, s), 2.75-2.84 (1H, m), 3.28 (1H, d), 3.70 (1H, d),3.70-3.94 (2H, m), 4.04 (1H, d), 4.41-4.44 (3H, m), 7.26-7.40 (5H, m)1-2123 1H-NMR (CDCl3) δ: 2.42-2.52 (!H, m), 2.75-2.84 (1H, m), 3.07 (3H,s), 3.78-3.95 (4H, m), 4.04 (1H, d), 4.40-4.45 (3H, m), 6.91 (1H, b),7.29-7.40 (4H, m) 1-2125 1H-NMR (CDCl3) δ: 1.51 (2H, b), 2.40-2.50 (1H,m), 2.75-2.85 (1H, m), 3.75-3.93 (4H, m), 4.04 (1H, d), 4.39 (1H, d),7.30-7.45 (3H, m) 1-2127 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.23 (2H, q),2.41-2.51 (1H, m), 2.74-2.83 (1H, m), 3.75-3.95 (2H, m), 4.03 (1H, d),4.33-4.41 (3H, m), 5.93 (1H, b), 7.32-7.44 (3H, m) 1-2128 1H-NMR (CDCl3)δ: 0.72-0.79 (2H, m), 0.95-0.99 (2H, m), 1.30-1.40 (1H, m), 2.40-2.51(1H, m), 2.74-2.83 (1H, m), 3.75-3.90 (2H, m), 4.04 (1H, d), 4.35-4.41(3H, m), 6.10 (1H, b), 7.31-7.44 (3H, m) 1-2129 1H-NMR (CDCl3) δ:2.41-2.52 (1H, m), 2.75-2.84 (1H, m), 3.05 (1H, d), 3.12 (1H, d),3.75-3.94 (2H, m), 4.04 (1H, d), 4.37-4.43 (3H, m), 6.25 (1H, b),7.29-7.44 (3H, m) 1-2130 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.41-2.49 (1H,m), 2.75-2.83 (1H, m), 3.21 (2H, s), 3.75-3.90 (2H, m), 4.07 (1H, d),4.37-4.42 (2H, m), 7.31-7.50 (4H, m) 1-2131 1H-NMR (CDCl3) δ: 2.41-2.52(1H, m), 2.68 (3H, s), 2.74-2.83 (1H, m), 3.27 (1H, d), 3.67-3.93 (3H,m), 4.04 (1H, d), 4.37-4.43 (3H, m), 7.30-7.44 (4H, m) 1-2132 1H-NMR(CDCl3) δ: 2.41-2.52 (1H, m), 2.74-2.84 (1H, m), 3.07 (3H, s), 3.75-3.95(4H, m), 4.03 (1H, d), 4.38-4.42 (3H, m), 6.92 (1H, b), 7.31-7.44 (3H,m) 1-2136 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.23 (2H, q), 2.52-2.60 (1H,m), 2.88-2.97 (1H, m), 3.75-3.96 (2H, m), 4.11 (1H, d), 4.35 (2H, d),4.54 (1H, d), 5.91 (1H, b), 7.34-7.92 (4H, m) 1-2137 1H-NMR (CDCl3) δ:0.73-0.79 (2H, m), 0.95-1.01 (2H, m), 1.32-1.40 (1H, m), 2.49-2.60 (1H,m), 2.88-2.97 (1H, m), 3.76-4.00 (2H, m), 4.11 (1H, d), 4.37 (2H, d),4.54 (1H, d), 6.12 (1H, b), 7.32-7.92 (4H, m) 1-2138 1H-NMR (CDCl3) δ:2.49-2.60 (1H, m), 2.88-2.98 (1H, m), 3.06 (1H, d), 3.12 (1H, d),3.76-4.00 (2H, m), 4.12 (1H, d), 4.39 (2H, d), 4.55 (1H, d), 6.22 (1H,b), 7.31-7.92 (4H, m) 1-2139 1H-NMR (CDCl3) δ: 2.11 (3H, s), 2.50-2.60(1H, m), 2.89-2.97 (1H, m), 3.21 (2H, s), 3.76-4.00 (2H, m), 4.12 (1H,d), 4.39 (2H, d), 4.55 (1H, d), 7.32-7.92 (5H, m) 1-2140 1H-NMR (CDCl3)δ: 2.50-2.60 (1H, m), 2.68 (3H, s), 2.88-2.97 (1H, m), 3.27 (1H, d),3.70 (1H, d), 3.76-3.95 (2H, m), 4.11 (1H, d), 4.43 (2H, d), 4.55 (1H,d), 7.36-7.92 (5H, m) 1-2141 1H-NMR (CDCl3) δ: 2.50-2.60 (1H, m),2.89-2.98 (1H, m), 3.08 (3H, s), 3.80-3.97 (4H, m), 4.11 (1H, d), 4.42(2H, d), 4.55 (1H, d), 6.96 (1H, b), 7.33-7.92 (4H, m) 1-2145 1H-NMR(CDCl3) δ: 1.82 (1H, t), 2.53-2.65 (1H, m), 2.90-3.05 (1H, m), 3.55-3.70(2H, m), 4.00 (1H, d), 4.55 (1H, d), 4.67 (2H, d), 6.34 (1H, d),7.57-7.91 (4H, m) 1-2151 1H-NMR (CDCl3) δ: 1.45 (9H, s), 2.42-2.52 (1H,m), 2.74-2.83 (1H, m), 3.75-3.95 (2H, m), 4.04 (1H, d), 4.22 (2H, d),4.42 (1H, d), 5.01 (1H, b), 7.21-7.39 (4H, m) 1-2152 1H-NMR (CDCl3) δ:1.45 (9H, s), 2.40-2.52 (1H, m), 2.74-2.83 (1H, m), 3.70-3.95 (2H, m),4.04 (1H, d), 4.22 (2H, d), 4.39 (1H, d), 4.99 (1H, b), 7.28-7.44 (3H,m) 1-2153 1H-NMR (CDCl3) δ: 1.45 (9H, s), 2.49-2.60 (1H, m), 2.88-3.00(1H, m), 3.77-4.00 (2H, m), 4.13 (1H, d), 4.23 (2H, d), 4.54 (1H, d),7.30-7.92 (4H, m) 1-2154 1H-NMR (CDCl3) δ: 1.46 (9H, s), 2.43-2.53 (1H,m), 2.75-2.83 (1H, m), 3.75-3.95 (2H, m), 4.06 (1H, d), 4.17 (2H, d),4.42 (1H, d), 4.75 (1H, b), 7.18-7.86 (5H, m) 1-2156 1H-NMR (CDCl3) δ:1.46 (9H, s), 2.50-2.60 (1H, m), 2.85-2.97 (1H, m), 3.77-4.00 (2H, m),4.13 (2H, d), 4.18 (1H, d), 4.54 (1H, d), 7.21-7.90 (6H, m) 1-21681H-NMR (CDCl3) δ: 2.38-2.51 (4H, m), 2.74-2.79 (1H, m), 3.51-3.66 (2H,m), 3.90-3.94 (3H, m), 4.08-4.13 (1H, m), 6.57 (1H, t), 7.04 (1H, dd),7.40 (2H, s). 1-2170 1H-NMR (CDCl3) δ: 1.18 (3H, t), 2.22 (2H, q),2.48-2.58 (1H, m), 2.83-2.91 (1H, m), 3.57-3.61 (2H, m), 3.95 (1H, d),4.34-4.43 (3H, m), 5.62 (1H, br s), 6.38 (1H, d), 7.44-7.49 (3H, m),8.09 (1H, d). 1-2171 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.23 (2H, q),2.62-2.67 (1H, m), 3.02-3.06 (1H, m), 3.59-3.68 (2H, m), 4.01 (1H, d),4.35 (2H, d), 4.56 (1H, d), 5.67 (1H, br s), 6.41 (1H, d), 7.50 (1H,dd), 7.87-7.91 (3H, m), 8.11 (1H, d). 2-8 1H-NMR (CDCl3) δ: 2.46-2.52(1H, m), 2.80-2.88 (1H, m), 3.78-3.79 (2H, m), 3.93-4.08 (3H, m),4.46-4.50 (1H, m), 6.02 (1H, br s), 7.22 (2H, s), 7.34 (1H, s), 8.58(1H, s). 2-34 1H-NMR (CDCl3) δ: 2.45-2.55 (1H, m), 2.84-2.86 (1H, m),3.75-3.80 (2H, m), 3.91-4.05 (3H, m), 4.46-4.55 (1H, m), 5.98 (1H, brs), 7.89 (3H, m), 8.56 (1H, s). 2-35 1H-NMR (CDCl3) δ: 2.54-2.58 (1H,m), 2.89-2.92 (1H, m), 3.84-3.87 (2H, m), 4.02-4.06 (1H, m), 4.53-4.57(1H, m), 4.74 (2H, d), 7.25-7.36 (5H, m), 7.69-7.72 (1H, m), 8.52-8.53(1H, m), 8.70 (1H, s). 2-55 1H-NMR (CDCl3) δ: 2.52-2.57 (1H, m),2.85-2.93 (1H, m), 3.82-3.85 (2H, m), 4.03-4.08 (1H, m), 4.53-4.57 (1H,m), 4.74 (2H, d), 7.21-7.73 (7H, m), 8.56 (1H, d), 8.85 (2H, s). 2-691H-NMR (CDCl3) δ: 2.47-2.57 (1H, m), 2.85-2.90 (1H, m), 3.80-3.83 (2H,m), 4.04-4.11 (3H, m), 4.50-4.54 (1H, m), 5.98 (1H, br s), 7.26-7.39(3H, m), 8.42 (1H, s). 2-613 1H-NMR (CDCl3) δ: 1.49 (9H, s), 2.59-2.66(1H, m), 3.00-3.08 (1H, m), 3.87-3.91 (2H, m), 4.08-4.10 (3H, m),4.66-4.70 (1H, m), 6.35 (1H, br s), 7.85 (2H, s), 7.93 (1H, s). 3-151H-NMR (CDCl3) δ: 0.16-0.20 (2H, m), 0.58-0.64 (2H, m), 0.88-0.93 (1H,m), 2.16 (2H, d), 2.47-2.58 (1H, m), 2.83-2.91 (1H, m), 3.81-3.86 (2H,m), 4.00 (1H, d), 4.46-4.50 (3H, m), 6.32 (1H, br s), 7.27-7.39 (3H, m),8.64 (1H, s). 3-45 1H-NMR (CDCl3) δ: 2.08 (3H, s), 2.47-2.58 (1H, m),2.85-2.89 (1H, m), 3.19 (2H, s), 3.80-3.83 (2H, m), 4.00 (1H, d),4.47-4.50 (3H, m), 7.26 (2H, d), 7.41 (1H, t), 8.62 (1H, s). 3-1401H-NMR (CDCl3) δ: 1.65 (2H, br s), 2.49-2.54 (1H, m), 2.82-2.91 (1H, m),3.68-4.16 (6H, m), 4.46-4.50 (1H, m), 7.44 (2H, s), 8.58 (1H, s). 3-1411H-NMR (CDCl3) δ: 1.98 (3H, s), 2.48-2.54 (1H, m), 2.86-2.93 (1H, m),3.80-3.86 (2H, m), 3.98-4.02 (1H, m), 4.41-4.48 (3H, m), 5.82 (1H, brs), 7.43 (2H, s), 8.63 (1H, s). 3-142 1H-NMR (CDCl3) δ: 1.16 (3H, t),2.21 (2H, q), 2.46-2.56 (1H, m), 2.82-2.90 (1H, m), 3.80-3.83 (2H, m),3.98-4.02 (1H, m), 4.42-4.47 (3H, m), 5.75-5.78 (1H, m), 7.43 (2H, s),8.63 (1H, s). 3-143 1H-NMR (CDCl3) δ: 0.72-1.43 (5H, m), 2.46-2.56 (1H,m), 2.95-3.08 (1H, m), 3.81-3.86 (2H, m), 3.98-4.02 (1H, m), 4.45-4.48(3H, m), 6.00 (1H, br s), 7.46 (2H, s), 8.62 (1H, s). 3-144 1H-NMR(CDCl3) δ: 2.46-2.57 (1H, m), 2.84-2.89 (1H, m), 3.07 (2H, q), 3.79-4.02(3H, m), 4.46-4.49 (3H, m), 6.07 (1H, br s), 7.43 (2H, s), 8.61 (1H, s).3-145 1H-NMR (CDCl3) δ: 1.15 (3H, t), 2.45-2.55 (1H, m), 2.81-2.90 (1H,m), 3.18 (2H, q), 3.75-3.82 (2H, m), 3.98-4.64 (6H, m), 7.43 (2H, s),8.67 (1H, s). 3-146 1H-NMR (CDCl3) δ: 2.55-2.65 (1H, m), 2.97-3.05 (1H,m), 3.73-3.85 (3H, m), 4.07-4.16 (2H, m), 4.61-4.65 (1H, m), 7.86-7.92(3H, m), 8.61 (1H, s). 3-148 1H-NMR (CDCl3) δ: 0.72-1.37 (5H, m),2.56-2.62 (1H, m), 2.96-3.04 (1H, m), 3.84-3.90 (2H, m), 4.06-4.16 (1H,m), 4.44-4.46 (2H, m), 4.60-4.64 (1H, m), 5.63 (1H, t), 7.85 (2H, s),7.92 (1H, s), 8.64 (1H, s). 3-149 1H-NMR (CDCl3) δ: 1.13 (3H, t), 2.20(2H, q), 2.59 (1H, m), 2.96-3.04 (1H, m), 3.84-3.90 (2H, m), 4.07-4.14(1H, m), 4.41-4.43 (2H, m), 4.60-4.64 (1H, m), 5.78 (1H, br s), 7.81(2H, s), 7.92 (1H, s), 8.65 (1H, s). 3-150 1H-NMR (CDCl3) δ: 2.55-2.65(1H, m), 3.04-3.11 (3H, m), 3.85-3.91 (2H, m), 4.08-4.12 (1H, m),4.46-4.48 (2H, m), 4.61-4.64 (1H, m), 6.10 (1H, br s), 7.84 (2H, s),7.92 (1H, s), 8.63 (1H, s). 3-151 1H-NMR (CDCl3) δ: 1.14 (3H, t),2.55-2.62 (1H, m), 2.95-3.04 (1H, m), 3.11-3.33 (2H, m), 3.73-4.40 (6H,m), 4.61-4.63 (2H, m), 7.85 (2H, s), 7.92 (1H, s), 8.69 (1H, s). 3-1571H-NMR (CDCl3) δ: 1.98 (3H, s), 2.49-2.54 (1H, m), 2.83-2.91 (1H, m),3.79-3.85 (2H, m), 3.98 (1H, d), 4.41-4.50 (3H, m), 5.86 (1H, br s),7.54 (2H, d), 7.67 (1H, t), 8.63 (1H, s). 3-158 1H-NMR (CDCl3) δ: 1.15(3H, t), 2.20 (2H, q), 2.44-2.57 (1H, m), 2.84-2.89 (1H, m), 3.79-3.85(2H, m), 3.98 (1H, d), 4.42-4.50 (3H, m), 5.81 (1H, br s), 7.48 (2H, s),7.69 (1H, t), 8.63 (1H, s). 3-159 1H-NMR (CDCl3) δ: 0.72-0.80 (2H, m),0.83-0.99 (2H, m), 1.23-1.38 (1H, m), 2.49-2.54 (1H, m), 2.84-2.89 (1H,m), 3.79-3.85 (2H, m), 3.98 (1H, d), 4.44-4.50 (3H, m), 6.02 (1H, br s),7.45 (2H, s), 7.66 (1H, t), 8.59 (1H, s). 3-160 1H-NMR (CDCl3) δ:2.47-2.57 (1H, m), 2.83-2.91 (1H, m), 3.10 (2H, q), 3.81-3.85 (2H, m),3.98 (1H, d), 4.47-4.51 (3H, m), 6.15 (1H, br s), 7.48 (2H, d), 7.70(1H, t), 8.60 (1H, s). 3-310 1H-NMR (CDCl3) δ: 2.43-2.58 (1H, m), 2.66(3H, s), 2.83-2.91 (1H, m), 3.28 (1H, d), 3.67 (1H, dz), 3.80-3.86 (2H,m), 4.00 (1H, d), 4.48-4.50 (3H, m), 7.28 (2H, d), 7.39 (2H, br s), 8.63(1H, s). 3-311 1H-NMR (CDCl3) δ: 2.50-2.55 (1H, m), 2.85-2.90 (1H, m),3.05 (3H, s), 3.79-3.82 (2H, m), 3.89 (2H, s), 3.99 (1H, d), 4.48-4.51(3H, m), 7.03 (1H, br s), 7.28 (2H, d), 7.39 (1H, t), 8.60 (1H, s).3-322 1H-NMR (CDCl3) δ: 2.12 (3H, s), 2.47-2.57 (1H, m), 2.85-2.90 (1H,m), 3.22 (2H, s), 3.79-3.81 (2H, m), 3.98 (1H, d), 4.47-4.50 (3H, m),7.48 (2H, s), 7.69 (1H, t), 8.62 (1H, s). 3-335 1H-NMR (CDCl3) δ:0.15-0.28 (2H, m), 0.61-0.65 (2H, m), 0.88-1.01 (1H, m), 2.21 (2H, s),2.52-2.57 (1H, m), 2.85-2.94 (1H, m), 3.84-3.90 (2H, m), 4.01-4.06 (1H,m), 4.48-4.51 (3H, m), 6.36 (1H, t), 7.46 (2H, s), 8.67 (1H, s). 3-3361H-NMR (CDCl3) δ: 1.00 (9H, s), 2.04 (2H, s), 2.48-2.54 (1H, m),2.82-2.90 (1H, m), 3.80-3.86 (2H, m), 3.98-4.03 (1H, m), 4.41-4.48 (3H,m), 5.68 (1H, br s), 7.42 (2H, s), 8.65 (1H, s). 3-339 1H-NMR (CDCl3) δ:2.08 (3H, s), 2.49-2.54 (1H, m), 2.82-2.91 (1H, m), 3.19 (2H, s),3.81-3.83 (2H, m), 3.98-4.02 (1H, m), 4.46-4.49 (3H, m), 7.43 (2H, s),8.62 (1H, s). 3-389 1H-NMR (CDCl3) δ: 2.55-2.65 (1H, m), 2.97-3.05 (4H,m), 3.84-3.88 (4H, m), 4.05-4.16 (1H, m), 4.50-4.62 (3H, m), 6.81 (1H,br s), 7.84 (2H, s), 7.92 (1H, s), 8.63 (1H, s). 3-340 1H-NMR (CDCl3) δ:2.49-2.54 (1H, m), 2.66 (3H, s), 2.82-2.91 (1H, m), 3.26 (1H, d), 3.67(1H, d), 3.81-3.87 (2H, m), 3.98-4.02 (1H, m), 4.47-4.50 (3H, m),7.30-7.34 (1H, m), 7.45 (2H, s), 8.64 (1H, s). 3-341 1H-NMR (CDCl3) δ:2.47-2.57 (1H, m), 2.83-2.91 (1H, m), 3.06 (3H, s), 3.83-3.98 (5H, m),4.47-4.49 (3H, m), 6.87-6.89 (1H, m), 7.40 (2H, s), 8.61 (1H, s). 3-3421H-NMR (CDCl3) δ: 1.30-1.35 (3H, m), 1.92 (3H, s), 2.04-2.10 (1H, m),2.48-2.53 (1H, m), 2.82-2.90 (1H, m), 3.80-3.85 (2H, m), 3.97-4.01 (1H,m), 4.34-4.56 (3H, m), 6.29-6.31 (1H, m), 7.14-7.15 (1H, m), 7.42 (2H,s), 8.56 (1H, s). 3-387 1H-NMR (CDCl3) δ: 2.08 (3H, s), 2.56-2.64 (1H,m), 2.98-3.03 (1H, m), 3.20 (2H, s), 3.85-3.87 (2H, m), 4.06-4.16 (1H,m), 4.54 (3H, s), 7.85 (2H, s), 7.92 (1H, s), 8.64 (1H, s). 3-388 1H-NMR(CDCl3) δ: 2.55-2.66 (4H, m), 2.97-3.05 (1H, m), 3.24 (1H, d), 3.67 (1H,d), 3.85-3.87 (2H, m), 4.05-4.16 (1H, m), 4.52-4.63 (3H, m), 7.31 (1Hm), 7.84 (2H, s), 7.92 (1H, s), 8.65 (1H, s). 3-433 1H-NMR (CDCl3) δ:0.20-0.02 (2H, m), 0.60-0.68 (2H, m), 0.91-0.97 (1H, m), 2.19 (2H, d),2.60-2.66 (1H, m), 3.00-3.08 (1H, m), 3.88-3.94 (2H, m), 4.09-4.19 (1H,m), 4.52-4.60 (3H, m), 6.36-6.38 (1H, m), 7.88 (2H, s), 7.95 (1H, s),8.69 (1H, s). 3-434 1H-NMR (CDCl3) δ: 1.00 (9H, s), 2.05 (2H, s),2.57-2.62 (1H, m), 2.96-3.05 (1H, m), 3.85-3.91 (2H, m), 4.06-4.16 (1H,m), 4.41-4.43 (2H, m), 4.59-4.63 (1H, m), 5.72 (1H, br s), 7.85 (2H, s),7.92 (1H, s), 8.67 (1H, s). 3-435 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m),2.72-3.01 (4H, m), 3.82-3.85 (2H, m), 3.99-4.03 (1H, m), 4.33-4.35 (2H,m), 4.47-4.58 (2H, m), 7.40 (2H, s), 8.61 (1H, s). 3-436 1H-NMR (CDCl3)δ: 2.56-2.66 (1H, m), 2.91-3.18 (4H, m), 3.86-3.92 (2H, m), 4.09-4.11(1H, m), 4.33-4.35 (2H, m), 4.60-4.72 (2H, m), 7.85 (2H, s), 7.93 (1H,s), 8.63 (1H, s). 3-437 1H-NMR (CDCl3) δ: 1.57 (3H, s), 2.57-2.65 (1H,m), 2.98-3.06 (1H, m), 3.85-3.87 (2H, m), 4.10 (1H, d), 4.54-4.68 (3H,m), 6.69 (1H, br s), 7.84 (2H, d), 7.93 (1H, t), 8.60 (1H, s). 3-4381H-NMR (CDCl3) δ: 2.44-2.64 (3H, m), 2.96-3.22 (3H, m), 3.84-3.87 (2H,m), 4.05-4.09 (1H, m), 4.40-4.42 (2H, m), 4.60-4.63 (1H, m), 5.90 (1H,br s), 7.17-7.34 (5H, m), 7.84 (2H, s), 7.92 (1H, s), 8.65 (1H, s).3-439 1H-NMR (CDCl3) δ: 1.04-1.17 (3H, m), 2.15-2.24 (2H, m), 2.56-2.61(1H, m), 2.91-2.99 (1H, m), 3.82-3.88 (2H, m), 4.05-4.16 (1H, m),4.41-4.43 (2H, m), 4.55-4.59 (1H, m), 5.78 (1H, br s), 7.54-7.63 (4H,m), 8.59 (1H, s). 3-440 1H-NMR (CDCl3) δ: 0.10-0.23 (2H, m), 0.53-0.64(2H, m), 0.85-0.98 (1H, m), 2.15 (2H, d), 2.56-2.61 (1H, m), 2.91-2.99(1H, m), 3.82-3.88 (2H, m), 4.08 (1H, d), 4.44-4.46 (2H, m), 4.60 (1H,d), 6.32 (1H, br s), 7.54-7.63 (4H, m), 8.63 (1H, s). 3-441 1H-NMR(CDCl3) δ: 2.08 (3H, s), 2.55-2.62 (1H, m), 2.91-3.00 (1H, m), 3.20 (2H,s), 3.82-3.85 (2H, m), 4.10 (1H, d), 4.47-4.58 (3H, m), 7.25 (1H, br s),7.52-7.64 (4H, m), 8.62 (1H, s). 3-442 1H-NMR (CDCl3) δ: 2.54-2.77 (4H,m), 2.92-2.97 (1H, m), 3.29 (1H, d), 3.67 (1H, d), 3.82-3.88 (2H, m),4.09 (1H, d), 4.50-4.58 (3H, m), 7.47 (1H, br s), 7.52-7.76 (4H, m),8.64 (1H, s). 3-443 1H-NMR (CDCl3) δ: 2.56-2.62 (1H, m), 2.92-3.00 (1H,m), 3.07 (3H, s), 3.82-3.87 (4H, m), 4.09 (1H, d), 4.49-4.58 (3H, m),6.92 (1H, br s), 7.55-7.64 (4H, m), 8.62 (1H, s). 3-444 1H-NMR (CDCl3)δ: 0.15-0.23 (2H, m), 0.58-0.61 (2H, m), 0.85-0.98 (1H, m), 2.18 (2H,d), 2.49-2.54 (1H, m), 2.83-2.91 (1H, m), 3.80-3.82 (2H, m), 3.98 (1H,d), 4.48-4.61 (3H, m), 6.33 (1H, br s), 7.48 (2H, s), 7.69 (1H, t), 8.64(1H, s). 4-1 1H-NMR (CDCl3) δ: 2.53-2.70 (m, 1H), 2.88-3.01 (m, 1H),3.51-3.75 (m, 2H), 3.97 (d, 1H), 4.43 (d, 1H), 5.93 (bs, 1H), 7.25 (d,2H), 7.41 (t, 1H) 4-2 1H-NMR (CDCl3) δ: 2.52-2.70 (m, 1H), 2.86-3.07 (m,4H), 3.50-3.74 (m, 2H), 3.95 (d, 1H), 4.41 (d, 1H), 6.12 (bs, 1H),7.18-7.25 (m, 2H), 7.39-7.42 (m, 1H) 4-3 1H-NMR (CDCl3) δ: 1.22 (t, 3H),2.52-2.68 (m, 1H), 2.83-3.00 (m, 1H), 3.35-3.50 (m, 2H), 3.51-3.72 (m,2H), 3.95 (d, 1H), 4.40 (d, 1H), 6.09 (bs, 1H), 7.21-7.28 (m, 2H),7.37-7.43 (m, 1H) 4-5 1H-NMR (CDCl3) δ: 0.55-0.64 (m, 2H), 0.80-0.91 (m,2H), 2.53-2.68 (m, 1H), 2.77-3.00 (m, 2H), 3.51-3.72 (m, 2H), 3.95 (d,1H), 4.40 (d, 1H), 6.22 (bs, 1H), 7.20-7.29 (m, 2H), 7.38-7.43 (m, 1H)4-8 1H-NMR (CDCl3) δ: 2.60-2.65 (1H, m), 2.93-2.98 (1H, m), 3.59-3.72(2H, m), 3.86-4.23 (3H, m), 4.41-4.45 (1H, m), 6.36 (1H, br s),7.25-7.53 (3H, m). 4-9 1H-NMR (CDCl3) δ: 2.59-2.64 (1H, m), 2.92-2.96(1H, m), 3.59-3.68 (2H, m), 3.92-3.97 (1H, m), 4.38-4.42 (1H, m),4.67-4.75 (2H, m), 6.98-7.74 (7H, m), 8.52-8.55 (1H, m). 4-21 1H-NMR(CDCl3) δ: 2.59-2.64 (1H, m), 2.97-3.00 (1H, m), 3.60-3.72 (2H, m),3.95-4.16 (3H, m), 4.41-4.45 (1H, m), 6.37 (1H, br s), 7.40 (2H, s).4-22 1H-NMR (CDCl3) δ: 2.58-2.63 (1H, m), 2.91-2.96 (1H, m), 3.59-3.72(2H, m), 3.99-4.12 (1H, m), 4.40-4.44 (1H, m), 4.70-4.72 (2H, m),7.20-7.72 (6H, m), 8.56-8.57 (1H, m). 4-34 1H-NMR (CDCl3) δ: 2.67-2.73(1H, m), 3.08-3.12 (1H, m), 3.66-3.74 (2H, m), 4.01-4.16 (3H, m),4.56-4.60 (1H, m), 6.38 (1H, br s), 7.80 (2H, s), 7.95 (1H, s). 4-351H-NMR (CDCl3) δ: 2.67-2.73 (1H, m), 3.07-3.11 (1H, m), 3.61-3.77 (2H,m), 4.06-4.13 (1H, m), 4.66-4.84 (3H, m), 7.35-7.80 (7H, m), 8.56-8.57(1H, m). 4-38 1H-NMR (CDCl3) δ: 2.64-2.75 (1H, m), 3.07-3.11 (1H, m),3.62-3.77 (5H, m), 4.04-4.07 (1H, m), 4.17-4.22 (2H, m), 4.56-4.60 (1H,m), 6.69-6.72 (1H, m), 7.80 (2H, s), 7.94 (1H, s). 4-128 1H-NMR(acetone-d6) δ: 2.72-2.96 (m, 1H), 3.07-3.20 (m, 1H), 3.65-3.77 (m, 2H),3.93-4.15 (m, 5H), 4.50 (d, 1H), 7.54-7.68 (m, 4H), 7.86 (bs, 1H) 4-2861H-NMR (CDCl3) δ: 1.29 (t, 3H), 2.57-2.70 (m, 1H), 2.91-3.02 (m, 1H),3.55-3.77 (m, 2H), 3.98 (d, 1H), 4.16 (q, 2H), 4.45 (d, 1H), 7.21-7.28(m, 2H), 4.40-4.48 (m, 1H), 7.68 (d, 1H), 8.99-9.11 (m, 1H) 4-613 1H-NMR(CDCl3) δ: 2.55-2.70 (m, 1H), 2.88-3.01 (m, 1H), 3.53-3.75 (m, 2H), 3.98(d, 1H), 4.43 (d, 1H), 4.85 (d, 1H), 7.20-7.30 (m, 3H), 7.37-7.42 (m,1H), 7.65 (bs, 1H), 8.74 (d, 2H) 4-614 1H-NMR (acetone-d6) δ: 2.75-2.96(m, 1H), 3.07-3.20 (m, 1H), 3.64-3.78 (m, 2H), 4.05-4.15 (m, 3H),4.44-4.59 (m, 3H), 7.18-7.25 (m, 1H), 7.36 (d, 1H), 7.52-7.78 (m, 5H),7.88 (bs, 1H), 8.49 (d, 1H) 4-615 1H-NMR (acetone-d6) δ: 2.78-2.96 (m,1H), 3.07-3.20 (m, 1H), 3.48-3.78 (m, 6H), 3.97-4.14 (m, 3H), 4.50 (d,1H), 7.51-7.67 (m, 3H) 4-616 1H-NMR (CDCl3) δ: 2.55-2.70 (m, 1H),2.88-3.02 (m, 1H), 3.52-3.75 (m, 2H), 3.84 (s, 3H), 3.97 (d, 1H), 4.43(d, 1H), 4.85 (d, 1H), 7.21-7.28 (m, 2H), 7.38-7.44 (m, 1H), 8.02 (bs,1H) 4-617 1H-NMR (CDCl3) δ: 2.55-2.70 (m, 1H), 2.88-3.02 (m, 1H), 3.15(s, 3H), 3.17 (s, 3H), 3.52-3.75 (m, 2H), 3.97 (d, 1H), 4.43 (d, 1H),4.85 (d, 1H), 5.12 (s, 1H), 7.21-7.28 (m, 2H), 7.38-7.44 (m, 1H) 4-6181H-NMR (CDCl3) δ: 2.30 (t, 1H), 2.54-2.69 (m, 1H), 2.87-3.01 (m, 1H),3.52-3.74 (m, 2H), 3.96 (d, 1H), 4.15-4.24 (m, 2H), 4.42 (d, 1H), 6.29(bs, 1H), 7.21-7.28 (m, 2H), 7.38-7.43 (m, 1H) 5-4 1H-NMR (CDCl3) δ:1.18 (3H, t), 2.21 (2H, q), 2.54-2.59 (1H, m), 2.85-2.93 (1H, m),3.57-3.63 (2H, m), 3.90-3.94 (1H, m), 4.33-4.37 (1H, m), 4.55-4.57 (2H,m), 5.91 (1H, br s), 7.27 (2H, s), 7.40 (1H, s). 5-7 1H-NMR (CDCl3) δ:0.75-0.84 (2H, m), 0.99-1.09 (2H, m), 1.31-1.40 (1H, m), 2.53-2.59 (1H,m), 2.87-2.91 (1H, m), 3.57-3.63 (2H, m), 3.91 (1H, d), 4.35 (1H, d),4.56-4.58 (2H, m), 6.10 (1H, br s), 7.26 (2H, d), 7.39 (1H, t). 5-151H-NMR (CDCl3) δ: 0.11-0.18 (2H, m), 0.58-0.62 (2H, m), 0.86-1.06 (1H,m), 2.18 (2H, d), 2.54-2.59 (1H, m), 2.87-2.92 (1H, m), 3.55-3.64 (2H,m), 3.92 (1H, d), 4.35 (1H, d), 4.58-4.60 (2H, m), 6.38 (1H, br s), 7.26(2H, d), 7.40 (1H, t). 5-22 1H-NMR (CDCl3) δ: 2.54-2.60 (1H, m),2.88-2.93 (1H, m), 3.10 (2H, q), 3.50-3.67 (2H, m), 3.90-3.94 (1H, m),4.34-4.38 (1H, m), 4.59-4.70 (2H, m), 6.32 (1H, t), 7.27 (2H, s), 7.41(1H, s) 5-45 1H-NMR (CDCl3) δ: 2.08 (3H, s), 2.47-2.62 (1H, m),2.91-2.95 (1H, m), 3.25 (2H, s), 3.52-3.63 (2H, m), 3.92 (1H, d), 4.36(1H, d), 4.61-4.63 (2H, m), 7.26 (2H, d), 7.36-7.39 (2H, m). 5-1401H-NMR (CDCl3) δ: 1.64 (2H, br s), 2.51-2.61 (1H, m), 2.88-2.92 (1H, m),3.56-3.65 (2H, m), 3.92-3.96 (1H, m), 4.02-4.16 (2H, m), 4.16-4.38 (1H,m), 7.41 (2H, s). 5-142 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.25 (2H, q),2.52-2.58 (1H, m), 2.87-2.91 (1H, m), 3.55-3.64 (2H, m), 3.91 (1H, m),4.34 (1H, m), 4.55-4.57 (2H, m), 5.91-5.93 (1H, m), 7.39 (2H, s). 5-1431H-NMR (CDCl3) δ: 0.72-1.39 (5H, m), 2.52-2.57 (1H, m), 2.84-2.93 (1H,m), 3.48-3.67 (2H, m), 3.89-3.93 (1H, m), 4.32-4.36 (1H, m), 4.56-4.58(2H, m), 6.09 (1H, t), 7.39 (2H, s). 5-144 1H-NMR (CDCl3) δ: 2.53-2.59(1H, m), 2.88-2.92 (1H, m), 3.12 (2H, q), 3.55-3.67 (2H, m), 3.90-3.94(1H, m), 4.34-4.37 (1H, m), 4.60-4.62 (2H, m), 6.22 (1H, br s), 7.39(2H, s). 5-148 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.21 (2H, q), 2.61-2.66(1H, m), 3.02-3.06 (1H, m), 3.55-3.72 (2H, m), 3.97-4.01 (1H, m),4.50-4.56 (3H, m), 5.94 (1H, t), 7.80 (2H, s), 7.93 (1H, s). 5-1501H-NMR (CDCl3) δ: 2.62-2.67 (1H, m), 3.04-3.12 (3H, m), 3.58-3.68 (2H,m), 3.98-4.02 (1H, m), 4.52-4.60 (3H, m), 6.33 (1H, t), 7.80 (2H, s),7.93 (1H, s). 5-151 1H-NMR (CDCl3) δ: 1.16 (3H, t), 2.59-2.67 (1H, m),3.01-3.05 (1H, m), 3.18-3.33 (2H, m), 3.60-3.71 (2H, m), 3.97-4.01 (1H,m), 4.35-4.37 (1H, m), 4.47-4.57 (3H, m), 4.78-4.81 (1H, m), 7.80 (2H,s), 7.93 (1H, s). 5-178 1H-NMR (CDCl3) δ: 1.13 (3H, t), 2.19-2.28 (5H,m), 2.49-2.68 (1H, m), 2.84-2.87 (1H, m), 3.52-3.62 (2H, m), 3.90 (1H,d), 4.35-4.49 (3H, m), 5.78 (1H, br s), 7.22 (2H, d), 7.38 (1H, t).5-179 1H-NMR (CDCl3) δ: 0.77-0.85 (2H, m), 0.95-0.99 (2H, m), 1.28-1.33(2H, m), 2.22 (3H, s), 2.52-2.57 (1H, m), 2.85-2.89 (1H, m), 3.53-3.62(2H, m), 3.91 (1H, d), 4.33 (1H, d), 4.41-4.42 (2H, m), 5.87 (1H, br s),7.26 (2H, d), 7.38 (1H, t). 5-193 1H-NMR (CDCl3) δ: 1.14 (3H, t), 2.23(2H, q), 2.53-2.59 (1H, m), 2.87-2.92 (1H, m), 3.54-3.60 (2H, m), 3.90(1H, d), 4.32-4.49 (3H, m), 5.92 (1H, br s), 7.25 (2H, d), 7.39 (1H, t).5-194 1H-NMR (CDCl3) δ: 0.72-0.85 (2H, m), 0.88-1.11 (2H, m), 1.31-1.39(1H, m), 2.53-2.58 (1H, m), 2.87-2.91 (1H, m), 3.50-3.58 (2H, m), 3.89(1H, d), 4.34 (1H, d), 4.42-4.44 (2H, m), 6.11 (1H, br s), 7.28 (2H, d),7.39 (1H, t). 5-228 1H-NMR (CDCl3) δ: 0.17-0.27 (2H, m), 0.59-0.65 (2H,m), 0.92-0.99 (1H, m), 2.16 (2H, d), 2.31 (3H, s), 2.52-2.61 (1H, m),2.85-2.90 (1H, m), 3.54-3.63 (2H, m), 3.91 (1H, d), 4.35 (1H, d),4.45-4.49 (2H, m), 6.11 (1H, br s), 7.26 (2H, d), 7.38 (1H, t). 5-2481H-NMR (CDCl3) δ: 0.18-0.21 (2H, m), 0.60-0.64 (2H, m), 0.89-1.00 (1H,m), 2.18 (2H, d), 2.53-2.59 (1H, m), 2.87-2.92 (1H, m), 3.55-3.61 (2H,m), 3.90 (1H, d), 4.34 (1H, d), 4.44-4.46 (2H, m), 6.29 (1H, br s), 7.28(2H, d), 7.39 (1H, t). 5-336 1H-NMR (CDCl3) δ: 0.18-0.21 (2H, m),0.55-0.65 (2H, m), 0.88-1.01 (1H, m), 2.18 (2H, d), 2.52-2.58 (1H, m),2.85-2.93 (1H, m), 3.55-3.68 (2H, m), 3.90-3.94 (1H, m), 4.33-4.36 (1H,m), 4.59 (2H, d), 6.35 (1H, t), 7.37 (2H, s). 5-337 1H-NMR (CDCl3) δ:1.00 (9H, s), 2.07 (2H, s), 2.52-2.58 (1H, m), 2.86-2.91 (1H, m),3.51-3.67 (2H, m), 3.90-3.94 (1H, m), 4.36-4.42 (1H, m), 4.53 (2H, d),5.85 (1H, t), 7.38 (2H, s). 5-340 1H-NMR (CDCl3) δ: 2.11 (3H, s),2.53-2.58 (1H, m), 2.85-2.93 (1H, m), 3.23 (2H, s), 3.55-3.64 (2H, m),3.90-3.94 (1H, m), 4.33-4.37 (1H, m), 4.61 (2H, d), 7.34-7.37 (3H, m).5-387 1H-NMR (CDCl3) δ: 2.13 (3H, s), 2.62-2.67 (1H, m), 3.02-3.06 (1H,m), 3.23 (2H, s), 3.53-3.65 (2H, m), 3.98-4.02 (1H, m), 4.47-4.51 (1H,m), 4.61-4.63 (2H, m), 7.35 (1H, br s), 7.81 (2H, s), 7.93 (1H, s).5-389 1H-NMR (CDCl3) δ: 2.55-2.65 (1H, m), 2.97-3.05 (4H, m), 3.84-3.88(4H, m), 4.05-4.16 (1H, m), 4.50-4.62 (3H, m), 6.81 (1H, br s), 7.84(2H, s), 7.92 (1H, s), 8.63 (1H, s). 5-433 1H-NMR (CDCl3) δ: 0.15-0.28(2H, m), 0.55-0.69 (2H, m), 0.89-1.05 (1H, m), 2.20 (2H, d), 2.62-2.68(1H, m), 3.03-3.07 (1H, m), 3.56-3.73 (2H, m), 3.99-4.03 (1H, m),4.52-4.59 (3H, m), 6.41 (1H, t), 7.81 (2H, s), 7.94 (1H, s). 5-4341H-NMR (CDCl3) δ: 0.99 (9H, s), 2.07 (2H, s), 2.61-2.66 (1H, m),3.01-3.06 (1H, m), 3.55-3.71 (2H, m), 3.98-4.02 (1H, m), 4.50-4.54 (3H,m), 5.86 (1H, tz), 7.80 (2H, s), 7.93 (1H, s). 5-435 1H-NMR (CDCl3) δ:2.32 (3H, s), 2.47-2.52 (1H, m), 2.81-2.85 (1H, m), 3.48-3.54 (2H, m),3.83 (1H, d), 4.28 (1H, d), 4.39-4.41 (2H, m), 5.68 (1H, br s), 7.18(2H, d), 7.32 (1H, t). 5-436 1H-NMR (CDCl3) δ: 2.24 (3H, s), 2.41 (3H,s), 2.49-2.60 (1H, m), 2.83-2.91 (1H, m), 3.53-3.62 (2H, m), 3.91 (1H,d), 4.33 (1H, d), 4.43-4.45 (2H, m), 5.62 (1H, br s), 7.26 (2H, d), 7.38(1H, t). 5-437 1H-NMR (CDCl3) δ: 2.40 (3H, s), 2.54-2.59 (1H, m),2.87-2.92 (1H, m), 3.56-3.65 (2H, m), 3.92 (1H, d), 4.35 (1H, d),4.59-4.61 (2H, m), 5.84 (1H, br s), 7.23 (2H, d), 7.40 (1H, t). 6-41H-NMR (CDCl3) δ: 1.18 (3H, t), 1.77-1.86 (1H, m), 2.22 (2H, q),2.50-2.64 (2H, m), 2.78-3.01 (3H, m), 3.45-3.58 (2H, m), 3.77 (1H, d),4.03 (1H, d), 5.41 (1H, dd), 5.56 (1H, d), 6.48 (1H, d), 6.49 (1H, s),7.18 (1H, d), 7.30 (1H, s), 7.38 (1H, t). 6-122 1H-NMR (CDCl3) δ: 1.48(9H, s), 1.74-1.86 (1H, m), 2.48-2.60 (2H, m), 2.74-2.99 (3H, m),3.41-3.57 (2H, m), 3.77 (1H, d), 4.02 (1H, d), 4.68 (1H, d), 5.10 (1H,d), 6.47-6.45 (2H, m), 7.22 (1H, d), 7.29 (2H, s), 7.37 (1H, t). 6-2671H-NMR (acetone-d6) δ: 1.73-1.82 (1H, m), 1.89 (3H, s), 2.34-2.49 (2H,m), 2.69-3.02 (3H, m), 3.44-3.57 (2H, m), 3.94 (1H, d), 4.19 (1H, d),5.26 (1H, dd), 6.55-6.52 (2H, m), 7.08 (1H, d), 7.82 (2H, s). 6-2681H-NMR (CDCl3) δ: 1.19 (3H, t), 1.74-1.86 (1H, m), 2.23 (2H, q),2.46-2.65 (2H, m), 2.78-3.01 (3H, m), 3.45-3.58 (2H, m), 3.77 (1H, d),4.02 (1H, d), 5.38-5.61 (2H, m), 6.46-6.49 (2H, m), 7.18 (1H, d), 7.43(2H, s). 6-273 1H-NMR (CDCl3) δ: 1.18 (3H, t), 1.75-1.86 (1H, m), 2.23(2H, q), 2.54-2.64 (2H, m), 2.79-3.02 (3H, m), 3.47-3.64 (2H, m), 3.84(1H, d), 4.15 (1H, d), 5.38-5.57 (2H, m), 6.52-6.49 (2H, m), 7.20 (1H,d), 7.85 (2H, s), 7.91 (1H, s). 6-293 1H-NMR (CDCl3) δ: 1.18 (3H, t),1.76-1.87 (3H, m), 1.95-2.04 (1H, m), 2.22 (2H, q), 2.54-2.86 (3H, m),2.91-3.00 (1H, m), 3.45-3.62 (2H, m), 3.82 (1H, d), 4.14 (1H, d),5.16-5.09 (1H, m), 5.58 (1H, d), 6.33 (1H, d), 6.50 (1H, dd), 7.18 (1H,d), 7.85 (2H, s), 7.91 (1H, s). 6-802 1H-NMR (CDCl3) δ: 1.48 (9H, s),1.74-1.86 (1H, m), 2.45-2.60 (2H, m), 2.75-2.99 (3H, m), 3.45-3.57 (2H,m), 3.76 (1H, d), 4.01 (1H, d), 4.67 (1H, d), 5.11 (1H, d), 6.48-6.46(2H, m), 7.22 (1H, d), 7.43 (2H, s). 7-1 1H-NMR (CDCl3) δ: 2.56-2.66(1H, m), 2.91-2.99 (1H, m), 3.55-3.71 (2H, m), 3.84 (1H, d), 4.16 (1H,d), 6.72 (1H, dd), 6.86 (1H, d), 7.27 (2H, d), 7.42 (1H, t), 7.65 (1H,d). 7-2 1H-NMR (CDCl3) δ: 2.57-2.64 (1H, m), 2.90-2.95 (1H, m),3.53-3.61 (2H, m), 3.81 (1H, d), 4.13 (1H, d), 6.50 (1H, dd), 6.64 (1H,d), 7.27 (2H, br s), 7.43 (1H, t), 7.50 (1H, d). 7-3 1H-NMR (CDCl3) δ:2.55-2.60 (1H, m), 2.89-2.93 (1H, m), 3.49-3.65 (2H, m), 3.74-3.79 (1H,m), 4.10-4.12 (1H, m), 6.52-6.54 (1H, m), 6.81-6.83 (1H, m), 7.24 (2H,s), 7.40-7.46 (2H, m). 7-4 1H-NMR (CDCl3) δ: 2.53-2.63 (1H, m),3.48-3.65 (1H, m), 3.52-3.62 (2H, m), 3.79 (1H, d), 4.11 (1H, d),6.29-6.40 (2H, m), 7.26 (2H, s), 7.40-7.43 (2H, m). 7-5 1H-NMR (CDCl3)δ: 2.49 (1H, s), 2.53-2.60 (4H, m), 2.84-2.92 (1H, m), 3.48-3.64 (2H,m), 3.79 (1H, d), 4.10 (1H, d), 6.40-6.43 (2H, m), 7.27 (2H, d), 7.40(1H, t), 7.45 (1H, d). 7-12 1H-NMR (CDCl3) δ: 2.55-2.65 (1H, m),2.90-2.98 (1H, m), 3.55-3.73 (2H, m), 3.83 (1H, d), 4.16 (1H, d), 6.72(1H, dd), 6.86 (1H, d), 7.42 (2H, s), 7.65 (1H, d). 7-13 1H-NMR (CDCl3)δ: 2.52-2.62 (1H, m), 2.87-2.95 (1H, m), 3.49-3.66 (2H, m), 3.79 (1H,d), 4.11 (1H, d), 6.49 (1H, dd), 6.63 (1H, d), 7.40 (2H, s), 7.47 (1H,d). 7-14 1H-NMR (CDCl3) δ: 2.51-2.61 (1H, m), 2.91-2.99 (1H, m),3.54-3.63 (2H, m), 3.76-3.80 (1H, m), 4.09-4.12 (1H, m), 6.53 (1H, dd),6.81 (1H, d), 7.40 (2H, s), 7.47 (1H, d). 7-23 1H-NMR (CDCl3) δ:2.63-2.74 (1H, m), 3.14-3.05 (1H, m), 3.77-3.61 (2H, m), 3.90 (1H, d),4.31 (1H, d), 6.76 (1H, dd), 6.89 (1H, d), 7.66 (1H, d), 7.83 (2H, s),7.96 (1H, s). 7-24 1H-NMR (CDCl3) δ: 2.60-2.71 (1H, m), 3.02-3.10 (1H,m), 3.71-3.54 (2H, m), 3.85 (1H, d), 4.25 (1H, d), 6.53 (1H, dd), 6.67(1H, d), 7.50 (1H, d), 7.82 (2H, s), 7.95 (1H, s). 7-25 1H-NMR (CDCl3)δ: 2.60-2.70 (1H, m), 3.10-3.01 (1H, m), 3.54-3.71 (2H, m), 3.85 (1H,d), 4.25 (1H, d), 6.57 (1H, dd), 6.84 (1H, d), 7.48 (1H, d), 7.82 (2H,s), 7.95 (1H, s). 7-28 1H-NMR (CDCl3) δ: 2.66-2.77 (1H, m), 3.08-3.17(1H, m), 3.65-3.81 (2H, m), 3.93 (1H, d), 4.35 (1H, d), 6.88 (1H, dd),7.44 (1H, d), 7.71 (1H, d), 7.83 (2H, s), 7.94 (1H, d). 7-35 1H-NMR(acetone-d6) δ: 2.84-2.95 (1H, m), 3.17-3.28 (1H, m), 3.74-3.80 (2H, m),4.21 (1H, d), 4.62 (1H, d), 7.04 (1H, dd), 7.14 (1H, d), 7.77 (1H, d),7.85 (1H, s), 7.91 (1H, s), 7.98 (1H, s). 7-46 1H-NMR (CDCl3) δ:2.50-2.63 (1H, m), 2.58 (3H, s), 2.85-2.94 (1H, m), 3.53-3.67 (2H, m),3.80 (1H, d), 4.11 (1H, d), 6.29-6.41 (2H, m), 7.11-7.46 (4H, m) 7-471H-NMR (CDCl3) δ: 1.76 (1H, t), 2.43-2.77 (5H, m), 3.65-4.00 (2H, m),4.21 (1H, d), 4.40 (1H, d), 4.59-4.62 (2H, m), 6.62 (1H, d), 7.29-7.38(4H, m) 7-49 1H-NMR (CDCl3) δ: 1.83 (1H, b), 2.48-2.59 (1H, m),2.83-2.91 (1H, m), 3.53-3.67 (2H, m), 3.93 (1H, d), 4.40 (1H, d), 4.65(2H, s), 6.30 (1H, d), 7.26-7.58 (4H, m) 7-51 1H-NMR (CDCl3) δ: 1.84(1H, b), 2.52-2.62 (1H, m), 2.88-2.96 (1H, m), 3.45-3.58 (2H, m), 3.79(1H, d), 4.00 (1H, d), 4.67 (2H, s), 6.53-7.65 (6H, m) 7-53 1H-NMR(CDCl3) δ: 1.84 (1H, t), 2.48-2.58 (1H, m), 2.81-2.89 (1H, m), 3.42-3.58(2H, m), 3.76 (1H, d), 4.03 (1H, d), 4.66 (2H, d), 6.53 (1H, dd), 6.79(1H, d), 7.28 (2H, s), 7.29 (1H, d), 7.39 (1H, t). 7-55 1H-NMR (CDCl3)δ: 1.82 (1H, t), 2.48-2.58 (1H, m), 2.80-2.89 (1H, m), 3.41-3.57 (2H,m), 3.74 (1H, d), 4.02 (1H, d), 4.62 (2H, d), 6.58 (1H, dd), 7.05 (1H,d), 7.28-7.26 (3H, m), 7.39 (1H, t). 7-57 1H-NMR (CDCl3) δ: 1.84 (1H, t,J = 6.3 Hz), 2.47-2.57 (1H, m), 2.80-2.88 (1H, m), 3.58-3.42 (2H, m),3.75 (1H, d), 4.02 (1H, d), 4.66 (2H, d), 6.53 (1H, dd), 6.79 (1H, d),7.30 (1H, d), 7.42 (2H, s). 7-63 1H-NMR (CDCl3) δ: 1.85 (1H, t),2.88-2.96 (1H, m), 3.53-3.74 (1H, m), 3.56-3.74 (2H, m), 4.05 (1H, d),4.23 (1H, dd), 4.71 (2H, d), 6.63 (1H, dd), 7.13 (1H, dd), 7.85 (2H, s),7.92 (1H, s). 7-67 1H-NMR (CDCl3) δ: 2.55-2.66 (1H, m), 2.95-3.03 (1H,m), 3.46-3.63 (2H, m), 3.81 (1H, d), 4.15 (1H, d), 4.62 (2H, d), 6.62(1H, dd), 7.09 (1H, d), 7.29 (1H, d), 7.84 (2H, s), 7.93 (1H, s). 7-691H-NMR (CDCl3) δ: 2.50-2.63 (1H, m), 2.88-2.96 (1H, m), 3.57 (1H, br s),3.64-3.76 (1H, m), 4.04 (1H, d), 4.23 (1H, dd), 4.68 (2H, s), 6.49-6.43(1H, m), 6.99-7.05 (1H, m), 7.85 (2H, s), 7.92 (1H, s). 7-71 1H-NMR(CDCl3) δ: 2.52-2.62 (1H, m), 2.90-2.99 (1H, m), 3.81-3.90 (1H, m),4.13-4.22 (1H, m), 4.33 (1H, dd), 4.51 (1H, dd), 6.70-6.78 (1H, m),7.31-7.25 (1H, m), 7.84 (2H, s), 7.94 (1H, s). 7-72 1H-NMR (CDCl3) δ:2.10-2.16 (1H, m), 2.33-2.43 (1H, m), 2.67-2.74 (1H, m), 3.44-3.59 (2H,m), 3.85-3.88 (1H, m), 3.99-4.04 (1H, m), 4.59 (2H, s), 6.49 (1H, t),6.92-7.11 (1H, m), 7.37 (2H, s). 7-76 1H-NMR (CDCl3) δ: 2.09-2.17 (3H,m), 2.33-2.36 (1H, m), 2.61-2.66 (1H, m), 3.41-3.46 (2H, m), 3.82-3.97(2H, m), 4.49 (2H, s), 6.42 (1H, t), 6.87 (1H, d), 7.35 (2H, s). 7-781H-NMR (CDCl3) δ: 1.67 (1H, t), 2.50-2.60 (1H, m), 2.84-2.92 (1H, m),3.48-3.63 (2H, m), 3.79 (1H, d), 4.08 (1H, d), 4.75 (2H, d), 6.75 (1H,dd), 6.82 (1H, d), 7.48 (2H, d), 7.50 (1H, d), 7.70 (1H, t). 7-86 1H-NMR(CDCl3) δ: 1.56 (1H, b), 2.49-2.59 (1H, m), 2.83-2.92 (1H, m), 3.55-3.70(2H, m), 3.93 (1H, d), 4.40 (2H, d), 4.65 (2H, s), 6.31 (1H, d),7.30-7.61 (4H, m) 7-92 1H-NMR (CDCl3) δ: 1.83 (2H, b), 2.53-2.66 (1H,m), 2.97-3.04 (1H, m), 3.55-3.68 (2H, m), 3.85 (2H, s), 3.99 (1H, d),4.54 (1H, d), 6.30-7.91 (5H, m) 7-93 1H-NMR (CDCl3) δ: 1.86 (1H, t),2.47-2.58 (1H, m), 2.82-2.91 (1H, m), 3.55-3.68 (2H, m), 3.93 (1H, d),4.40 (1H, d), 4.66 (2H, d), 6.31 (1H, d), 7.44-7.59 (3H, m) 7-95 1H-NMR(CDCl3) δ: 2.56-2.67 (1H, m), 2.97-3.06 (1H, m), 3.55-3.70 (2H, m), 4.00(1H, d), 4.55 (1H, d), 4.67 (2H, d), 6.34 (1H, d), 7.57-7.91 (4H, m)7-97 1H-NMR (CDCl3) δ: 2.47-2.58 (1H, m), 2.82-2.91 (1H, m), 3.90-4.11(4H, m), 4.54 (1H, d), 7.27-7.42 (4H, m) 7-98 1H-NMR (CDCl3) δ:2.46-2.57 (1H, m), 2.82-2.90 (1H, m), 3.90-4.11 (3H, m), 4.53 (1H, d),7.36-7.41 (3H, m) 7-99 1H-NMR (CDCl3) δ: 2.54-2.65 (1H, m), 2.97-3.05(1H, m), 3.90-4.70 (3H, m), 4.68 (1H, d), 7.40 (1H, d), 7.83-7.95 (3H,m) 7-100 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m), 2.79-2.88 (1H, m),3.40-3.55 (2H, m), 3.78 (1H, d), 3.93 (3H, s), 4.04 (1H, d), 4.59 (2H,b), 6.10-6.17 (2H, m), 7.12-7.39 (4H, m) 7-102 1H-NMR (CDCl3) δ:2.61-2.72 (1H, m), 3.03-3.11 (1H, m), 3.54-3.73 (2H, m), 3.86 (1H, d),4.25 (1H, d), 6.49-6.58 (2H, m), 7.26-7.96 (4H, m) 7-103 1H-NMR (CDCl3)δ: 2.55-2.65 (1H, m), 2.90-2.98 (1H, m), 3.55-3.71 (2H, m), 3.82 (1H,d), 4.16 (1H, d), 6.72 (1H, dd), 6.86 (1H, d), 7.46 (2H, d), 7.65 (1H,d), 7.73 (1H, t). 7-105 1H-NMR (CDCl3) δ: 1.37 (3H, t), 2.54-2.64 (1H,m), 2.90-2.99 (1H, m), 3.71-3.74 (2H, m), 4.02 (1H, d), 4.36 (2H, q),4.51 (1H, d), 6.65 (1H, s), 7.43 (2H, s), 8.84 (1H, s). 7-107 1H-NMR(CDCl3) δ: 2.55-2.64 (1H, m), 2.88-2.97 (1H, m), 3.71-3.75 (2H, m), 4.01(1H, d), 4.49 (1H, d), 4.70 (2H, d), 6.61 (1H, s), 7.44 (2H, s), 8.42(1H, s). 7-108 1H-NMR (CDCl3) δ: 1.38 (3H, t), 2.62-2.73 (1H, m),3.06-3.14 (1H, m), 3.76-3.79 (2H, m), 4.08 (1H, d), 4.37 (2H, q), 4.68(1H, d), 6.68 (1H, s), 7.85 (2H, s), 7.94 (1H, s), 8.86 (1H, s). 7-1101H-NMR (CDCl3) δ: 2.63-2.69 (1H, m), 3.05-3.09 (1H, m), 3.66-3.75 (2H,m), 4.04 (1H, d), 4.62 (1H, d), 4.73 (2H, d), 6.62 (1H, s), 7.86 (2H,s), 7.93 (1H, s), 8.41 (1H, s). 7-111 1H-NMR (CDCl3) δ: 2.49-2.59 (1H,m), 2.83-2.92 (1H, m), 3.57-3.70 (2H, m), 3.95 (1H, d), 4.42 (1H, d),4.76 (2H, s), 6.59 (1H, d), 7.30 (2H, s), 7.38 (1H, s), 7.76 (1H, d).7-112 1H-NMR (CDCl3) δ: 2.53-2.64 (1H, m), 2.90-3.00 (1H, m), 3.69-3.74(2H, m), 4.01 (1H, d), 4.50 (1H, d), 4.75 (2H, s), 6.59 (1H, d), 7.44(2H, s), 7.75 (1H, d). 7-113 1H-NMR (CDCl3) δ: 1.37 (3H, t), 2.54-2.60(1H, m), 2.90-2.99 (1H, m), 3.57-3.75 (2H, m), 4.01 (1H, d), 4.35 (2H,q), 4.45 (1H, d), 6.55 (1H, d), 7.56-7.61 (3H, m), 8.02 (1H, d). 7-1141H-NMR (CDCl3) δ: 2.54-2.59 (1H, m), 2.91-2.98 (1H, m), 3.55-3.79 (2H,m), 4.00 (1H, d), 4.44 (1H, d), 4.78 (2H, d), 6.56 (1H, d), 7.53-7.65(3H, m), 7.78 (1H, d). 7-115 1H-NMR (CDCl3) δ: 1.36 (3H, t), 2.53-2.63(1H, m), 2.89-3.01 (1H, m), 3.55-3.74 (2H, m), 4.03 (1H, d), 4.30-4.52(3H, m), 6.56 (1H, d), 7.51-7.80 (4H, m), 8.03 (1H, d). 7-117 1H-NMR(CDCl3) δ: 2.53-2.61 (1H, m), 2.88-3.01 (1H, m), 3.53-3.71 (2H, m), 4.00(1H, d), 4.42 (1H, d), 4.75 (2H, s), 6.57 (1H, d), 7.42-7.79 (4H, m),7.78 (1H, d). 7-119 1H-NMR (CDCl3) δ: 2.64-2.74 (1H, m), 3.05-3.14 (1H,m), 3.75-3.81 (2H, m), 4.06 (1H, d), 4.65-4.80 (3H, m), 6.59 (1H, s),7.69-7.96 (4H, m) 7-120 1H-NMR (CDCl3) δ: 1.36 (3H, t), 2.46-2.60 (1H,m), 2.82-2.91 (1H, m), 3.56-3.70 (2H, m), 3.94 (1H, d), 4.34-4.45 (3H,m), 6.54 (1H, d), 7.48 (2H, s), 7.69 (1H, t), 8.01 (1H, d). 7-121 1H-NMR(CDCl3) δ: 2.46-2.59 (1H, m), 2.83-2.94 (1H, m), 3.52-3.72 (2H, m), 3.93(1H, d), 4.39 (1H, d), 4.75 (2H, s), 6.59 (1H, d), 7.47 (2H, s),7.68-7.80 (2H, m). 7-122 1H-NMR (CDCl3) δ: 1.38 (3H, t), 2.53-2.55 (1H,m), 2.75 (3H, s), 2.85-2.90 (1H, m), 3.64-3.67 (2H, m), 4.00 (1H, d),4.31 (2H, q), 4.47 (1H, d), 6.22 (1H, dz), 7.31 (2H, s), 7.39 (1H, t),8.06 (1H, d). 7-124 1H-NMR (CDCl3) δ: 2.49-2.52 (4H, m), 2.80-2.89 (1H,m), 3.57-3.62 (2H, m), 3.96 (1H, d), 4.39 (1H, d), 4.60 (2H, d), 6.21(1H, d), 7.35-7.40 (4H, m). 7-125 1H-NMR (CDCl3) δ: 0.95-0.97 (2H, m),1.13-1.18 (2H, m), 1.39 (3H, t), 2.46-2.56 (1H, m), 2.79-2.87 (1H, m),3.25-3.28 (1H, m), 3.57-3.69 (2H, m), 3.94 (1H, d), 4.31-4.39 (3H, m),6.14 (1H, d), 7.27-7.38 (3H, m), 8.01 (1H, d). 7-127 1H-NMR (CDCl3) δ:0.90-0.95 (2H, m), 1.13-1.17 (2H, m), 2.12-2.26 (1H, m), 2.45-2.58 (1H,m), 2.79-2.90 (1H, m), 3.51-3.70 (2H, m), 3.94 (1H, d), 4.30 (1H, d),4.75 (2H, d), 6.15 (1H, d), 7.27-7.40 (4H, m). 7-128 1H-NMR (CDCl3) δ:0.94-0.99 (2H, m), 1.14-1.19 (2H, m), 1.41 (3H, t), 2.50-2.65 (1H, m),2.91-2.97 (1H, m), 3.25-3.30 (1H, m), 3.45-3.65 (2H, m), 4.02 (1H, d),4.29-4.40 (3H, m), 6.14 (1H, d), 7.84-8.05 (4H, m). 7-129 1H-NMR (CDCl3)δ: 0.92-0.95 (2H, m), 1.13-1.19 (2H, m), 2.15-2.25 (1H, m), 2.50-2.64(1H, m), 2.90-2.99 (1H, m), 3.45-3.66 (2H, m), 4.03 (1H, d), 4.34 (1H,d), 4.73 (2H, d), 6.14 (1H, d), 7.38 (1H, d), 7.84-7.90 (3H, m). 7-1301H-NMR (CDCl3) δ: 2.49-2.60 (1H, m), 2.86-2.94 (1H, m), 3.85-3.88 (5H,m), 4.05 (1H, d), 4.57 (1H, d,), 7.30 (2H, d), 7.39 (1H, d), 8.90 (2H,s). 7-132 1H-NMR (CDCl3) δ: 1.38 (3H, t), 2.52-2.59 (1H, m), 2.89-2.93(1H, m), 3.87-3.90 (2H, m), 4.09 (1H, d), 4.41 (2H, q), 4.57 (1H, d),7.29 (2H, s), 7.40 (1H, s), 8.95 (1H, s). 7-134 1H-NMR (CDCl3) δ:2.51-2.60 (1H, m), 2.86-2.93 (1H, m), 3.82-3.91 (2H, m), 4.07 (1H, d),4.57 (1H, d), 4.75 (2H, d), 7.29 (2H, s), 7.41 (1H, s), 8.65 (1H, s).7-135 1H-NMR (CDCl3) δ: 1.40 (3H, t), 2.50-2.60 (1H, m), 2.89-2.93 (1H,m), 3.87-3.89 (2H, m), 4.06 (1H, d), 4.37 (2H, q), 4.54 (1H, d), 7.45(2H, s), 8.95 (1H, s). 7-137 1H-NMR (CDCl3) δ: 2.50-2.55 (1H, m),2.83-2.92 (1H, m), 3.82-3.88 (2H, m), 4.02 (1H, d), 4.49 (1H, d), 4.73(2H, d), 7.44 (2H, s), 8.63 (1H, s). 7-139 1H-NMR (CDCl3) δ: 1.41 (3H,t), 2.55-2.61 (1H, m), 2.91-2.97 (1H, m), 3.82-3.90 (2H, m), 4.03-4.15(1H, m), 4.35 (2H, q), 4.60 (1H, d), 7.50-7.67 (4H, m), 8.96 (1H, s).7-141 1H-NMR (CDCl3) δ: 2.54-2.61 (1H, m), 2.92-3.01 (1H, m), 3.80-3.88(2H, m), 4.01-4.16 (1H, m), 4.57 (1H, d), 4.74 (2H, d), 7.54-7.64 (4H,m), 8.64 (1H, s). 7-142 1H-NMR (CDCl3) δ: 1.38 (3H, t), 2.63-2.66 (1H,m), 3.01-3.09 (1H, m), 3.91-3.93 (2H, m), 4.11 (1H, d), 4.38 (2H, q),4.71 (1H, d), 7.84 (2H, s), 7.94 (1H, s), 8.96 (1H, d). 7-144 1H-NMR(CDCl3) δ: 2.56-2.66 (1H, m), 2.98-3.06 (1H, m), 3.86-3.92 (2H, m), 4.09(1H, d), 4.64-4.73 (3H, m), 7.85 (2H, s), 7.92 (1H, s), 8.65 (1H, s).7-147 1H-NMR (CDCl3) δ: 2.48-2.58 (1H, m), 2.84-2.92 (1H, m), 3.80-3.83(2H, m), 4.00 (1H, d), 4.52 (1H, d), 4.73 (2H, d), 7.49 (2H, s), 7.69(1H, s), 8.63 (1H, s). 7a-1 1H-NMR (CDCl3) δ: 2.50-2.65 (1H, m),2.92-2.99 (1H, m), 3.65-3.85 (2H, m), 4.10 (1H, d), 4.52 (1H, d), 7.25(3H, m), 9.80 (1H, s). 7a-3 1H-NMR (CDCl3) δ: 1.39 (3H, t), 2.52-2.67(4H, m), 2.88-2.96 (1H, m), 3.59-3.68 (2H, m), 4.03 (1H, d), 4.23-4.30(2H, q), 4.38-4.43 (1H, d), 7.26 (2H, d), 7.40 (1H, t). 7a-5 1H-NMR(CDCl3) δ: 2.24 (3H, s), 2.47-2.61 (1H, m), 2.86-2.90 (1H, m), 3.51-3.67(2H, m), 3.93 (1H, d), 4.35 (1H, d), 4.65 (2H, br s), 7.26 (2H, d), 7.39(1H, t). 7a-6 1H-NMR (CDCl3) δ: 1.35 (3H, t), 2.57-2.68 (1H, m),2.92-3.00 (1H, m), 3.64-3.67 (2H, m), 3.98 (1H, d), 4.32 (2H, q), 4.44(1H, d), 7.30 (2H, s), 7.42 (1H, t). 7a-8 1H-NMR (CDCl3) δ: 2.55-2.68(1H, m), 2.91-2.99 (1H, m), 3.60-3.67 (2H, m), 3.97 (1H, d), 4.44 (1H,d), 4.84-4.87 (2H, m), 7.26 (2H, s), 7.42 (1H, t). 7a-9 1H-NMR (CDCl3)δ: 1.30 (3H, t), 2.59-2.64 (1H, m), 2.93-2.97 (1H, m), 3.61-3.73 (2H,m), 3.98 (1H, d), 4.32 (2H, q), 4.44 (1H, d), 7.41 (2H, s). 7a-11 1H-NMR(CDCl3) δ: 2.57-2.61 (1H, m), 2.87-2.95 (1H, m), 3.56-3.70 (2H, m), 3.95(1H, d), 4.38 (1H, d), 4.86 (2H, d), 7.40 (2H, s). 7a-12 1H-NMR (CDCl3)δ: 1.35 (3H, t), 2.65-2.75 (1H, m), 3.09-3.13 (1H, m), 3.65-3.75 (2H,m), 4.05 (1H, d), 4.33 (2H, q), 4.59 (1H, d), 7.80 (2H, s), 7.95 (1H,s). 7a-14 1H-NMR (CDCl3) δ: 2.63-2.69 (1H, m), 3.03-3.07 (1H, m),3.57-3.74 (2H, m), 4.03 (1H, d), 4.53 (1H, d), 4.85-4.87 (2H, m), 7.81(2H, s), 7.93 (1H, s).

If not mentioned otherwise, all sample solutions were prepared asdescribed in Biological Test Example 1 and diluted to the appropriate(predetermined) concentrations.

BIOLOGICAL TEST EXAMPLE 1 Test for Larvae of Spodotera litura

Sample Solution Preparation:

Solvent: 3 parts by weight of dimethylformamide

Emulsifier: 1 part by weight of polyoxyethylene alkyl phenyl ether

To prepare a suitable composition comprising the active compound, 1 partby weight of the active compound was mixed with the above amount of thesolvent containing the above amount of the emulsifier, and the resultingmixture was diluted with water to predetermined concentrations.

Leaves of a sweet potato were immersed in the sample solution dilutedwith water to predetermined concentrations, and after the solution wasair-dried, the resultant leaves were put in a petri dish of 9 cm indiameter, into which 10 of the 3rd-instar larvae of Spodoptera liturawere then released. The dish was put in a temperature controlled room at25° C., followed by addition of leaves of a sweet potato to the dish onthe second day and fourth day and the number of dead insects after 7days was determined to calculate the insecticidal rate. The results werethe averages of two petri dishes per group in this test.

In the above biological test example 1 the following compounds, asrepresentative examples, showed a pest-controlling effect with 100%insectidical rate at 100 ppm of the active ingredient concentrationafter 7 days:

Compound Nos. 1-3, 1-4, 1-7, 1-12, 1-19, 1-21, 1-25, 1-30, 1-39, 1-42,1-72, 1-74, 1-75, 1-77, 1-78, 1-79, 1-80, 1-81, 1-87, 1-88, 1-97, 1-99,1-113, 1-118, 1-141, 1-143, 1-145, 1-146, 1-150, 1-155, 1-162, 1-164,1-173, 1-174, 1-180, 1-182, 1-183, 1-185, 1-186, 1-188, 1-220, 1-222,1-224, 1-227, 1-230, 1-231, 1-232, 1-238, 1-243, 1-254, 1-255, 1-258,1-260, 1-270, 1-274, 1-275, 1-285, 1-295, 1-296, 1-297, 1-298, 1-299,1-301, 1-302, 1-303, 1-304, 1-305, 1-306, 1-307, 1-308, 1-309, 1-312,1-313, 1-314, 1-317, 1-319, 1-321, 1-322, 1-324, 1-327, 1-328, 1-329,1-330, 1-334, 1-336, 1-338, 1-339, 1-340, 1-341, 1-345, 1-346, 1-347,1-355, 1-356, 1-357, 1-380, 1-381, -386, 1-404, 1-444, 1-446, 1-461,1-467, 1-468, 1-469, 1-494, 1-495, 1-496, 1-498, 1-499, 1-500, 1-501,1-504, 1-505, 1-506, 1-507, 1-508, 1-509, 1-513, 1-516, 1-520, 1-521,1-522, 1-523, 1-525, 1-558, 1-574, 1-728, 1-729, 1-730, 1-731, 1-732,1-733, 1-734, 1-963, 1-966, 1-967, 1-968, 1-969, 1-970, 1-971, 1-1169,1-1171, 1-1174, 1-1467, 1-1471, 1-1472, 2-8, 2-34, 2-35, 3-140, 3-141,3-142, 3-143, 3-144, 3-145, 3-146, 3-148, 3-149, 3-150, 3-151, 3-335,3-339, 3-342, 4-8, 4-21, 4-22, 4-34, 5-4, 5-22, 5-142, 5-143, 5-144,5-148, 5-150, 5-336, 5-340, 6-4, 6-267, 6-268, 6-273, 6-802, 7-12, 7-13and 7-14.

BIOLOGICAL TEST EXAMPLE 2 Test for Tetranychus urticae (Spray Test)

Test method: 50 to 100 of adult Tetranychus urticae were inoculated toleaves at 2-leaf stage of kidney bean planted in pots of 6 cm indiameter, to which, 1 day later, the sample solution which was dilutedwith water to the desired concentration was sufficiently sprayed with aspray gun. After the compounds were sprayed, the pots were left in agreenhouse and the acaricidal rate was calculated seven days later.

Test result: As representative examples, the following compounds showeda pest-controlling efficacy with 100% acaricidal rate at a concentrationof 100 ppm after 7 days:

Compound Nos. 1-3, 1-4, 1-7, 1-8, 1-12, 1-15, 1-19, 1-21, 1-24, 1-25,1-30, 1-32, 1-36, 1-39, 1-40, 1-42, 1-52, 1-72, 1-75, 1-77, 1-78, 1-79,1-80, 1-81, 1-87, 1-88, 1-97, 1-99, 1-115, 1-117, 1-118, 1-123, 1-143,1-145, 1-146, 1-150, 1-151, 1-155, 1-162, 1-164, 1-173, 1-174, 1-180,1-185, 1-186, 1-198, 1-210, 1-220, 1-222, 1-224, 1-227, 1-230, 1-231,1-232, 1-243, 1-244, 1-254, 1-257, 1-258, 1-285, 1-296, 1-297, 1-299,1-302, 1-303, 1-304, 1-305, 1-307, 1-308, 1-309, 1-312, 1-313, 1-314,1-319, 1-321, 1-322, 1-327, 1-328, 1-329, 1-330, 1-334, 1-338, 1-339,1-340, 1-341, 1-345, 1-346, 1-347, 1-355, 1-356, 1-357, 1-380, 1-381,1-404, 1-442, 1-443, 1-444, 1-458, 1-461, 1-464, 1-467, 1-468, 1-469,1-494, 1-495, 1-496, 1-498, 1-499, 1-500, 1-501, 1-503, 1-504, 1-505,1-506, 1-507, 1-508, 1-509, 1-513, 1-517, 1-521, 1-523, 1-558, 1-694,1-723, 1-728, 1-729, 1-730, 1-731, 1-732, 1-733, 1-734, 1-735, 1-963,1-966, 1-967, 1-968, 1-969, 1-970, 1-971, 1-1169, 1-1171, 1-1172,1-1174, 1-1467, 1-1471, 1-1472, 3-141, 3-142, 3-143, 3-144, 3-145,3-148, 3-149, 3-150, 3-151, 3-335, 3-336, 3-339, 3-342, 5-22, 5-340,6-4, 6-267, 6-268 and 6-273.

BIOLOGICAL TEST EXAMPLE 3 Test for Aulacophora femoralis (Spray Test)

Leaves of cucumbers were immersed in the water-diluted solutioncontaining the active compound at the predetermined concentration whichwas prepared above and, after the solution was air-dried, the leaveswere put onto sterilized black soil in a plastic cup, into which five ofthe 2nd-instar larvae of Aulacophora femoralis were then released. Sevendays later, the number of dead insects was counted to calculate theinsecticidal rate.

The following compounds showed a pest-controlling efficay of 100%insecticidal rate at 100 ppm of the active ingredient concentrationafter 7 days:

Compound Nos. 1-3, 1-4, 1-8, 1-12, 1-19, 1-21, 1-24, 1-25, 1-30, 1-36,1-40, 1-42, 1-73, 1-74, 1-75, 1-77, 1-78, 1-79, 1-80, 1-81, 1-88, 1-97,1-98, 1-99, 1-113, 1-115, 1-117, 1-118, 1-123, 1-143, 1-145, 1-146,1-150, 1-154, 1-155, 1-162, 1-164, 1-166, 1-173, 1-174, 1-180, 1-183,1-186, 1-198, 1-220, 1-224, 1-227, 1-228, 1-231, 1-238, 1-243, 1-244,1-254, 1-257, 1-258, 1-260, 1-270, 1-285, 1-295, 1-296, 1-297, 1-298,1-299, 1-300, 1-301, 1-302, 1-303, 1-304, 1-305, 1-307, 1-308, 1-309,1-312, 1-313, 1-314, 1-317, 1-319, 1-321, 1-322, 1-327, 1-328, 1-329,1-330, 1-338, 1-339, 1-340, 1-341, 1-345, 1-346, 1-347, 1-355, 1-356,1-357, 1-380, 1-381, 1-386, 1-404, 1-442, 1-443, 1-446, 1-458, 1-461,1-464, 1-467, 1-493, 1-494, 1-495, 1-496, 1-498, 1-499, 1-500, 1-501,1-502, 1-503, 1-504, 1-505, 1-506, 1-507, 1-508, 1-509, 1-513, 1-521,1-522, 1-523, 1-525, 1-558, 1-727, 1-728, 1-729, 1-730, 1-731, 1-732,1-733, 1-734, 1-735, 1-963, 1-966, 1-967, 1-968, 1-969, 1-970, 1-971,1-1169, 1-1171, 1-1172, 1-1174, 1-1467, 1-1471, 1-1472, 2-8, 2-34,3-141, 3-142, 3-143, 3-144, 3-145, 3-148, 3-149, 3-150, 3-151, 3-335,3-339, 3-342, 4-8, 4-34, 4-35, 5-4, 5-22, 5-143, 5-144, 5-150, 5-151,5-340, 6-4, 6-267, 6-268, 6-273, 6-802.

BIOLOGICAL TEST EXAMPLE 4 Test for Organic Phosphorus Agent- andCarbamate Agent-Resistant Myzus persicae

About 30 to 50 of grown organic phosphorus agent- and carbamateagent-resistant Myzus persicae per seedling were inoculated to leaves at2-leaf stage of eggplants grown in a pot of 6 cm in diameter, to which,after 1 day from the inoculation, the above prepared water-dilutedsolution of above active compound of the predetermined concentration wassufficiently sprayed with a spray gun. After the spraying, the pot wasleft in a greenhouse at room temperature for 7 days, followed by thepest-controlling rate calculated. The test was repeated twice.

Compound Nos. 1-143, 1-309, 1-314, 1-328, 1-356 and 3-142 showed apest-controlling efficacy with 100% insecticidal rate at 100 ppm of anactive ingredient concentration.

BIOLOGICAL TEST EXAMPLE 5 Amblyomma hebraeum—Test (AMBYHE)

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith water to the desired concentration. Nymphs of the tick Amblyommahebraeum are placed in perforated plastic beakers and immersed inaqueous compound solution for one minute. Ticks are transferred to afilter paper in a Petri dish and incubated in a climate chamber for 42days.

After 42 days mortality in % is determined, 100% means that all theticks have been killed; 0% means that none of the ticks have beenkilled.

In this test for example, the following compounds from the preparationexamples showed good activity of 80% at application rate of 100 ppm:Compound Nos. 1-230, 1-307 and 1-340.

In this test for example, the following compounds from the preparationexamples showed good activity of 85% at application rate of 100 ppm:Compound Nos. 1-238 and 1-404.

In this test for example, the following compounds from the preparationexamples showed good activity of 90% at application rate of 100 ppm:Compound Nos. 1-118, 1-297, 1-305, 1-347, 1-467, 1-509 and 1-734.

In this test for example, the following compound from the preparationexamples showed good activity of 95% at application rate of 100 ppm:Compound No. 1-313.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 100 ppm:Compound Nos. 1-3, 1-4, 1-8, 1-12, 1-19, 1-30, 1-36, 1-42, 1-81, 1-88,1-143, 1-146, 1-150, 1-155, 1-162, 1-164, 1-186, 1-224, 1-231, 1-25,1-258, 1-260, 1-285, 1-296, 1-297, 1-305, 1-307, 1-309, 1-312, 1-314,1-319, 1-327, 1-329, 1-330, 1-338, 1-339, 1-340, 1-341, 1-345, 1-346,1-347, 1-357, 1-380, 1-404, 1-499, 1-501, 1-729, 1-732, 1-733, 5-144 and6-267.

BIOLOGICAL TEST EXAMPLE 6 Lucillia cuprina—Test

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith water to the desired concentration. Approximately 20-30 (Luciliacuprina larvae) are transferred into a test tube containing 1 cm³ ofminced horse meat and 0.5 ml aqueous dilution of test compound. After 2days mortality in % is determined, 100% means that all the larvae havebeen killed; 0% means that none of the larvae have been killed.

In this test for example, the following compounds from the preparationexamples showed good activity of 80% at application rate of 100 ppm:Compound Nos. 1-87, 1-244, 1-694 and 4-9.

In this test for example, the following compounds from the preparationexamples showed good activity of 90% at application rate of 100 ppm:Compound Nos. 1-74, 1-79, 1-97, 1-306, 1-334, 1-336 and 2-69.

In this test for example, the following compounds from the preparationexamples showed good activity of 95% at application rate of 100 ppm:Compound Nos. 1-243 and 1-257.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 100 ppm:Compound Nos. 1-3, 1-4, 1-8, 1-12, 1-19, 1-21, 1-24, 1-25, 1-30, 1-39,1-40, 1-75, 1-77, 1-78, 1-81, 1-88, 1-99, 1-113, 1-118, 1-143, 1-145,1-146, 1-150, 1-155, 1-162, 1-164, 1-173, 1-174, 1-180, 1-183, 1-186,1-188, 1-198, 1-220, 1-222, 1-224, 1-227, 1-230, 1-231, 1-232, 1-238,1-258, 1-260, 1-285, 1-295, 1-296, 1-297, 1-298, 1-299, 1-300, 1-301,1-302, 1-303, 1-304, 1-305, 1-307, 1-308, 1-309, 1-312, 1-313, 1-314,1-317, 1-319, 1-327, 1-329, 1-330, 1-338, 1-339, 1-340, 1-341, 1-345,1-346, 1-347, 1-357, 1-36, 1-380, 1-381, 1-386, 1-404, 1-42, 1-458,1-467, 1-468, 1-494, 1-495, 1-499, 1-500, 1-501, 1-503, 1-504, 1-505,1-509, 1-558, 1-728, 1-729, 1-730, 1-732, 1-733, 1-734, 1-963, 1-966,1-967, 1-968, 1-969, 1-970, 1-971, 2-34, 2-35, 3-141, 3-142, 3-143,3-144, 3-145, 3-148, 3-149, 3-150, 3-151, 4-8, 4-21, 4-22, 4-34, 4-35,5-142, 5-143, -5-144, 5-150, 5-22, 5-4, 6-267, 6-4 and 6-802.

BIOLOGICAL TEST EXAMPLE 7 Ctenocephalides felis—Test (CTECFE)

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith cattle blood to the desired concentration. Approximately 10 to 15adult unfed (Ctenocephalides felis) are placed in flea chambers. Theblood chamber, are sealed with parafilm on the bottom are filled withcattle blood supplied with compound solution and placed on top of theflea chamber, so that the fleas are able to suck the blood. The bloodchamber is heated to 37° C. whereas the flea chamber is kept at roomtemperature. After 2 days mortality in % is determined. 100% means thatall the fleas have been killed; 0% means that none of the fleas havebeen killed.

In this test for example, the following compounds from the preparationexamples showed good activity of 80% at application rate of 100 ppm:Compound Nos. 1-12, 1-19, 1-74, 1-118, 1-141, 1-145, 1-146, 1-150,1-186, 1-503, 1-558, 1-734, 3-148, 4-22, 5-22 and 5-4.

In this test for example, the following compounds from the preparationexamples showed good activity of 90% at application rate of 100 ppm:Compound Nos. 1-21, 1-79, 1-87, 1-113, 1-143, 1-155, 1-174, 1-198,1-230, 1-232, 1-260, 1-458, 1-505, 1-509, 1-732 and 4-35.

In this test for example, the following compounds from the preparationexamples showed good activity of 95% at application rate of 100 ppm:Compound Nos. 1-78, 1-99, 1-164, 1-173, 1-180, 1-188, 1-222, 1-224,1-254, 1-298, 1-380, 1-499, 1-504, 1-969, 1-971, 3-145, 3-149, 3-151,4-34, 4-8 and 5-143.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 100 ppm:Compound Nos. 1-3, 1-4, 1-7, 1-8, 1-30, 1-36, 1-40, 1-42, 1-81, 1-88,1-77, 1-162, 1-183, 1-220, 1-227, 1-231, 1-238, 1-243, 1-244, 1-25,1-257, 1-258, 1-285, 1-296, 1-297, 1-299, 1-301, 1-302, 1-303, 1-304,1-305, 1-307, 1-308, 1-309, 1-312, 1-313, 1-314, 1-317, 1-319, 1-327,1-329, 1-330, 1-338, 1-339, 1-340, 1-341, 1-345, 1-346, 1-347, 1-357,1-381, 1-386, 1-393, 1-404, 1-467, 1-494, 1-495, 1-500, 1-501, 1-728,1-729, 1-730, 1-733, 1-963, 1-966, 1-967, 1-968, 1-970, 2-34, 2-35,3-141, 3-142, 3-143, 3-144, 4-21, 5-142, 5-144, 6-4 and 6-267.

BIOLOGICAL TEST EXAMPLE 8 Musca domestica—Test

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith water to the desired concentration. Prior to the assay, a piece orkitchen sponge is soaked with a mixture of sugar and compound solutionand placed into a container. 10 adults (Musca domestica) are placed intothe container and closed with a perforated lid. After 2 days mortalityin % is determined. 100% means that all the flies have beer killed; 0%means that none of the flies have been killed.

In this test for example, the following compounds from the preparationexamples showed good activity of 80% at application rate of 100 ppm:Compound Nos. 1-8, 1-78, 1-304, 1-340, 1-504, 1-970, 2-69, 3-151 and6-4.

In this test for example, the following compound from the preparationexamples showed good activity of 85% at application rate of 100 ppm:Compound No. 5-4.

In this test for example, the following compounds from the preparationexamples showed good activity of 90% at application rate of 100 ppm:Compound Nos. 1-39, 1-220, 1-238, 1-499 and 4-21.

In this test for example, the following compounds from the preparationexamples showed good activity of 95% at application rate of 100 ppm:Compound Nos. 1-231, 5-150 and 5-22.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 100 ppm:Compound Nos. 1-4, 1-42, 1-81, 1-88, 1-99, 1-118, 1-143, 1-146, 1-150,1-155, 1-162, 1-183, 1-186, 1-224, 1-258, 1-285, 1-296, 1-297, 1-301,1-302, 1-305, 1-307, 1-308, 1-309, 1-312, 1-313, 1-314, 1-319, 1-327,1-329, 1-330, 1-338, 1-339, 1-341, 1-345, 1-346, 1-347, 1-357, 1-380,1-381, 1-386, 1-404, 1-467, 1-494, 1-495, 1-500, 1-501, 1-509, 1-728,1-729, 1-730, 1-963, 1-966, 1-967, 1-968, 2-34, 3-141, 3-142, 3-143,3-144, 3-148, 3-149, 3-150, 4-8, 5-142, 5-143, 5-144 and 6-267.

BIOLOGICAL TEST EXAMPLE 9 Boophilus microplus (dip)

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith water to the desired concentration. Eight to ten adult engorgedfemale Boophilus microplus ticks are placed in perforated plasticbeakers and immersed in aqueous compound solution for one minute. Ticksare transferred to a filter paper in a plastic tray. Egg deposition offertile eggs is monitored after. After 7 days mortality in % isdetermined. 100% means that all the ticks have been killed; 0% meansthat none of the ticks have been killed.

In this test for example, the following compounds from the preparationexamples showed good activity of 80% at application rate of 100 ppm:Compound Nos. 1-7, 1-77, 1-78, 1-174, 1-301, 1-305 and 1-558.

In this test for example, the following compounds from the preparationexamples showed good activity of 90% at application rate of 100 ppm:Compound Nos. 1-302 and 1-467.

In this test for example, the following compounds from the preparationexamples showed good activity of 95% at application rate of 100 ppm:Compound Nos. 1-162 and 1-164.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 100 ppm:Compound Nos. 1-3, 1-4, 1-12, 1-19, 1-25, 1-30, 1-36, 1-42, 1-74, 1-75,1-81, 1-88, 1-118, 1-143, 1-145, 1-146, 1-150, 1-155, 1-173, 1-180,1-186, 1-220, 1-224, 1-231, 1-258, 1-260, 1-285, 1-296, 1-297, 1-307,1-309, 1-312, 1-314, 1-319, 1-327, 1-329, 1-330, 1-338, 1-339, 1-340,1-341, 1-345, 1-346, 1-347, 1-357, 1-380, 1-461, 1-499, 1-500, 1-501,1-728, 1-729, 1-730, 1-732, 1-963, 3-142, 3-143, 3-144, 3-149, 5-143 and6-267.

BIOLOGICAL TEST EXAMPLE 10 Boophilus microplus—Test (Injection)

Solvent: dimethyl sulfoxide

To produce a suitable preparation of active compound, 10 mg of activecompound are dissolved in 0.5 ml solvent, and the concentrate is dilutedwith solvent to the desired concentration. Five adult engorged femaleticks (Boophilus microplus) are injected with compound solution into theabdomen. Ticks are transferred into replica plates and incubated in aclimate chamber for a period of time. Egg deposition of fertile eggs ismonitored. After 7 days mortality in % is determined. 100% means thatall eggs are infertile; 0% means that all eggs are fertile.

In this test for example, the following compounds from the preparationexamples showed good activity of 100% at application rate of 20μg/animal: Compound Nos. 1-3, 1-4, 1-7, 1-8, 1-12, 1-19, 1-24, 1-25,1-30, 1-39, 1-40, 1-42, 1-74, 1-75, 1-77, 1-78, 1-79, 1-81, 1-87, 1-88,1-97, 1-99, 1-113, 1-118, 1-141, 1-143, 1-145, 1-146, 1-150, 1-155,1-162, 1-164, 1-173, 1-174, 1-180, 1-183, 1-186, 1-188, 1-198, 1-21,1-220, 1-222, 1-224, 1-227, 1-230, 1-231, 1-232, 1-238, 1-243, 1-244,1-254, 1-257, 1-258, 1-260, 1-270, 1-285, 1-295, 1-296, 1-297, 1-298,1-299, 1-300, 1-301, 1-302, 1-303, 1-304, 1-305, 1-307, 1-308, 1-309,1-312, 1-313, 1-314, 1-317, 1-319, 1-327, 1-329, 1-330, 1-334, 1-336,1-338, 1-339, 1-340, 1-341, 1-345, 1-346, 1-347, 1-357, 1-36, 1-380,1-381, 1-386, 1-404, 1-442, 1-446, 1-458, 1-467, 1-468, 1-494, 1-495,1-499, 1-500, 1-501, 1-503, 1-504, 1-505, 1-509, 1-558, 1-694, 1-728,1-729, 1-730, 1-732, 1-733, 1-734, 1-963, 1-966, 1-967, 1-968, 1-969,1-970, 1-971, 2-34, 2-35, 2-69, 3-141, 3-142, 3-143, 3-144, 3-145,3-146, 3-148, 3-149, 3-150, 3-151, 4-21, 4-22, 4-34, 4-35, 4-8, 5-142,5-143, 5-144, 5-150, 5-22, 5-4, 6-267, 6-4, 6-802, 7-12 and 7-13.

Comparison of the Biological Activity of Compounds According to theInvention and Compounds Described in WO2008/128711

Compound No. 1-143 and the following compound which in WO2008/128711 islisted as compound No. 3-5 are tested in the Amblyomma hebraeum—test(AMBYHE) under the conditions described above.

The results are as follows

Activity at Activity at Compound No. 4 ppm 0.8 ppm No. 1-143 (accord. tothe invention 100% 100% No. 3-5 according to WO2008/128711  70%  10%

PREPARATION EXAMPLE 1 Granules

To a mixture containing 10 parts of the compound of the presentinvention (No. 1-3), 30 parts of bentonite (montmorillonite), 58 partsof talc and 2 parts of lignin sulfonate was added 25 parts of water, andthe mixture was well kneaded and granulated with 10 to 40 meshes by anextruding granulator and dried at 40 to 50° C. to obtain granules.

PREPARATON EXAMPLE 2 Granules

95 parts of clay mineral granules having particle diameter distributionwithin the range of 0.2 to 2 mm were put into a rotary mixer, and thenwetted evenly by spraying of 5 parts of the compound of the presentinvention (No. 1-3) together with a liquid diluent under rotatingcondition and dried at 40 to 50° C. to obtain granules.

PREPARATION EXAMPLE 3 Emulsion

30 parts of the compound of the present invention (No. 1-3), 55 parts ofxylene, 8 parts of polyoxyethylene alkyl phenyl ether and 7 parts ofcalcium alkylbenzenesulfonate were mixed together to obtain theemulsion.

PREPARATION EXAMPLE 4 Wettable Agent

15 parts of the compound of the present invention (No. 1-3), 80 parts ofa mixture of white carbon (hydrated amorphous silicon oxide fine powder)and powdered clay (1:5), formalin condensate of 2 parts of sodiumalkylbenzenesulfonate and 3 parts of sodium alkylnaphthalenesulfonatewere mixed together and the mixture was crushed to obtain a wettableagent.

PREPARATION EXAMPLE 5 Wettable Granules

20 parts of the active compound of the present invention (No. 1-3), 30parts of lignin sodium sulfonate, 15 parts of bentonite and 35 parts ofcalcined diatomaceous earth powder were well mixed, and after additionof water, the mixture was then extruded with a screen of 0.3 mm anddried to obtain wettable granules.

The invention claimed is:
 1. An arylpyrrolidine compound having theformula

or salts thereof, wherein A¹ represents C—Y²⁻⁴ or nitrogen; X¹, X²⁻¹,X²⁻², X²⁻³ and X²⁻⁴ each independently represents hydrogen, halogen,nitro, cyano, hydroxy, mercapto, amino, alkyl, haloalkyl, alkoxy,haloalkoxy, alkylsulfanyl, alkylsulfinyl, alkylsulfonyl,haloalkylsulfanyl, haloalkylsulfinyl, haloalkylsulfonyl, acylamino,alkoxycarbonylamino, haloalkoxycarbonylamino, alkoxyimino,haloalkoxyimino, alkylsulfonylamino, or pentafluorosulfur; Y²⁻¹, Y²⁻³,and Y²⁻⁴ each independently represents hydrogen, halogen, nitro, cyano,hydroxy, mercapto, amino, alkyl, haloalkyl, cycloalkyl, cyclohaloalkyl,alkenyl, alkynyl, alkoxy, haloalkoxy, alkylsulfanyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfanyl, haloalkylsulfinyl, haloalkylsulfonyl,alkylsulfonyloxy, haloalkylsulfonyloxy, alkylaminosulfonyl,haloalkylaminosulfonyl, dialkylaminosulfonyl,di(haloalkyl)aminosulfonyl, alkylamino, dialkylamino, acylamino,alkoxycarbonylamino, haloalkoxycarbonylamino, alkylsulfonylamino,haloalkylsulfonylamino, trialkylsilyl, alkoxyimino, haloalkoxyimino,alkoxyiminoalkyl, haloalkoxyiminoalkyl, alkylsulfinylimino,alkylsulfinyliminoalkyl, alkylsulfinyliminoalkylcarbonyl,alkylsulfoxyimino, alkylsulfoxyiminoalkyl, alkoxycarbonyl,alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, aminothiocarbonyl,alkylaminothiocarbonyl, dialkylaminocarbonyl, ordialkylaminothiocarbonyl; R³ and R⁴ each independently representshydrogen, cyano, alkyl, alkenyl, alkynyl, cycloalkyl or alkoxycarbonyl;R⁵⁻¹ represents hydrogen, amino, hydroxy, cyano, alkyl, haloalkyl,cycloalkyl, alkenyl, alkynyl, alkoxy, aminocarbonylalkyl, iminoalkyl,alkylcarbonyl, alkylcarbonylamino, alkylimino, aryl, aralkyl, aheterocycle, a heterocyclic ring substituted alkyl, R⁷—C(═O)—, orR⁷—C(═S)—; R⁶⁻¹ represents C₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl,C₁₋₄-alkoxy(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-S(C₁₋₄)alkylcarbonyl,C₁₋₄alkyl-SO(C₁₋₄)alkylcarbonyl, C₁₋₄ alkyl-SO₂(C₁₋₄)alkylcarbonyl,

R⁷ represents phenyl or a saturated or unsaturated heterocyclic ring. 2.The arylpyrrolidine compound of claim 1, wherein X¹, X²⁻¹, X²⁻², X²⁻³and X²-4 each independently represents hydrogen, halogen or haloalkyl;Y²⁻¹, Y²⁻³, and Y²⁻⁴ each independently represents hydrogen, halogen,alkyl, haloalkyl, alkoxy, cycloalkyl, haloalkoxy, alkylsulfonyl, orhaloalkylsulfinyl; R³, R⁴ each independently represents hydrogen oralkyl; R⁵⁻¹ represents hydrogen, alkyl, or haloalkyl; and R⁶⁻¹represents C₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl,C₁₋₄alkoxy(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-S(C₁₋₄)alkylcarbonyl,C₁₋₄alkyl-SO(C₁₋₄)alkylcarbonyl, C₁₋₄ alkyl-SO₂(C₁₋₄)alkylcarbonyl,


3. The arylpyrrolidine compound of claim 1, wherein X¹, Y²⁻¹, Y²⁻², Y²⁻³and X²⁻⁴ each independently represents hydrogen, halogen orC₁₋₄-haloalkyl; Y²⁻¹, Y²⁻³, and Y²⁻⁴ each independently representshydrogen, halogen, C₁₋₄-alkyl, C₁₋₄-alkoxy, C₁₋₄-haloalkoxy,C₃₋₆-cycloalkyl, C₁₋₄-haloalkyl, C₁₋₄alkylsulfanyl, orC₁₋₄-haloalkylsulfanyl; R³ or R⁴ independently of each other representshydrogen; R⁵⁻¹ represents hydrogen, C₁₋₄ alkyl or C₁₋₄-haloalkyl; andR⁶⁻¹ is selected from the group consisting of


4. The arylpyrrolidine compound of claim 2, wherein at least one of X¹,X²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ is hydrogen.
 5. The arylpyrrolidine compoundof claim 2, wherein at least one of X¹, X²⁻², and X²⁻⁴ is hydrogen. 6.The arylpyrrolidine compound of claim 2, wherein X¹ and X²⁻⁴ arehydrogen, and X²⁻¹, X²⁻², and X²⁻³ each independently is selected fromthe group consisting of CF₃, F, Cl, and Br.
 7. An arylpyrrolidinecompound having the formula

or salts thereof, wherein X¹, X²⁻¹, X²⁻², X²⁻³ and X²⁻⁴ eachindependently represents hydrogen, halogen, nitro, cyano, hydroxy,mercapto, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylsulfanyl,alkylsulfinyl, alkylsulfonyl, haloalkylsulfanyl, haloalkylsulfinyl,haloalkylsulfonyl, acylamino, alkoxycarbonylamino,haloalkoxycarbonylamino, alkoxyimino, haloalkoxyimino,alkylsulfonylamino, or pentafluorosulfur; Y²⁻³ and Y²⁻⁴ eachindependently represents hydrogen, halogen, nitro, cyano, hydroxy,mercapto, amino, alkyl, haloalkyl, cycloalkyl, cyclohaloalkyl, alkenyl,alkynyl, alkoxy, haloalkoxy, alkylsulfanyl, alkylsulfinyl,alkylsulfonyl, haloalkylsulfanyl, haloalkylsulfinyl, haloalkylsulfonyl,alkylsulfonyloxy, haloalkylsulfonyloxy, alkylaminosulfonyl,haloalkylaminosulfonyl, dialkylaminosulfonyl,di(haloalkyl)aminosulfonyl, alkylamino, dialkylamino, acylamino,alkoxycarbonylamino, haloalkoxycarbonylamino, alkylsulfonylamino,haloalkylsulfonylamino, trialkylsilyl, alkoxyimino, haloalkoxyimino,alkoxyiminoalkyl, haloalkoxyiminoalkyl, alkylsulfinylimino,alkylsulfinyliminoalkyl, alkylsulfinyliminoalkylcarbonyl,alkylsulfoxyimino, alkylsulfoxyiminoalkyl, alkoxycarbonyl,alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, aminothiocarbonyl,alkylaminothiocarbonyl, dialkylaminocarbonyl, ordialkylaminothiocarbonyl; R³ and R⁴ each independently representshydrogen, cyano, alkyl, alkenyl, alkynyl, cycloalkyl or alkoxycarbonyl;R⁵⁻¹ represents hydrogen, amino, hydroxy, cyano, alkyl, haloalkyl,cycloalkyl, alkenyl, alkynyl, alkoxy, aminocarbonylalkyl, iminoalkyl,alkylcarbonyl, alkylcarbonylamino, alkylimino, aryl, aralkyl, aheterocycle, a heterocyclic ring substituted alkyl, R⁷—C(═O)—, orR⁷—C(═S)—; R⁶⁻¹ represents C₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl,C₁₋₄alkoxy(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-S(C₁₋₄)alkylcarbonyl,C₁₋₄alkyl-SO(C₁₋₄alkylcarbonyl, C₁₋₄ alkyl-SO₂(C₁₋₄)alkylcarbonyl,

R⁷ represents phenyl or a saturated or unsaturated heterocyclic ring. 8.The arylpyrrolidine compound of claim 7, wherein X₁, X²⁻¹, X²⁻², X²⁻³and X²⁻⁴ each independently represents hydrogen, halogen or haloalkyl;Y²⁻³ and Y²⁻⁴ each independently represents hydrogen, halogen, alkyl,haloalkyl, alkoxy, cycloalkyl, haloalkoxy, alkylsulfonyl, orhaloalkylsulfinyl; R³ and R⁴ each independently represents hydrogen oralkyl; R⁵⁻¹ represents hydrogen, alkyl, or haloalkyl; and R⁶⁻¹represents C₃₋₆cycloalkyl(C₁₋₄)alkylcarbonyl,C₁₋₄alkoxy(C₁₋₄)alkylcarbonyl, C₁₋₄alkyl-S(C₁₋₄)alkylcarbonyl,C₁₋₄alkyl-SO(C₁₋₄)alkylcarbonyl, C₁₋₄ alkyl-SO₂(C₁₋₄)alkylcarbonyl,


9. The arylpyrrolidine compound of claim 7, wherein X¹, X²⁻¹, X²⁻², X²⁻³and X²⁻⁴ each independently represents hydrogen, halogen orC₁₋₄-haloalkyl; Y²⁻³ and Y²⁻⁴ each independently represents hydrogen,halogen, C₁₋₄-alkyl, C₁₋₄-alkoxy, C₁₋₄-haloalkoxy, C₃₋₆-cycloalkyl,C₁₋₄-haloalkyl, C₁₋₄-alkylsulfanyl, or C₁₋₄-haloalkylsulfanyl; R³ and R⁴independently of each other represents hydrogen; R⁵⁻¹ representshydrogen, C₁₋₄ alkyl or C₁₋₄haloalkyl; and R⁶⁻¹ is selected from thegroup consisting of


10. The arylpyrrolidine compound of claim 7, wherein at least one of X¹,X²⁻¹, X²⁻², X²⁻³ and A²⁻⁴ is hydrogen.
 11. The arylpyrrolidine compoundof claim 7, wherein at least one of X¹, X²⁻², and X²⁻⁴ is hydrogen. 12.The arylpyrrolidine compound of claim 7, wherein X¹ and X²⁻⁴ arehydrogen, and X²⁻¹, X²⁻², and X²⁻³ each independently is selected fromthe group consisting of CF₃, F, Cl, and Br.
 13. A composition comprisingone or more compounds selected from the compounds according to claim 1and one or more diluents, emulsifiers, or a combination thereof.
 14. Acomposition comprising one or more compounds selected from the compoundsaccording to claim 3 and one or more diluents, emulsifiers, or acombination thereof.
 15. A composition comprising one or more compoundsselected from the compounds according to claim 7 and one or morediluents, emulsifiers, or a combination thereof.
 16. A compositioncomprising one or more compounds selected from the compounds accordingto claim 9 and one or more diluents, emulsifiers, or a combinationthereof.
 17. A method for controlling plant damaging animal pestscomprising applying the composition according to claim 13 or 14 to saidpests, their habitat, or a combination thereof.
 18. The method of claim17, wherein the composition according to claim 14 is applied to saidpests, their habitat, or a combination thereof.
 19. A method forcontrolling parasites in or on an animal comprising administering thecomposition according to claim 15 or 16 to said animal.
 20. The methodof claim 19, wherein the composition according to claim 16 is applied tosaid animal.
 21. A method for treating seeds of conventional ortransgenic plants comprising administering the composition according toclaim 13 or 14 to said seeds.
 22. The method of claim 21, wherein thecomposition according to claim 14 is applied to said seeds.
 23. Thearylpyrrolidine compound of claim 1, wherein the compound is


24. The arylpyrrolidine compound of claim 1, wherein the compound is


25. The arylpyrrolidine compound of claim 1, wherein the compound is


26. The arylpyrrolidine compound of claim 1, wherein the compound is


27. A composition comprising any of the compounds according to any ofclaims 23-26 and one or more diluents, emulsifiers, or a combinationthereof.